EKS-MAM-00040

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00040

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/VRK	416.1	9.0E-125	29	292	264

Status

Unreviewed

Ensembl Protein

ENSMMUP00000002709

UniProt Accession

G7NA38;

Protein Name

Protein Synonyms/Alias

Putative uncharacterized protein;

Gene Name

VRK2

Gene Synonyms/Alias

EGK_05345;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000002025	ENSMMUP00000002709	ENSMMUT00000002866

Organism

Macaca mulatta

Functional Description

Protein Length

342

Protein Sequence
(FASTA)

MPPKRNEKYK LPIPLPEGKV LDDMEGNQWV LGKKIGSGGF GLIYLAFPTN KPEKDARHVV 60

KVEYQENGPL FSELKFYQRV AKKDYIKKWI ERKQLDYLGI PLFYGSGLTE FKGKSYRFMV 120

IERLGIDLQK ISGQNGAFKK STVLQLGIRM LDVLEYIHEN EYVHGDIKAA NLLLGYKNPD 180

RVYLADYGLS YRYCPNGNHK QYQENPRKGH NGTIEFTSLD AHKGVALSRR SDVEILGYCM 240

LRWLCGKLPW EQSLKDPVAV QTAKTNLLDE LPQSVLKWAP SGSSCCEIAQ FLVCAHSLAY 300

DEKPNYQALK KILNPDGIPL GSLDFSTEGQ SINVHTPNSQ KV 342

Nucleotide Sequence
(FASTA)

ATGCCACCAA AAAGAAATGA AAAATACAAA CTTCCTATTC CACTTCCAGA AGGCAAGGTT 60

CTGGATGATA TGGAAGGCAA TCAGTGGGTA CTGGGCAAGA AGATTGGCTC TGGAGGATTT 120

GGATTGATAT ATTTAGCTTT CCCCACAAAT AAACCAGAGA AAGATGCAAG ACATGTAGTA 180

AAAGTGGAAT ATCAAGAAAA TGGCCCGTTA TTTTCAGAAC TTAAATTTTA TCAGAGAGTT 240

GCAAAAAAAG ACTATATCAA AAAGTGGATA GAACGCAAAC AACTTGATTA TTTGGGAATT 300

CCTCTGTTTT ATGGATCTGG TCTGACTGAA TTCAAGGGAA AAAGTTACAG ATTTATGGTA 360

ATAGAAAGAC TAGGAATAGA TTTACAGAAG ATCTCAGGCC AGAATGGTGC CTTTAAAAAG 420

TCAACTGTCC TGCAATTAGG TATCCGAATG TTGGATGTAC TGGAATATAT ACATGAAAAT 480

GAATATGTTC ATGGTGATAT AAAAGCAGCA AATCTACTTT TGGGTTACAA AAATCCAGAC 540

CGGGTTTATC TTGCAGATTA TGGACTTTCC TACAGATATT GTCCCAATGG GAACCACAAA 600

CAGTATCAGG AAAATCCTAG AAAAGGCCAT AATGGGACAA TAGAGTTTAC CAGCTTGGAT 660

GCCCACAAGG GAGTAGCCCT GTCCAGACGA AGTGACGTTG AGATCCTTGG CTACTGCATG 720

CTGCGGTGGT TGTGTGGGAA ACTTCCCTGG GAACAGAGCC TGAAGGACCC TGTGGCTGTG 780

CAGACTGCTA AAACAAATCT ATTGGATGAG CTTCCCCAGT CAGTGCTTAA ATGGGCTCCT 840

TCTGGAAGCA GTTGCTGTGA AATAGCCCAG TTTTTGGTAT GTGCTCATAG TTTAGCCTAT 900

GATGAAAAGC CAAACTATCA AGCGCTCAAG AAAATTTTGA ACCCTGATGG AATACCTTTG 960

GGATCACTGG ACTTTTCCAC AGAAGGACAG AGTATAAATG TCCATACTCC AAACAGTCAA 1020

AAAGTA 1026

Domain Profile

S: 1     wklgkkigkggfGeiylaltckkeekdaklvvkvepkenGpLfvelkfyqraakkeqikk  60

         w lgkkig+ggfG iyla++++k+ekda++vvkve++enGpLf+elkfyqr+akk+ ikk

Q: 29    WVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDYIKK  88

         99**********************************************************

S: 61    wkkkkklkllgiPtliasGlhefegekyRflvlprlgrdLqklleqngkrlsektvlqla  120

         w+++k+l++lgiP +++sGl+ef+g++yRf+v++rlg+dLqk+  qng  ++++tvlql+

Q: 89    WIERKQLDYLGIPLFYGSGLTEFKGKSYRFMVIERLGIDLQKISGQNGA-FKKSTVLQLG  147

         ************************************************6.**********

S: 121   vrlldvleylHeneYvHgdikAanllleeeeasqvyLvdyGlayrycpegkhkeykedkr  180

         +r+ldvley+HeneYvHgdikAanlll+++++++vyL+dyGl+yrycp+g+hk+y+e++r

Q: 148   IRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDRVYLADYGLSYRYCPNGNHKQYQENPR  207

         ************************************************************

S: 181   raHdGtleftslDaHkGvapsrRsDleiLgYcllkWltgkLPWeallkdpekvqkakekf  240

         + H+Gt+eftslDaHkGva srRsD+eiLgYc+l+Wl+gkLPWe+ lkdp +vq+ak+++

Q: 208   KGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQSLKDPVAVQTAKTNL  267

         ************************************************************

S: 241   ldelpellkkllkkkssseelakyl  265

         ldelp+++ k+++++ss++e+a++l

Q: 268   LDELPQSVLKWAPSGSSCCEIAQFL  292

         ***********************97

Domain Sequence
(FASTA)

WVLGKKIGSG GFGLIYLAFP TNKPEKDARH VVKVEYQENG PLFSELKFYQ RVAKKDYIKK 60

WIERKQLDYL GIPLFYGSGL TEFKGKSYRF MVIERLGIDL QKISGQNGAF KKSTVLQLGI 120

RMLDVLEYIH ENEYVHGDIK AANLLLGYKN PDRVYLADYG LSYRYCPNGN HKQYQENPRK 180

GHNGTIEFTS LDAHKGVALS RRSDVEILGY CMLRWLCGKL PWEQSLKDPV AVQTAKTNLL 240

DELPQSVLKW APSGSSCCEI AQFL 264

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005789	; C:endoplasmic reticulum membrane
GO:0031966	; C:mitochondrial membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0046777	; P:protein autophosphorylation
GO:2000659	; P:regulation of interleukin-1-mediated signaling pathway
GO:0043408	; P:regulation of MAPK cascade
GO:0006979	; P:response to oxidative stress

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013