EPS-MAM-00132

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MAM-00132

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP5	621.8	3.0E-187	185	496	312

Status

Unreviewed

Ensembl Protein

ENSMMUP00000000309

UniProt Accession

F6XI05;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP5C

Gene Synonyms/Alias

PPP5C; EGK_10788;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000000217	ENSMMUP00000000309	ENSMMUT00000000328
ENSMMUG00000000217	ENSMMUP00000000308	ENSMMUT00000000327
ENSMMUG00000000217	ENSMMUP00000031561	ENSMMUT00000038462

Organism

Macaca mulatta

Functional Description

Protein Length

499

Protein Sequence
(FASTA)

MAMAEGERTE CAEPPRDEHP ADGALKRAEE LKTQANDYFK AKDYENAIKF YSQAIELNPS 60

NAIYYGNRSL AYLRTECYGY ALGDATRAIE LDKKYIKGYY RRAASNMALG KFRAALRDYE 120

TVVKVKPHDK DAKMKYQECN KIVKQKAFER AIAGDEHKRS VVDSLDIESM TIEDEYSGPK 180

LEDGKVTITF MKELMQWYKD QKKLHRKCAY QILVQVKEVL SKLSTLVETT LKETEKITVC 240

GDTHGQFYDL LNIFELNGLP SETNPYIFNG DFVDRGSFSV EVILTLFGFK LLYPDHFHLL 300

RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL AQCINGKVLI MHGGLFSEDG 360

VTLDDIRKIE RNRQPPDSGP MCDLLWSDPQ PQNGRSVSKR GVSCQFGPDV TKAFLEENNL 420

DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN YCDQMGNKAS YIHLQGSDLR PQFHQFTAVP 480

HPNVKPMAYA NTLLQLGMM 499

Nucleotide Sequence
(FASTA)

ATGGCGATGG CGGAGGGCGA GCGGACTGAG TGTGCTGAGC CCCCCCGGGA CGAGCACCCG 60

GCTGATGGCG CTCTGAAGCG GGCAGAGGAG CTCAAGACTC AGGCCAATGA CTACTTCAAA 120

GCCAAGGACT ATGAGAACGC CATCAAGTTC TACAGCCAGG CCATCGAGCT GAACCCCAGC 180

AATGCCATCT ACTATGGCAA CCGCAGCCTG GCCTACCTGC GCACCGAGTG CTATGGCTAC 240

GCACTGGGAG ATGCCACGCG GGCCATCGAG CTGGACAAGA AATACATCAA GGGTTATTAC 300

CGCCGGGCTG CCAGCAACAT GGCACTGGGC AAGTTCCGGG CCGCGCTGCG AGACTACGAG 360

ACGGTTGTCA AGGTGAAGCC CCACGACAAG GACGCCAAAA TGAAATACCA GGAGTGCAAC 420

AAGATCGTGA AGCAGAAGGC CTTTGAGCGG GCCATCGCGG GCGACGAGCA CAAGCGCTCC 480

GTGGTGGACT CACTGGACAT CGAGAGCATG ACCATTGAGG ATGAGTACAG CGGACCCAAG 540

CTTGAGGATG GCAAAGTGAC AATCACTTTC ATGAAGGAGC TCATGCAGTG GTACAAGGAC 600

CAGAAAAAAC TGCACCGGAA ATGCGCCTAC CAGATTCTGG TACAGGTCAA AGAGGTCCTC 660

TCCAAGCTGA GCACGCTCGT GGAAACCACA CTCAAAGAGA CAGAGAAGAT TACAGTATGC 720

GGGGACACCC ATGGCCAGTT CTATGACCTC CTCAACATAT TCGAGCTCAA CGGTTTACCC 780

TCGGAGACCA ACCCCTATAT ATTTAATGGT GACTTTGTGG ACCGAGGCTC CTTCTCTGTA 840

GAAGTGATCC TCACCCTTTT CGGCTTCAAG CTCCTGTACC CAGATCACTT TCACCTACTT 900

CGAGGCAACC ACGAGACAGA CAACATGAAC CAGATCTACG GTTTCGAGGG TGAGGTGAAG 960

GCCAAGTACA CAGCCCAGAT GTACGAGCTC TTTAGCGAGG TGTTCGAGTG GCTCCCGTTG 1020

GCCCAGTGCA TCAACGGCAA AGTGCTGATC ATGCACGGAG GCCTGTTCAG TGAAGATGGC 1080

GTCACCCTGG ATGACATCCG GAAAATCGAG CGAAATCGAC AACCCCCCGA TTCAGGTCCC 1140

ATGTGTGACC TGCTCTGGTC AGATCCACAG CCGCAGAACG GGCGCTCGGT CAGCAAGCGG 1200

GGCGTGAGCT GTCAGTTTGG GCCTGACGTC ACCAAGGCCT TCTTGGAAGA GAACAACCTG 1260

GACTACATCA TCCGCAGCCA CGAGGTCAAG GCCGAGGGCT ATGAGGTGGC TCACGGAGGC 1320

CGCTGTGTCA CCGTCTTCTC TGCCCCCAAC TACTGCGACC AGATGGGGAA CAAAGCCTCC 1380

TACATCCACC TCCAGGGCTC CGACCTACGG CCTCAGTTCC ACCAGTTCAC AGCAGTGCCT 1440

CATCCCAACG TCAAGCCCAT GGCCTACGCC AACACGCTGC TGCAGCTAGG AATGATGTGA 1500

Domain Profile

S: 2     kvsiefikklvndlklkkkllrkkavailvsvadvlfklevelennskedvkitvcGdth  61

         kv+i f+k+l++++k++kkl+rk+a++ilv+v++vl+kl++++e+++ke++kitvcGdth

Q: 185   KVTITFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTH  244

         799*********************************************************

S: 62    GqfydllnifelnGlpseknpylfnGdfvdrGsfsveviltlfglkllyPdhffllrGnh  121

         GqfydllnifelnGlpse+npy+fnGdfvdrGsfsveviltlfg+kllyPdhf+llrGnh

Q: 245   GQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNH  304

         ************************************************************

S: 122   esdnmnkiyGfegevkakytaklyelfaevfewlPlaqlingkvlvmhGGlfsedgvtld  181

         e+dnmn+iyGfegevkakyta++yelf+evfewlPlaq+ingkvl+mhGGlfsedgvtld

Q: 305   ETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLD  364

         ************************************************************

S: 182   dirkiernaqPPeeGalcellWsdPqeanGrgvskrGvglqfGpdvtkrfleenkldyii  241

         dirkiern+qPP++G++c+llWsdPq++nGr+vskrGv++qfGpdvtk+fleen+ldyii

Q: 365   DIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSVSKRGVSCQFGPDVTKAFLEENNLDYII  424

         ************************************************************

S: 242   rshevkaegveveqkgklvtvfsapnycdsqgnlasvihvrnddlrliietfeavehpdv  301

         rshevkaeg+ev+++g++vtvfsapnycd++gn+as+ih++++dlr+++++f+av+hp+v

Q: 425   RSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNV  484

         ************************************************************

S: 302   kpmaysngllgl  313

         kpmay+n+ll+l

Q: 485   KPMAYANTLLQL  496

         *********997

Domain Sequence
(FASTA)

KVTITFMKEL MQWYKDQKKL HRKCAYQILV QVKEVLSKLS TLVETTLKET EKITVCGDTH 60

GQFYDLLNIF ELNGLPSETN PYIFNGDFVD RGSFSVEVIL TLFGFKLLYP DHFHLLRGNH 120

ETDNMNQIYG FEGEVKAKYT AQMYELFSEV FEWLPLAQCI NGKVLIMHGG LFSEDGVTLD 180

DIRKIERNRQ PPDSGPMCDL LWSDPQPQNG RSVSKRGVSC QFGPDVTKAF LEENNLDYII 240

RSHEVKAEGY EVAHGGRCVT VFSAPNYCDQ MGNKASYIHL QGSDLRPQFH QFTAVPHPNV 300

KPMAYANTLL QL 312

Keyword

Complete proteome; Hydrolase; Iron; Metal-binding; Reference proteome; Repeat; TPR repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0004871	; F:signal transducer activity
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0006470	; P:protein dephosphorylation
GO:0043278	; P:response to morphine

KEGG

mcc:716214

;

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.
IPR011236	; Ser/Thr_PPase_5.
IPR001440	; TPR-1.
IPR013026	; TPR-contain_dom.
IPR011990	; TPR-like_helical.
IPR019734	; TPR_repeat.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.
PF00515	; TPR_1; 1.

SMARTs

SM00156	; PP2Ac; 1.
SM00028	; TPR; 3.

Prosites

PS00125	; SER_THR_PHOSPHATASE; 1.
PS50005	; TPR; 3.
PS50293	; TPR_REGION; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013