EKS-MAM-00402
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00402
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR604.41.2E-181589924336
StatusUnreviewed
Ensembl ProteinENSMMUP00000004082
UniProt AccessionF6V858;
Protein Name
Protein Synonyms/Alias Mast/stem cell growth factor receptor; Mast/stem cell growth factor receptor isoform 1;
Gene NameKIT
Gene Synonyms/Alias KIT; EGK_15881;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000003057ENSMMUP00000004082ENSMMUT00000004330
OrganismMacaca mulatta
Functional Description
Protein Length976
Protein Sequence
(FASTA)
MRGARGAWDF LCVLLFLLHV QTGSSQPSVS PGEPSPPSIH PAKSELIVRV GNEIRLLCID 60
PGFVKWTFEI LDETNENKQN EWITEKAEAT NTGKYTCTNK HGLSSSIYVF VRDPAKLFLV 120
DRSLYGKEDN DTLVRCPLTD PEVTSYSLKG CQGKPLPKDL RFVPDPKAGI TIKSVKRAYH 180
RLCLHCSADQ EGKSVLSDKF ILKVRPAFKA VPVVSVSKAS YLLREGEEFT VTCTIKDVSS 240
SVYSTWKREN SQTKLQEKYN SWHHGDFNYE RQATLTISSA RVNDSGVFMC YANNTFGSAN 300
VTTTLEVVDK GFINIFPMIN TTVFVNDGEN VDLIVEYEAF PKPEHQQWIY MNRTFTDKWE 360
DYPKSENESN IRYVSELHLT RLKGTEGGTY TFLVSNSDVN ASIAFNVYVN TKPEILTYDR 420
LVNGMLQCVA AGFPEPTIDW YFCPGTEQRC SASVLPVDVQ TLNASGPPFG KLVVQSSIDS 480
SAFKHNGTVE CKAYNDVGKT SAYFNFAFKG NNKEQIHPHT LFTPLLIGFV IVAGMMCIIV 540
MILTYKYLQK PMYEVQWKVV EEINGNNYVY IDPTQLPYDH KWEFPRNRLS FGKTLGAGAF 600
GKVVEATAYG LIKSDAAMTV AVKMLKPSAH LTEREALMSE LKVLSYLGNH MNIVNLLGAC 660
TIGGPTLVIT EYCCYGDLLN FLRRKRDSFI CSKQEDHAES ALYKNLLHSK ESSCSDSTNE 720
YMDMKPGVSY VVPTKADKRR SARIGSYIER DVTPAIMEDD ELALDLEDLL SFSYQVAKGM 780
AFLASKNCIH RDLAARNILL THGRITKICD FGLARDIKND SNYVVKGNAR LPVKWMAPES 840
IFNCVYTFES DVWSYGIFLW ELFSLGSSPY PGMPVDSKFY KMIKEGFRML SPEHAPAEMY 900
DIMKTCWDAD PLKRPTFKQI VQLIEKQISE STNHIYSNLA NCSPNRQKPV VDHSVRINSV 960
GSTASSSQPL LVHDDV 976
Nucleotide Sequence
(FASTA)
ATGAGAGGCG CTCGCGGCGC CTGGGATTTT CTCTGCGTTC TGCTCTTCCT GCTCCACGTC 60
CAGACAGGCT CTTCTCAACC ATCTGTGAGT CCAGGGGAAC CGTCTCCACC ATCCATCCAT 120
CCAGCAAAAT CAGAGTTAAT AGTCCGAGTG GGCAACGAGA TTAGGCTGTT GTGCATTGAT 180
CCAGGCTTTG TCAAATGGAC TTTTGAGATC CTGGATGAAA CGAATGAGAA TAAGCAGAAT 240
GAATGGATCA CAGAAAAGGC AGAGGCCACC AACACCGGCA AATACACGTG CACCAACAAA 300
CACGGCTTAA GCAGTTCCAT TTATGTGTTT GTTAGAGATC CTGCCAAGCT TTTCCTTGTT 360
GACCGCTCCT TGTATGGGAA AGAAGACAAT GACACACTGG TCCGCTGTCC TCTCACAGAC 420
CCAGAAGTGA CCAGTTATTC CCTCAAGGGG TGCCAGGGGA AGCCTCTTCC CAAGGACTTG 480
AGGTTTGTTC CTGACCCCAA GGCTGGCATC ACGATCAAAA GCGTGAAACG CGCCTACCAT 540
CGGCTCTGTC TGCATTGTTC CGCGGACCAG GAGGGCAAGT CAGTGCTGTC GGACAAGTTC 600
ATCCTGAAAG TGAGGCCAGC CTTCAAAGCT GTGCCTGTTG TGTCTGTTTC CAAAGCAAGC 660
TATCTTCTTA GGGAAGGGGA AGAATTCACA GTGACATGCA CAATAAAAGA TGTGTCTAGT 720
TCTGTGTACT CAACGTGGAA AAGAGAAAAC AGTCAGACTA AACTACAGGA GAAATATAAT 780
AGCTGGCATC ACGGTGACTT CAATTATGAA CGTCAGGCAA CGTTGACTAT CAGTTCAGCG 840
AGAGTTAATG ATTCTGGAGT GTTCATGTGT TATGCCAATA ATACTTTTGG ATCAGCAAAT 900
GTCACAACAA CCTTGGAAGT AGTAGATAAA GGATTCATTA ATATCTTCCC CATGATAAAC 960
ACTACAGTAT TTGTAAACGA TGGAGAAAAT GTAGATTTGA TTGTTGAATA TGAGGCATTC 1020
CCCAAACCTG AACACCAGCA GTGGATCTAT ATGAACAGAA CCTTCACTGA TAAATGGGAA 1080
GATTATCCCA AGTCTGAGAA TGAAAGTAAT ATCAGATACG TAAGTGAACT TCATCTAACC 1140
AGATTAAAAG GCACTGAAGG AGGCACTTAC ACATTCCTAG TGTCCAATTC TGACGTCAAT 1200
GCTTCCATAG CATTTAATGT TTATGTGAAT ACAAAACCAG AAATCCTGAC TTACGACAGG 1260
CTCGTGAATG GCATGCTCCA ATGTGTGGCA GCAGGATTCC CAGAACCCAC AATAGATTGG 1320
TATTTTTGTC CGGGAACTGA GCAGAGATGC TCTGCTTCTG TACTGCCAGT GGATGTGCAG 1380
ACACTAAACG CATCTGGGCC ACCGTTTGGA AAACTAGTGG TTCAGAGTTC CATAGATTCT 1440
AGTGCATTCA AGCACAATGG CACGGTTGAA TGTAAGGCTT ACAACGATGT GGGCAAGACT 1500
TCTGCCTATT TTAACTTTGC ATTTAAAGGT AACAACAAAG AGCAAATCCA TCCCCACACC 1560
CTGTTCACTC CTTTGCTGAT TGGTTTTGTA ATCGTAGCTG GCATGATGTG CATTATTGTG 1620
ATGATTCTCA CCTACAAATA TTTACAGAAA CCCATGTATG AAGTACAGTG GAAGGTTGTT 1680
GAGGAGATAA ATGGAAACAA TTACGTTTAC ATAGACCCAA CACAACTTCC TTATGATCAC 1740
AAATGGGAGT TTCCCAGAAA CAGGCTGAGT TTTGGGAAAA CCCTGGGTGC TGGCGCTTTT 1800
GGGAAGGTTG TTGAGGCAAC TGCTTATGGC TTAATTAAGT CGGACGCGGC CATGACTGTC 1860
GCTGTAAAGA TGCTCAAACC AAGTGCCCAT TTAACAGAAC GAGAAGCCCT CATGTCTGAA 1920
CTCAAAGTCC TGAGTTACCT TGGTAATCAT ATGAATATTG TGAATCTTCT TGGAGCCTGC 1980
ACCATTGGAG GGCCCACCCT GGTCATTACA GAATATTGTT GCTATGGTGA TCTTTTGAAT 2040
TTTTTGAGAA GAAAACGTGA TTCTTTTATT TGTTCAAAGC AGGAAGATCA TGCAGAATCT 2100
GCACTTTATA AGAATCTTCT GCATTCAAAG GAGTCTTCCT GCAGCGATAG TACTAATGAG 2160
TACATGGACA TGAAACCTGG AGTTTCTTAT GTCGTCCCAA CCAAGGCTGA CAAAAGGAGA 2220
TCTGCGAGAA TAGGCTCATA TATAGAAAGA GATGTGACAC CCGCCATCAT GGAGGATGAC 2280
GAGTTGGCTT TAGACTTAGA AGACTTGCTG AGCTTTTCTT ACCAGGTGGC AAAGGGCATG 2340
GCTTTCCTTG CCTCCAAGAA TTGTATTCAC AGAGACTTGG CAGCCAGAAA TATCCTCCTT 2400
ACTCATGGTC GGATCACAAA GATTTGTGAT TTTGGCCTAG CCAGAGACAT CAAGAATGAT 2460
TCTAATTATG TGGTTAAAGG AAATGCTCGA CTACCTGTGA AGTGGATGGC ACCTGAAAGC 2520
ATTTTCAACT GTGTGTACAC ATTTGAAAGT GACGTCTGGT CCTATGGGAT TTTTCTTTGG 2580
GAGCTATTCT CTTTAGGAAG CAGCCCCTAT CCTGGAATGC CAGTCGATTC TAAATTCTAC 2640
AAGATGATCA AGGAAGGCTT CCGGATGCTC AGCCCTGAAC ATGCGCCTGC TGAAATGTAT 2700
GACATAATGA AGACTTGCTG GGATGCGGAT CCCCTAAAAA GACCAACATT CAAGCAAATT 2760
GTTCAGCTAA TTGAGAAGCA GATTTCAGAG AGCACCAATC ATATTTACTC CAACTTAGCA 2820
AACTGCAGCC CCAACCGACA GAAGCCTGTA GTGGACCATT CCGTGCGGAT CAATTCTGTC 2880
GGCAGCACCG CTTCCTCCTC CCAACCTCTG CTTGTGCACG ACGACGTCTG A 2931
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveatayGl+ksda+++vavkmlk++a+ +e+ealmselk+ls+lG
Q: 589   LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG  648
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGact gGp++viteyccyGdlln+lrrkr+sf+   ++k+++++e++ +k+
Q: 649   NHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFI---CSKQEDHAESALYKN  705
         ******************************************...99999*********9
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
         l     l+sk+s++s+s++ey+d+k++vs+v ++kadk++s+++ s++er+v++a++e+d
Q: 706   L-----LHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSARIGSYIERDVTPAIMEDD  760
         9.....9*****************************************************
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
         + +l+ledllsfsyqvakGm+flasknc+hrdlaarn+llt+G+++kicdfGlardi++d
Q: 761   ELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKND  820
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvvkGnarlpvkwmapesif+++yt++sdvwsyGi+lwe+fslGs+pypg++vdskfy
Q: 821   SNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFY  880
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         k+ikeG+rm +p++a++e+y+im++cw+a+p krp+fkq+v+l+
Q: 881   KMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLI  924
         *****************************************996
Domain Sequence
(FASTA)
LSFGKTLGAG AFGKVVEATA YGLIKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG 60
NHMNIVNLLG ACTIGGPTLV ITEYCCYGDL LNFLRRKRDS FICSKQEDHA ESALYKNLLH 120
SKESSCSDST NEYMDMKPGV SYVVPTKADK RRSARIGSYI ERDVTPAIME DDELALDLED 180
LLSFSYQVAK GMAFLASKNC IHRDLAARNI LLTHGRITKI CDFGLARDIK NDSNYVVKGN 240
ARLPVKWMAP ESIFNCVYTF ESDVWSYGIF LWELFSLGSS PYPGMPVDSK FYKMIKEGFR 300
MLSPEHAPAE MYDIMKTCWD ADPLKRPTFK QIVQLI 336
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-DAR-00787
EKS-EQC-00394
EKS-FEC-00386
EKS-GAG-00341
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORN-00514
EKS-ORA-00347
EKS-ORC-00378
EKS-ORL-00472
EKS-OTG-00405
EKS-PAT-00381
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0005737; C:cytoplasm
GO:0009897; C:external side of plasma membrane
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005020; F:stem cell factor receptor activity
GO:0031532; P:actin cytoskeleton reorganization
GO:0000187; P:activation of MAPK activity
GO:0097067; P:cellular response to thyroid hormone stimulus
GO:0048066; P:developmental pigmentation
GO:0038093; P:Fc receptor signaling pathway
GO:0035234; P:germ cell programmed cell death
GO:0006687; P:glycosphingolipid metabolic process
GO:0007243; P:intracellular protein kinase cascade
GO:0002320; P:lymphoid progenitor cell differentiation
GO:0008584; P:male gonad development
GO:0002551; P:mast cell chemotaxis
GO:0032762; P:mast cell cytokine production
GO:0043303; P:mast cell degranulation
GO:0002573; P:myeloid leukocyte differentiation
GO:0002318; P:myeloid progenitor cell differentiation
GO:0043069; P:negative regulation of programmed cell death
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:0010628; P:positive regulation of gene expression
GO:0043410; P:positive regulation of MAPK cascade
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0048070; P:regulation of developmental pigmentation
GO:0009314; P:response to radiation
GO:0007286; P:spermatid development
KEGG
mcc:696759;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013