EKS-MAM-00203

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00203

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/MAST	467.1	3.3E-140	356	626	271

Status

Unreviewed

Ensembl Protein

ENSMMUP00000004227

UniProt Accession

F7EP62;

Protein Name

Protein Synonyms/Alias

Gene Name

MAST3

Gene Synonyms/Alias

MAST3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000003161	ENSMMUP00000004227	ENSMMUT00000004479

Organism

Macaca mulatta

Functional Description

Protein Length

1295

Protein Sequence
(FASTA)

LQKELSLPRR GRGCRSGNRK SLVVGTPSPT LSRPLSPLSV PTAGSSPLDS PRNFSAVSAL 60

NFPFARRADG RRWSLASLPS SGYGTNTPSS TLSSSSSSRE RLHQLPFQPT PDELHFLSKH 120

FRSSENVLDE EGGRSPRLRP RSRSLSPGRA TGTFDNEIVM MNHVYRERFP KATAQMEGRL 180

QEFLTAYAPG ARLALADGVL GFIHHQIVEL ARDCLAKSGE NLVTSRYFLE MQEKLERLLQ 240

DAHERSDSEE VSFIVQLVRK LLIIISRPAR LLECLEFDPE EFYHLLEAAE GHAREGQGIK 300

TDLPQYIIGQ LGLAKDPLEE MVPLSHLEEE QPPAPESPES RALVGQSRRK PCESDFETIK 360

LISNGAYGAV YLVRHRDTRQ RFAIKKINKQ NLILRNQIQQ VFVERDILTF AENPFVVSMF 420

CSFETRRHLC MVMEYVEGGD CATLLKNMGP LPVDMARLYF AETVLALEYL HNYGIVHRDL 480

KPDNLLITSL GHIKLTDFGL SKIGLMSMAT NLYEGHIEKD AREFIDKQVC GTPEYIAPEV 540

IFRQGYGKPV DWWAMGVVLY EFLVGCVPFF GDTPEELFGQ VVSGSWMPGG EAAGHCAQPI 600

FLVLCCPYPL GISAGGTHEV KQHPFFLALD WAGLLRHKAE FVPQLEAEDD TSYFDTRSER 660

YRHLGSEDDE TNDEESSTEI PQFSSCSHRF SKVYSSSEFL AVQPTPTFAE RSFSEDREEG 720

WERSEVDYGR RLSADIRLRS WTSSGSSCQS SSSQPERGPS PSLLNTISLD TMPKFAFSSE 780

DEAAGPAPAG PKRPVFILGE PDPPPAATPV MPKPSSLSAD TAALSHARLR SNSIGARHST 840

PRPLDAGRGR RLGGPRDPAP EKSRASSSGG SGGGGGGRVP KSASVSALSL IITADDGSGG 900

PLMSPLSPRS LSSNPSSRDS SPSRDPSPVC GNLRPPIVIH SSGKKYGFSL RAIRVYMGDS 960

DVYAVHHVVW SVEDGSPAQE AGLRAGDLIT HINGESVLGL VHMDVVELLL KSGNKISLRT 1020

TALENTSIKV GPARKNVAKG RMARRSKRSR RRETQDRRKS LFKKISKQTS VLHTSRSFSS 1080

GLHHSLSSSE SLPGSPTHSL SPSPTTPCRS PAPDVPADTT ASPPSASPSS SSPASPAAAG 1140

HTRPSSLHGL AAKLGPPRPK TGRRKSTSSI PPSPLACPPI SAPPPRSPSP LPGHPPAPAR 1200

SPRLRRGQSA DKLGTGERLD GEAGRRSRGP EAELVVMRRL HLSERRDSFK KQEAVQEVSF 1260

DEPQEEATGL PASVPQIAVE GEEAVPVALG PTGRD 1295

Nucleotide Sequence
(FASTA)

TTGCAGAAGG AGCTGAGCCT GCCACGCCGG GGACGTGGCT GCCGCAGCGG GAACCGCAAG 60

AGCTTGGTGG TAGGAACGCC CTCCCCGACC CTCTCCCGCC CCCTGTCGCC ACTGTCAGTC 120

CCAACGGCAG GCAGCAGCCC CTTGGATAGT CCTCGGAATT TCTCGGCTGT CTCTGCCCTC 180

AATTTCCCCT TTGCCCGGAG GGCAGACGGC AGAAGATGGT CCCTCGCGTC TCTCCCATCT 240

TCCGGCTATG GAACCAACAC ACCCAGCTCC ACCCTCTCGT CAAGCTCATC CTCCCGGGAA 300

CGTCTCCACC AGCTTCCCTT CCAGCCGACG CCAGACGAGC TGCACTTCCT GTCCAAGCAC 360

TTCCGCAGCT CAGAGAACGT GCTTGATGAG GAAGGCGGCC GGTCACCCCG CCTCCGCCCC 420

CGCTCTCGCA GCCTCAGCCC GGGCCGCGCA ACGGGGACCT TCGACAATGA GATTGTCATG 480

ATGAACCATG TGTACCGGGA GAGGTTCCCC AAGGCCACAG CACAGATGGA GGGCCGTCTG 540

CAGGAGTTCC TGACGGCCTA CGCGCCTGGC GCCCGGCTGG CGCTGGCTGA TGGCGTCTTG 600

GGCTTCATCC ACCACCAGAT CGTCGAGCTG GCCCGAGACT GCCTGGCCAA GTCTGGCGAG 660

AACCTCGTCA CCTCCCGCTA CTTCCTAGAG ATGCAGGAGA AGCTGGAGCG GCTTCTGCAG 720

GATGCCCATG AGCGCTCGGA CAGTGAGGAG GTCAGCTTCA TTGTCCAGCT TGTCCGGAAA 780

CTGCTAATCA TCATCTCGCG GCCAGCTCGG CTGCTGGAGT GTCTGGAGTT TGACCCTGAG 840

GAGTTTTACC ACCTGCTGGA GGCGGCTGAG GGCCATGCGC GGGAGGGCCA AGGCATTAAG 900

ACTGACCTTC CACAGTACAT CATTGGGCAG CTGGGCCTGG CCAAGGACCC CCTGGAGGAG 960

ATGGTGCCAC TGAGTCACCT TGAAGAAGAA CAGCCCCCAG CACCTGAGTC CCCGGAGAGC 1020

CGCGCCCTGG TCGGCCAGTC ACGGAGGAAG CCATGCGAAA GCGACTTTGA GACCATCAAA 1080

CTCATTAGCA ACGGAGCCTA TGGGGCTGTC TACCTGGTGC GGCACCGTGA CACGCGGCAG 1140

CGCTTTGCCA TCAAGAAGAT CAACAAACAG AACTTGATCC TGCGTAACCA GATCCAGCAG 1200

GTCTTTGTGG AACGTGACAT TCTCACCTTT GCCGAGAACC CCTTTGTGGT CAGCATGTTC 1260

TGCTCCTTTG AGACCCGGCG CCACCTGTGT ATGGTCATGG AATATGTGGA AGGCGGCGAC 1320

TGCGCCACGC TCTTGAAGAA CATGGGCCCG CTGCCCGTGG ACATGGCCCG CCTGTACTTC 1380

GCCGAGACGG TGTTGGCGCT CGAGTACCTG CACAACTACG GCATCGTGCA CCGTGACCTC 1440

AAACCAGACA ACCTGCTCAT CACCTCGCTT GGCCACATCA AGCTCACGGA CTTTGGCCTG 1500

TCCAAGATCG GCCTCATGAG CATGGCCACC AACCTCTACG AGGGCCACAT CGAGAAGGAC 1560

GCCCGAGAGT TCATAGACAA GCAGGTGTGT GGAACACCGG AGTACATAGC CCCCGAGGTG 1620

ATCTTCCGCC AGGGCTATGG GAAGCCAGTG GACTGGTGGG CCATGGGCGT CGTCCTCTAT 1680

GAGTTTCTGG TGGGCTGCGT GCCTTTCTTT GGAGACACCC CCGAGGAACT CTTCGGTCAG 1740

GTGGTCAGCG GGAGTTGGAT GCCAGGTGGG GAGGCGGCGG GCCACTGTGC CCAGCCCATT 1800

TTTCTGGTTC TGTGTTGTCC CTACCCTCTG GGCATATCTG CAGGTGGCAC CCATGAAGTG 1860

AAGCAGCACC CCTTTTTCCT GGCCCTGGAC TGGGCAGGGC TTCTCCGACA CAAAGCCGAG 1920

TTCGTGCCCC AGCTCGAAGC CGAGGATGAT ACCAGCTACT TTGACACCCG TTCGGAACGT 1980

TACCGCCACC TGGGCTCCGA GGACGACGAA ACCAATGATG AAGAATCATC CACAGAGATC 2040

CCCCAGTTCT CCTCCTGCTC CCACCGGTTC AGCAAGGTCT ACAGCAGCTC TGAGTTCCTG 2100

GCCGTCCAGC CCACTCCTAC CTTCGCTGAA AGGAGCTTCA GTGAAGACCG GGAGGAGGGA 2160

TGGGAGCGCA GCGAGGTGGA CTATGGCCGC CGGCTGAGTG CTGACATCCG GCTGAGGTCC 2220

TGGACATCCT CTGGATCCTC CTGTCAGTCA TCTTCGTCCC AGCCCGAGCG AGGTCCCAGC 2280

CCATCTCTCC TGAATACCAT CAGCCTGGAC ACAATGCCCA AGTTTGCCTT CTCATCAGAG 2340

GATGAGGCGG CAGGCCCGGC CCCTGCAGGC CCCAAGAGGC CTGTCTTCAT TCTAGGGGAG 2400

CCTGACCCAC CCCCAGCAGC CACCCCAGTG ATGCCCAAGC CCTCGAGCCT TTCCGCCGAC 2460

ACAGCTGCCC TCAGCCACGC CCGCCTACGG AGCAACAGCA TCGGCGCCCG ACACTCCACA 2520

CCGAGGCCTC TCGATGCCGG CCGGGGCCGC CGCCTTGGGG GCCCAAGAGA CCCAGCCCCT 2580

GAGAAGTCCA GAGCCTCCTC CAGCGGTGGC AGTGGTGGCG GCGGTGGGGG CCGTGTGCCC 2640

AAGTCGGCCT CTGTCTCTGC CCTGTCCCTC ATCATCACGG CAGATGATGG CAGCGGCGGC 2700

CCCCTCATGA GCCCCCTGTC CCCGCGCTCT CTGTCCTCGA ACCCGTCGTC CCGTGACTCC 2760

TCGCCGAGCC GAGACCCGTC CCCCGTGTGT GGCAACCTGC GGCCCCCCAT CGTCATCCAC 2820

AGCTCCGGCA AGAAGTACGG CTTCAGCCTG CGGGCAATCC GCGTCTACAT GGGTGATAGC 2880

GACGTCTACG CTGTGCACCA CGTCGTCTGG AGTGTGGAGG ATGGAAGCCC CGCCCAGGAG 2940

GCTGGCCTGC GGGCCGGGGA CCTCATCACC CACATCAACG GGGAGTCGGT GCTGGGGCTG 3000

GTGCACATGG ACGTCGTGGA GCTGCTGCTG AAGAGCGGCA ACAAGATATC CCTGCGGACC 3060

ACGGCCCTGG AGAACACCTC CATCAAGGTG GGCCCCGCAC GGAAGAATGT GGCCAAGGGC 3120

CGCATGGCGC GCAGGAGCAA GCGGAGCCGT CGGCGGGAGA CCCAGGACCG GCGGAAGTCG 3180

CTCTTCAAGA AGATCTCCAA GCAGACCTCC GTGCTTCACA CCAGCCGCAG CTTCTCCTCC 3240

GGACTCCACC ACTCACTGTC ATCCAGCGAG AGCCTCCCTG GCTCGCCCAC CCACAGCCTC 3300

TCCCCCAGCC CCACCACTCC CTGCCGAAGC CCAGCCCCTG ATGTCCCAGC AGATACCACT 3360

GCATCCCCAC CCAGCGCATC CCCGAGCTCC AGCAGCCCCG CCTCCCCAGC TGCTGCCGGC 3420

CACACCCGCC CCAGCTCCCT GCATGGCCTG GCTGCCAAGC TTGGGCCACC CCGCCCCAAG 3480

ACGGGCCGTC GCAAGTCCAC CAGCAGCATC CCACCCTCCC CGCTGGCCTG CCCGCCCATC 3540

TCTGCACCCC CACCCCGCTC GCCCTCACCC CTGCCCGGGC ACCCACCCGC ACCTGCCCGA 3600

TCCCCGCGGC TGCGCCGAGG CCAGTCAGCT GACAAGCTGG GCACAGGGGA GCGGCTGGAT 3660

GGGGAGGCAG GGCGGCGCAG TCGTGGGCCA GAAGCCGAGC TCGTGGTCAT GCGACGGCTG 3720

CACCTGTCCG AGCGCCGAGA CTCCTTCAAG AAGCAGGAGG CCGTGCAGGA GGTTAGCTTC 3780

GATGAGCCGC AGGAGGAGGC CACTGGGCTG CCCGCCTCAG TGCCACAGAT TGCCGTGGAG 3840

GGCGAGGAAG CTGTGCCAGT AGCTCTCGGG CCCACCGGGA GAGACTGA 3888

Domain Profile

S: 1     feiiklisrGayGavylvrhketrkrfavkkikkqdlilknqvqqvfaerdilalaenpf  60

         fe+iklis+GayGavylvrh++tr+rfa+kki+kq+lil+nq+qqvf+erdil++aenpf

Q: 356   FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPF  415

         99**********************************************************

S: 61    vvslyysletrrnlylvmeyveGGdvksllkniGaldvemarlyiaevvlaleylhryGi  120

         vvs+++s+etrr+l++vmeyveGGd+++llkn+G+l+v+marly+ae+vlaleylh+yGi

Q: 416   VVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGI  475

         ************************************************************

S: 121   vhrdlkPdnllitseGhikltdfGlskvglmslttnlyegyidkdarefldkqvcgtPey  180

         vhrdlkPdnllits GhikltdfGlsk+glms++tnlyeg+i+kdaref+dkqvcgtPey

Q: 476   VHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEY  535

         ************************************************************

S: 181   iaPevilrqgygkpvdwwalgiilyeflvgivpffgdtpeelfaqvlsdeivwPekdeal  240

         iaPevi+rqgygkpvdwwa+g++lyeflvg+vpffgdtpeelf+qv+s    +P ++ a

Q: 536   IAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSGSW-MPGGE-AA  593

         ***********************************************9863.46555.55

S: 241   ssealelisellesnPrerlgtgsaaevkqhefl  274

            a+ +   l    P   +++g+++evkqh+f+

Q: 594   GHCAQPIFLVLCCPYPLG-ISAGGTHEVKQHPFF  626

         566666666666667765.588899******997

Domain Sequence
(FASTA)

FETIKLISNG AYGAVYLVRH RDTRQRFAIK KINKQNLILR NQIQQVFVER DILTFAENPF 60

VVSMFCSFET RRHLCMVMEY VEGGDCATLL KNMGPLPVDM ARLYFAETVL ALEYLHNYGI 120

VHRDLKPDNL LITSLGHIKL TDFGLSKIGL MSMATNLYEG HIEKDAREFI DKQVCGTPEY 180

IAPEVIFRQG YGKPVDWWAM GVVLYEFLVG CVPFFGDTPE ELFGQVVSGS WMPGGEAAGH 240

CAQPIFLVLC CPYPLGISAG GTHEVKQHPF F 271

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR015022	; MA_Ser/Thr_Kinase_dom.
IPR023142	; MAST_pre-PK_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF08926	; DUF1908; 1.
PF00595	; PDZ; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00228	; PDZ; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50106	; PDZ; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013