EKS-MAM-00157

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00157

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	497.7	1.2E-149	423	680	258

Status

Unreviewed

Ensembl Protein

ENSMMUP00000002844

UniProt Accession

F6UNV6;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA3

Gene Synonyms/Alias

RPS6KA3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000002134	ENSMMUP00000041175	ENSMMUT00000048138
ENSMMUG00000002134	ENSMMUP00000002844	ENSMMUT00000003012

Organism

Macaca mulatta

Functional Description

Protein Length

741

Protein Sequence
(FASTA)

MPLAQLADPW QKMAVESPSD SAENGQQIMD EPMGEEEINP QTEEVSIKEI AITHHVKEGH 60

EKADPSQFEL LKVLGQGSFG KVFLVKKISG TDARQLYAMK VLKKATLKVR DRVRTKMERD 120

ILVEVNHPFI VKLHYAFQTE GKLYLILDFL RGGDLFTRLS KEVMFTEEDV KFYLAELALA 180

LDHLHSLGII YRDLKPENIL LDEEGHIKLT DFGLSKESID HEKKAYSFCG TVEYMAPEVV 240

NRRGHTQSAD WWSFGVLMFE MLTGTLPFQG KDRKETMTMI LKAKLGMPQF LSPEAQSLLR 300

MLFKRNPANR LDKVGHGGSC LPRQENYLTT QEVEKLYRRE IHPPFKPATG RPEDTFYFDP 360

EFTAKTPKDS PGIPPSANAH QLFRGFSFVA ITSDDESQAM QTVGVHSIVQ QLHRNSIQFT 420

DGYEVKEDIG VGSYSVCKRC IHKATNMEFA VKIIDKSKRD PTEEIEILLR YGQHPNIITL 480

KDVYDDGKYV YVVTELMKGG ELLDKILRQK FFSEREASAV LFTITKTVEY LHAQGVVHRD 540

LKPSNILYVD ESGNPESIRI CDFGFAKQLR AENGLLMTPC YTANFVAPEV LKRQGYDAAC 600

DIWSLGVLLY TMLTGYTPFA NGPDDTPEEI LARIGSGKFS LSGGYWNSVS DTAKDLVSKM 660

LHVDPHQRLT AALVLRHPWI VHWDQLPQYQ LNRQDAPHLV KGAMAATYSA LNRNQSPVLE 720

PVGRSTLAQR RGIKKITSTA L 741

Nucleotide Sequence
(FASTA)

ATGCCGCTGG CGCAGCTGGC GGACCCGTGG CAGAAGATGG CTGTGGAGAG CCCGTCCGAC 60

AGCGCTGAGA ATGGACAACA AATTATGGAT GAACCTATGG GAGAGGAGGA GATTAACCCA 120

CAAACTGAAG AAGTCAGTAT CAAAGAAATT GCCATCACAC ATCATGTAAA GGAAGGACAT 180

GAAAAGGCAG ATCCTTCCCA GTTTGAACTT TTAAAAGTAT TAGGGCAGGG ATCATTTGGA 240

AAGGTTTTCT TAGTTAAAAA AATCTCAGGC ACTGATGCTA GGCAGCTTTA TGCCATGAAG 300

GTATTGAAGA AGGCCACACT GAAAGTTCGA GACCGAGTTC GGACAAAAAT GGAACGTGAT 360

ATCTTGGTAG AGGTTAATCA TCCTTTTATT GTCAAGTTGC ATTATGCTTT TCAAACTGAA 420

GGGAAGTTGT ATCTTATTTT GGATTTTCTC AGGGGAGGAG ATTTGTTTAC ACGCTTATCC 480

AAAGAGGTGA TGTTCACAGA AGAAGATGTC AAATTCTACT TGGCTGAACT TGCACTTGCT 540

TTAGACCATC TACATAGCCT GGGAATAATT TATAGAGACT TAAAACCAGA AAACATACTT 600

CTTGATGAAG AAGGTCACAT CAAGTTAACA GATTTTGGCC TAAGTAAAGA GTCTATTGAC 660

CATGAGAAGA AGGCATATTC TTTTTGTGGA ACTGTGGAGT ATATGGCTCC AGAAGTAGTT 720

AATCGTCGAG GTCATACTCA GAGTGCTGAC TGGTGGTCTT TTGGTGTGTT AATGTTTGAA 780

ATGCTTACTG GTACACTACC TTTCCAAGGA AAAGATCGAA AAGAAACAAT GACTATGATT 840

CTTAAAGCCA AACTTGGAAT GCCACAGTTT TTGAGTCCTG AAGCCCAGAG TCTTTTGCGA 900

ATGCTTTTCA AGCGAAATCC TGCAAACAGA TTAGACAAGG TTGGGCATGG GGGCTCATGC 960

CTACCAAGGC AGGAGAATTA CTTGACTACT CAGGAAGTTG AGAAACTGTA TAGAAGAGAA 1020

ATTCATCCAC CATTTAAACC TGCAACGGGC AGGCCTGAAG ATACATTCTA TTTTGATCCT 1080

GAGTTTACTG CAAAAACTCC CAAAGATTCA CCTGGCATTC CACCTAGTGC TAATGCACAT 1140

CAGCTTTTTC GGGGGTTTAG TTTTGTTGCT ATTACCTCAG ATGATGAAAG CCAGGCTATG 1200

CAGACAGTTG GTGTACATTC AATTGTTCAG CAGTTACACA GGAACAGTAT TCAGTTTACT 1260

GATGGATATG AAGTAAAAGA AGATATTGGA GTTGGCTCCT ACTCTGTTTG CAAGAGATGT 1320

ATACATAAAG CTACAAACAT GGAGTTTGCA GTGAAGATTA TTGATAAAAG CAAGAGAGAC 1380

CCTACAGAAG AAATTGAAAT TCTTCTTCGT TATGGACAGC ATCCAAACAT TATTACTCTA 1440

AAGGATGTAT ATGATGATGG AAAATATGTG TATGTAGTAA CAGAACTTAT GAAAGGAGGT 1500

GAATTGCTGG ATAAAATTCT TAGACAAAAA TTTTTCTCTG AACGAGAGGC CAGTGCTGTC 1560

CTGTTCACTA TAACCAAAAC CGTTGAATAT CTTCACGCAC AAGGGGTGGT TCATAGAGAC 1620

TTGAAACCTA GCAACATTCT TTATGTGGAT GAATCTGGTA ATCCAGAATC TATTCGAATT 1680

TGTGATTTTG GCTTTGCAAA ACAGCTGAGA GCGGAAAATG GTCTTCTCAT GACTCCTTGT 1740

TATACTGCAA ATTTTGTTGC ACCAGAGGTT TTAAAACGAC AAGGCTATGA TGCTGCTTGT 1800

GATATATGGA GTCTTGGTGT CCTACTCTAT ACAATGCTTA CCGGTTACAC TCCATTTGCA 1860

AATGGTCCTG ATGATACACC AGAGGAAATA TTGGCACGAA TAGGTAGCGG AAAATTCTCA 1920

CTCAGTGGTG GTTACTGGAA TTCTGTTTCA GACACAGCAA AGGACCTGGT GTCAAAGATG 1980

CTTCATGTAG ACCCTCATCA GAGACTGACT GCTGCTCTTG TGCTCAGACA TCCTTGGATC 2040

GTCCACTGGG ACCAACTGCC ACAATACCAA CTAAACAGAC AGGATGCACC ACATCTAGTA 2100

AAGGGTGCCA TGGCAGCTAC ATATTCTGCT TTGAACCGTA ATCAGTCACC AGTTTTGGAA 2160

CCAGTAGGCC GCTCTACTCT TGCTCAGCGG AGAGGTATTA AAAAAATCAC CTCAACAGCC 2220

CTGTGA 2226

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         yevked+GvGsysvckrc+hkatn+efavkiidkskrd++eeieillry+qhpni+tlkd

Q: 423   YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKD  482

         789*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyddgkyvy+v+el+kGGelld+i+++kffsereasa+l+t++k+veylh+qGvvhrdlk

Q: 483   VYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLK  542

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvdes+n+esi+i+dfGfak++raengll+tpcyt+nfvapevlkrqGyd+acd+

Q: 543   PSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI  602

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslGvllytml+Gy+pfangp+dt+eeila+i++GkfslsG++w+svs++akdlvsk+l+

Q: 603   WSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLH  662

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl+++ +l+h+w+

Q: 663   VDPHQRLTAALVLRHPWI  680

         *****************8

Domain Sequence
(FASTA)

YEVKEDIGVG SYSVCKRCIH KATNMEFAVK IIDKSKRDPT EEIEILLRYG QHPNIITLKD 60

VYDDGKYVYV VTELMKGGEL LDKILRQKFF SEREASAVLF TITKTVEYLH AQGVVHRDLK 120

PSNILYVDES GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDI 180

WSLGVLLYTM LTGYTPFANG PDDTPEEILA RIGSGKFSLS GGYWNSVSDT AKDLVSKMLH 240

VDPHQRLTAA LVLRHPWI 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0043027	; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0032496	; P:response to lipopolysaccharide
GO:0002224	; P:toll-like receptor signaling pathway

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013