EKS-MAM-00252

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00252

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	309.9	2.1E-92	74	325	252

Status

Unreviewed

Ensembl Protein

ENSMMUP00000001638

UniProt Accession

F7D9P3;

Protein Name

Protein Synonyms/Alias

Serine/threonine-protein kinase NIM1;

Gene Name

NIM1

Gene Synonyms/Alias

NIM1; MGC42105; EGK_21192;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000001224	ENSMMUP00000001638	ENSMMUT00000001738

Organism

Macaca mulatta

Functional Description

Protein Length

436

Protein Sequence
(FASTA)

MTAVYTNGGG LVNPHYARWD RRDSVESGCQ AESSKEGEEG QPRQLTPFEK LTQDMSQDEK 60

VVREITLGKR IGFYRIRGEI GSGNFSQVKL GIHSLTKEKV AIKILDKTKL DQKTQRLLSR 120

EISSMEKLHH PNIIRLYEVV ETLSKLHLVM EYAGGGELFG KISTEGKLSE PESKLIFSQI 180

VSAVKHMHEN QIIHRDLKAE NVFYTSNTCV KVGDFGFSTV SKKGEMLNTF CGSPPYAAPE 240

LFRDEHYIGI YVDIWALGVL LYFMVTGIMP FRAETVTKLK KSILEGTYSV PPHVSEPCHR 300

LIRGVLQQIP MERYGIDCIM NDEWMQGVPY PTPLEPFQLD PKHLSETGTL KEEENEVKST 360

LEHLGITEEH IRNNQGRDAR SSITGVYRII LHRVQRKKAL ESVPVMMLPD PKERDLKKGS 420

RVYRGIRHTS KFCSIL 436

Nucleotide Sequence
(FASTA)

ATGACTGCAG TGTATACAAA TGGAGGCGGC CTGGTGAACC CCCACTATGC CCGGTGGGAT 60

CGGCGCGACA GCGTAGAAAG TGGCTGTCAG GCCGAGAGCA GCAAGGAGGG CGAGGAAGGA 120

CAGCCCCGCC AGCTGACGCC CTTCGAGAAA CTGACACAGG ACATGTCCCA AGATGAGAAG 180

GTGGTGAGGG AGATCACTCT GGGGAAACGG ATAGGCTTCT ACCGAATTCG AGGGGAAATC 240

GGAAGTGGCA ACTTCTCCCA AGTGAAGCTC GGGATTCACT CCCTAACCAA AGAAAAGGTG 300

GCCATTAAGA TCCTGGACAA GACCAAGTTA GACCAGAAAA CCCAGAGGCT ACTATCCCGA 360

GAAATCTCCA GCATGGAAAA GCTGCACCAT CCCAACATCA TCCGCCTTTA CGAAGTCGTG 420

GAGACCCTAT CTAAGCTGCA CTTGGTGATG GAATATGCAG GGGGTGGGGA GCTGTTCGGA 480

AAAATTAGCA CTGAGGGGAA GCTCTCTGAA CCAGAAAGCA AGCTCATCTT CTCCCAGATT 540

GTGTCTGCCG TGAAGCACAT GCATGAAAAC CAAATTATTC ACAGAGATCT GAAAGCAGAA 600

AATGTATTCT ATACCAGTAA TACTTGTGTG AAGGTGGGCG ATTTTGGATT CAGCACAGTA 660

AGTAAAAAAG GTGAAATGCT AAACACTTTC TGTGGGTCTC CTCCCTATGC TGCACCTGAA 720

CTCTTCCGGG ACGAGCACTA CATCGGCATT TACGTGGATA TCTGGGCCTT GGGGGTGCTT 780

TTGTACTTCA TGGTGACTGG CATCATGCCA TTTCGGGCAG AAACCGTGAC CAAACTAAAA 840

AAGAGCATCC TTGAGGGCAC ATACAGTGTA CCGCCCCACG TGTCAGAGCC CTGCCACCGA 900

CTCATCCGAG GAGTCCTTCA GCAGATTCCC ATGGAGAGGT ACGGGATCGA CTGCATCATG 960

AATGATGAAT GGATGCAAGG GGTGCCATAC CCTACACCTT TGGAACCTTT CCAACTGGAT 1020

CCCAAACATT TATCGGAAAC CGGCACTCTC AAGGAAGAAG AAAATGAAGT CAAAAGCACT 1080

TTAGAGCATT TGGGCATTAC AGAAGAGCAT ATTCGAAATA ACCAAGGGAG AGACGCTCGC 1140

AGCTCAATCA CAGGGGTCTA TAGAATTATT TTACATAGAG TCCAAAGGAA GAAGGCTTTG 1200

GAAAGTGTCC CAGTCATGAT GCTACCAGAC CCTAAAGAAA GAGACCTCAA AAAAGGGTCC 1260

CGTGTCTACA GAGGGATAAG ACACACATCC AAATTTTGCT CGATTTTATA A 1311

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++  ++G+g+f++Vkl +h++tkekva+Ki++k+kl++++++ ++rEi+ ++kl+hpni

Q: 74    YRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLHHPNI  133

         89999*******************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         i+l+ev+et +kl+lv+eya ggeLf +i+++g+l+e e++ +f+q+vsavk++h+++i+

Q: 134   IRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHENQII  193

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eN++ ++++ +k+ DFG++++ k+g++l+tfcGsppYaaPel+++++Y g  vD

Q: 194   HRDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYIGIYVD  253

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +W+lGv+Ly++vtg +Pf++e++++l+++il+g++++p ++s+ +++L+r +L++ p +R

Q: 254   IWALGVLLYFMVTGIMPFRAETVTKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQIPMER  313

         ************************************************************

S: 241   atieeilkhewl  252

         + i+ i+++ew+

Q: 314   YGIDCIMNDEWM  325

         ***********8

Domain Sequence
(FASTA)

YRIRGEIGSG NFSQVKLGIH SLTKEKVAIK ILDKTKLDQK TQRLLSREIS SMEKLHHPNI 60

IRLYEVVETL SKLHLVMEYA GGGELFGKIS TEGKLSEPES KLIFSQIVSA VKHMHENQII 120

HRDLKAENVF YTSNTCVKVG DFGFSTVSKK GEMLNTFCGS PPYAAPELFR DEHYIGIYVD 180

IWALGVLLYF MVTGIMPFRA ETVTKLKKSI LEGTYSVPPH VSEPCHRLIR GVLQQIPMER 240

YGIDCIMNDE WM 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

mcc:699870

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013