EKS-MAM-00192
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00192
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/LISK484.61.2E-145339604266
StatusUnreviewed
Ensembl ProteinENSMMUP00000004182
UniProt AccessionH9H2W5;
Protein Name
Protein Synonyms/Alias
Gene NameLIMK1
Gene Synonyms/Alias LIMK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000003128ENSMMUP00000004182ENSMMUT00000004433
ENSMMUG00000003128ENSMMUP00000032130ENSMMUT00000039048
OrganismMacaca mulatta
Functional Description
Protein Length647
Protein Sequence
(FASTA)
MRLTLLCCTW REERMGEEGS ELPVCASCGQ RIYDGQYLQA LNADWHADCF RCCDCSASLS 60
HQYYEKDGQL FCKKDYWARY GESCHGCSEQ ITKGLVMVSA PCLAHSPGVG VLTVYSFLYN 120
TDQAGLEDNK KLASGHCYYQ TVVTPVIEQI LPDSPGSHLP HTVTLVSIPA SSHGKRGLSV 180
SIDPPHGPPG CGTEHAHTVR VQGVDPGCMS PDVKNSIHVG DRILEINGTP IRNVPLDEID 240
LLIQETSRLL QLTLEHDPHD TLGHGLGPET SPLSSPVHTP SGEAGGSARQ KPVLRSCSID 300
RSPGASSLGS PASQRKDLGR SESLRVVCRP HRIFRPSDLI HGEVLGKGCF GQAIKVTHRE 360
TGEVMVMKEL IRFDEETQRT FLKEVKVMRC LEHPNVLKFI GVLYKDKRLN FITEYIKGGT 420
LRGIIKSMDS QYPWSQRVSF AKDIASGMAY LHSMNIIHRD LNSHNCLVRE NKNVVVADFG 480
LARLMVDEKT QPEDLRSLKK PDRKKRYTVV GNPYWMAPEM INGRSYDEKV DVFSFGIVLC 540
EIIGRVNADP DYLPRTMDFG LNVRGFLDRY CPANCPPSFF PITVRCCDLD PEKRPSFVKL 600
EHWLETLRMH LAGHLPLGPQ LEQLDRGFWE TYRRGESGLP AHPEVPD 647
Nucleotide Sequence
(FASTA)
ATGAGGTTGA CGCTACTTTG TTGCACCTGG AGGGAAGAAC GTATGGGAGA GGAAGGAAGC 60
GAGTTGCCCG TGTGTGCAAG CTGCGGCCAG AGGATCTATG ATGGCCAGTA CCTCCAGGCC 120
CTGAACGCGG ACTGGCACGC AGACTGCTTC AGGTGTTGTG ACTGCAGTGC CTCCCTGTCG 180
CACCAGTACT ATGAGAAGGA TGGGCAGCTC TTCTGCAAGA AGGACTACTG GGCCCGCTAT 240
GGCGAGTCCT GCCATGGGTG CTCGGAGCAA ATCACCAAGG GACTGGTTAT GGTGAGCGCC 300
CCCTGCCTTG CACACTCACC TGGGGTGGGG GTCCTGACTG TCTATTCTTT CTTATACAAC 360
ACTGATCAGG CTGGATTAGA GGACAACAAA AAGCTGGCCA GCGGGCACTG CTACTACCAG 420
ACTGTGGTGA CCCCCGTCAT CGAGCAAATC CTGCCCGACT CCCCTGGCTC CCACCTGCCC 480
CACACCGTCA CCCTAGTGTC CATCCCAGCC TCATCTCATG GCAAGCGTGG ACTTTCAGTC 540
TCCATCGACC CCCCGCACGG CCCGCCGGGC TGCGGCACCG AGCATGCACA CACCGTCCGC 600
GTCCAGGGAG TGGATCCAGG CTGCATGAGC CCAGATGTGA AGAATTCCAT CCACGTCGGA 660
GACCGGATCT TGGAAATCAA TGGCACGCCC ATCCGAAATG TGCCCCTGGA TGAGATTGAC 720
CTGCTGATTC AGGAAACCAG CCGCCTGCTC CAGCTCACCC TCGAGCACGA CCCTCACGAT 780
ACACTGGGCC ATGGGCTGGG GCCTGAGACC AGCCCCCTGA GTTCTCCGGT TCACACTCCC 840
AGCGGGGAGG CGGGCGGCTC TGCCCGGCAG AAGCCTGTCT TGAGGAGCTG CAGCATCGAC 900
AGGTCTCCAG GTGCCAGCTC ACTGGGCTCC CCGGCCTCCC AGCGCAAGGA CCTGGGTCGC 960
TCTGAGTCCC TCCGCGTAGT CTGCCGGCCA CACCGCATCT TCCGGCCATC GGACCTCATC 1020
CACGGGGAGG TGCTGGGCAA GGGCTGCTTT GGCCAGGCCA TCAAGGTGAC ACACCGTGAG 1080
ACGGGTGAGG TGATGGTGAT GAAGGAGCTG ATCCGGTTCG ACGAGGAGAC CCAGAGGACG 1140
TTCCTCAAGG AGGTGAAGGT CATGCGATGC CTGGAACACC CCAACGTGCT CAAGTTCATC 1200
GGGGTGCTCT ACAAGGACAA GAGGCTCAAC TTCATCACTG AGTACATCAA GGGCGGCACC 1260
CTCCGGGGCA TCATCAAGAG CATGGACAGC CAGTACCCAT GGAGCCAGAG AGTGAGCTTT 1320
GCCAAGGACA TCGCGTCGGG GATGGCCTAC CTCCACTCCA TGAACATTAT CCACCGAGAC 1380
CTCAACTCCC ACAACTGCCT GGTCCGTGAG AACAAGAACG TGGTGGTGGC TGACTTTGGG 1440
CTGGCACGGC TCATGGTAGA TGAAAAGACT CAGCCCGAGG ACCTGCGGAG CCTCAAGAAG 1500
CCAGACCGCA AGAAGCGCTA CACCGTGGTG GGTAACCCCT ACTGGATGGC GCCCGAGATG 1560
ATCAATGGCC GCAGCTATGA TGAGAAGGTG GATGTGTTCT CCTTTGGGAT CGTCCTGTGC 1620
GAGATCATCG GGCGGGTGAA CGCAGACCCC GACTACCTGC CCCGCACCAT GGACTTTGGC 1680
CTCAACGTAC GAGGCTTCCT GGACCGCTAC TGCCCTGCAA ACTGCCCCCC GAGCTTCTTC 1740
CCCATCACCG TGCGCTGTTG CGATCTGGAC CCCGAGAAGA GGCCGTCCTT CGTGAAGCTG 1800
GAACACTGGC TGGAGACCCT CCGCATGCAC CTGGCCGGCC ACCTGCCACT GGGCCCGCAG 1860
CTGGAGCAGC TGGACAGGGG TTTCTGGGAG ACCTACCGGC GCGGCGAGAG CGGACTGCCT 1920
GCCCACCCTG AGGTCCCCGA CTGA 1944
Domain Profile
S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60
         li+ge+lGkG+f++++kvthr++Gevmv+kelir+dee+++++lkevk++r+lehpnvlk
Q: 339   LIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLK  398
         689*********************************************************
S: 61    fiGvlvkdkklhllteyiegGtlkellkskes.lpwtqrvrlakdiasGlsylhskgiih  119
         fiGvl+kdk+l+++teyi+gGtl+ ++ks++s +pw+qrv++akdiasG++ylhs++iih
Q: 399   FIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSqYPWSQRVSFAKDIASGMAYLHSMNIIH  458
         ******************************999***************************
S: 120   rdlnsknclvredksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywmaP  179
         rdlns+nclvre+k+vvvadfGlarl+v+e++++e+lrslkk drkkr+tvvG+PywmaP
Q: 459   RDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEDLRSLKKPDRKKRYTVVGNPYWMAP  518
         ************************************************************
S: 180   evlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcPea  239
         e+++g+sydekvdvfsfGivlceii+rv+adPdylPrt+dfgl+v+ f +++++++cP++
Q: 519   EMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPANCPPS  578
         ************************************************************
S: 240   flklavvccdldpesrpsfeelekkl  265
         f++++v+ccdldpe+rpsf++le++l
Q: 579   FFPITVRCCDLDPEKRPSFVKLEHWL  604
         ***********************997
Domain Sequence
(FASTA)
LIHGEVLGKG CFGQAIKVTH RETGEVMVMK ELIRFDEETQ RTFLKEVKVM RCLEHPNVLK 60
FIGVLYKDKR LNFITEYIKG GTLRGIIKSM DSQYPWSQRV SFAKDIASGM AYLHSMNIIH 120
RDLNSHNCLV RENKNVVVAD FGLARLMVDE KTQPEDLRSL KKPDRKKRYT VVGNPYWMAP 180
EMINGRSYDE KVDVFSFGIV LCEIIGRVNA DPDYLPRTMD FGLNVRGFLD RYCPANCPPS 240
FFPITVRCCD LDPEKRPSFV KLEHWL 266
KeywordComplete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00180
EKS-ANC-00185
EKS-BOT-00191
EKS-CAF-00197
EKS-CAP-00216
EKS-CII-00124
EKS-CIS-00229
EKS-DAR-00492
EKS-DIO-00098
EKS-DRM-00101
EKS-EQC-00186
EKS-FEC-00179
EKS-GAM-00108
EKS-GAG-00164
EKS-GAA-00234
EKS-GOG-00189
EKS-HOS-00197
EKS-ICT-00183
EKS-LAC-00202
EKS-LOA-00189
EKS-MAE-00074
EKS-MEG-00151
EKS-MIM-00089
EKS-MOD-00190
EKS-MUM-00194
EKS-MUP-00195
EKS-MYL-00196
EKS-OCP-00125
EKS-ORN-00242
EKS-ORA-00170
EKS-ORC-00174
EKS-ORL-00227
EKS-OTG-00197
EKS-PAT-00182
EKS-PES-00169
EKS-POA-00188
EKS-RAN-00185
EKS-SAH-00188
EKS-SUS-00165
EKS-TAG-00217
EKS-TAR-00248
EKS-TEN-00242
EKS-TUT-00179
EKS-XET-00223
EKS-XIM-00238
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005925; C:focal adhesion
GO:0043005; C:neuron projection
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0008270; F:zinc ion binding
GO:0051444; P:negative regulation of ubiquitin-protein ligase activity
GO:0032233; P:positive regulation of actin filament bundle assembly
GO:0045773; P:positive regulation of axon extension
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR001478; PDZ.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781; Znf_LIM.
Pfam
PF00412; LIM; 1.
PF00595; PDZ; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00132; LIM; 1.
SM00228; PDZ; 1.
Prosites
PS00478; LIM_DOMAIN_1; 1.
PS50023; LIM_DOMAIN_2; 1.
PS50106; PDZ; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013