EKS-MAM-00142

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00142

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/RIO	286.3	2.9E-85	96	318	223

Status

Unreviewed

Ensembl Protein

ENSMMUP00000000416

UniProt Accession

F6YV79;

Protein Name

Protein Synonyms/Alias

Serine/threonine-protein kinase RIO2 isoform 1;

Gene Name

RIOK2

Gene Synonyms/Alias

RIOK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000000307	ENSMMUP00000000416	ENSMMUT00000000449

Organism

Macaca mulatta

Functional Description

Protein Length

551

Protein Sequence
(FASTA)

MGKVNVAKLR YMSRDDFRVL TAVEMGMKNH EIVPGSLIAS IASLKHGGCN KVLRELVKHK 60

LIAWERTKTV QGYRLTNAGY DYLALKTLSS RQVVESVGNQ MGVGKESDIY IVANEEGQQF 120

ALKLHRLGRT SFRNLKNKRD YHKHRHNVSW LYLSRLSAMK EFAYMKALYE RKFPVPKPID 180

YNRHAVVMEL INGYPLCQIH HVEDPASVYD EAMELIVKLA NHGLIHGDFN EFNLILDEND 240

HITMIDFPQM VSTSHPNAEW YFDRDVKCIR DFFMKRFSYE SELFPTFRDI RREDTLDVEV 300

SASGYTKEMQ ADDELLHPLG PDDKNIETEE RSEFSFSDGE VAEEAEVYRS ENESEQNSLE 360

ESEGCYCRSS GDPEQIKEDS LSKESADARC FEMTEFNQAL EEIKGQVVEN NSVTEFSEEK 420

SRTENYNGQD GQRVQGGVPA GSEEYDDECP HLIALSLNRE FRPFRDEENM GAMNQYRTRT 480

LSITSSGSVV SCSTIPPELV KQKVKRQLTK QQKSAVRRRL QKGEANIFTK QRRENMQNIK 540

SSMEAASFWG E 551

Nucleotide Sequence
(FASTA)

ATGGGGAAGG TGAATGTGGC CAAGTTGCGT TACATGAGCC GAGATGACTT CAGGGTCTTG 60

ACCGCGGTTG AAATGGGCAT GAAGAACCAT GAAATTGTTC CCGGCAGTTT GATTGCTTCT 120

ATAGCCAGCC TTAAACATGG TGGCTGTAAT AAAGTTTTAA GAGAATTAGT GAAACATAAA 180

CTCATAGCTT GGGAGCGTAC CAAAACTGTC CAGGGCTATC GGTTGACAAA TGCGGGATAT 240

GATTACCTAG CTTTGAAAAC ACTTTCTTCT AGGCAAGTAG TTGAGTCTGT TGGAAACCAG 300

ATGGGTGTTG GCAAAGAATC AGATATTTAC ATTGTTGCAA ATGAAGAAGG ACAACAATTT 360

GCATTAAAGC TTCACAGACT AGGAAGAACC TCCTTTCGAA ATCTGAAAAA CAAACGTGAT 420

TATCATAAAC ATAGGCATAA TGTGTCTTGG CTTTATTTAT CTCGTCTCTC TGCCATGAAG 480

GAATTTGCCT ATATGAAGGC ATTGTATGAG AGGAAATTTC CAGTTCCGAA GCCAATTGAT 540

TACAATCGTC ATGCAGTTGT CATGGAACTC ATAAATGGTT ATCCACTATG TCAGATACAC 600

CATGTTGAAG ATCCTGCATC AGTATATGAT GAAGCTATGG AACTAATTGT CAAACTTGCA 660

AATCATGGGC TGATTCATGG AGATTTTAAT GAATTTAATC TCATTTTGGA TGAAAATGAC 720

CATATCACCA TGATTGATTT TCCACAGATG GTTTCAACTT CTCATCCCAA TGCTGAGTGG 780

TATTTTGACA GAGATGTTAA ATGCATTAGA GATTTCTTCA TGAAACGTTT CAGCTACGAA 840

AGTGAGCTTT TTCCAACCTT TAGGGATATC AGGAGGGAAG ACACTCTTGA TGTGGAGGTT 900

TCTGCCAGTG GCTACACGAA GGAAATGCAG GCAGATGATG AACTGCTTCA TCCATTAGGT 960

CCAGATGATA AAAATATTGA AACAGAAGAG AGATCTGAAT TCTCATTTTC AGATGGAGAA 1020

GTGGCAGAAG AAGCAGAGGT TTATAGGTCA GAAAATGAAA GTGAACAGAA CTCTCTAGAA 1080

GAATCAGAGG GCTGCTATTG CAGATCATCT GGAGACCCTG AACAAATAAA GGAAGACAGT 1140

TTATCAAAAG AGAGTGCTGA TGCACGGTGT TTTGAAATGA CTGAATTCAA TCAAGCTTTA 1200

GAAGAAATAA AAGGGCAGGT TGTTGAAAAC AACTCTGTAA CTGAATTTTC TGAGGAGAAA 1260

AGCAGAACTG AAAATTACAA CGGGCAAGAT GGTCAGAGAG TTCAAGGAGG AGTCCCTGCT 1320

GGCTCTGAGG AGTATGACGA TGAATGCCCT CATCTAATTG CCTTGTCATT AAATAGAGAA 1380

TTCAGGCCTT TCAGAGATGA AGAAAATATG GGAGCTATGA ATCAGTATAG AACAAGAACT 1440

CTGAGTATCA CTTCTTCAGG CAGTGTTGTA AGCTGTTCAA CAATTCCTCC GGAACTGGTG 1500

AAACAGAAGG TGAAACGTCA GTTGACAAAA CAGCAAAAAT CAGCTGTCAG ACGTCGATTG 1560

CAGAAAGGAG AAGCAAATAT ATTTACCAAG CAACGTAGGG AAAACATGCA AAATATCAAA 1620

TCAAGTATGG AAGCAGCTAG CTTTTGGGGA GAATAA 1656

Domain Profile

S: 2     svgntigvgkesdvykvsekngeeraiKiy...ktsllvlknrdkYvdgefrfkksrska  58

         svgn++gvgkesd+y v++++g+++a+K++   +ts+++lkn+++Y       +k+r+++

Q: 96    SVGNQMGVGKESDIYIVANEEGQQFALKLHrlgRTSFRNLKNKRDY-------HKHRHNV  148

         79********************************************.......9******

S: 59    nprklsrlwAeKEfrnlkrlyekgvpvPepidlkrhvlvmeligrdgypapklkdvklke  118

         ++++lsrl+A+KEf+++k+lye+++pvP+pid++rh++vmeli  +gyp+++++    +

Q: 149   SWLYLSRLSAMKEFAYMKALYERKFPVPKPIDYNRHAVVMELI--NGYPLCQIH----HV  202

         *******************************************..*********....9*

S: 119   eeikelYsdllalivklynegrLvHaDlsEfnill.eddklvliDvsqsveieHpdalef  177

         e+ +++Y+++++livkl+n+g L+H+D++Efn++l e+d++++iD++q+v+++Hp+a+++

Q: 203   EDPASVYDEAMELIVKLANHG-LIHGDFNEFNLILdENDHITMIDFPQMVSTSHPNAEWY  261

         *********************.*************889**********************

S: 178   lrrDvknvkefFkkklvy.........dvlrerelfelvsasgltkekeaddeilea  225

         ++rDvk++++fF+k+++y         d++re++l+ +vsasg+tke++adde+l++

Q: 262   FDRDVKCIRDFFMKRFSYeselfptfrDIRREDTLDVEVSASGYTKEMQADDELLHP  318

         *****************************************************9987

Domain Sequence
(FASTA)

SVGNQMGVGK ESDIYIVANE EGQQFALKLH RLGRTSFRNL KNKRDYHKHR HNVSWLYLSR 60

LSAMKEFAYM KALYERKFPV PKPIDYNRHA VVMELINGYP LCQIHHVEDP ASVYDEAMEL 120

IVKLANHGLI HGDFNEFNLI LDENDHITMI DFPQMVSTSH PNAEWYFDRD VKCIRDFFMK 180

RFSYESELFP TFRDIRREDT LDVEVSASGY TKEMQADDEL LHP 223

Keyword

Complete proteome; Kinase; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

mcc:700738

;

InterPros

IPR011009	; Kinase-like_dom.
IPR018934	; RIO-like_kinase.
IPR015285	; RIO2_kinase_winged_hlx_N.
IPR018935	; RIO_kinase_CS.
IPR011991	; WHTH_trsnscrt_rep_DNA-bd.

Pfam

PF01163	; RIO1; 1.
PF09202	; Rio2_N; 1.

SMARTs

Prosites

PS01245

; RIO1; 1.

Prints

Created Date

20-Feb-2013