EKS-MYL-00436

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00436

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	413.6	3.5E-124	5	235	231

Status

Unreviewed

Ensembl Protein

ENSMLUP00000015098

UniProt Accession

G1PUX0;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPB

Gene Synonyms/Alias

CDC42BPB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000016550	ENSMLUP00000015098	ENSMLUT00000016570

Organism

Myotis lucifugus

Functional Description

Protein Length

1621

Protein Sequence
(FASTA)

WVQEQEAQTA CFREERDVLV NGDCQWITTL HYAFQDENYL YLVMDYYVGG DLLTLLSKFE 60

DKLPEDMARF YIGEMVLAID SIHQLHYVHS NRDIKPDNVL LDANGHIRLA DFGSCLKMND 120

DGTVRSSVAV GTPDYISPEI LQAMEDGMGK YGPECDWWSL GVCMYEMLYG ETPFYAESLV 180

ETYGKIMNHE ERFQFPSHVT DVSEEAKDLM QRLICSRERR LGQNGIEDFK KHPFFQGLNW 240

ENIRNLEAPY IPDVSSPSDT SNFDVDDDVL RNIEMLPPGS HTGFSGLHLP FIGFTFTTES 300

CFSDRGSLKS MMQSSTLTKD EGVQRDLESS LQAEAYERRI RRLEQEKLEL SRKLQESTQT 360

VQSLHSSARG LGGVARDKEV KKLTEEIERL KNKIADSNKL ERQLEDAVAL RSEQEGSALR 420

LKGLEKQYRV ARQEKEDFHK QLVEASERLK SQAKELKDAH QQRKLALQEF SELSERVAEL 480

RAQKQKVSRQ LRDKEEEVEA AMQKVDSMRQ EVRKSERLRK ELEARLEDAV AEASKERKLR 540

EHSESFSKQL ESELEALKGK QGGRGPGASL EHQQEISKIK SELEKKVLFY EEELVRREAS 600

HVLEVKTVRK EVHDSESHQL ALQKEILMLK DKLEKSKRER LSEVEEAVGT VKDKLERDRA 660

VLSEENKKLA AEKERLCSFV DKLTAQNRQL EDELQDLAAK KESVAHWEAQ IAEIIQWVSD 720

EKDARGYLQA LASKMTEELE ALRSSSLGSR TLDPLWKVRR SQKLDMSARL ELQSALEAEI 780

RAKQLVQEEL RKAKDSNLSF ESKLKDSEAK NKELLEEMEI LKKKMEEKFR ADTGLKLPDF 840

QDSIFEYFNT APLAHDLTFR EAAECRASPT PRAPFPAPRV PHLPLFRRSS CPNLSVFSPQ 900

PKAHQFSIKS FSSPTQCSHC TSLMVGLLRQ GYACEVCSFA CHVSCRDSAP QVCPLPPEQA 960

RRPLGVDVQR GIGTAYKGYV KVPKPTGVKK GWQRAYAVVC DCKLFLYDLP EGKSTQPGVV 1020

ASQVLDLRDE EFSVSSVLAS DVIHASRRDI PCIFRVTASL LGSPSKTSSL LILTENENEK 1080

RKWVGILEGL QSILQKNRLR NQVVHVPQEA YDSSLPLVKA VLAAAVLDGD RIVVGLEEGL 1140

YVIEVTRDVI VRVADYKKVY QIELAPKEKV AALLCGRNHH VHLCPWSAFD GTESNVDVKL 1200

PETKGCQLLA TATLKKSAAT CLLVAVKRLV LCYEVQRTRP FHRKVTELAA PGSVQCMAVL 1260

KDKLCVGYPS GFSLLSLQGD GQALPLVNPH DPSLAFLSQQ SFDALCAVEL KSEEYLLCFS 1320

HMGLYVDPQG RRSRTQELMW PAVPVACSCS PSHVTVYSEY GVDVFDVCTM EWVQTIGLRR 1380

IRPLNTEGTL NLLNCEPPRL IYFKSKFSAG TVLNVPDTSD NSRKQMLRTR SKRRFVFKVP 1440

EEERLQQRRE MLRDPELEIQ DDFQPRTNFN HVAHMGPGDG NAGCSWTSTW PRGSFRGGAG 1500

AAASLPIEGK AAPAPAGSPA SGDAAETTGQ RGRWALTQAA PGLESLPSRP LPPPDGREGL 1560

CSAHGSPGVH LRAREAEQPD SDSTKHSTPS NSSNPSGPPS PTSPHRSQLP LEGLEPPAYD 1620

A 1621

Nucleotide Sequence
(FASTA)

TGGGTGCAGG AGCAGGAGGC ACAGACGGCG TGTTTCCGGG AGGAGCGCGA CGTGCTGGTG 60

AACGGGGACT GCCAGTGGAT CACCACCCTG CACTACGCCT TCCAGGACGA GAATTACCTG 120

TACTTGGTCA TGGATTACTA CGTGGGCGGT GACCTACTGA CCCTGCTCAG TAAGTTTGAA 180

GACAAGCTCC CCGAGGACAT GGCGCGGTTC TACATCGGGG AGATGGTGCT GGCCATCGAC 240

TCCATCCACC AGCTCCACTA CGTGCACAGC AACAGGGACA TCAAACCCGA CAACGTCCTC 300

CTGGACGCGA ACGGGCACAT CCGCCTGGCC GACTTCGGGT CGTGTCTGAA GATGAATGAT 360

GATGGGACGG TGCGGTCGTC GGTGGCCGTG GGCACGCCGG ACTACATCTC GCCGGAGATT 420

CTGCAGGCCA TGGAGGACGG CATGGGCAAG TACGGCCCCG AGTGCGACTG GTGGTCGCTG 480

GGCGTCTGCA TGTACGAGAT GCTTTACGGG GAAACGCCCT TCTACGCGGA GTCGCTTGTG 540

GAGACCTACG GAAAGATCAT GAACCACGAA GAGCGGTTCC AGTTCCCGTC CCACGTCACA 600

GATGTGTCTG AGGAGGCGAA GGACCTCATG CAGAGGCTGA TCTGCAGCAG GGAGCGCCGG 660

CTGGGCCAGA ATGGGATCGA GGACTTCAAA AAGCACCCCT TCTTCCAAGG GCTGAACTGG 720

GAAAACATAC GGAATCTGGA AGCACCTTAC ATTCCCGACG TGAGCAGTCC TTCTGACACG 780

TCCAACTTCG ACGTGGACGA CGATGTGCTG AGGAACATCG AGATGCTGCC TCCTGGCTCT 840

CACACGGGTT TCTCCGGGCT GCACTTGCCG TTCATCGGTT TCACGTTCAC CACGGAAAGC 900

TGTTTTTCTG ACCGAGGCTC TCTGAAGAGC ATGATGCAGT CCAGCACCTT AACCAAGGAC 960

GAGGGCGTGC AGCGGGACCT GGAGAGCAGC CTGCAGGCGG AGGCCTATGA GCGGAGGATC 1020

CGGAGGCTGG AGCAAGAGAA ACTGGAGCTA AGCAGGAAGC TGCAAGAGTC TACGCAGACC 1080

GTGCAGTCCC TCCACAGCTC AGCTCGGGGC CTGGGCGGTG TGGCCCGAGA TAAAGAGGTG 1140

AAAAAGCTGA CTGAGGAGAT CGAGCGCCTG AAGAATAAAA TAGCAGACTC AAATAAGCTC 1200

GAGCGACAAC TGGAGGACGC CGTGGCGCTT CGCTCGGAGC AGGAGGGTTC CGCGCTCCGG 1260

CTGAAAGGCC TGGAAAAGCA GTACCGCGTG GCGCGGCAGG AGAAGGAGGA CTTCCACAAG 1320

CAACTGGTCG AAGCGTCCGA GCGCTTGAAG TCCCAGGCCA AAGAGCTGAA AGATGCCCAC 1380

CAGCAGCGGA AGCTGGCCCT GCAGGAGTTC TCGGAGCTCA GCGAGCGCGT GGCAGAGCTG 1440

CGCGCTCAGA AGCAGAAGGT GTCCCGGCAG CTCCGCGACA AGGAGGAGGA GGTGGAGGCC 1500

GCCATGCAGA AGGTCGACTC CATGCGGCAG GAGGTCCGCA AATCCGAGAG GCTCAGGAAG 1560

GAGCTGGAAG CTCGGCTCGA GGACGCCGTG GCCGAGGCCT CCAAGGAGCG CAAGCTTCGC 1620

GAGCACAGCG AGAGCTTCTC CAAGCAACTC GAAAGCGAGC TCGAGGCCCT CAAGGGAAAG 1680

CAAGGGGGCC GGGGACCAGG GGCCTCCTTA GAGCATCAGC AAGAGATTTC CAAAATCAAG 1740

TCTGAGCTGG AGAAGAAGGT CTTGTTCTAC GAAGAGGAGC TGGTCAGACG CGAGGCCTCC 1800

CACGTGCTGG AGGTAAAAAC TGTGAGGAAG GAGGTGCATG ACTCTGAGAG CCACCAGCTG 1860

GCCCTGCAGA AGGAGATCTT AATGTTAAAA GACAAATTGG AGAAGTCAAA GCGAGAACGG 1920

CTCAGTGAGG TGGAGGAGGC AGTGGGCACC GTCAAAGACA AGTTGGAGCG AGACCGAGCC 1980

GTGCTGTCGG AGGAGAACAA GAAGCTGGCC GCCGAGAAGG AGAGGCTTTG CTCCTTCGTG 2040

GACAAGCTCA CAGCTCAGAA CAGGCAACTG GAGGACGAGC TGCAGGACCT GGCGGCCAAG 2100

AAGGAGTCGG TGGCCCACTG GGAAGCTCAG ATCGCCGAGA TCATCCAGTG GGTCAGCGAC 2160

GAGAAAGACG CGCGGGGTTA CCTCCAGGCT CTGGCTTCGA AGATGACGGA AGAGCTCGAG 2220

GCGTTGAGGA GCTCCAGCCT GGGGTCTCGA ACACTGGACC CCCTCTGGAA GGTGCGCCGC 2280

AGTCAGAAGC TGGACATGTC CGCGCGGCTG GAGCTGCAGT CGGCGCTGGA GGCCGAGATC 2340

CGGGCCAAGC AGCTGGTTCA GGAGGAGCTG AGGAAGGCCA AGGACTCGAA CCTCTCCTTT 2400

GAAAGTAAAC TAAAGGACTC GGAAGCCAAA AATAAAGAAT TATTAGAAGA AATGGAAATT 2460

TTGAAGAAGA AGATGGAAGA AAAATTTAGA GCAGATACCG GACTCAAACT TCCAGATTTT 2520

CAGGATTCTA TTTTTGAGTA TTTCAACACT GCACCGCTTG CACATGACCT GACCTTCAGA 2580

GAAGCGGCAG AATGCAGGGC GAGCCCCACT CCCCGTGCAC CGTTTCCCGC GCCTCGGGTG 2640

CCGCATCTTC CCCTTTTCAG AAGAAGTTCA TGTCCTAACT TGTCGGTGTT CTCCCCACAG 2700

CCCAAAGCCC ACCAGTTCAG CATCAAGTCC TTCTCCAGCC CCACTCAGTG CAGCCACTGC 2760

ACCTCCCTGA TGGTGGGGCT CCTCCGCCAG GGCTATGCCT GCGAGGTGTG CTCGTTCGCT 2820

TGCCACGTGT CCTGCCGAGA CAGCGCCCCC CAGGTGTGCC CCCTCCCTCC CGAGCAGGCC 2880

AGGCGGCCCC TGGGCGTGGA CGTGCAGCGG GGCATCGGGA CCGCCTACAA GGGCTACGTG 2940

AAGGTCCCGA AGCCGACGGG CGTGAAGAAG GGGTGGCAGC GGGCCTACGC CGTGGTCTGC 3000

GACTGCAAGC TCTTCCTGTA CGACCTGCCC GAGGGGAAGT CCACGCAGCC CGGCGTGGTC 3060

GCCAGCCAGG TCCTGGACCT CAGAGATGAA GAGTTCTCGG TGAGCTCAGT CCTGGCCTCT 3120

GACGTCATTC ACGCTTCACG ACGAGACATT CCGTGTATCT TCAGGGTGAC GGCCTCTCTC 3180

TTAGGTTCAC CTTCTAAGAC CAGCTCACTG CTCATTCTGA CAGAGAACGA GAACGAGAAG 3240

AGGAAGTGGG TTGGGATTCT GGAAGGACTG CAGTCCATCC TGCAGAAGAA CCGCCTGCGC 3300

AACCAGGTGG TGCACGTCCC GCAGGAGGCC TACGACTCCT CGCTGCCGCT CGTCAAGGCC 3360

GTGCTGGCGG CCGCCGTGCT GGATGGCGAC AGGATTGTGG TCGGCTTAGA AGAAGGGCTC 3420

TACGTCATCG AGGTGACCCG TGACGTGATC GTCCGCGTCG CTGACTACAA GAAAGTCTAC 3480

CAGATCGAGC TCGCCCCCAA GGAGAAGGTC GCCGCGCTCC TCTGCGGCCG GAACCACCAC 3540

GTCCACCTCT GCCCGTGGTC TGCCTTCGAC GGCACAGAAA GCAACGTGGA CGTCAAGCTT 3600

CCGGAAACGA AGGGCTGCCA GCTCCTCGCC ACGGCGACGC TGAAGAAGAG CGCGGCCACC 3660

TGCCTGCTCG TGGCGGTGAA GCGGCTGGTG CTGTGCTATG AGGTCCAGCG GACCCGGCCT 3720

TTCCACAGGA AGGTCACGGA GCTCGCGGCC CCTGGCAGCG TGCAGTGCAT GGCCGTGCTC 3780

AAGGACAAGC TCTGTGTTGG CTACCCTTCG GGGTTCTCTC TGTTGAGCCT CCAGGGAGAT 3840

GGGCAGGCCC TGCCGCTGGT AAATCCCCAT GACCCCTCGC TTGCGTTCCT CTCACAGCAG 3900

TCTTTTGACG CCCTTTGTGC TGTGGAGCTC AAAAGCGAGG AGTACCTGCT TTGCTTCAGC 3960

CACATGGGAC TGTACGTGGA CCCACAAGGC CGGAGGTCGC GCACGCAGGA GCTCATGTGG 4020

CCTGCGGTGC CTGTTGCCTG TAGTTGCAGC CCCTCGCACG TCACGGTGTA CAGCGAGTAC 4080

GGGGTGGACG TCTTCGACGT GTGCACCATG GAGTGGGTGC AGACCATCGG CCTGCGGAGG 4140

ATAAGACCGC TGAACACGGA GGGCACCCTC AACCTGCTCA ACTGTGAGCC TCCCCGCCTC 4200

ATCTACTTCA AGAGCAAGTT CTCGGCAGGA ACCGTGCTCA ATGTGCCCGA CACCTCGGAC 4260

AACAGCCGGA AGCAGATGCT GCGGACCCGG AGCAAGAGGC GGTTCGTCTT CAAGGTGCCG 4320

GAGGAGGAGA GGCTGCAGCA GCGGCGGGAG ATGCTTAGAG ACCCAGAACT TGAGATCCAG 4380

GATGATTTCC AACCCCGAAC CAACTTCAAC CACGTGGCCC ACATGGGCCC GGGCGACGGG 4440

AATGCAGGGT GCTCATGGAC CTCCACGTGG CCCAGGGGTA GTTTCAGGGG AGGGGCGGGG 4500

GCAGCTGCGT CACTGCCCAT AGAAGGAAAA GCAGCCCCTG CCCCAGCCGG CAGCCCAGCC 4560

AGTGGAGATG CTGCCGAGAC CACGGGCCAG AGGGGCCGCT GGGCTCTAAC TCAGGCAGCC 4620

CCTGGTCTTG AGAGCCTTCC CTCTCGGCCT CTCCCTCCCC CTGATGGCCG CGAGGGCCTG 4680

TGCTCAGCGC ATGGGTCCCC TGGCGTTCAC TTGCGGGCGC GTGAGGCAGA GCAGCCGGAT 4740

TCCGATTCCA CCAAACACTC AACTCCTTCC AACAGCTCCA ACCCCAGCGG CCCGCCAAGC 4800

CCCACCTCCC CCCACAGGAG CCAGCTCCCC CTTGAAGGCC TGGAGCCGCC GGCCTACGAC 4860

GCCTGA 4866

Domain Profile

S: 39    kraesaffreerdvlvkadsewivqlqyafqdekylylvmeylvGGdlltllskyedklp  98

         ++a++a+freerdvlv++d++wi++l+yafqde+ylylvm+y+vGGdlltllsk+edklp

Q: 5     QEAQTACFREERDVLVNGDCQWITTLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLP  64

         5689********************************************************

S: 99    eelarfylaelvlaldsvhelgyvh..rdikpdnilldksGhikladfGsclklnedgtv  156

         e++arfy+ e+vla+ds+h+l+yvh  rdikpdn+lld +Ghi+ladfGsclk+n+dgtv

Q: 65    EDMARFYIGEMVLAIDSIHQLHYVHsnRDIKPDNVLLDANGHIRLADFGSCLKMNDDGTV  124

         *************************999********************************

S: 157   kssvavGtpdyispevlkaleegkgeygkecdwwslGvilyellvgetpfyaeslvetys  216

         +ssvavGtpdyispe+l+a+e+g+g+yg+ecdwwslGv++ye+l+getpfyaeslvety+

Q: 125   RSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYG  184

         ************************************************************

S: 217   kilnhkeslkfpede.kvseeakdlikklltsreerlgregiedlkkhpff  266

         ki+nh+e+++fp+++ +vseeakdl+++l++sre+rlg++gied+kkhpff

Q: 185   KIMNHEERFQFPSHVtDVSEEAKDLMQRLICSRERRLGQNGIEDFKKHPFF  235

         **************99**********************************9

Domain Sequence
(FASTA)

QEAQTACFRE ERDVLVNGDC QWITTLHYAF QDENYLYLVM DYYVGGDLLT LLSKFEDKLP 60

EDMARFYIGE MVLAIDSIHQ LHYVHSNRDI KPDNVLLDAN GHIRLADFGS CLKMNDDGTV 120

RSSVAVGTPD YISPEILQAM EDGMGKYGPE CDWWSLGVCM YEMLYGETPF YAESLVETYG 180

KIMNHEERFQ FPSHVTDVSE EAKDLMQRLI CSRERRLGQN GIEDFKKHPF F 231

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50003	; PH_DOMAIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013