EKS-MAM-00032
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00032
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak269.56.1E-80590864275
StatusUnreviewed
Ensembl ProteinENSMMUP00000004150
UniProt AccessionF7DRD4;
Protein Name
Protein Synonyms/Alias
Gene NameTYK2
Gene Synonyms/Alias TYK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000003110ENSMMUP00000004150ENSMMUT00000004400
OrganismMacaca mulatta
Functional Description
Protein Length1175
Protein Sequence
(FASTA)
MPLHHRGTTR GSKPVGDGAQ PMAAMGGLKV LLHWAGPGGG EPWVTFSESS LTAEEVCIHI 60
AHKVGITPPC FNLFALFDAQ AQVWLPPNHI LEIPRDASLM LYFRMRFYFR NWHGMNPQEL 120
AVYRCGPPGT EASSDQTAQG MQLLDPASFE YLFEQGKHEF VNDVASLWEL SSEEEIHHFK 180
NESLGMAFLH LCHLALCRGV PLEEVAKKTS FKDCIPLSFR RQIRQHSALT RLRLRNVFRR 240
FLQDFQPDRL SQQMVMVKYL ATLERLAPRF GTERVPVCHL RLLAQAEGEP CYIRDSGEAP 300
TDPGPESAAR PPTHEVLVTG TGGIQWWPVQ EEVNKEEGSS GGSGRNPQAS LSGKKAKAHK 360
AIGQPADRLR EPLWAYFCDF RDITHVVLKE CCVSIHRQDN KCLELSLPSR AAALSFVSLV 420
DGYFRLTADS SHYLCHEVAP PRLVMSIQDG IHGPLLEPFV QAKLRPEDGL YLIQWSTSHP 480
YRLILTVAQR SQAPDGTQSL RLRKFPIEQQ AGAFVLEGWG RSFPSVRELG AALQGCLLRA 540
GDDCFSLRRR CLPQPGETSN LIIMRGARAS TRTLNLSQLS FHRVDQKEIT QLSHLGQGTR 600
TNVYEGRLRV EGSGDPEEGK MDDEDPLVPG RDRGQELRVV LKVLDPSHHD IALVSQEIET 660
ILANTAHLYL LFCETGCVFA DIMVTEYVEH GPLDVWLRRE RGHVPMAWKM VVAQQLASAL 720
SYLENKNLVH GNVCGRNILL ARLGLAEGTS PFIKLSDPGV GLGALSREER VERIPWMAPE 780
CLPGGPNSLS IAMDKWGFGA TLLEICFDGE APLQSRSSSE KEHFYQRQHR LPEPSCPELA 840
TLTSQCLTYE PTQRPSFRTI LRDLTRLQPH NLADVLIVNP DSSASDPTVF HKRYLKKIRD 900
LGEGHFGKVS LYCYDPTNDG TGEMVAVKAL KADCGPQHRS GWKQEIEILR TLYHEHIVKY 960
KGCCEDQGEK SLQLVMEYVP LGSLRDYLPR HSVGLAQLLL FAQQICEALL SLADLRIGRL 1020
AWPHPLLQAT THCRLGPSQL ALLPSVASLA PSLLSGLTSF CLLIFVFLVE MGFHHVGQAG 1080
LELLTSGDPP QPPKKFLELI GITQGQMTVL RLTELLERGE RLPRPDKCPC EVYHLMKNCW 1140
ETEASFRPTF KNLIPILKTV HEKYQGQAPS VFSVC 1175
Nucleotide Sequence
(FASTA)
ATGCCTCTGC ACCATCGGGG GACGACCAGG GGCAGCAAGC CCGTTGGGGA TGGAGCCCAG 60
CCCATGGCTG CTATGGGAGG CCTGAAGGTG CTTCTGCACT GGGCTGGTCC AGGCGGCGGA 120
GAGCCCTGGG TCACTTTCAG CGAGTCATCG CTGACAGCTG AGGAAGTCTG CATCCACATT 180
GCACATAAAG TCGGTATCAC TCCTCCTTGT TTCAATCTCT TCGCCCTCTT CGATGCTCAG 240
GCCCAAGTCT GGTTGCCCCC AAACCACATC CTAGAGATCC CCAGAGATGC AAGCCTGATG 300
CTGTATTTCC GCATGAGGTT TTATTTCCGG AACTGGCATG GCATGAATCC TCAGGAGCTG 360
GCTGTGTACC GTTGTGGGCC CCCAGGAACC GAGGCATCCT CAGATCAGAC AGCACAGGGG 420
ATGCAACTCC TGGACCCAGC CTCATTTGAG TACCTCTTTG AGCAGGGCAA GCATGAGTTT 480
GTGAATGACG TGGCATCACT GTGGGAGCTA TCGAGCGAGG AGGAGATCCA CCACTTTAAG 540
AATGAGAGCC TGGGCATGGC CTTTCTGCAC CTCTGTCACC TCGCTCTCTG CCGTGGTGTC 600
CCCCTGGAGG AGGTGGCCAA GAAGACCAGC TTCAAGGACT GTATCCCGCT CTCCTTCCGT 660
CGGCAGATCC GGCAGCACAG CGCCCTGACC CGGCTGCGCC TTCGGAACGT CTTCCGCAGG 720
TTCCTGCAGG ACTTCCAGCC GGACAGACTC TCCCAGCAGA TGGTCATGGT CAAATACCTG 780
GCCACACTCG AACGGCTGGC ACCCCGCTTT GGCACAGAGC GTGTGCCCGT GTGCCACCTG 840
AGGCTGCTGG CCCAGGCAGA GGGAGAGCCC TGCTACATCC GGGACAGTGG GGAGGCCCCT 900
ACAGACCCTG GCCCTGAGTC TGCTGCTAGA CCCCCAACCC ATGAGGTGCT GGTGACAGGC 960
ACTGGTGGCA TCCAGTGGTG GCCAGTACAG GAGGAGGTGA ACAAGGAGGA GGGTTCTAGT 1020
GGCGGCAGCG GCAGGAACCC CCAAGCCAGC CTGTCTGGGA AGAAGGCCAA GGCTCACAAG 1080
GCAATCGGCC AGCCGGCGGA CAGGCTGCGG GAGCCACTGT GGGCCTACTT CTGCGACTTC 1140
CGGGACATCA CCCACGTGGT GCTGAAAGAG TGCTGTGTCA GCATCCACCG GCAGGACAAC 1200
AAGTGCCTGG AGCTGAGCCT GCCTTCCCGG GCTGCAGCGC TGTCCTTCGT GTCGCTGGTG 1260
GACGGCTATT TCCGCCTGAC GGCCGACTCC AGCCACTACC TGTGCCACGA GGTGGCTCCC 1320
CCACGGCTGG TGATGAGCAT CCAGGATGGG ATCCATGGAC CCCTGCTGGA GCCATTTGTG 1380
CAGGCCAAGC TGCGGCCCGA GGACGGCCTG TACCTCATTC AGTGGAGCAC CAGCCACCCC 1440
TACCGCCTGA TCCTCACAGT GGCCCAGCGT AGCCAGGCAC CAGACGGCAC ACAGAGCTTG 1500
CGGCTCCGAA AGTTCCCCAT TGAGCAGCAG GCCGGGGCCT TTGTGCTGGA GGGCTGGGGC 1560
CGGTCCTTCC CCAGCGTTCG GGAACTTGGG GCCGCCTTGC AGGGCTGCTT GCTGAGGGCT 1620
GGGGACGACT GCTTCTCTCT GCGTCGCCGT TGCCTGCCCC AACCAGGAGA AACCTCCAAC 1680
CTCATCATCA TGCGGGGGGC TCGGGCCAGC ACCAGGACAC TCAACCTCAG CCAGCTCAGC 1740
TTCCACCGGG TTGACCAGAA GGAGATCACC CAGCTGTCCC ACTTGGGCCA GGGCACAAGG 1800
ACCAACGTGT ACGAGGGCCG CCTGCGAGTG GAGGGCAGTG GGGACCCTGA GGAGGGCAAG 1860
ATGGACGACG AGGACCCCCT CGTGCCTGGA AGGGACCGTG GGCAGGAGCT ACGAGTGGTG 1920
CTCAAAGTGC TGGACCCAAG TCACCATGAC ATAGCCCTGG TGAGTCAGGA GATCGAGACC 1980
ATCCTGGCTA ACACGGCTCA CCTTTATCTC CTTTTTTGTG AGACAGGCTG TGTCTTTGCA 2040
GATATCATGG TGACAGAGTA CGTGGAGCAC GGACCCCTGG ACGTGTGGCT GCGGAGGGAG 2100
CGGGGCCATG TGCCCATGGC TTGGAAGATG GTGGTGGCCC AGCAGCTAGC CAGCGCCCTC 2160
AGCTACCTGG AGAACAAGAA CCTGGTACAT GGTAATGTGT GTGGCCGGAA CATCCTGCTG 2220
GCTCGGCTGG GGCTGGCAGA GGGCACGAGC CCCTTCATCA AGCTGAGTGA TCCCGGCGTG 2280
GGCCTCGGCG CCCTCTCCAG GGAGGAGCGG GTGGAGCGGA TCCCCTGGAT GGCCCCCGAA 2340
TGCCTCCCAG GTGGGCCCAA CAGCCTAAGC ATTGCCATGG ACAAGTGGGG GTTTGGTGCC 2400
ACCCTCCTGG AGATCTGCTT TGATGGAGAG GCCCCGCTGC AGAGCCGCAG CTCCTCCGAG 2460
AAGGAGCATT TCTACCAGAG GCAGCACCGG CTGCCCGAGC CCTCCTGCCC AGAGCTGGCC 2520
ACACTCACCA GCCAGTGTCT GACCTATGAG CCAACCCAGA GGCCTTCATT CCGCACCATC 2580
CTGCGTGACC TCACCCGGCT GCAGCCCCAC AATCTTGCTG ATGTCTTGAT TGTGAACCCG 2640
GACTCATCGG CGTCAGACCC TACGGTTTTC CACAAGCGCT ATTTGAAAAA GATCCGAGAT 2700
CTGGGCGAGG GTCACTTCGG CAAGGTCAGT TTGTACTGCT ACGATCCGAC CAACGACGGC 2760
ACTGGCGAGA TGGTGGCGGT GAAAGCCCTT AAGGCAGACT GCGGCCCCCA GCACCGCTCG 2820
GGCTGGAAGC AGGAGATTGA GATTCTGCGC ACGCTCTATC ACGAGCACAT CGTCAAGTAC 2880
AAGGGCTGCT GCGAGGATCA AGGCGAGAAG TCGCTGCAGC TGGTCATGGA GTACGTGCCC 2940
CTGGGCAGCC TCCGAGACTA CCTGCCCCGG CACAGCGTCG GGCTGGCCCA GCTGCTGCTC 3000
TTCGCCCAGC AGATCTGCGA GGCCCTCTTG TCCTTGGCTG ACCTCCGAAT TGGTCGGCTT 3060
GCTTGGCCAC ACCCCCTCCT CCAAGCGACC ACGCACTGCA GGCTTGGCCC CTCCCAACTC 3120
GCCCTCCTGC CCAGCGTTGC TAGTCTAGCC CCGTCCCTGC TCTCTGGCTT AACCTCCTTT 3180
TGCTTGCTAA TTTTTGTATT TTTAGTAGAG ATGGGGTTTC ACCATGTTGG CCAGGCTGGT 3240
CTCGAACTCC TGACTTCAGG TGATCCACCC CAGCCTCCCA AAAAATTCCT TGAGCTCATA 3300
GGCATCACCC AGGGTCAGAT GACAGTTCTG AGACTCACCG AGTTGCTGGA ACGAGGGGAG 3360
AGGCTGCCAC GACCTGACAA ATGTCCCTGT GAGGTCTATC ATCTCATGAA GAACTGCTGG 3420
GAGACAGAGG CGTCCTTCCG CCCAACCTTC AAGAACCTCA TACCCATCCT GAAGACAGTC 3480
CATGAGAAGT ACCAAGGCCA GGCCCCTTCC GTGTTCAGTG TGTGCTGA 3528
Domain Profile
S: 2     kqiesLgkgtftkvfevre................d..aegdsteee..valkvLkesge  41
         +q+++Lg+gt+t+v+e+r+                d    g+++++e  v+lkvL++s++
Q: 590   TQLSHLGQGTRTNVYEGRLrvegsgdpeegkmddeDplVPGRDRGQElrVVLKVLDPSHH  649
         7899*********************999999975537877777777778***********
S: 42    disrdfkreaeilsqlshehivklkgvcvaegenrlVmeyvesGsLdiyLrkkkealsls  101
         di+   ++   il +  h  +++ +  cv  +  ++V+eyve+G+Ld++Lr+++ +++++
Q: 650   DIALVSQEIETILANTAHLYLLFCETGCVFAD--IMVTEYVEHGPLDVWLRRERGHVPMA  707
         ****9999999999999988888775555443..7*************************
S: 102   slldvakqlakameYLedkklvhrdvaarnvLveresn.egtppfvklsdpglakavnqd  160
         +++ va+qla+a++YLe+k+lvh++v++rn+L++r +  egt+pf+klsdpg+   +   
Q: 708   WKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLaEGTSPFIKLSDPGVGLGA---  764
         **************************************99*****************...
S: 161   eYylvreerdsripwlapeclseakn.lstasdvWsFgvtlyelltcskgesplrsesle  219
            l+reer +ripw+apecl    n ls+a+d+W+Fg+tl+e+  c +ge+pl+s+s++
Q: 765   ---LSREERVERIPWMAPECLPGGPNsLSIAMDKWGFGATLLEI--CFDGEAPLQSRSSS  819
         ...********************9999*****************..**************
S: 220   rklelleekerlpkpkcpaelaelmtnclsyepsqrpsFrailedl  265
         +k++++++++rlp+p+cp ela+l+++cl+yep+qrpsFr+il+dl
Q: 820   EKEHFYQRQHRLPEPSCP-ELATLTSQCLTYEPTQRPSFRTILRDL  864
         ******************.*************************98
Domain Sequence
(FASTA)
TQLSHLGQGT RTNVYEGRLR VEGSGDPEEG KMDDEDPLVP GRDRGQELRV VLKVLDPSHH 60
DIALVSQEIE TILANTAHLY LLFCETGCVF ADIMVTEYVE HGPLDVWLRR ERGHVPMAWK 120
MVVAQQLASA LSYLENKNLV HGNVCGRNIL LARLGLAEGT SPFIKLSDPG VGLGALSREE 180
RVERIPWMAP ECLPGGPNSL SIAMDKWGFG ATLLEICFDG EAPLQSRSSS EKEHFYQRQH 240
RLPEPSCPEL ATLTSQCLTY EPTQRPSFRT ILRDL 275
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00028
EKS-ANC-00027
EKS-BOT-00034
EKS-CAJ-00031
EKS-CAF-00033
EKS-CAP-00033
EKS-FEC-00030
EKS-GOG-00031
EKS-HOS-00033
EKS-ICT-00028
EKS-LOA-00031
EKS-MEG-00026
EKS-MOD-00031
EKS-MUM-00034
EKS-MUP-00034
EKS-MYL-00034
EKS-NOL-00030
EKS-OCP-00021
EKS-ORC-00032
EKS-OTG-00034
EKS-PAT-00030
EKS-POA-00029
EKS-PRC-00015
EKS-PTV-00032
EKS-RAN-00033
EKS-SAH-00031
EKS-XET-00032
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR019749; Band_41_domain.
IPR019748; FERM_central.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045; Tyr_kinase_non-rcpt_TYK2_N.
Pfam
PF07714; Pkinase_Tyr; 3.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
Prints
PR01823; JANUSKINASE.
PR00109; TYRKINASE.
PR01827; YKINASETYK2.
Created Date20-Feb-2013