EKS-MYL-00174

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00174

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	495.3	3.3E-149	453	711	259

Status

Unreviewed

Ensembl Protein

ENSMLUP00000015787

UniProt Accession

G1PWK5;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

PRKG2

Gene Synonyms/Alias

PRKG2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000017311	ENSMLUP00000015787	ENSMLUT00000017318

Organism

Myotis lucifugus

Functional Description

Protein Length

762

Protein Sequence
(FASTA)

MGNGSVKPKH PKHPDGHSGN LTYNALQSKV AELERELRRK DAEIQEREYH LKELREQLSK 60

QTVAIAELTE ELQNKCIQLN KLQDVVHIQG GSLLQASPER IPLEVHRKSS GLVSLHSRRG 120

AKAGVSAEPT TRTYDLNKPP EFSFEKARVR KDSSEKKLIT DALNKNQFLK RLDPQQIKDM 180

VECMYGRNYQ QGSYIIKQGE PGNHIFVLAE GRVEVFQGEK LISCIPMWTT FGELAILYNC 240

TRTASVKALT NVKTWALDRE VFQNIMRRTA QARDEQYRNF LRSVSLLKNL PEDKLTKIID 300

CLEVEYYDKG DYIIREGEEG STFFILAKGT VKVTQSTEGH DQPQVIKTLQ KGEYFGEKAL 360

ISEDVRSANI VAEENDVACL VIDRETFNQT VGTFEELQKY LEGYVANLNR DDEKRHAKRS 420

MSHRNLSKAL SLEMIQLKEK VARFSSSSPF QNLEIIATLG VGGFGRVELV KVKNENVAFA 480

MKCIRKKHIV DTKQQEHVYS EKRILEELCS PFVVKLYRTF KDNKYVYMLL EACLGGELWS 540

ILRDRGSFDE PTSKFCVACV TEAFDYLHRL GIIYRDLKPE NLILDAEGYL KLVDFGFAKK 600

IGSGQKTWTF CGTPEYVAPE VILNKGHDFS VDFWSLGILV YELLTGNPPF SGTDQMMTYN 660

LILKGIEKMD FPRKITRKPE DLIRRLCRQN PTERLGNLKN GINDIKKHRW LSGFNWEGLK 720

ARNLPSPLRR ELSGPTDHSY FDKYPPEKGI PPDELSGWDK DF 762

Nucleotide Sequence
(FASTA)

ATGGGAAATG GTTCAGTGAA ACCCAAACAT CCCAAGCATC CAGATGGCCA CTCCGGGAAC 60

CTCACCTACA ATGCCCTGCA GAGCAAGGTG GCAGAGCTGG AGAGAGAGCT GAGGAGGAAG 120

GATGCCGAGA TCCAGGAGCG GGAGTACCAT CTGAAGGAAC TGCGGGAGCA GCTGTCGAAG 180

CAGACCGTGG CCATCGCGGA GCTCACGGAG GAGCTGCAGA ACAAGTGCAT CCAGCTGAAC 240

AAGCTGCAGG ATGTGGTGCA CATCCAGGGC GGCAGCCTGC TTCAGGCCTC TCCAGAGAGG 300

ATCCCCCTGG AGGTGCACCG GAAGTCCTCG GGGCTGGTCT CTCTCCACAG CAGGAGGGGA 360

GCAAAGGCTG GGGTGTCTGC CGAGCCAACA ACCCGAACCT ATGACCTCAA CAAACCCCCG 420

GAATTTTCCT TTGAGAAAGC AAGAGTCAGG AAGGATTCCA GTGAGAAGAA GCTCATTACA 480

GATGCTCTCA ATAAAAATCA GTTTTTGAAG AGACTGGATC CTCAGCAAAT CAAAGACATG 540

GTGGAATGCA TGTATGGAAG AAACTACCAG CAAGGGAGTT ACATTATTAA GCAGGGAGAA 600

CCAGGAAACC ACATCTTTGT GTTGGCAGAG GGCCGAGTAG AGGTGTTTCA AGGGGAGAAA 660

TTGATATCAT GCATTCCTAT GTGGACCACG TTCGGGGAAC TAGCCATTTT ATACAACTGT 720

ACAAGGACCG CCTCTGTGAA AGCTCTTACC AATGTTAAAA CTTGGGCACT AGATCGAGAG 780

GTATTCCAGA ATATAATGAG AAGGACGGCT CAAGCTAGAG ATGAACAGTA CAGAAACTTC 840

CTCAGAAGTG TATCCTTGCT GAAGAACTTA CCTGAAGACA AGTTAACCAA GATCATTGAC 900

TGCTTGGAAG TGGAATACTA TGACAAAGGA GATTACATTA TTCGAGAAGG CGAGGAAGGA 960

AGTACCTTTT TCATTTTAGC CAAAGGAACG GTAAAAGTCA CCCAGAGTAC AGAGGGCCAC 1020

GATCAACCAC AAGTGATAAA AACACTGCAG AAAGGAGAAT ACTTTGGAGA AAAAGCTCTT 1080

ATCAGTGAAG ATGTCAGATC AGCGAACATT GTTGCTGAGG AAAATGATGT CGCATGCCTG 1140

GTTATAGATC GAGAAACATT CAACCAAACA GTTGGGACTT TTGAAGAACT CCAAAAATAC 1200

CTTGAAGGGT ATGTGGCAAA CCTGAACCGT GATGATGAAA AAAGACATGC AAAGAGATCC 1260

ATGTCTCACC GGAACCTGTC CAAAGCGCTC TCTCTGGAGA TGATTCAGCT GAAGGAGAAG 1320

GTGGCCAGAT TTTCCTCATC GTCCCCATTC CAGAACCTTG AGATTATCGC CACACTGGGC 1380

GTTGGTGGGT TCGGAAGAGT TGAGCTTGTT AAAGTAAAAA ATGAGAATGT TGCTTTTGCT 1440

ATGAAGTGCA TAAGGAAGAA GCACATAGTG GATACTAAGC AACAGGAGCA TGTCTACTCC 1500

GAGAAGAGGA TCCTGGAGGA GCTGTGTTCT CCCTTCGTTG TGAAATTGTA TCGTACTTTC 1560

AAGGACAATA AGTATGTATA CATGCTTCTG GAAGCCTGCT TAGGTGGGGA GCTATGGAGT 1620

ATATTAAGGG ACAGAGGCAG CTTTGATGAA CCCACCTCCA AGTTCTGCGT GGCTTGTGTG 1680

ACTGAAGCAT TTGATTACCT GCATCGACTA GGTATTATCT ACAGAGACCT GAAGCCAGAA 1740

AACTTAATTC TGGATGCTGA GGGCTATCTG AAATTGGTTG ACTTTGGATT TGCTAAGAAA 1800

ATAGGATCTG GACAGAAAAC ATGGACATTC TGTGGGACCC CAGAGTATGT AGCCCCTGAA 1860

GTCATTCTCA ACAAAGGCCA CGACTTCAGT GTGGATTTCT GGTCCCTGGG GATTCTAGTG 1920

TATGAGCTCC TGACTGGCAA CCCGCCCTTT TCCGGGACTG ACCAAATGAT GACCTACAAT 1980

TTGATTCTCA AAGGAATTGA AAAAATGGAT TTTCCCAGAA AAATAACAAG AAAACCTGAG 2040

GATTTGATTA GGAGGCTTTG CAGGCAAAAT CCAACAGAAA GGCTGGGAAA TCTGAAGAAT 2100

GGAATCAATG ACATTAAGAA ACACAGGTGG TTAAGTGGTT TTAATTGGGA GGGACTGAAA 2160

GCACGGAACC TTCCATCACC TTTACGAAGA GAGCTCAGTG GACCCACAGA TCACAGCTAC 2220

TTTGACAAGT ATCCACCTGA AAAAGGAATA CCTCCAGATG AGCTGTCAGG CTGGGATAAA 2280

GACTTCTGA 2289

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l++iatlgvggfgrvelvkvk+ e+ afa+k+++kkhivdtkqqehv+sekrilee++s+

Q: 453   LEIIATLGVGGFGRVELVKVKN-ENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSP  511

         689******************9.999**********************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         f+vklyrtfkd+kyvy+lleaclggelw+ilrdrgsfd+ t+kf+vacv+ea++ylh+ +

Q: 512   FVVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLG  571

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         iiyrdlkpenl+ld+egylklvdfgfakk++sg+ktwtfcgtpeyvape+ilnkghd+sv

Q: 572   IIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSV  631

         ************************************************************

S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240

         d+w+lgilvyelltg+ppfsg+d+++tynlilkgi+k+++prkit+++edli++lcr+np

Q: 632   DFWSLGILVYELLTGNPPFSGTDQMMTYNLILKGIEKMDFPRKITRKPEDLIRRLCRQNP  691

         ************************************************************

S: 241   aerlgylkggikdikkhkwf  260

         +erlg+lk+gi+dikkh+w+

Q: 692   TERLGNLKNGINDIKKHRWL  711

         *******************7

Domain Sequence
(FASTA)

LEIIATLGVG GFGRVELVKV KNENVAFAMK CIRKKHIVDT KQQEHVYSEK RILEELCSPF 60

VVKLYRTFKD NKYVYMLLEA CLGGELWSIL RDRGSFDEPT SKFCVACVTE AFDYLHRLGI 120

IYRDLKPENL ILDAEGYLKL VDFGFAKKIG SGQKTWTFCG TPEYVAPEVI LNKGHDFSVD 180

FWSLGILVYE LLTGNPPFSG TDQMMTYNLI LKGIEKMDFP RKITRKPEDL IRRLCRQNPT 240

ERLGNLKNGI NDIKKHRWL 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013