EKS-MYL-00286

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MYL-00286

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	397.5	3.3E-119	244	537	294

Status

Unreviewed

Ensembl Protein

ENSMLUP00000015965

UniProt Accession

G1PX13;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2

Gene Synonyms/Alias

TGFBR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMLUG00000017507	ENSMLUP00000015965	ENSMLUT00000017512

Organism

Myotis lucifugus

Functional Description

Protein Length

567

Protein Sequence
(FASTA)

AGAFLARGGW IMQKIKWSLV IVTLYLFFPS TVNSDVMITD NNGALKFSQL CKFCDVRSST 60

CDNQKSCRSN CSITSICEKP NEVCVAVWRK NDENITLETV CHDPALVYHG FVLEDAASPK 120

CIMKEKKVDG ETFFMCSCNT DECNDHIIFS EEYSTNNPDL MLVIFQVTGV SLLPPLVIAI 180

AVIIIFYCYR VHRKQKLTPS WETSKPRKLM DLSERLAIII EDDRSDISST CANNINHNTE 240

LLPIELDTLV GKGRFAEVYK AKLKQNTSEQ FETVAVKIFP YEEYASWKME KDIFSDINLK 300

HENILQFLTA EERKTELGKQ YWLITAFHAK GNLQEYLTRH VISWEDLCKL GSSLARGIAH 360

LHSDHTLCGR PKMPIVHRDL KSSNILVKND LTCCLCDFGL SLRLDPTLSV DDLANSGQVG 420

TARYMAPEVL ESRMNLENVE SFKQTDVYSM ALVLWEMTSR CNAVGEVKEY EPPFGSKVRE 480

HPCVESMKDN VLRDRGRPEI PSSWLNHQGI QMVCETLTEC WDHDPEARLT AQCVAERFSE 540

LEHLDRLSGR SCSEEKIPED GSLGTTK 567

Nucleotide Sequence
(FASTA)

GCAGGAGCAT TCTTAGCGAG AGGAGGTTGG ATTATGCAGA AGATAAAATG GAGTCTGGTC 60

ATTGTTACTT TGTATCTTTT TTTCCCCTCC ACAGTTAATA GTGATGTGAT GATCACCGAC 120

AACAATGGTG CACTCAAGTT TTCACAATTG TGTAAATTCT GTGACGTGAG ATCTTCCACC 180

TGTGACAACC AGAAATCATG CAGGAGCAAC TGCAGTATCA CATCCATCTG TGAGAAGCCC 240

AATGAAGTCT GTGTGGCCGT CTGGAGGAAA AACGATGAGA ACATAACACT AGAGACGGTC 300

TGCCACGACC CCGCGCTCGT CTACCATGGG TTTGTTCTTG AAGATGCCGC TTCTCCAAAG 360

TGTATTATGA AAGAGAAGAA AGTGGATGGC GAGACTTTCT TCATGTGTTC CTGCAACACG 420

GACGAGTGCA ATGACCACAT CATCTTTTCA GAGGAATATT CCACCAACAA CCCTGACTTA 480

ATGTTAGTCA TATTCCAAGT GACAGGCGTC AGCCTCCTGC CACCACTGGT CATCGCCATT 540

GCCGTCATCA TCATCTTCTA CTGCTACCGT GTCCACCGGA AGCAGAAGCT GACCCCGTCC 600

TGGGAGACCA GCAAGCCACG GAAGCTCATG GACCTCAGTG AGCGCCTGGC CATCATCATA 660

GAAGATGACC GCTCCGACAT CAGCTCCACG TGTGCCAACA ACATCAACCA CAACACGGAG 720

CTGCTGCCCA TTGAGCTGGA CACCCTGGTG GGGAAAGGTC GCTTTGCCGA GGTCTACAAG 780

GCCAAGCTGA AGCAGAACAC TTCAGAGCAG TTCGAGACCG TGGCAGTCAA GATCTTCCCT 840

TATGAGGAGT ACGCCTCCTG GAAGATGGAG AAAGACATCT TCTCAGACAT CAACCTGAAG 900

CATGAGAACA TCCTCCAGTT CCTGACGGCC GAGGAGCGGA AGACGGAGTT GGGGAAGCAG 960

TACTGGCTGA TCACTGCTTT CCATGCCAAG GGCAACCTAC AGGAGTATCT CACGAGACAC 1020

GTCATCAGCT GGGAGGACCT GTGCAAGCTG GGCAGCTCCC TGGCCAGGGG CATAGCTCAC 1080

CTGCACAGTG ACCACACCCT GTGCGGGAGG CCCAAGATGC CCATCGTGCA CAGGGACCTC 1140

AAGAGTTCCA ATATCCTGGT GAAGAACGAC CTGACCTGCT GCCTGTGTGA CTTTGGGCTT 1200

TCCCTGCGTC TGGACCCCAC TCTGTCTGTG GATGACTTGG CCAACAGTGG GCAGGTGGGA 1260

ACTGCAAGAT ACATGGCCCC GGAAGTCTTA GAGTCCAGGA TGAACTTGGA GAATGTCGAG 1320

TCCTTCAAGC AGACGGACGT CTACTCCATG GCTCTGGTGC TCTGGGAGAT GACGTCCCGC 1380

TGCAATGCGG TGGGAGAAGT GAAAGAGTAT GAGCCTCCTT TTGGTTCCAA AGTGCGGGAG 1440

CATCCCTGTG TCGAAAGCAT GAAGGACAAT GTGTTGAGAG ATCGGGGACG ACCGGAAATT 1500

CCTAGCTCCT GGCTCAACCA CCAGGGCATC CAGATGGTGT GTGAGACTCT GACTGAGTGC 1560

TGGGACCACG ACCCAGAAGC CCGGCTCACG GCCCAGTGTG TGGCCGAGCG CTTCAGCGAG 1620

CTGGAACACC TGGACAGACT CTCGGGGAGG AGCTGCTCCG AGGAGAAGAT TCCCGAAGAT 1680

GGCTCGCTGG GCACCACCAA ATAG 1704

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr++eV+kakl++      e+vAvKif++e+ aswk Ek+i++ ++l+hen

Q: 244   IELDTLVGKGRFAEVYKAKLKQntseqfETVAVKIFPYEEYASWKMEKDIFSDINLKHEN  303

         678899***************99999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         ilqf++a+++++++ ++++l+t++h kg+L++yL+r+++++e+l++l +sla+G+ahLH+

Q: 304   ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLCKLGSSLARGIAHLHS  363

         ************************************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + ++ +g+ K+ i+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt

Q: 364   D-HTLCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA  422

         *.7888******************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc++  +ev+ey++pf ++v+++

Q: 423   RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNA-VGEVKEYEPPFGSKVREH  481

         *****************************************.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         P++e+mk+ v++++ rP+ip++w +++ +++++++l+ecWd+dpeaRlta++v++r

Q: 482   PCVESMKDNVLRDRGRPEIPSSWLNHQGIQMVCETLTECWDHDPEARLTAQCVAER  537

         *****************************************************987

Domain Sequence
(FASTA)

IELDTLVGKG RFAEVYKAKL KQNTSEQFET VAVKIFPYEE YASWKMEKDI FSDINLKHEN 60

ILQFLTAEER KTELGKQYWL ITAFHAKGNL QEYLTRHVIS WEDLCKLGSS LARGIAHLHS 120

DHTLCGRPKM PIVHRDLKSS NILVKNDLTC CLCDFGLSLR LDPTLSVDDL ANSGQVGTAR 180

YMAPEVLESR MNLENVESFK QTDVYSMALV LWEMTSRCNA VGEVKEYEPP FGSKVREHPC 240

VESMKDNVLR DRGRPEIPSS WLNHQGIQMV CETLTECWDH DPEARLTAQC VAER 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013