EKS-MAM-00138
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00138
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/Akt504.41.2E-151150408259
StatusUnreviewed
Ensembl ProteinENSMMUP00000001399
UniProt AccessionF6SAS5;
Protein Name
Protein Synonyms/Alias RAC-alpha serine/threonine-protein kinase;
Gene NameAKT1
Gene Synonyms/Alias AKT1; EGK_18599;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000001044ENSMMUP00000001399ENSMMUT00000001488
ENSMMUG00000001044ENSMMUP00000032525ENSMMUT00000039437
OrganismMacaca mulatta
Functional Description
Protein Length480
Protein Sequence
(FASTA)
MSDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVDQREA PLNNFSVAQC 60
QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWT TAIQTVADGL KKHEEEMMDF 120
RSGSPSDNSG AEEMEVSLAK PKHRVTMNEF EYLKLLGKGT FGKVILVKEK ATGRYYAMKI 180
LKKEVIVAKD EVAHTLTENR VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS 240
RERVFSEDRA RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI 300
KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL 360
ILMEEIRFPR TLGPEAKSLL SGLLKKDPKQ RLGGGSEDAK EIMQHRFFAG IVWQHVYEKK 420
LSPPFKPQVT SETDTRYFDE EFTAQMITIT PPDQDDSMEC VDSERRPHFP QFSYSASGTA 480
Nucleotide Sequence
(FASTA)
ATGAGCGACG TGGCTATTGT GAAGGAGGGC TGGCTGCACA AACGAGGGGA GTACATCAAG 60
ACCTGGCGAC CACGCTACTT CCTCCTCAAG AATGATGGCA CTTTCATTGG CTATAAGGAG 120
CGGCCGCAGG ACGTGGACCA ACGTGAGGCC CCCCTCAACA ACTTCTCTGT GGCACAGTGC 180
CAGCTGATGA AGACGGAGCG GCCCCGGCCC AACACCTTCA TCATCCGCTG CCTGCAGTGG 240
ACCACTGTCA TCGAACGCAC CTTCCACGTG GAGACTCCCG AGGAGCGGGA GGAGTGGACA 300
ACCGCCATCC AGACAGTGGC CGATGGCCTC AAGAAGCATG AGGAGGAGAT GATGGACTTC 360
CGGTCGGGCT CACCCAGCGA CAACTCAGGG GCTGAAGAGA TGGAGGTGTC CCTGGCCAAA 420
CCCAAGCACC GTGTGACCAT GAACGAGTTT GAGTACCTGA AGCTGCTGGG CAAGGGCACT 480
TTCGGGAAGG TGATCCTGGT GAAGGAGAAG GCAACGGGCC GCTACTATGC CATGAAGATC 540
CTCAAGAAGG AGGTCATCGT GGCCAAGGAC GAGGTGGCCC ACACACTCAC CGAGAACCGT 600
GTTCTGCAGA ACTCCAGGCA CCCCTTCCTC ACGGCCCTGA AGTACTCCTT CCAGACCCAC 660
GACCGCCTCT GCTTCGTCAT GGAGTACGCC AATGGGGGCG AGCTCTTCTT CCACCTGTCC 720
CGGGAGCGTG TGTTCTCTGA GGACCGGGCC CGCTTCTATG GCGCCGAGAT CGTGTCAGCC 780
CTGGACTACC TGCACTCGGA GAAGAATGTG GTGTACCGGG ACCTCAAGCT GGAGAACCTC 840
ATGCTGGACA AGGACGGGCA CATTAAGATC ACAGACTTCG GGCTGTGCAA GGAGGGGATC 900
AAGGACGGCG CCACCATGAA GACCTTCTGC GGCACACCTG AGTACCTGGC TCCCGAGGTG 960
CTGGAGGACA ATGACTACGG CCGTGCGGTG GACTGGTGGG GGCTGGGCGT GGTCATGTAT 1020
GAGATGATGT GCGGCCGCCT GCCCTTCTAC AACCAGGACC ACGAGAAGCT TTTTGAGCTC 1080
ATCCTCATGG AGGAGATCCG CTTCCCGCGC ACGCTTGGTC CTGAGGCCAA GTCCTTGCTC 1140
TCAGGGCTGC TCAAGAAGGA CCCCAAGCAG AGGCTTGGCG GGGGCTCTGA GGACGCCAAG 1200
GAGATCATGC AGCATCGCTT CTTTGCCGGC ATCGTGTGGC AGCACGTGTA TGAGAAGAAG 1260
CTCAGCCCAC CCTTCAAGCC CCAGGTCACA TCGGAGACCG ACACCAGGTA TTTTGATGAG 1320
GAGTTCACGG CCCAGATGAT CACCATCACA CCACCTGACC AAGACGACAG CATGGAGTGC 1380
GTGGACAGCG AGCGCAGGCC CCACTTCCCC CAGTTCTCCT ACTCGGCCAG CGGCACGGCC 1440
TGA 1443
Domain Profile
S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60
         f++lkllGkGtfGkvilv+ekat+++ya+kilkkevivakdevahtlte+rvl++++hpf
Q: 150   FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF  209
         9***********************************************************
S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhs.kd  119
         l+alkysfqt+++lc+v+ey+nGGelffhls+ervfsedrarfygaeivsaldylhs k+
Q: 210   LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSeKN  269
         ********************************************************9789
S: 120   vvyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygka  179
         vvyrdlklenl+ldkdGhikitdfGlcke+ikdg+++ktfcGtpeylapevled+dyg+a
Q: 270   VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRA  329
         ************************************************************
S: 180   vdwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpk  239
         vdwwglGvv+yem+cGrlpfyn+dheklfelil+ee++fpr+l++eaksllsGllkkdpk
Q: 330   VDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPK  389
         ************************************************************
S: 240   krlGggkddakeireheff  258
         +rlGgg++dakei++h+ff
Q: 390   QRLGGGSEDAKEIMQHRFF  408
         ******************9
Domain Sequence
(FASTA)
FEYLKLLGKG TFGKVILVKE KATGRYYAMK ILKKEVIVAK DEVAHTLTEN RVLQNSRHPF 60
LTALKYSFQT HDRLCFVMEY ANGGELFFHL SRERVFSEDR ARFYGAEIVS ALDYLHSEKN 120
VVYRDLKLEN LMLDKDGHIK ITDFGLCKEG IKDGATMKTF CGTPEYLAPE VLEDNDYGRA 180
VDWWGLGVVM YEMMCGRLPF YNQDHEKLFE LILMEEIRFP RTLGPEAKSL LSGLLKKDPK 240
QRLGGGSEDA KEIMQHRFF 259
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00133
EKS-BOT-00141
EKS-CAE-00113
EKS-CAF-00147
EKS-CAP-00138
EKS-CII-00086
EKS-CIS-00177
EKS-EQC-00138
EKS-GAG-00116
EKS-GOG-00140
EKS-HOS-00143
EKS-ICT-00132
EKS-LAC-00148
EKS-MEG-00106
EKS-MOD-00137
EKS-MUM-00143
EKS-MUP-00144
EKS-NOL-00134
EKS-ORN-00171
EKS-ORL-00160
EKS-OTG-00144
EKS-PES-00123
EKS-PEM-00075
EKS-PRC-00020
EKS-PTV-00131
EKS-RAN-00136
EKS-SAH-00133
EKS-TAG-00168
EKS-TAR-00183
EKS-TEN-00171
EKS-XET-00127
EKS-XIM-00166
Gene Ontology
GO:0005737; C:cytoplasm
GO:0030027; C:lamellipodium
GO:0005634; C:nucleus
GO:0005819; C:spindle
GO:0005524; F:ATP binding
GO:0030235; F:nitric-oxide synthase regulator activity
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0006924; P:activation-induced cell death of T cells
GO:0042640; P:anagen
GO:0008637; P:apoptotic mitochondrial changes
GO:0071364; P:cellular response to epidermal growth factor stimulus
GO:0032869; P:cellular response to insulin stimulus
GO:0007281; P:germ cell development
GO:0042593; P:glucose homeostasis
GO:0006006; P:glucose metabolic process
GO:0015758; P:glucose transport
GO:0060709; P:glycogen cell differentiation involved in embryonic placenta development
GO:0005977; P:glycogen metabolic process
GO:0006954; P:inflammatory response
GO:0048009; P:insulin-like growth factor receptor signaling pathway
GO:0060716; P:labyrinthine layer blood vessel development
GO:0001893; P:maternal placenta development
GO:0043066; P:negative regulation of apoptotic process
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0031999; P:negative regulation of fatty acid beta-oxidation
GO:0010748; P:negative regulation of plasma membrane long-chain fatty acid transport
GO:0090201; P:negative regulation of release of cytochrome c from mitochondria
GO:0001649; P:osteoblast differentiation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0032287; P:peripheral nervous system myelin maintenance
GO:0043536; P:positive regulation of blood vessel endothelial cell migration
GO:0031659; P:positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane
GO:0045600; P:positive regulation of fat cell differentiation
GO:0046326; P:positive regulation of glucose import
GO:0045725; P:positive regulation of glycogen biosynthetic process
GO:0046889; P:positive regulation of lipid biosynthetic process
GO:0045429; P:positive regulation of nitric oxide biosynthetic process
GO:0051000; P:positive regulation of nitric-oxide synthase activity
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0010765; P:positive regulation of sodium ion transport
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0030163; P:protein catabolic process
GO:0000060; P:protein import into nucleus, translocation
GO:0043491; P:protein kinase B signaling cascade
GO:0016567; P:protein ubiquitination
GO:0010975; P:regulation of neuron projection development
GO:0034405; P:response to fluid shear stress
GO:0032094; P:response to food
GO:0070141; P:response to UV-A
GO:0051146; P:striated muscle cell differentiation
KEGG
mcc:697747;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR017892; Pkinase_C.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00169; PH; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00233; PH; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013