EKS-MAM-00300
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00300
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR500.12.0E-150708965258
StatusUnreviewed
Ensembl ProteinENSMMUP00000002249
UniProt AccessionF7G3H1;
Protein Name
Protein Synonyms/Alias
Gene NameERBB4
Gene Synonyms/Alias ERBB4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000001674ENSMMUP00000002249ENSMMUT00000002378
ENSMMUG00000001674ENSMMUP00000002247ENSMMUT00000002376
OrganismMacaca mulatta
Functional Description
Protein Length1298
Protein Sequence
(FASTA)
MKPATGLWVW VSLLVAAGTV QPSDSQSVCA GTENKLSSLS DLEQQYRALR KYYENCEVVM 60
GNLEITSIEH NRDLSFLRSV REVTGYVLVA LNQFRYLPLE NLRIIRGTKL YEDRYALAIF 120
LNYRKDGNFG LQELGLKNLT EILNGGVYVD QNKFLCYADT IHWQDIVRNP WPSNLTLVST 180
NGSSGCKKRE KTGVGSCWAE TPTSVTSMTR TVCAEQCDGR CYGPYVSDCC HRECAGGCSG 240
PKDTDCFACM NFNDSGACVT QCPQTFVYNP TTFQLEHNFN AKYTYGAFCV KKCPHNFVVD 300
SSSCVRACPS SKMEVEENGI KMCKPCTDIC PKACDGIGTG SLMSAQTVDS SNIDKFINCT 360
KINGNLIFLV TGIHGDPYNA IEAIDPEKLN VFRTVREITG FLNIQSWPPN MTDFSVFSNL 420
VTIGGRVLYS GLSLLILKQQ GITSLQFQSL KEISAGNIYI TDNSNLCYYH TINWTTLFST 480
INQRIVIRDN RKAENCTAEG MVCNHLCSSD GCWGPGPDQC LSCRRFSRGR ICIESCNLYD 540
GEFREFENGS ICVECDPQCE KMEDGLLTCH GPGPDNCTKC SHFKDGPNCV EKCPDGLQGA 600
NSFIFKYADP DRECHPCHPN CTQGCIGSSI EDCIGLMDRT PLIAAGVIGG LFILVIVGLT 660
FAVYVRRKSI KKKRALRRFL ETELVEPLTP SGTAPNQAQL RILKETELKR VKVLGSGAFG 720
TVYKGIWVPE GETVKIPVAI KILNETTGPK ANVEFMDEAL IMASMDHPHL VRLLGVCLSP 780
TIQLVTQLMP HGCLLEYVHE HKDNIGSQLL LNWCVQIAKG MMYLEERRLV HRDLAARNVL 840
VKSPNHVKIT DFGLARLLEG DEKEYNADGG KMPIKWMALE CIHYRKFTHQ SDVWSYGVTI 900
WELMTFGGKP YDGIPTREIP DLLEKGERLP QPPICTIDVY MVMVKCWMID ADSRPKFKEL 960
AADFSILIFN IPKNILKDGD DRMKLPSPND SKFFQNLLDE EDLEDMMDAE EYLVPQAFNI 1020
PPPIYTSRAR IDSNRSEIGH SPPPAYTPMS GNQFVYRDGG FAAEQGVSVP YRAPTSTIPE 1080
APVAQGATAE IFDDSCCNGT LRKPVAPHVQ EDSSTQRYSA DPTVFAPERS PRGELDEEGY 1140
MTPMRDKPKQ EYLNPVEENP FVSRRKNGDL QALDNPEYHS ASNGPPKAED EYVNEPLYLN 1200
TFANALGKAD YLKNNVLSVP EKAKKAFDNP DYWNHSLPPR STLQHPDYLQ EYSTKYFYKQ 1260
NGRIRPIVAE NPEYLSEFSL KPGTVLPPPP YRHRNTVV 1298
Nucleotide Sequence
(FASTA)
ATGAAGCCGG CGACAGGACT TTGGGTCTGG GTGAGCCTTC TCGTGGCGGC GGGGACCGTC 60
CAGCCCAGCG ATTCTCAGTC AGTGTGTGCA GGAACGGAGA ATAAACTGAG CTCTCTCTCT 120
GACCTGGAAC AGCAGTACCG AGCCTTGCGC AAGTACTATG AAAACTGTGA GGTTGTCATG 180
GGCAACCTGG AGATAACCAG CATTGAGCAC AACCGAGACC TCTCCTTTCT GCGGTCTGTT 240
CGAGAAGTCA CAGGCTATGT GTTAGTGGCT CTTAATCAGT TTCGTTACCT GCCTCTGGAG 300
AATTTACGCA TTATTCGTGG AACGAAACTT TATGAGGATC GATATGCCTT GGCAATATTT 360
TTAAACTACA GAAAAGATGG AAACTTTGGA CTTCAAGAAC TTGGATTAAA GAACTTGACA 420
GAAATCCTAA ATGGTGGAGT CTATGTAGAC CAGAACAAAT TCCTTTGTTA TGCGGACACC 480
ATTCATTGGC AAGATATTGT TCGGAACCCA TGGCCTTCCA ACTTGACTCT TGTGTCAACA 540
AATGGTAGTT CAGGATGTAA GAAGAGAGAG AAAACTGGAG TTGGGAGCTG TTGGGCTGAG 600
ACCCCCACAT CAGTGACATC TATGACAAGG ACGGTGTGTG CAGAACAATG TGACGGCAGA 660
TGCTACGGGC CTTACGTCAG TGACTGCTGC CATCGAGAAT GTGCTGGAGG CTGCTCAGGA 720
CCTAAGGACA CAGACTGCTT TGCCTGCATG AATTTCAATG ACAGTGGAGC ATGTGTTACT 780
CAGTGTCCCC AAACCTTTGT CTACAATCCA ACCACTTTTC AACTGGAGCA CAATTTCAAT 840
GCGAAGTACA CATATGGAGC ATTCTGTGTC AAGAAATGTC CACATAACTT TGTGGTAGAT 900
TCCAGTTCTT GTGTGCGTGC CTGCCCTAGT TCCAAGATGG AAGTAGAAGA AAATGGGATT 960
AAAATGTGTA AACCTTGCAC TGACATTTGC CCAAAAGCTT GTGATGGCAT TGGCACAGGA 1020
TCATTGATGT CAGCTCAGAC TGTGGATTCC AGTAACATTG ACAAATTCAT AAACTGTACC 1080
AAGATCAATG GGAATTTGAT CTTTCTAGTC ACTGGTATTC ACGGGGACCC TTACAATGCA 1140
ATTGAAGCCA TAGACCCAGA GAAACTGAAT GTCTTTCGGA CAGTCAGAGA GATAACAGGT 1200
TTCCTGAACA TACAGTCATG GCCGCCAAAC ATGACTGATT TCAGTGTTTT TTCTAACCTA 1260
GTGACCATTG GTGGAAGAGT ACTCTATAGT GGCCTCTCCT TGCTTATCCT CAAGCAACAG 1320
GGCATCACCT CTCTACAGTT CCAGTCCCTG AAGGAAATCA GCGCAGGAAA CATCTATATT 1380
ACTGACAACA GCAACTTGTG TTATTATCAT ACCATTAACT GGACAACACT CTTCAGCACA 1440
ATCAACCAAA GAATAGTAAT CCGGGACAAT AGAAAAGCTG AAAACTGTAC TGCTGAAGGA 1500
ATGGTGTGCA ACCATCTGTG TTCCAGTGAT GGCTGTTGGG GACCTGGGCC AGACCAATGT 1560
CTGTCGTGTC GCCGCTTCAG TAGAGGAAGG ATCTGCATAG AGTCTTGTAA CCTCTATGAT 1620
GGTGAATTTC GGGAGTTTGA GAACGGCTCC ATCTGTGTGG AGTGTGACCC TCAGTGTGAG 1680
AAGATGGAAG ATGGTCTCCT CACATGCCAT GGACCGGGTC CTGACAACTG TACAAAGTGC 1740
TCTCATTTTA AAGATGGCCC AAACTGTGTG GAAAAATGTC CAGATGGCTT ACAGGGGGCA 1800
AACAGTTTCA TTTTCAAGTA TGCTGATCCA GATCGGGAGT GCCATCCATG CCATCCAAAC 1860
TGCACCCAAG GGTGCATAGG CTCAAGTATT GAAGACTGCA TCGGCCTGAT GGATAGAACT 1920
CCCCTGATTG CGGCTGGAGT AATTGGTGGG CTCTTCATTC TGGTCATTGT TGGTCTGACA 1980
TTTGCTGTTT ATGTTAGAAG GAAGAGCATC AAAAAGAAAA GAGCCTTGAG AAGATTCTTG 2040
GAAACAGAGT TGGTGGAACC TTTAACTCCC AGTGGCACAG CACCCAATCA AGCTCAACTT 2100
CGTATTTTGA AAGAAACTGA GTTGAAGAGG GTAAAAGTCC TTGGCTCGGG TGCTTTTGGA 2160
ACGGTTTATA AAGGCATTTG GGTACCTGAA GGAGAAACTG TGAAGATTCC TGTGGCTATT 2220
AAGATTCTTA ATGAGACAAC TGGTCCCAAG GCAAATGTGG AGTTCATGGA TGAAGCTCTG 2280
ATCATGGCAA GTATGGATCA TCCACACCTA GTCCGGTTGC TGGGTGTGTG TCTGAGCCCA 2340
ACCATCCAGC TGGTTACTCA ACTTATGCCC CATGGCTGCC TGTTGGAGTA TGTCCACGAG 2400
CACAAGGATA ACATTGGATC ACAACTGCTG CTTAACTGGT GTGTCCAGAT AGCTAAGGGA 2460
ATGATGTACC TGGAAGAAAG ACGGCTCGTT CATCGGGATT TGGCGGCCCG TAATGTCTTA 2520
GTGAAATCTC CAAACCATGT GAAAATCACA GATTTTGGAC TAGCCAGACT CTTGGAAGGA 2580
GATGAAAAAG AATACAATGC TGATGGAGGA AAGATGCCAA TTAAATGGAT GGCTCTGGAG 2640
TGTATACATT ACAGGAAATT CACCCATCAG AGTGACGTTT GGAGCTATGG AGTTACTATA 2700
TGGGAACTGA TGACCTTTGG AGGAAAACCC TATGATGGAA TTCCAACGCG AGAAATCCCT 2760
GATTTATTGG AGAAAGGAGA ACGTTTGCCT CAGCCTCCCA TCTGCACCAT TGACGTTTAC 2820
ATGGTCATGG TCAAATGTTG GATGATTGAT GCTGACAGTA GACCTAAATT TAAGGAACTG 2880
GCTGCTGATT TCAGTATATT AATATTTAAT ATACCCAAAA ATATTTTAAA AGATGGTGAT 2940
GATCGTATGA AGCTTCCCAG TCCAAATGAC AGCAAGTTCT TTCAGAATCT CTTGGATGAA 3000
GAGGATTTGG AAGATATGAT GGATGCTGAG GAGTACTTGG TTCCTCAGGC TTTCAACATC 3060
CCACCTCCCA TCTATACTTC CAGAGCAAGA ATTGACTCGA ATAGGAGTGA AATTGGACAC 3120
AGCCCTCCTC CTGCCTACAC CCCCATGTCA GGAAATCAGT TTGTATACCG AGATGGAGGT 3180
TTTGCTGCAG AACAAGGAGT GTCTGTGCCC TACAGAGCCC CAACTAGCAC AATTCCAGAA 3240
GCTCCTGTTG CACAGGGTGC TACAGCTGAG ATTTTTGATG ACTCCTGCTG TAATGGCACC 3300
CTACGCAAGC CAGTGGCACC CCATGTCCAA GAGGACAGTA GCACCCAGAG GTACAGCGCT 3360
GACCCCACCG TGTTTGCCCC AGAACGGAGC CCACGAGGAG AGCTGGATGA GGAAGGTTAC 3420
ATGACTCCTA TGCGAGACAA ACCCAAACAA GAATACCTGA ATCCAGTGGA GGAGAACCCT 3480
TTTGTTTCTC GGAGAAAAAA TGGAGACCTT CAAGCATTGG ATAATCCCGA ATATCACAGT 3540
GCATCCAATG GTCCACCCAA GGCCGAGGAT GAGTATGTGA ATGAGCCGCT GTACCTCAAC 3600
ACCTTTGCCA ACGCCTTGGG AAAAGCTGAT TACCTGAAGA ACAATGTACT GTCTGTGCCA 3660
GAGAAGGCCA AGAAAGCGTT TGACAACCCT GACTACTGGA ACCACAGCCT GCCACCTCGG 3720
AGCACCCTTC AGCACCCAGA CTACCTGCAG GAGTACAGCA CAAAATATTT TTATAAACAG 3780
AATGGGCGGA TCCGGCCTAT TGTGGCAGAG AATCCGGAAT ACCTCTCTGA GTTCTCCCTG 3840
AAGCCAGGCA CTGTGCTGCC GCCTCCACCT TACAGACACC GAAATACTGT AGTGTAA 3897
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lk++kvlGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as+dh
Q: 708   LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDH  767
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++lvrllg+cls t+qlvtql+p+Gcll+yv+ehkd++Gsq llnwcvqiakGm+ylee+
Q: 768   PHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  827
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+lle deke++a+ggk+pikw+ale+i++rk+
Q: 828   RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF  887
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvt+wel+tfG kpydgip++eipdllekGerl+qppictidvymv+vkcw
Q: 888   THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW  947
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mida+srpkfkela++fs
Q: 948   MIDADSRPKFKELAADFS  965
         **************9996
Domain Sequence
(FASTA)
LKRVKVLGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD EALIMASMDH 60
PHLVRLLGVC LSPTIQLVTQ LMPHGCLLEY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LEGDEKEYNA DGGKMPIKWM ALECIHYRKF 180
THQSDVWSYG VTIWELMTFG GKPYDGIPTR EIPDLLEKGE RLPQPPICTI DVYMVMVKCW 240
MIDADSRPKF KELAADFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00279
EKS-ANC-00288
EKS-BOT-00300
EKS-CAJ-00303
EKS-CAF-00303
EKS-CAP-00332
EKS-CII-00175
EKS-EQC-00288
EKS-GAG-00250
EKS-GAA-00369
EKS-GOG-00294
EKS-HOS-00303
EKS-LAC-00313
EKS-LOA-00307
EKS-MEG-00242
EKS-MOD-00291
EKS-MUM-00328
EKS-MUP-00294
EKS-MYL-00299
EKS-NOL-00273
EKS-ORN-00387
EKS-ORA-00263
EKS-ORC-00279
EKS-ORL-00356
EKS-OTG-00306
EKS-PAT-00282
EKS-PES-00266
EKS-PEM-00164
EKS-POA-00290
EKS-RAN-00313
EKS-SUS-00266
EKS-TAG-00313
EKS-TAR-00389
EKS-TEN-00384
EKS-VIP-00031
EKS-XET-00370
EKS-XIM-00381
Gene Ontology
GO:0016323; C:basolateral plasma membrane
GO:0016021; C:integral to membrane
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0044212; F:transcription regulatory region DNA binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0061026; P:cardiac muscle tissue regeneration
GO:0045165; P:cell fate commitment
GO:0021551; P:central nervous system morphogenesis
GO:0009880; P:embryonic pattern specification
GO:0007507; P:heart development
GO:0007595; P:lactation
GO:0060749; P:mammary gland alveolus development
GO:0060644; P:mammary gland epithelial cell differentiation
GO:0043066; P:negative regulation of apoptotic process
GO:0008285; P:negative regulation of cell proliferation
GO:0001755; P:neural crest cell migration
GO:0021889; P:olfactory bulb interneuron differentiation
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:2000366; P:positive regulation of STAT protein import into nucleus
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0030334; P:regulation of cell migration
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 4.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013