EKS-MAM-00277
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00277
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR468.21.7E-14096383288
StatusUnreviewed
Ensembl ProteinENSMMUP00000039558
UniProt AccessionH9FBZ3;
Protein Name
Protein Synonyms/Alias TGF-beta receptor type-1 isoform 1;
Gene NameTGFBR1
Gene Synonyms/Alias TGFBR1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000001304ENSMMUP00000039558ENSMMUT00000046526
ENSMMUG00000001304ENSMMUP00000001739ENSMMUT00000001844
OrganismMacaca mulatta
Functional Description
Protein Length394
Protein Sequence
(FASTA)
ALQCFCHLCT KDNFTCVTDG LCFVSVTETT DKVIHNSMCI AEIDLIPRDR PFVCAPSSKT 60
GSVTTTYCCN QDHCNKIELP TTGLPLLVQR TIARTIVLQE SIGKGRFGEV WRGKWRGEEV 120
AVKIFSSREE RSWFREAEIY QTVMLRHENI LGFIAADNKD NGTWTQLWLV SDYHEHGSLF 180
DYLNRYTVTV EGMIKLALST ASGLAHLHME IVGTQGKPAI AHRDLKSKNI LVKKNGTCCI 240
ADLGLAVRHD SATDTIDIAP NHRVGTKRYM APEVLDDSIN MKHFESFKRA DIYAMGLVFW 300
EIARRCSIGG IHEDYQLPYY DLVPSDPSVE EMRKVVCEQK LRPNIPNRWQ SCEALRVMAK 360
IMRECWYANG AARLTALRIK KTLSQLSQQE GIKM 394
Nucleotide Sequence
(FASTA)
GCATTACAGT GTTTCTGCCA CCTCTGTACA AAAGACAATT TTACTTGTGT GACAGATGGG 60
CTCTGCTTTG TCTCTGTCAC AGAGACCACA GACAAAGTTA TACACAACAG CATGTGTATA 120
GCTGAAATTG ACTTAATTCC TCGAGATAGG CCATTTGTAT GTGCACCCTC TTCAAAAACT 180
GGGTCTGTGA CTACAACATA TTGCTGCAAT CAGGACCATT GCAATAAAAT AGAACTTCCA 240
ACTACTGGTT TACCATTGCT TGTTCAGAGA ACAATTGCGA GAACTATTGT GTTACAAGAA 300
AGCATTGGCA AAGGTCGATT TGGAGAAGTG TGGCGAGGAA AGTGGCGGGG AGAAGAAGTT 360
GCTGTTAAGA TATTCTCTTC TAGAGAAGAA CGTTCATGGT TCCGTGAGGC AGAGATTTAT 420
CAAACTGTGA TGTTACGTCA TGAAAACATC CTGGGATTTA TAGCAGCAGA CAATAAAGAC 480
AATGGCACTT GGACTCAGCT CTGGTTGGTG TCAGATTATC ATGAGCATGG ATCCCTTTTT 540
GATTACTTAA ACAGATACAC AGTTACTGTG GAAGGAATGA TAAAACTTGC TCTGTCCACA 600
GCGAGCGGTC TTGCCCATCT TCACATGGAG ATTGTTGGTA CCCAAGGAAA GCCAGCCATT 660
GCTCACAGAG ATTTGAAATC AAAGAATATC TTGGTAAAGA AGAATGGAAC TTGCTGTATT 720
GCAGACTTAG GACTGGCAGT AAGACACGAT TCAGCCACAG ATACCATTGA TATTGCTCCA 780
AACCACAGAG TGGGAACAAA AAGGTACATG GCCCCTGAAG TTCTTGATGA TTCCATAAAT 840
ATGAAACATT TTGAATCCTT CAAACGTGCT GACATCTATG CAATGGGCTT AGTATTCTGG 900
GAAATTGCTC GACGATGTTC CATTGGTGGA ATTCATGAAG ATTACCAGCT GCCTTATTAT 960
GATCTTGTAC CTTCTGACCC ATCAGTGGAA GAAATGAGAA AAGTTGTTTG TGAACAGAAG 1020
TTAAGGCCAA ATATCCCAAA CAGATGGCAG AGCTGCGAAG CCTTGAGAGT AATGGCTAAA 1080
ATTATGAGAG AATGTTGGTA TGCCAACGGA GCAGCTAGGC TTACAGCATT GCGGATTAAG 1140
AAAACATTAT CACAACTCAG TCAACAGGAA GGCATCAAAA TGTAA 1185
Domain Profile
S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60
         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia
Q: 96    IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  155
         57899*******************************************************
S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120
         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+
Q: 156   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  215
         ************************************************************
S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180
         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE
Q: 216   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  273
         *..*********************************************************
S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240
         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem
Q: 274   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  332
         ***********************************.************************
S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291
         ++vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l
Q: 333   RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  383
         *************************************************97
Domain Sequence
(FASTA)
IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60
ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120
GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180
DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV 240
VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288
KeywordATP-binding; Kinase; Nucleotide-binding; Receptor; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gadus morhua"; ?>Homo sapiens"; ?>Mus musculus"; ?>
EKS-GAM-00172
EKS-HOS-00281
EKS-MUM-00306
Gene Ontology
GO:0044459; C:plasma membrane part
GO:0043235; C:receptor complex
GO:0005923; C:tight junction
GO:0005524; F:ATP binding
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0000186; P:activation of MAPKK activity
GO:0001525; P:angiogenesis
GO:0009952; P:anterior/posterior pattern specification
GO:0048844; P:artery morphogenesis
GO:0001824; P:blastocyst development
GO:0071560; P:cellular response to transforming growth factor beta stimulus
GO:0030199; P:collagen fibril organization
GO:0048701; P:embryonic cranial skeleton morphogenesis
GO:0043542; P:endothelial cell migration
GO:0001837; P:epithelial to mesenchymal transition
GO:0008354; P:germ cell migration
GO:0007507; P:heart development
GO:0006917; P:induction of apoptosis
GO:0001822; P:kidney development
GO:0002088; P:lens development in camera-type eye
GO:0043066; P:negative regulation of apoptotic process
GO:0032331; P:negative regulation of chondrocyte differentiation
GO:0048663; P:neuron fate commitment
GO:0060021; P:palate development
GO:0060017; P:parathyroid gland development
GO:0060389; P:pathway-restricted SMAD protein phosphorylation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0060037; P:pharyngeal system development
GO:0030307; P:positive regulation of cell growth
GO:0008284; P:positive regulation of cell proliferation
GO:0051272; P:positive regulation of cellular component movement
GO:0051491; P:positive regulation of filopodium assembly
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0060391; P:positive regulation of SMAD protein import into nucleus
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0009791; P:post-embryonic development
GO:0043393; P:regulation of protein binding
GO:0031396; P:regulation of protein ubiquitination
GO:0048538; P:thymus development
GO:0007179; P:transforming growth factor beta receptor signaling pathway
KEGG
InterPros
IPR000472; Activin_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR003605; TGF_beta_rcpt_GS.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
SMARTs
SM00467; GS; 1.
Prosites
PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013