EKS-MAM-00079

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00079

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/GSK	450.5	4.2E-135	56	340	285

Status

Unreviewed

Ensembl Protein

ENSMMUP00000002644

UniProt Accession

F6VAR2;

Protein Name

Protein Synonyms/Alias

Gene Name

GSK3B

Gene Synonyms/Alias

GSK3B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000001980	ENSMMUP00000002642	ENSMMUT00000002798
ENSMMUG00000001980	ENSMMUP00000002644	ENSMMUT00000002800

Organism

Macaca mulatta

Functional Description

Protein Length

420

Protein Sequence
(FASTA)

MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK 60

VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG 120

EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR 180

DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV 240

WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 300

WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL PNGRDTPALF 360

NFTTQVLRNS EFIVLALFKT TFQITAWKAI QFTAYSWNNA NTGDRGQTNN AASASASNST 420

Nucleotide Sequence
(FASTA)

ATGTCAGGGC GGCCCAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCGGT GCAGCAGCCT 60

TCAGCTTTTG GCAGCATGAA AGTTAGCAGA GACAAGGATG GCAGCAAGGT GACCACAGTG 120

GTAGCAACTC CTGGGCAGGG TCCAGACAGG CCACAAGAAG TCAGCTATAC AGACACTAAA 180

GTGATTGGAA ATGGATCATT TGGTGTGGTG TATCAAGCCA AACTTTGTGA TTCAGGAGAA 240

CTGGTCGCCA TCAAGAAAGT ATTGCAGGAC AAGAGATTTA AGAACCGAGA GCTCCAGATC 300

ATGAGAAAGC TAGATCACTG TAACATAGTC CGATTGCGTT ATTTCTTCTA CTCCAGTGGT 360

GAGAAGAAAG ATGAGGTCTA TCTTAATCTG GTGCTGGACT ATGTTCCGGA AACAGTATAC 420

AGAGTTGCCA GACACTATAG TCGAGCCAAA CAGACGCTCC CTGTGATTTA TGTCAAGTTA 480

TATATGTATC AGCTGTTCCG AAGTTTAGCC TATATCCATT CCTTTGGAAT CTGCCATCGG 540

GATATTAAAC CACAGAACCT CTTGTTGGAT CCTGATACAG CCGTATTAAA ACTCTGTGAC 600

TTTGGAAGTG CAAAGCAGCT GGTCCGAGGA GAACCCAATG TTTCGTATAT CTGTTCTCGG 660

TACTATAGGG CACCAGAGTT GATCTTTGGA GCCACTGATT ATACCTCTAG TATAGATGTA 720

TGGTCTGCTG GCTGTGTGTT GGCTGAGCTG CTACTAGGAC AACCAATATT TCCAGGGGAT 780

AGTGGTGTGG ATCAATTGGT GGAAATAATC AAGGTCCTGG GAACTCCAAC AAGGGAGCAA 840

ATCAGAGAAA TGAACCCAAA CTACACAGAA TTTAAATTCC CTCAAATTAA GGCACATCCC 900

TGGACTAAGG TCTTCCGACC CCGAACTCCA CCAGAGGCAA TTGCACTGTG TAGCCGTCTG 960

CTGGAGTATA CGCCAACTGC CCGACTAACA CCACTGGAAG CTTGTGCACA TTCATTTTTT 1020

GATGAATTAC GGGACCCAAA TGTCAAACTA CCAAATGGGC GAGACACACC TGCACTCTTC 1080

AACTTCACCA CTCAAGTACT TAGAAATTCA GAGTTCATAG TGTTGGCCTT ATTTAAAACA 1140

ACCTTCCAAA TAACAGCTTG GAAGGCCATA CAATTCACAG CCTACAGTTG GAACAATGCT 1200

AATACTGGAG ACCGTGGACA GACCAATAAT GCTGCTTCCG CATCAGCTTC CAACTCCACC 1260

TGA 1263

Domain Profile

S: 1     leelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLly  60

         ++++k+ig+GsFg+Vyqa+l+++ e  vaiKkvlqdk++kn+El+i+rkl+H+nivrL+y

Q: 56    YTDTKVIGNGSFGVVYQAKLCDSGEL-VAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRY  114

         5789**********************.*********************************

S: 61    ffsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhs  120

         ff++s ekkd+vylnlvl+y+Pet+++v+r+++++k++l+v++vkly+yQlfr+lay+hs

Q: 115   FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS  174

         ************************************************************

S: 121   leivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakey  180

         ++i+HrDiKPqNll+d++t+vlKlcDfGsak+l+++epnvsYi+sRyYRaPEL++ga++y

Q: 175   FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY  234

         ************************************************************

S: 181   ttkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfk  240

         t++iDvWsagcvlaEll+g+++f+g+s++dql++i+kvlGtpt+e+i+emn++y+e+kf+

Q: 235   TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFP  294

         ************************************************************

S: 241   kikkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286

         +ik+++++kv++ ++++ea++l++++l+y+p++Rl++le++ah+ff

Q: 295   QIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF  340

         *********************************************9

Domain Sequence
(FASTA)

YTDTKVIGNG SFGVVYQAKL CDSGELVAIK KVLQDKRFKN RELQIMRKLD HCNIVRLRYF 60

FYSSGEKKDE VYLNLVLDYV PETVYRVARH YSRAKQTLPV IYVKLYMYQL FRSLAYIHSF 120

GICHRDIKPQ NLLLDPDTAV LKLCDFGSAK QLVRGEPNVS YICSRYYRAP ELIFGATDYT 180

SSIDVWSAGC VLAELLLGQP IFPGDSGVDQ LVEIIKVLGT PTREQIREMN PNYTEFKFPQ 240

IKAHPWTKVF RPRTPPEAIA LCSRLLEYTP TARLTPLEAC AHSFF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0030877	; C:beta-catenin destruction complex
GO:0005813	; C:centrosome
GO:0005829	; C:cytosol
GO:0043198	; C:dendritic shaft
GO:0030426	; C:growth cone
GO:0043025	; C:neuronal cell body
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0030529	; C:ribonucleoprotein complex
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0050321	; F:tau-protein kinase activity
GO:0007409	; P:axonogenesis
GO:0044337	; P:canonical Wnt receptor signaling pathway involved in positive regulation of apoptotic process
GO:0016477	; P:cell migration
GO:0001837	; P:epithelial to mesenchymal transition
GO:0006983	; P:ER overload response
GO:0045444	; P:fat cell differentiation
GO:0005977	; P:glycogen metabolic process
GO:0021766	; P:hippocampus development
GO:0044027	; P:hypermethylation of CpG island
GO:0035556	; P:intracellular signal transduction
GO:0007520	; P:myoblast fusion
GO:0043066	; P:negative regulation of apoptotic process
GO:0051534	; P:negative regulation of NFAT protein import into nucleus
GO:0032091	; P:negative regulation of protein binding
GO:0031333	; P:negative regulation of protein complex assembly
GO:0009887	; P:organ morphogenesis
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0001954	; P:positive regulation of cell-matrix adhesion
GO:0033138	; P:positive regulation of peptidyl-serine phosphorylation
GO:0010800	; P:positive regulation of peptidyl-threonine phosphorylation
GO:0032092	; P:positive regulation of protein binding
GO:0031334	; P:positive regulation of protein complex assembly
GO:0046827	; P:positive regulation of protein export from nucleus
GO:0032855	; P:positive regulation of Rac GTPase activity
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0006611	; P:protein export from nucleus
GO:0035372	; P:protein localization to microtubule
GO:0000320	; P:re-entry into mitotic cell cycle
GO:0006349	; P:regulation of gene expression by genetic imprinting
GO:0032886	; P:regulation of microtubule-based process
GO:0071109	; P:superior temporal gyrus development

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013