EKS-MAM-00039

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00039

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/VRK	439.9	4.9E-132	37	303	267

Status

Unreviewed

Ensembl Protein

ENSMMUP00000004588

UniProt Accession

F7F549;

Protein Name

Protein Synonyms/Alias

Serine/threonine-protein kinase VRK1;

Gene Name

VRK1

Gene Synonyms/Alias

VRK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000003443	ENSMMUP00000004588	ENSMMUT00000004869

Organism

Macaca mulatta

Functional Description

Protein Length

396

Protein Sequence
(FASTA)

MPRVKAAQAG RQGPAKRHLA EQFAVGEIIT DMAKKEWKVG LPIGQGGFGC IYLADMNSSE 60

SVGSDAPCVV KVEPSDNGPL FTELKFYQRA AKPEQIQKWI RTHKLKYLGV PKYWGSGLHD 120

KNGKSYRFMI MDRFGSDLQK IYEANAKRFS RKTVLQLSLR ILDILEYIHE HEYVHGDIKA 180

SNLLLNYKNP DQVYLVDYGL AYRYCPEGVH KEYKEDPKRC HDGTIEFTSI DAHNGVAPSR 240

RGDLEILGYC MIQWLTGHLP WEDNLKDPKY VRDSKIRYRE NIASLMDKCF PEKNKPGEIA 300

KYMETVKLLD YTEKPLYQNL RDILLQGLKA IGSKDDGKLD LSVVENGGLK AKTITKKRKK 360

EMEESKEPGV EDMEWSDTQT EEAIQTRSRT RKRVQK 396

Nucleotide Sequence
(FASTA)

ATGCCTCGTG TAAAAGCAGC TCAAGCTGGA AGACAGGGCC CCGCAAAGAG ACATCTTGCA 60

GAACAGTTTG CAGTTGGGGA GATAATAACT GACATGGCAA AAAAGGAATG GAAAGTAGGA 120

TTACCTATTG GCCAAGGAGG CTTTGGCTGT ATATATCTTG CTGATATGAA TTCTTCAGAG 180

TCAGTTGGCA GTGATGCACC TTGTGTTGTA AAAGTGGAAC CCAGTGACAA TGGACCTCTT 240

TTTACTGAAT TAAAGTTCTA CCAACGAGCT GCAAAACCGG AGCAAATTCA GAAATGGATT 300

CGTACCCATA AGCTGAAGTA CCTGGGTGTT CCTAAGTATT GGGGGTCTGG TCTACATGAC 360

AAAAATGGAA AAAGTTATAG GTTTATGATA ATGGATCGCT TTGGGAGTGA CCTTCAGAAA 420

ATATATGAAG CAAATGCCAA AAGGTTTTCT CGGAAAACTG TCTTGCAGCT AAGCTTAAGA 480

ATTCTGGATA TTCTGGAATA TATTCACGAG CATGAGTATG TGCATGGAGA TATCAAGGCC 540

TCAAATCTTC TTCTGAACTA CAAGAATCCT GACCAGGTGT ACTTGGTAGA TTATGGCCTT 600

GCTTATCGGT ACTGCCCAGA AGGAGTTCAT AAAGAATACA AAGAAGACCC CAAAAGATGT 660

CATGATGGCA CTATTGAATT CACGAGCATC GATGCACACA ATGGTGTGGC CCCATCAAGA 720

CGTGGTGATT TGGAAATACT TGGTTATTGC ATGATCCAAT GGCTTACTGG CCATCTTCCT 780

TGGGAGGATA ATTTGAAAGA TCCTAAATAT GTTAGAGATT CCAAAATTAG ATATAGAGAA 840

AATATTGCAA GTTTGATGGA CAAATGTTTT CCTGAGAAAA ACAAACCAGG TGAAATTGCC 900

AAATATATGG AAACAGTGAA ATTACTAGAC TACACTGAAA AACCTCTTTA TCAAAATTTA 960

CGTGATATTC TTTTGCAAGG ACTAAAAGCT ATAGGAAGTA AGGATGATGG AAAATTGGAC 1020

CTCAGTGTTG TGGAGAATGG AGGTTTGAAA GCAAAAACAA TAACAAAGAA GCGAAAGAAA 1080

GAAATGGAAG AAAGCAAGGA ACCTGGTGTT GAAGATATGG AATGGTCAGA CACACAGACA 1140

GAGGAGGCCA TACAGACCCG TTCAAGAACC AGAAAGAGAG TCCAGAAGTA A 1191

Domain Profile

S: 1     wklgkkigkggfGeiyla..ltckkeekdaklvvkvepkenGpLfvelkfyqraakkeqi  58

         wk+g +ig+ggfG+iyla  ++++++++da +vvkvep++nGpLf+elkfyqraak+eqi

Q: 37    WKVGLPIGQGGFGCIYLAdmNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI  96

         9*****************99999*************************************

S: 59    kkwkkkkklkllgiPtliasGlhefegekyRflvlprlgrdLqklleqngkrlsektvlq  118

         +kw++++klk+lg+P++++sGlh+++g++yRf++++r+g+dLqk++e+n+kr+s+ktvlq

Q: 97    QKWIRTHKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQ  156

         ************************************************************

S: 119   lavrlldvleylHeneYvHgdikAanllleeeeasqvyLvdyGlayrycpegkhkeyked  178

         l++r+ld+ley+He+eYvHgdikA+nlll++++++qvyLvdyGlayrycpeg+hkeyked

Q: 157   LSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKED  216

         ************************************************************

S: 179   krraHdGtleftslDaHkGvapsrRsDleiLgYcllkWltgkLPWeallkdpekvqkake  238

         ++r+HdGt+efts+DaH+GvapsrR+DleiLgYc+++Wltg+LPWe++lkdp++v+++k

Q: 217   PKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKI  276

         ************************************************************

S: 239   kfldelpellkkllkkkssseelakyl  265

         ++ +++++l++k++++k++++e+aky+

Q: 277   RYRENIASLMDKCFPEKNKPGEIAKYM  303

         **************************8

Domain Sequence
(FASTA)

WKVGLPIGQG GFGCIYLADM NSSESVGSDA PCVVKVEPSD NGPLFTELKF YQRAAKPEQI 60

QKWIRTHKLK YLGVPKYWGS GLHDKNGKSY RFMIMDRFGS DLQKIYEANA KRFSRKTVLQ 120

LSLRILDILE YIHEHEYVHG DIKASNLLLN YKNPDQVYLV DYGLAYRYCP EGVHKEYKED 180

PKRCHDGTIE FTSIDAHNGV APSRRGDLEI LGYCMIQWLT GHLPWEDNLK DPKYVRDSKI 240

RYRENIASLM DKCFPEKNKP GEIAKYM 267

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005795	; C:Golgi stack
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0090166	; P:Golgi disassembly
GO:0046777	; P:protein autophosphorylation

KEGG

mcc:704798

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013