EKS-MAM-00324

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00324

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	329.2	3.2E-98	17	291	275

Status

Unreviewed

Ensembl Protein

ENSMMUP00000001340

UniProt Accession

F6SQU7;

Protein Name

Protein Synonyms/Alias

Serine/threonine-protein kinase OSR1;

Gene Name

OXSR1

Gene Synonyms/Alias

OXSR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000000996	ENSMMUP00000001340	ENSMMUT00000001423

Organism

Macaca mulatta

Functional Description

Protein Length

527

Protein Sequence
(FASTA)

MSEDSSALPW SINRDDYELQ EVIGSGATAV VQAAYCAPKK EKVAIKRINL EKCQTSMDEL 60

LKEIQAMSQC HHPNIVSYYT SFVVKDELWL VMKLLSGGSV LDIIKHIVAK GEHKSGVLDE 120

STIATILREV LEGLEYLHKN GQIHRDVKAG NILLGEDGSV QIADFGVSAF LATGGDITRN 180

KVRKTFVGTP CWMAPEVMEQ VRGYDFKADI WSFGITAIEL ATGAAPYHKY PPMKVLMLTL 240

QNDPPSLETG VQDKEMLKKY GKSFRKMISL CLQKDPEKRP TAAELLRHKF FQKAKNKEFL 300

QEKILQRAPT ISERAKKVRR VPGSSGRLHK TEDGGWEWSD DEFDEESEEG KAAISQLRSP 360

RVKESISNSE LFPTTDPVGT LLQVPEQISA HLPQPAGQMP TQPTQVSLPP TAEPAKTAQA 420

LSSGSGSQET KIPISLVLRL RNSKKELNDI RFEFTPGRDT AEGVSQELIS AGLVDGRDLV 480

IVAANLQKIV EEPQSNRSVT FKLASGVEGS DIPDDGKLIG FAQLSIS 527

Nucleotide Sequence
(FASTA)

ATGTCCGAGG ACTCGAGCGC CCTGCCCTGG TCCATCAACA GGGACGATTA CGAGCTGCAG 60

GAGGTGATCG GGAGTGGAGC AACTGCTGTG GTCCAAGCAG CTTATTGTGC CCCTAAAAAG 120

GAGAAAGTGG CAATCAAACG GATAAACCTT GAGAAATGTC AAACTAGCAT GGATGAACTC 180

CTGAAAGAAA TTCAAGCCAT GAGTCAGTGC CATCATCCTA ATATTGTATC TTACTACACG 240

TCTTTTGTGG TAAAAGATGA GCTGTGGCTT GTCATGAAGC TGCTAAGTGG AGGTTCTGTT 300

CTGGATATTA TTAAGCACAT TGTGGCAAAA GGGGAACACA AAAGTGGAGT CCTAGATGAA 360

TCTACCATTG CTACGATACT CCGAGAAGTA CTGGAAGGAC TGGAATATCT GCATAAAAAT 420

GGACAGATCC ACAGAGATGT GAAAGCTGGA AACATTCTTC TTGGAGAAGA TGGCTCAGTA 480

CAGATTGCAG ACTTTGGGGT TAGTGCTTTT TTAGCAACTG GTGGTGATAT TACCCGAAAT 540

AAAGTGAGAA AGACCTTTGT TGGCACTCCT TGTTGGATGG CACCTGAAGT TATGGAACAG 600

GTCCGAGGTT ATGATTTCAA AGCTGATATT TGGAGTTTTG GAATTACAGC AATTGAATTG 660

GCCACGGGGG CAGCTCCTTA CCATAAATAT CCACCAATGA AGGTTTTAAT GCTGACACTG 720

CAGAATGATC CTCCTTCTTT GGAAACTGGT GTTCAAGATA AAGAAATGCT GAAAAAATAT 780

GGAAAATCAT TTAGAAAAAT GATTTCATTG TGCCTTCAAA AAGATCCAGA AAAAAGACCA 840

ACAGCAGCAG AACTGTTAAG GCACAAATTT TTCCAGAAAG CAAAGAATAA AGAATTTCTT 900

CAAGAAAAAA TATTGCAGAG AGCACCAACC ATTTCTGAAA GAGCAAAAAA GGTTCGGAGA 960

GTACCAGGTT CCAGTGGCCG CCTCCATAAG ACAGAGGATG GAGGCTGGGA GTGGAGTGAT 1020

GATGAATTTG ATGAAGAAAG TGAGGAAGGG AAAGCAGCAA TTTCACAACT CAGGTCTCCC 1080

CGAGTGAAAG AATCAATATC AAATTCTGAG CTTTTTCCAA CAACTGATCC TGTGGGTACT 1140

TTGCTCCAAG TTCCAGAACA GATCTCCGCT CATCTACCTC AGCCAGCTGG GCAGATGCCT 1200

ACACAGCCAA CTCAAGTCTC TCTCCCACCC ACCGCAGAGC CAGCAAAAAC AGCACAGGCT 1260

TTGTCTTCAG GATCAGGTTC ACAAGAAACC AAGATCCCAA TTAGTCTAGT ACTAAGATTA 1320

AGGAATTCCA AAAAAGAACT AAATGATATT CGATTTGAAT TTACTCCTGG GAGAGATACA 1380

GCGGAGGGTG TCTCTCAGGA ACTCATTTCT GCTGGCCTGG TCGACGGAAG GGATTTAGTA 1440

ATAGTGGCAG CTAATTTGCA GAAAATTGTG GAAGAACCTC AGTCAAATCG ATCTGTCACT 1500

TTCAAACTGG CATCTGGTGT CGAAGGCTCG GATATTCCTG ATGATGGTAA ACTGATAGGA 1560

TTTGCCCAGC TCAGCATCAG CTAA 1584

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekq.ekleelqkeisvlkklkhpniv  59

         yel+e+ig+Ga++ v++a++ +++e+vaik+inlek+ ++++el kei+++++++hpniv

Q: 17    YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCqTSMDELLKEIQAMSQCHHPNIV  76

         99***********************************8899*******************

S: 60    eylesflkeeelwlvmeylagGslsdlvk......eelkselkEeqiayilrevlkaLey  113

         +y++sf++++elwlvm++l+gGs+ d++k      e+++  l+E++ia+ilrevl++Ley

Q: 77    SYYTSFVVKDELWLVMKLLSGGSVLDIIKhivakgEHKSGVLDESTIATILREVLEGLEY  136

         *****************************9*99999999*********************

S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlek....trkk.rktvvgtpywmAPE  168

         lH++++iHrd+ka+niLl e+g+V+++dfgv+a l++    tr+k rkt+vgtp+wmAPE

Q: 137   LHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATggdiTRNKvRKTFVGTPCWMAPE  196

         ***********************************99999988899**************

S: 169   viaqeekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklksk.....  223

         v++q  +gYd kaDiws+GItaiela+g++P+++++p+k+l+++l+n+pp+l++

Q: 197   VMEQ-VRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGvqdke  255

         ***5.9*********************************************976677778

S: 224   ..kkfskefkefvekclqknpekRpsasellkhkFl  257

           kk++k+f+++++ clqk+pekRp+a+ell+hkF+

Q: 256   mlKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF  291

         8899*******************************7

Domain Sequence
(FASTA)

YELQEVIGSG ATAVVQAAYC APKKEKVAIK RINLEKCQTS MDELLKEIQA MSQCHHPNIV 60

SYYTSFVVKD ELWLVMKLLS GGSVLDIIKH IVAKGEHKSG VLDESTIATI LREVLEGLEY 120

LHKNGQIHRD VKAGNILLGE DGSVQIADFG VSAFLATGGD ITRNKVRKTF VGTPCWMAPE 180

VMEQVRGYDF KADIWSFGIT AIELATGAAP YHKYPPMKVL MLTLQNDPPS LETGVQDKEM 240

LKKYGKSFRK MISLCLQKDP EKRPTAAELL RHKFF 275

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0006979	; P:response to oxidative stress

KEGG

mcc:696362

;

InterPros

IPR011009	; Kinase-like_dom.
IPR024678	; Kinase_OSR1/WNK_CCT.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF12202	; OSR1_C; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013