EPS-MAM-00006
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-MAM-00006
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
DSP/aDSP157.63.2E-4631177147
StatusUnreviewed
Ensembl ProteinENSMMUP00000003147
UniProt AccessionF7C5I2;
Protein Name
Protein Synonyms/Alias Dual specificity protein phosphatase 3;
Gene NameDUSP3
Gene Synonyms/Alias DUSP3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000002351ENSMMUP00000003147ENSMMUT00000003334
OrganismMacaca mulatta
Functional Description
Protein Length185
Protein Sequence
(FASTA)
MSGSFELSVQ DLNDLLSDGS GCYSLPSQPC NEVTPRIYVG NASVAQDIPK LQKLGITHVL 60
NAAEGRSFMH VNTNANFYKD SGITYLGIKA NDTQEFNLSA YFERAADFID QALAQKNGRV 120
LVHCREGYSR SPTLVIAYLM MRQKMDVKSA LSIVRQNREI GPNDGFLAQL CQLNDRLAKE 180
GKLKP 185
Nucleotide Sequence
(FASTA)
ATGTCCGGCT CGTTCGAGCT CTCGGTGCAG GATCTCAACG ACCTGCTCTC GGACGGCAGC 60
GGCTGCTACA GCCTCCCGAG CCAACCCTGC AACGAGGTCA CCCCGCGGAT CTACGTGGGC 120
AACGCGTCTG TGGCTCAGGA TATCCCCAAG CTGCAGAAAC TAGGCATCAC CCATGTTCTG 180
AACGCGGCTG AGGGCAGGTC CTTCATGCAC GTCAACACCA ATGCCAACTT CTACAAGGAC 240
TCCGGCATCA CATACCTGGG CATCAAGGCC AACGACACAC AGGAGTTCAA CCTCAGCGCT 300
TACTTTGAAA GGGCTGCTGA CTTCATCGAC CAGGCTTTGG CTCAAAAGAA TGGCCGGGTG 360
CTCGTCCACT GCCGGGAAGG TTACAGCCGC TCTCCAACGC TAGTTATTGC CTACCTCATG 420
ATGCGGCAGA AGATGGATGT CAAGTCTGCC CTGAGCATCG TGAGGCAGAA CCGTGAGATT 480
GGCCCCAACG ATGGCTTCCT GGCCCAGCTG TGCCAGCTCA ATGACAGACT AGCCAAGGAG 540
GGGAAGTTGA AACCCTAG 558
Domain Profile
S: 3     teilpglylgdqataldrreLsklgitvvinaslsv..ikvqviPeylikkgityknipv  60
         +e++p++y+g++ +a d  +L+klgit+v+na+ ++  ++v++  +++ ++gity++i++
Q: 31    NEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRsfMHVNTNANFYKDSGITYLGIKA  90
         79******************************9754227889999***************
S: 61    dDsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdA  119
         +D+++++l+ yf++aa+fid+a  +k+g+vlvHC+ G+sRS+tlv+aYLm+++++ +++A
Q: 91    NDTQEFNLSAYFERAADFIDQAlAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSA  150
         **********************9999**********************************
S: 120   ieavkrkrpsiepnegfleQLlelekkl  147
         ++ v+++r +i pn+gfl+QL++l+ +l
Q: 151   LSIVRQNR-EIGPNDGFLAQLCQLNDRL  177
         ********.***************9876
Domain Sequence
(FASTA)
NEVTPRIYVG NASVAQDIPK LQKLGITHVL NAAEGRSFMH VNTNANFYKD SGITYLGIKA 60
NDTQEFNLSA YFERAADFID QALAQKNGRV LVHCREGYSR SPTLVIAYLM MRQKMDVKSA 120
LSIVRQNREI GPNDGFLAQL CQLNDRL 147
KeywordComplete proteome; Hydrolase; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EPS-AIM-00015
EPS-ANC-00015
EPS-BOT-00007
EPS-CAJ-00011
EPS-CAF-00013
EPS-CAP-00007
EPS-DAR-00015
EPS-DIO-00004
EPS-ECT-00009
EPS-EQC-00010
EPS-ERE-00003
EPS-GAM-00015
EPS-GAG-00015
EPS-GAA-00015
EPS-GOG-00012
EPS-HOS-00006
EPS-ICT-00008
EPS-LAC-00013
EPS-LOA-00007
EPS-MEG-00017
EPS-MIM-00007
EPS-MOD-00007
EPS-MUM-00007
EPS-MUP-00009
EPS-MYL-00007
EPS-NOL-00011
EPS-OCP-00003
EPS-ORN-00011
EPS-ORC-00011
EPS-ORL-00018
EPS-OTG-00008
EPS-PAT-00006
EPS-PES-00013
EPS-PEM-00007
EPS-POA-00013
EPS-PRC-00004
EPS-PTV-00008
EPS-RAN-00009
EPS-SAH-00007
EPS-SOA-00001
EPS-SUS-00008
EPS-TAG-00012
EPS-TAR-00018
EPS-TEN-00012
EPS-TUB-00007
EPS-TUT-00007
EPS-VIP-00007
EPS-XET-00011
EPS-XIM-00020
Gene Ontology
GO:0005829; C:cytosol
GO:0001772; C:immunological synapse
GO:0005634; C:nucleus
GO:0033549; F:MAP kinase phosphatase activity
GO:0004725; F:protein tyrosine phosphatase activity
GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity
GO:0070373; P:negative regulation of ERK1 and ERK2 cascade
GO:0046329; P:negative regulation of JNK cascade
GO:0050868; P:negative regulation of T cell activation
GO:0050860; P:negative regulation of T cell receptor signaling pathway
GO:0045931; P:positive regulation of mitotic cell cycle
KEGG
mcc:713686;
InterPros
IPR020417; Atypical_DUSP.
IPR020405; Atypical_DUSP_famA.
IPR000340; Dual-sp_phosphatase_cat-dom.
IPR020422; Dual-sp_phosphatase_subgr_cat.
IPR024950; DUSP.
IPR000387; Tyr/Dual-specificity_Pase.
IPR016130; Tyr_Pase_AS.
Pfam
PF00782; DSPc; 1.
SMARTs
SM00195; DSPc; 1.
Prosites
PS00383; TYR_PHOSPHATASE_1; 1.
PS50056; TYR_PHOSPHATASE_2; 1.
PS50054; TYR_PHOSPHATASE_DUAL; 1.
Prints
PR01908; ADSPHPHTASE.
PR01909; ADSPHPHTASEA.
Created Date20-Feb-2013