EKS-MAM-00302
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00302
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR494.51.0E-148439696258
StatusUnreviewed
Ensembl ProteinENSMMUP00000001803
UniProt AccessionF7D6W0;
Protein Name
Protein Synonyms/Alias
Gene NameERBB2
Gene Synonyms/Alias ERBB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000001348ENSMMUP00000001802ENSMMUT00000001909
ENSMMUG00000001348ENSMMUP00000001803ENSMMUT00000001910
OrganismMacaca mulatta
Functional Description
Protein Length974
Protein Sequence
(FASTA)
MPNPEGRYTF GASCVTACPY NYLSTDVGSC TLVCPLHNQE VTAEDGTQRC EKCSKPCARV 60
CYGLGMEHLR EVRAVTSANI QEFAGCKKIF GSLAFLPESF DGDPASNTAP LQPEQLRVFE 120
TLEEITGYLY ISAWPDSLPD LSVLQNLQVI RGRILHNGAY SLTLQGLGIS WLGLRSLREL 180
GSGLALIHHN TRLCFVHTVP WDQLFRNPHQ ALLHTANRPE DECVGEGLAC HQLCARGHCW 240
GPGPTQCVNC SQFLRGQECV EECRVLQGLP REYVNARHCL PCHPECQPQN GSVTCFGPEA 300
DQCVACAHYK DPPFCVARCP SGVKPDLSYM PIWKFPDEEG TCQSCPINCT HSCVDLDDKG 360
CPAEQRASPL TSIISAVVGI LLVVVLGVVF GILIKRRQQK IRKYTMRRLL QETELVEPLT 420
PSGAMPNQAQ MRILKETELR KVKVLGSGAF GTVYKGIWIP DGENVKIPVA IKVLRENTSP 480
KANKEILDEA YVMAGVGSPY VSRLLGICLT STVQLVTQLM PYGCLLDHVR ENRGRLGSQD 540
LLNWCMQIAK GMSYLEDVRL VHRDLAARNV LVKSPNHVKI TDFGLARLLD IDETEYHADG 600
GKVPIKWMAL ESILRRRFTH QSDVWSYGVT VWELMTFGAK PYDGIPAREI PDLLEKGERL 660
PQPPICTIDV YMIMVKCWMI DSECRPRFRE LVSEFSRMAR DPQRFVVIQN EDLGPASPLD 720
STFYRSLLED DDMGDLVDAE EYLVPQQGFF CPDPAPGTGG MVHHRHRSSS TRSGGGDLTL 780
GLEPSEEEAP RSPRAPSEGT GSDVFDGDLG MGAAKGLQSL PAHDPSPLQR YSEDPTVPLP 840
SETDGYVAPL TCSPQPEYVN QPDVRPQPPS PQEGPLSPAR PTGATLERPK TLSPGKNGVV 900
KDVFAFGGAV ENPEYLAPRG GAAPQPHLPP AFSPAFDNLY YWDQDPSERG APPSTFKGTP 960
TAENPEYLGL DVPV 974
Nucleotide Sequence
(FASTA)
ATGCCCAACC CCGAGGGCCG GTATACATTC GGCGCCAGCT GTGTGACTGC CTGTCCCTAC 60
AACTACCTTT CTACGGACGT GGGATCCTGC ACCCTCGTCT GCCCCCTGCA CAACCAAGAG 120
GTGACAGCGG AGGACGGAAC ACAGCGATGT GAGAAGTGCA GCAAGCCCTG TGCCCGAGTG 180
TGCTATGGTC TGGGCATGGA GCACTTGCGA GAGGTGAGGG CGGTCACCAG TGCCAATATC 240
CAGGAGTTTG CTGGCTGCAA GAAGATCTTT GGGAGCTTGG CATTTCTGCC AGAGAGCTTT 300
GATGGCGACC CAGCCTCCAA CACCGCCCCG CTTCAGCCGG AGCAGCTCCG AGTGTTTGAG 360
ACTCTGGAAG AGATCACAGG TTACCTATAC ATCTCAGCAT GGCCAGACAG CCTGCCTGAC 420
CTTAGCGTCC TCCAGAACCT GCAAGTAATC CGGGGACGAA TTCTGCACAA TGGCGCCTAC 480
TCACTGACCC TGCAAGGGCT GGGCATCAGC TGGCTGGGGC TGCGCTCGCT GAGGGAACTG 540
GGCAGTGGAC TGGCCCTCAT CCACCATAAC ACCCGCCTCT GCTTTGTGCA CACGGTGCCC 600
TGGGACCAGC TCTTCCGGAA CCCGCACCAA GCCCTGCTCC ACACTGCCAA CCGGCCAGAG 660
GACGAGTGTG TGGGCGAGGG CCTGGCCTGC CACCAGCTGT GCGCCCGAGG GCACTGCTGG 720
GGTCCAGGGC CCACCCAGTG TGTCAACTGC AGCCAGTTCC TTCGGGGCCA GGAGTGCGTG 780
GAGGAATGCC GAGTACTGCA GGGGCTCCCC AGGGAGTATG TGAATGCCAG ACACTGTTTG 840
CCGTGCCACC CTGAGTGTCA GCCCCAGAAT GGCTCAGTGA CATGTTTTGG ACCGGAGGCT 900
GACCAGTGTG TGGCCTGTGC CCACTATAAG GACCCTCCCT TCTGCGTGGC CCGCTGCCCC 960
AGCGGTGTGA AACCTGACCT CTCCTACATG CCCATCTGGA AGTTTCCAGA TGAGGAGGGC 1020
ACGTGCCAGT CTTGCCCCAT CAACTGCACC CACTCCTGTG TGGACCTGGA TGACAAGGGC 1080
TGCCCCGCCG AGCAGAGAGC CAGCCCTCTG ACGTCCATCA TCTCTGCTGT GGTGGGCATT 1140
CTGCTGGTCG TGGTCTTGGG GGTGGTCTTT GGAATCCTCA TCAAGCGACG GCAGCAGAAG 1200
ATCCGGAAGT ACACGATGCG GAGGCTGCTG CAGGAAACGG AGCTGGTGGA GCCACTGACA 1260
CCGAGTGGAG CGATGCCCAA CCAGGCGCAG ATGCGGATCC TGAAAGAGAC GGAGCTGAGG 1320
AAGGTGAAGG TGCTTGGATC TGGAGCTTTT GGCACAGTCT ACAAGGGCAT CTGGATCCCT 1380
GATGGGGAGA ATGTGAAAAT TCCAGTGGCC ATCAAAGTGT TGAGGGAAAA CACATCCCCC 1440
AAAGCCAACA AAGAAATCTT AGACGAAGCA TATGTGATGG CTGGTGTGGG CTCCCCATAT 1500
GTCTCCCGCC TCCTGGGCAT CTGCCTGACA TCCACGGTGC AGCTGGTGAC ACAGCTTATG 1560
CCCTATGGCT GCCTCTTAGA CCATGTCCGA GAAAACCGCG GACGCCTGGG CTCCCAGGAC 1620
CTGCTGAACT GGTGTATGCA GATTGCCAAG GGGATGAGCT ACCTGGAGGA TGTGCGGCTC 1680
GTACACAGGG ACTTGGCTGC TCGGAACGTG CTGGTCAAGA GTCCCAACCA TGTCAAAATT 1740
ACAGACTTTG GGCTGGCTCG GCTGCTGGAC ATTGACGAGA CAGAGTACCA TGCAGATGGG 1800
GGCAAGGTGC CCATCAAGTG GATGGCGCTG GAGTCCATTC TCCGACGGCG GTTCACCCAC 1860
CAGAGTGATG TGTGGAGTTA TGGTGTGACT GTGTGGGAGC TGATGACTTT TGGGGCCAAA 1920
CCTTACGATG GGATCCCAGC CCGGGAGATC CCTGACCTGC TGGAAAAGGG GGAGCGGCTG 1980
CCCCAGCCCC CCATCTGCAC CATTGATGTC TACATGATCA TGGTCAAATG TTGGATGATT 2040
GACTCTGAAT GTCGGCCGAG ATTCCGGGAG TTGGTGTCGG AATTCTCCCG CATGGCCAGG 2100
GACCCCCAGC GCTTTGTGGT CATCCAGAAT GAGGACTTGG GCCCAGCCAG TCCCTTGGAC 2160
AGCACCTTCT ACCGCTCACT GCTGGAGGAC GATGACATGG GGGACCTGGT GGATGCTGAG 2220
GAGTATCTGG TACCCCAGCA GGGCTTCTTC TGTCCAGACC CTGCCCCGGG CACTGGGGGC 2280
ATGGTCCACC ACAGGCACCG CAGCTCATCT ACCAGGAGTG GCGGTGGGGA CCTGACGCTA 2340
GGGCTGGAGC CCTCTGAAGA GGAGGCCCCC AGGTCTCCAC GGGCACCCTC CGAAGGGACT 2400
GGCTCTGATG TATTTGATGG TGACCTAGGA ATGGGGGCAG CCAAGGGGCT GCAAAGCCTC 2460
CCCGCACATG ACCCCAGCCC TCTACAGCGG TACAGTGAGG ACCCCACGGT ACCCCTGCCT 2520
TCTGAGACTG ACGGCTACGT TGCCCCCCTG ACCTGCAGTC CCCAGCCCGA ATATGTGAAC 2580
CAGCCAGATG TTCGGCCACA GCCCCCTTCG CCCCAAGAGG GCCCTCTGTC TCCTGCCCGA 2640
CCTACTGGTG CCACTCTGGA AAGGCCCAAG ACTCTCTCCC CAGGGAAGAA TGGGGTTGTC 2700
AAAGACGTTT TTGCCTTTGG GGGTGCTGTG GAGAACCCCG AGTACTTGGC ACCCCGGGGA 2760
GGAGCTGCCC CTCAGCCCCA CCTTCCTCCT GCCTTCAGCC CAGCCTTCGA CAACCTCTAT 2820
TACTGGGACC AGGACCCATC AGAGCGGGGG GCTCCACCTA GCACCTTCAA AGGGACACCT 2880
ACGGCAGAGA ACCCAGAGTA CCTGGGTCTG GACGTGCCAG TGTGA 2925
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+k+kvlGsGafGtvykGiwip+genvkipvaikvl+e+t++kanke+ldea+v+a + +
Q: 439   LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS  498
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+qlvtql+p+Gclld+vre++++lGsq+llnwc+qiakGmsyle+ 
Q: 499   PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDV  558
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+r++
Q: 559   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF  618
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGakpydgipa+eipdllekGerl+qppictidvym++vkcw
Q: 619   THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCW  678
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mid+e+rp+f+el++efs
Q: 679   MIDSECRPRFRELVSEFS  696
         ****************96
Domain Sequence
(FASTA)
LRKVKVLGSG AFGTVYKGIW IPDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 60
PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VRENRGRLGS QDLLNWCMQI AKGMSYLEDV 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF 180
THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI DVYMIMVKCW 240
MIDSECRPRF RELVSEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00280
EKS-ANC-00289
EKS-BOT-00298
EKS-CAJ-00305
EKS-CAF-00305
EKS-CAP-00334
EKS-EQC-00290
EKS-FEC-00284
EKS-GAA-00370
EKS-GOG-00296
EKS-HOS-00305
EKS-ICT-00281
EKS-LAC-00310
EKS-LOA-00309
EKS-MEG-00240
EKS-MOD-00293
EKS-MUM-00330
EKS-MUP-00296
EKS-MYL-00300
EKS-NOL-00275
EKS-ORC-00281
EKS-OTG-00303
EKS-PAT-00284
EKS-PES-00267
EKS-RAN-00315
EKS-SAH-00280
EKS-SUS-00262
EKS-XET-00372
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0016323; C:basolateral plasma membrane
GO:0010008; C:endosome membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007507; P:heart development
GO:0008045; P:motor neuron axon guidance
GO:0042552; P:myelination
GO:0033088; P:negative regulation of immature T cell proliferation in thymus
GO:0007528; P:neuromuscular junction development
GO:0007422; P:peripheral nervous system development
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0045785; P:positive regulation of cell adhesion
GO:0030307; P:positive regulation of cell growth
GO:0050679; P:positive regulation of epithelial cell proliferation
GO:0043406; P:positive regulation of MAP kinase activity
GO:0032321; P:positive regulation of Rho GTPase activity
GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter
GO:0045945; P:positive regulation of transcription from RNA polymerase III promoter
GO:0045727; P:positive regulation of translation
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0032886; P:regulation of microtubule-based process
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0042060; P:wound healing
KEGG
InterPros
IPR021157; Cyt_c1_TM_anchor_C.
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 1.
SMARTs
SM00261; FU; 2.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013