EKS-MYL-00376
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MYL-00376
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK330.66.6E-9980338259
StatusUnreviewed
Ensembl ProteinENSMLUP00000014923
UniProt AccessionG1QAN8;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K10
Gene Synonyms/Alias MAP3K10;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMLUG00000016366ENSMLUP00000020771ENSMLUT00000023548
ENSMLUG00000016366ENSMLUP00000014923ENSMLUT00000016375
OrganismMyotis lucifugus
Functional Description
Protein Length928
Protein Sequence
(FASTA)
PIWTAVFDYE VTGDEELTLR RGDRVQVLSQ DCAVSGDEGW WTGRLPGGRV GVFPSDYVAP 60
PRPAGPPASL PREIPFHELQ LEEIIGVGGF GKVYRALWRG EEVAVKAARL DPERDPAVTA 120
EQVRKEARLL RSSAAPTILL LRGACLSPPH LCLVMEYARG GALSRVLAGR QVPPHVLVNW 180
AVQVARGMNY LHNEAPVPII HRDLKSINIL ILEAIENHNL ADTVLKITDF GLAREWHKTT 240
KMSAAGTYAW MAPEVIRLSL FSKSSDVWSF GVLLWELLTG EVPYREIDAL AVAYGVAMNK 300
LTLPIPSTCP EPFARLLEEC WDPDPHGRPD FSSILKQLEV IEQSALFQMP LESFHSLQED 360
WKLEIQHMFN DLRTKEKELR SREEELLRAA QEQRCQEEQL RRREQELAQR EMDIVERELH 420
LLMCQLSQEK PRVRRRKGNF RRTRLLKLRE GGSHISLPSG FEHKITVQAS PTLDKRKGSD 480
GTSPPASPSI IPRLRAIRCS GSSGSSTWGR SGPPKKEELV GGKKKGRTWG PSSTLQKEQA 540
EGEERLKALG EGSKQWSSSA PNLGKSPKHT PIAPGFASLN EMEELAEAEG NSSGPHSPHS 600
TLAYLEVPLP TQPSPGVPLP PTPTRPALGA RRRRCEFALL GCATLLGAVG LGADVAEARA 660
ADGEEQRRWL DGLFFHRAGR FPRGLSPPAR SPGRPNAASA GPGLAPSATL VSLSSVSDCN 720
STRSLLRSDS DEAAPAAPSP TPSPVAPSPN TNPLVDLELE SFKKDPRQSL TPTHVTVTAT 780
RAVNRGHRRT PSDGALGQRG APEPTGPGPA TLGSTSLTSS DPLLPGPRDP LDFPHLPTPQ 840
APFPTHLQPP EFPGRPTTLT FTPRPRPAAS RPCLDPWKRV SFGRTLSISP PNRLDAPESP 900
GPPSMQPTLL DMDMEGQSQD GTVPLCGA 928
Nucleotide Sequence
(FASTA)
CCCATCTGGA CCGCGGTGTT CGACTACGAG GTGACGGGCG ACGAGGAGCT GACCCTGCGT 60
AGGGGGGACC GGGTCCAGGT GCTGTCCCAG GACTGTGCGG TGTCGGGCGA CGAGGGCTGG 120
TGGACCGGGC GGCTCCCCGG CGGCCGGGTG GGGGTCTTCC CCAGCGACTA CGTGGCCCCG 180
CCGCGGCCGG CGGGCCCGCC GGCCTCCCTG CCGCGGGAGA TCCCCTTCCA CGAGCTGCAG 240
CTGGAGGAGA TCATCGGCGT CGGGGGCTTC GGCAAGGTCT ACCGGGCCCT GTGGCGCGGC 300
GAGGAGGTGG CCGTCAAGGC CGCCAGGCTG GACCCTGAGC GGGACCCGGC AGTGACCGCA 360
GAGCAGGTGC GCAAAGAAGC CCGGCTCCTC CGAAGCTCTG CGGCACCCAC CATCCTTTTA 420
CTCCGGGGCG CCTGCCTCAG CCCCCCGCAC CTCTGCCTGG TGATGGAGTA TGCCCGGGGG 480
GGCGCGCTGA GCAGGGTGCT GGCGGGTCGC CAGGTGCCCC CGCATGTACT GGTCAACTGG 540
GCGGTGCAGG TGGCCCGGGG CATGAACTAC CTACACAATG AGGCCCCCGT GCCCATCATC 600
CACCGGGACC TCAAGTCCAT CAACATCCTC ATTCTGGAGG CCATCGAGAA CCACAACCTC 660
GCGGACACGG TGCTCAAGAT CACGGACTTC GGCCTCGCCC GAGAGTGGCA CAAGACCACC 720
AAAATGAGCG CAGCAGGGAC TTACGCCTGG ATGGCCCCGG AGGTTATTCG TCTCTCCCTC 780
TTCTCCAAAA GCAGTGACGT CTGGAGCTTC GGGGTGCTGC TCTGGGAGCT GCTGACGGGT 840
GAGGTCCCCT ACCGTGAAAT CGACGCCTTG GCTGTGGCAT ATGGCGTGGC TATGAACAAG 900
CTGACACTGC CCATCCCCTC CACATGCCCC GAGCCCTTTG CCCGCCTACT GGAGGAGTGC 960
TGGGACCCAG ACCCCCACGG GCGGCCAGAT TTCAGCAGCA TCTTGAAGCA GCTTGAAGTC 1020
ATAGAACAGT CAGCCCTATT CCAGATGCCA CTGGAGTCCT TCCACTCACT GCAGGAAGAC 1080
TGGAAGCTGG AGATTCAGCA CATGTTCAAT GATCTCCGAA CCAAGGAGAA GGAGCTCCGC 1140
AGCCGTGAGG AGGAGCTACT GCGGGCGGCC CAGGAGCAGC GCTGCCAAGA GGAGCAGCTG 1200
CGACGGCGAG AGCAGGAGCT GGCGCAGCGT GAGATGGACA TCGTGGAGCG GGAGCTGCAC 1260
CTGCTGATGT GCCAGCTGAG CCAGGAAAAG CCCCGTGTCC GCAGACGCAA GGGCAACTTC 1320
AGGCGCACCC GCCTTCTCAA GCTGCGGGAA GGTGGCAGCC ACATCAGCCT GCCCTCTGGC 1380
TTTGAGCACA AGATCACAGT CCAGGCCTCT CCAACCTTGG ACAAGCGGAA AGGATCCGAT 1440
GGGACCAGCC CCCCCGCGAG CCCCAGCATC ATCCCCCGGC TGAGGGCCAT TCGCTGCAGC 1500
GGTAGTAGCG GCAGTAGTAC CTGGGGCCGC AGCGGGCCCC CAAAGAAGGA AGAACTGGTT 1560
GGGGGCAAGA AGAAAGGCCG GACCTGGGGG CCCAGCTCCA CCCTGCAGAA GGAGCAGGCT 1620
GAAGGAGAAG AGAGGCTGAA GGCCCTGGGG GAAGGAAGCA AACAGTGGTC ATCCAGCGCC 1680
CCCAACCTGG GCAAGTCCCC CAAACACACC CCCATTGCCC CAGGCTTCGC CAGCCTCAAT 1740
GAGATGGAGG AGCTCGCGGA GGCAGAGGGA AACAGCAGCG GGCCCCACTC CCCCCACAGC 1800
ACCCTGGCCT ACCTCGAGGT GCCGCTGCCC ACCCAGCCCT CCCCTGGGGT GCCGCTGCCC 1860
CCCACACCCA CCCGACCCGC GCTTGGCGCC CGGCGGAGGC GCTGCGAATT TGCGCTGCTG 1920
GGCTGTGCCA CGCTGCTGGG CGCGGTGGGC TTGGGCGCTG ACGTGGCGGA AGCGCGCGCA 1980
GCGGATGGTG AGGAGCAGCG GAGATGGCTC GACGGCCTCT TCTTCCACCG CGCTGGCCGC 2040
TTCCCACGGG GCCTCAGCCC GCCTGCACGC TCCCCTGGAC GCCCCAACGC AGCCTCCGCC 2100
GGCCCTGGCC TGGCGCCTTC GGCCACCCTG GTATCGCTGT CCTCCGTGTC CGACTGCAAC 2160
TCCACGCGCT CACTGCTGCG CTCCGACAGC GACGAGGCTG CGCCAGCCGC ACCCTCCCCG 2220
ACGCCCTCTC CTGTTGCGCC CTCGCCCAAC ACCAACCCCC TGGTGGATCT GGAGCTGGAG 2280
AGTTTCAAGA AGGACCCCCG CCAGTCACTG ACGCCCACCC ACGTCACAGT CACTGCCACA 2340
CGCGCTGTGA ACCGCGGGCA CCGGAGGACC CCCTCGGATG GGGCGCTAGG GCAGCGGGGG 2400
GCGCCAGAGC CCACAGGCCC TGGCCCTGCC ACCCTCGGCT CCACCTCACT CACCTCCTCT 2460
GATCCTCTCT TACCAGGCCC TCGAGATCCC CTGGACTTCC CCCACCTGCC TACACCCCAG 2520
GCTCCATTTC CCACCCACCT CCAGCCCCCC GAGTTTCCTG GCCGCCCCAC CACCCTGACC 2580
TTCACTCCGA GACCCCGGCC TGCTGCCAGC CGCCCCTGCC TGGACCCCTG GAAACGGGTC 2640
TCCTTCGGCC GGACACTCAG CATCTCGCCG CCCAATAGGC TGGACGCTCC AGAGAGCCCC 2700
GGGCCCCCCA GCATGCAGCC CACGCTGCTT GACATGGACA TGGAGGGGCA GAGCCAGGAC 2760
GGCACAGTGC CCCTGTGTGG GGCC 2784
Domain Profile
S: 2     eleeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpnii  59
         +lee+ig g fgkvy+a wr++evavK++r + e+  + ++e++++ea+ll++ + p i+
Q: 80    QLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPERdpAVTAEQVRKEARLLRSSAAPTIL  139
         789*******************************988999********************
S: 60    ellGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseap  119
          l+G+cl++p+l+lvmey++gg+Ls+vl++   r+++++vlv+wa+q+ArGm+YLh+eap
Q: 140   LLRGACLSPPHLCLVMEYARGGALSRVLAG---RQVPPHVLVNWAVQVARGMNYLHNEAP  196
         ******************************...9**************************
S: 120   kkiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvl  172
         ++iihrdLks n+L+       + ++++lki+dFG are++k+tkmsaagt+awmaPEv+
Q: 197   VPIIHRDLKSINILIleaienhNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVI  256
         ********************99999***********************************
S: 173   keekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkL  232
         + + +s++sDvwS+gv+LWellt+evPy++++ la+ay+va+++l+lpips+cpe++++L
Q: 257   RLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARL  316
         ************************************************************
S: 233   mkecwnedpekRpsfseivksl  254
         ++ecw+ dp+ Rp+fs+i+k+l
Q: 317   LEECWDPDPHGRPDFSSILKQL  338
         ******************9986
Domain Sequence
(FASTA)
QLEEIIGVGG FGKVYRALWR GEEVAVKAAR LDPERDPAVT AEQVRKEARL LRSSAAPTIL 60
LLRGACLSPP HLCLVMEYAR GGALSRVLAG RQVPPHVLVN WAVQVARGMN YLHNEAPVPI 120
IHRDLKSINI LILEAIENHN LADTVLKITD FGLAREWHKT TKMSAAGTYA WMAPEVIRLS 180
LFSKSSDVWS FGVLLWELLT GEVPYREIDA LAVAYGVAMN KLTLPIPSTC PEPFARLLEE 240
CWDPDPHGRP DFSSILKQL 259
KeywordComplete proteome; Kinase; Reference proteome; Serine/threonine-protein kinase; SH3 domain; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>
EKS-AIM-00351
EKS-ANC-00366
EKS-BOT-00379
EKS-CAJ-00382
EKS-CAF-00385
EKS-CAP-00410
EKS-FEC-00366
EKS-GOG-00369
EKS-HOS-00385
EKS-ICT-00357
EKS-LOA-00388
EKS-MOD-00368
EKS-MUM-00411
EKS-MUP-00371
EKS-NOL-00352
EKS-ORN-00485
EKS-ORC-00355
EKS-OTG-00380
EKS-PAT-00359
EKS-POA-00368
EKS-RAN-00393
EKS-SUS-00331
EKS-TEN-00479
EKS-TUT-00103
Gene Ontology
GO:0005524; F:ATP binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0000165; P:MAPK cascade
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR015785; MAPKKK9/10/11-like.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR001452; SH3_domain.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00018; SH3_1; 1.
SMARTs
SM00326; SH3; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50002; SH3; 1.
Prints
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013