EKS-MYL-00017

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00017

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	533.7	7.2E-161	785	1052	268

Status

Unreviewed

Ensembl Protein

ENSMLUP00000015675

UniProt Accession

G1PWB2;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

IGF1R

Gene Synonyms/Alias

IGF1R;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000017190	ENSMLUP00000015675	ENSMLUT00000017195

Organism

Myotis lucifugus

Functional Description

Protein Length

1155

Protein Sequence
(FASTA)

CPSACGKRAC TENNECCHPE CLGGCTAPDD EAACVACKHY YHEGVCVTDC PPNTYRFEGW 60

RCVDRDFCAT IPNADSFELE GFVIHDGECM QECPSGFIRN DSLSMYCIPC EGPCPKICEE 120

DKGTKTIDSV TSAQMLQGCT IFKGNLLINI RRGNNIASEL ENFMGLIEVV TGYIKIRHSH 180

ALVSLSFFKS LRQILGEDQL EGNYSFYVLD NQNLQQLWDW DHHNLTIKSG KMYFAFNPKL 240

CVSEIYRMEE MTGAKGRQGK GDINTRNNGE RASCESDMLH FTSTNTWKNR IIVTWHRYRP 300

PDYRDLISFT VYYKEAPYKN VTEYDGQDAC GSNSWNMVDV DLPANKDMEP GILLHGLKPW 360

TQYAIYVKAV TLTMVDNDHI RGAKSDILYL RTNASVPSIP LDVISASNSS SQLIVKWNPP 420

SLPNGNLSYY IVRWQQQPQD AYLYQHNYCS KDKLPVRKYT DGTFDIEEVT ENPKAESCNT 480

PKGPCCACPK TEAEKQAEKE EAEYRKVFEN FLHNSIFVPR PDRKRRDVGQ ISNTTLSGRS 540

RNSTVTDPFN STDSDDRETD YPFFESRVDK KERTVISNLK PFTLYRIDIH SCNHEAEKLG 600

CSASNFVFAR TMPADGADDI PGPITWEVKP DNTIFLKWPE PENPNGLILM YEIKYGSQSS 660

DQRECVSRQD YRKHGGAKLQ KLSPGNYTAR IQATSLSGNG SWTEPVFFYV QDKAAFDSHA 720

HLVIALPIAI VLTVLGLALT LYIIHRKRRS NRMGNGVLYA SVNPEYFSAA DVYVPDEWEV 780

AREKITMNRE LGQGSFGMVY EGVAKGVVKD EPETRVAIKT VNESASMRER IEFLNEASVM 840

KEFNCHHVVR LLGVVSQGQP TLVIMELMPR GDLKSYLRSL RPEIENHPVL SPPTLSKMIQ 900

MAGEIADGMA YLNANKFVHR DLAARNCMVA EDLTVKIGDF GMTRDIYETD YYRKGGKGLL 960

PVRWMSPESL KDGVFTTHSD VWSFGVVLWE IATLAEQPYQ GLSNEQVLRF VMEGGLLDKP 1020

DNCPDMLFEL MQVCWHFNPK MRPSFLDIIG SIKDELEPGF IEVSFYYSDE NKPPDTEELD 1080

LDAEHLECVP LDPSASCSSL PLPERHCPHH RPENGIGHRV LVYHRASFDE RQAYAHMNGG 1140

RKNERPVPLP QSSTC 1155

Nucleotide Sequence
(FASTA)

TGCCCGAGCG CGTGCGGGAA GCGGGCGTGC ACGGAGAACA ACGAATGCTG CCACCCCGAG 60

TGCCTGGGCG GCTGCACGGC CCCCGACGAC GAGGCGGCCT GCGTGGCCTG CAAGCACTAC 120

TACCACGAGG GCGTCTGCGT GACCGACTGC CCCCCCAACA CCTACCGCTT CGAGGGCTGG 180

CGCTGCGTGG ACCGCGACTT CTGCGCCACC ATCCCCAACG CCGACAGCTT CGAGCTGGAG 240

GGCTTCGTGA TTCACGACGG CGAGTGCATG CAGGAGTGCC CCTCCGGCTT CATCCGCAAC 300

GACAGCCTGA GCATGTACTG CATCCCCTGT GAAGGGCCGT GCCCCAAAAT CTGTGAGGAA 360

GACAAGGGGA CGAAGACCAT CGACTCGGTG ACCTCGGCTC AGATGCTCCA GGGCTGCACC 420

ATCTTCAAGG GCAACCTGCT CATTAACATC CGCAGGGGCA ATAACATCGC CTCGGAACTG 480

GAGAACTTCA TGGGGCTCAT CGAGGTGGTC ACGGGCTACA TCAAGATCCG CCACTCCCAC 540

GCGCTGGTCT CCCTGTCCTT CTTCAAGAGC CTCCGCCAGA TCCTCGGCGA GGACCAGCTG 600

GAGGGGAACT ACTCCTTCTA CGTCCTGGAC AACCAGAACC TGCAGCAGCT GTGGGACTGG 660

GACCACCACA ACCTGACCAT CAAGTCCGGG AAGATGTACT TCGCCTTCAA CCCCAAGCTG 720

TGCGTGTCCG AGATCTACCG CATGGAGGAG ATGACCGGGG CCAAGGGGCG CCAGGGCAAA 780

GGCGACATCA ACACCAGGAA CAACGGCGAG CGGGCCTCCT GTGAGAGCGA CATGCTGCAC 840

TTCACCTCCA CCAACACCTG GAAGAACCGC ATCATCGTCA CGTGGCACCG GTACCGGCCC 900

CCAGACTACA GGGACCTCAT CAGCTTCACC GTCTACTACA AGGAAGCGCC CTACAAGAAC 960

GTCACCGAGT ACGACGGCCA GGACGCCTGC GGCTCCAACA GCTGGAACAT GGTGGACGTG 1020

GACCTGCCGG CCAACAAGGA CATGGAGCCC GGCATCCTGC TGCACGGCCT GAAGCCCTGG 1080

ACGCAGTACG CCATCTACGT GAAGGCCGTG ACGCTGACCA TGGTGGACAA CGACCACATC 1140

CGCGGGGCCA AGAGCGACAT CCTCTACCTC CGCACCAACG CCTCAGTGCC TTCCATCCCC 1200

CTGGACGTCA TCTCCGCCTC CAACTCGTCC TCCCAGCTGA TCGTCAAGTG GAACCCGCCC 1260

TCCCTGCCCA ACGGCAACCT GAGCTACTAC ATCGTGCGCT GGCAGCAGCA GCCGCAGGAC 1320

GCCTACCTGT ACCAGCACAA CTACTGCTCC AAAGACAAGC TCCCCGTCCG CAAGTACACG 1380

GACGGCACCT TCGACATCGA GGAGGTGACG GAGAACCCCA AGGCCGAGTC GTGCAACACG 1440

CCCAAGGGGC CCTGCTGCGC GTGTCCCAAA ACCGAGGCCG AGAAGCAGGC GGAGAAGGAG 1500

GAGGCCGAGT ACCGCAAAGT CTTCGAGAAC TTCCTGCACA ACTCCATCTT CGTGCCCAGG 1560

CCCGACAGGA AGCGCAGGGA CGTGGGGCAG ATCTCCAACA CCACCCTTTC CGGCCGGAGC 1620

AGGAACAGCA CGGTGACGGA CCCCTTCAAC AGCACGGACT CGGACGACAG GGAGACGGAC 1680

TACCCTTTCT TCGAGAGCAG GGTGGACAAG AAGGAGAGGA CCGTCATCTC CAACCTGAAG 1740

CCCTTCACCC TCTACCGCAT CGACATCCAC AGCTGCAACC ACGAGGCCGA GAAGCTGGGC 1800

TGCAGCGCCT CCAACTTCGT CTTTGCGAGA ACCATGCCTG CAGACGGAGC GGATGACATT 1860

CCCGGGCCGA TAACCTGGGA GGTGAAGCCT GACAACACCA TCTTCTTAAA GTGGCCCGAA 1920

CCGGAGAATC CCAATGGACT GATTCTCATG TACGAGATAA AGTACGGATC GCAGTCGAGC 1980

GACCAGCGGG AGTGCGTGTC GCGGCAGGAC TACCGGAAGC ACGGCGGGGC CAAGCTGCAG 2040

AAGCTCAGCC CGGGCAACTA CACGGCCCGC ATCCAGGCCA CCTCTCTGTC GGGGAACGGG 2100

TCCTGGACGG AGCCCGTGTT CTTCTACGTC CAGGACAAAG CAGCGTTTGA CAGCCACGCC 2160

CACCTGGTCA TCGCGCTGCC CATCGCCATC GTGCTGACCG TCTTGGGGCT GGCCCTCACG 2220

CTGTACATCA TCCACCGGAA GCGGCGCAGT AATCGGATGG GCAATGGAGT GCTGTACGCC 2280

TCTGTGAACC CGGAGTATTT CAGCGCGGCC GACGTGTACG TGCCCGACGA GTGGGAGGTG 2340

GCCCGGGAGA AGATCACCAT GAACCGGGAG CTGGGCCAGG GCTCCTTCGG CATGGTGTAC 2400

GAGGGCGTGG CCAAGGGCGT GGTCAAGGAC GAGCCGGAAA CCCGGGTGGC CATCAAGACC 2460

GTCAACGAGT CGGCCAGCAT GCGGGAGCGG ATCGAGTTCC TCAACGAGGC TTCGGTGATG 2520

AAGGAGTTCA ACTGTCACCA CGTGGTGCGT TTGCTGGGCG TGGTGTCCCA GGGCCAGCCG 2580

ACCCTGGTCA TCATGGAGCT CATGCCCCGC GGAGACCTCA AGAGTTACCT CAGGTCTCTG 2640

AGACCGGAAA TCGAGAATCA CCCCGTCCTC TCACCGCCAA CCCTCAGCAA GATGATCCAG 2700

ATGGCCGGGG AGATCGCGGA CGGCATGGCG TACCTCAACG CCAACAAGTT CGTCCATAGA 2760

GACCTTGCTG CCCGGAACTG CATGGTGGCT GAAGATTTGA CCGTCAAGAT CGGAGACTTC 2820

GGCATGACTC GCGACATCTA CGAGACCGAC TATTACCGGA AGGGCGGGAA GGGGCTGCTT 2880

CCTGTGCGCT GGATGTCCCC CGAGTCCCTC AAGGACGGCG TGTTCACCAC CCACTCTGAT 2940

GTCTGGTCCT TTGGCGTCGT GCTCTGGGAG ATCGCCACGC TGGCCGAGCA GCCCTACCAA 3000

GGCCTGTCCA ACGAGCAGGT CCTGCGCTTC GTCATGGAGG GCGGCCTTCT GGACAAGCCC 3060

GACAACTGCC CCGACATGCT GTTCGAGCTC ATGCAGGTGT GCTGGCACTT CAACCCCAAG 3120

ATGAGGCCTT CGTTCCTGGA CATCATTGGC AGCATCAAGG ACGAGCTGGA GCCCGGCTTC 3180

ATCGAGGTGT CCTTCTACTA CAGCGACGAG AACAAGCCGC CCGACACCGA GGAGCTGGAC 3240

CTGGACGCCG AACACCTGGA GTGCGTGCCC CTGGACCCCT CGGCCTCCTG CTCCTCCCTG 3300

CCGCTGCCCG AGCGCCACTG CCCGCACCAC CGCCCCGAGA ACGGCATTGG CCACCGCGTG 3360

CTGGTCTACC ACCGGGCCAG CTTCGACGAG AGGCAGGCGT ACGCGCACAT GAATGGGGGG 3420

CGCAAGAACG AGAGGCCCGT GCCTCTGCCG CAGTCCTCCA CCTGCTGA 3468

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+++relGqGsfGmvyeGvak+vvk+e etrvaiktvne+as+reriefl+easvmkef+

Q: 785   ITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNESASMRERIEFLNEASVMKEFN  844

         799*********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvs+gqp+lv+melm +Gdlksylrslrpe en+++l+pp+l+k+iqma+e

Q: 845   CHHVVRLLGVVSQGQPTLVIMELMPRGDLKSYLRSLRPEIENHPVLSPPTLSKMIQMAGE  904

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+a+kfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw

Q: 905   IADGMAYLNANKFVHRDLAARNCMVAEDLTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  964

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         mspeslkdGvft++sdvwsfGvvlwei+tlaeqpyqGlsneqvl+fv++gg+l+kp+ncp

Q: 965   MSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCP  1024

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

         ++l+elm++cw++npk+rpsfl+i+ ++

Q: 1025  DMLFELMQVCWHFNPKMRPSFLDIIGSI  1052

         ************************9875

Domain Sequence
(FASTA)

ITMNRELGQG SFGMVYEGVA KGVVKDEPET RVAIKTVNES ASMRERIEFL NEASVMKEFN 60

CHHVVRLLGV VSQGQPTLVI MELMPRGDLK SYLRSLRPEI ENHPVLSPPT LSKMIQMAGE 120

IADGMAYLNA NKFVHRDLAA RNCMVAEDLT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180

MSPESLKDGV FTTHSDVWSF GVVLWEIATL AEQPYQGLSN EQVLRFVMEG GLLDKPDNCP 240

DMLFELMQVC WHFNPKMRPS FLDIIGSI 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 1.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013