EKS-MAM-00155

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00155

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	623.7	6.0E-188	407	686	280

Status

Unreviewed

Ensembl Protein

ENSMMUP00000014069

UniProt Accession

F6U958;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK2

Gene Synonyms/Alias

TLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000002166	ENSMMUP00000002885	ENSMMUT00000003056
ENSMMUG00000002166	ENSMMUP00000014069	ENSMMUT00000015015

Organism

Macaca mulatta

Functional Description

Protein Length

717

Protein Sequence
(FASTA)

MMEELHSLDP RRQELLEARF TGVGVSKGPL NSESSNQSLC SVGSLSDKEV ETPEKKQNDQ 60

RNRKRKAEPY ETSQGKGTPR GHKISDYFER RVEQPLYGLD GSAAKEATEE QSALPTLMSV 120

MLAKPRLDTE QLAQRGAGLC FTFVSAQQNS PSSTGSGNTE HSCSSQKQIS IQHRQTQSDL 180

TIEKISALEN SKNSDLEKKE GRIDDLLRAN CDLRRQIDEQ QKMLEKYKER LNRCVTMSKK 240

LLIEKSKQEK MACRDKSMQD RLRLGHFTTV RHGASFTEQW TDGYAFQNLI KQQERINSQR 300

EEIERQRKML AKRKPPAMGQ APPATNEQKQ RKSKTNGAEN ETYTPHHTPK YKCPHLPLAF 360

HKINEAEIQA ELERLERVRN LHIRELKRIH NEDNSQFKDH PTLNDRYLLL HLLGRGGFSE 420

VYKAFDLTEQ RYVAVKIHQL NKNWRDEKKE NYHKHACREY RIHKELDHPR IVKLYDYFSL 480

DTDSFCTVLE YCEGNDLDFY LKQHKLMSEK EARSIIMQIV NALKYLNEIK PPIIHYDLKP 540

GNILLVNGTA CGEIKITDFG LSKIMDDDSY NSVDGMELTS QGAGTYWYLP PECFVVGKEP 600

PKISNKVDVW SVGVIFYQCL YGRKPFGHNQ SQQDILQENT ILKATEVQFP PKPVVTPEAK 660

AFIRRCLAYR KEDRIDVQQL ACDPYLLPHI RKSVSTSSPA GAAIASTSGA SNNSSSN 717

Nucleotide Sequence
(FASTA)

ATGATGGAAG AATTGCATAG CCTGGACCCA CGACGGCAGG AATTATTGGA GGCCAGGTTT 60

ACTGGAGTAG GTGTTAGTAA GGGACCACTT AATAGTGAGT CTTCCAACCA GAGTTTGTGT 120

AGCGTGGGAT CCTTGAGTGA TAAAGAAGTA GAGACTCCCG AGAAAAAGCA GAATGACCAG 180

CGAAATCGGA AAAGAAAAGC TGAACCATAT GAAACTAGCC AAGGGAAAGG CACTCCTAGG 240

GGACATAAAA TTAGTGATTA CTTTGAGCGA CGAGTAGAAC AGCCCCTCTA TGGTTTAGAT 300

GGCAGTGCTG CAAAGGAGGC AACGGAGGAG CAGTCTGCTC TGCCAACCCT CATGTCAGTG 360

ATGCTAGCAA AACCTCGGCT TGACACAGAG CAGCTGGCAC AAAGGGGAGC TGGCCTCTGC 420

TTCACTTTTG TTTCAGCTCA GCAAAACAGT CCCTCATCTA CAGGATCTGG CAACACAGAG 480

CATTCCTGCA GCTCCCAAAA ACAGATCTCC ATCCAGCACA GACAGACCCA GTCCGACCTC 540

ACAATAGAAA AAATATCTGC ACTAGAAAAC AGTAAGAATT CTGACTTAGA GAAGAAGGAG 600

GGAAGAATAG ATGATTTATT AAGAGCCAAC TGTGATTTGA GACGGCAGAT TGATGAACAG 660

CAAAAGATGC TAGAGAAATA CAAGGAACGA TTAAATAGAT GTGTGACAAT GAGCAAGAAA 720

CTCCTTATAG AAAAGTCAAA ACAAGAGAAG ATGGCATGTA GAGATAAGAG CATGCAAGAC 780

CGCTTGAGAT TGGGCCACTT TACTACTGTC CGACATGGGG CCTCATTTAC TGAACAGTGG 840

ACAGATGGTT ATGCTTTTCA GAATCTTATC AAGCAACAGG AAAGGATAAA TTCACAGAGG 900

GAAGAGATAG AAAGACAACG GAAAATGTTA GCAAAGCGGA AACCTCCTGC CATGGGTCAG 960

GCCCCTCCTG CAACCAATGA GCAAAAACAG CGGAAAAGCA AGACCAATGG AGCTGAAAAT 1020

GAAACGTATA CACCACACCA CACCCCCAAA TACAAATGTC CTCACCTTCC TCTAGCCTTT 1080

CATAAGATAA ATGAAGCAGA GATCCAGGCA GAGCTGGAGA GGCTAGAAAG GGTTAGAAAT 1140

CTACATATCA GGGAACTAAA AAGGATACAT AATGAAGATA ATTCACAATT TAAAGATCAT 1200

CCAACGCTAA ATGACAGATA TTTGTTGTTA CATCTTTTGG GTAGAGGAGG TTTCAGTGAA 1260

GTTTACAAGG CATTTGATCT AACAGAGCAA AGATACGTAG CTGTGAAAAT TCACCAGTTA 1320

AATAAAAACT GGAGAGATGA GAAAAAGGAG AATTACCACA AGCATGCATG TAGGGAATAC 1380

CGGATTCATA AAGAACTGGA TCATCCCAGA ATAGTTAAGC TGTATGATTA CTTTTCACTG 1440

GATACTGACT CGTTTTGTAC AGTATTAGAA TACTGTGAGG GAAATGATCT GGACTTCTAC 1500

CTGAAACAGC ACAAATTAAT GTCGGAGAAA GAGGCCCGGT CCATTATCAT GCAGATTGTG 1560

AATGCTTTAA AGTACTTAAA TGAAATAAAA CCTCCCATCA TACACTATGA CCTCAAACCA 1620

GGTAATATTC TTTTAGTAAA TGGTACAGCG TGTGGAGAGA TAAAAATTAC AGATTTTGGT 1680

CTTTCGAAGA TCATGGATGA TGATAGCTAC AATTCAGTGG ATGGCATGGA GCTAACATCA 1740

CAAGGTGCTG GTACTTATTG GTATTTACCA CCAGAGTGTT TTGTGGTTGG GAAAGAACCA 1800

CCAAAGATCT CAAATAAAGT TGATGTGTGG TCAGTGGGTG TGATCTTCTA TCAGTGTCTT 1860

TATGGAAGGA AGCCTTTTGG CCATAACCAG TCTCAGCAAG ACATCCTACA AGAGAATACG 1920

ATTCTTAAAG CTACTGAAGT GCAGTTCCCG CCAAAGCCAG TAGTAACACC TGAAGCAAAG 1980

GCGTTTATTC GACGATGCTT GGCCTACCGA AAGGAGGACC GCATTGATGT CCAGCAGCTG 2040

GCCTGTGATC CCTACTTGTT GCCTCACATC CGAAAGTCAG TCTCTACGAG TAGCCCTGCT 2100

GGAGCTGCTA TTGCATCAAC CTCTGGGGCA TCCAATAACA GTTCTTCTAA TTGA 2154

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqryvavkihqlnk+w+dekkeny+kha+reyrihkel

Q: 407   YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL  466

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtdsfctvley+egndldfylkqhkl+sekearsiimqiv+alkyl

Q: 467   DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL  526

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy+s+dg+eltsqgagty

Q: 527   NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY  586

         ************************************************************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvifyqclyg+kpfghnqsqqdil+entilkate

Q: 587   WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE  646

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvv++eakafirrclayrkedridvqqla+d+yl

Q: 647   VQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL  686

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LTEQRYVAVK IHQLNKNWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDSFC TVLEYCEGND LDFYLKQHKL MSEKEARSII MQIVNALKYL 120

NEIKPPIIHY DLKPGNILLV NGTACGEIKI TDFGLSKIMD DDSYNSVDGM ELTSQGAGTY 180

WYLPPECFVV GKEPPKISNK VDVWSVGVIF YQCLYGRKPF GHNQSQQDIL QENTILKATE 240

VQFPPKPVVT PEAKAFIRRC LAYRKEDRID VQQLACDPYL 280

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005882	; C:intermediate filament
GO:0005634	; C:nucleus
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction
GO:0001672	; P:regulation of chromatin assembly or disassembly

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013