EKS-MAM-00139
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00139
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/Akt503.52.2E-151152409258
StatusUnreviewed
Ensembl ProteinENSMMUP00000004834
UniProt AccessionF6QE96;
Protein Name
Protein Synonyms/Alias RAC-beta serine/threonine-protein kinase; RAC-beta serine/threonine-protein kinase isoform 1;
Gene NameAKT2
Gene Synonyms/Alias AKT2; EGK_10619;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000003621ENSMMUP00000004834ENSMMUT00000005130
ENSMMUG00000003621ENSMMUP00000031604ENSMMUT00000038504
OrganismMacaca mulatta
Functional Description
Protein Length481
Protein Sequence
(FASTA)
MNEVSVIKEG WLHKRGEYIK TWRPRYFLLK SDGSFIGYKE RPEAPDQTLP PLNNFSVAEC 60
QLMKTERPRP NTFVIRCLQW TTVIERTFHV DSPDEREEWM RAIQMVANSL KQRAPGEDPM 120
DYKCGSPSDS SAAEEMEVAV SKARAKVTMN DFDYLKLLGK GTFGKVILVR EKATGRYYAM 180
KILRKEVIIA KDEVAHTVTE SRVLQNTRHP FLTALKYAFQ THDRLCFVME YANGGELFFH 240
LSRERVFTEE RARFYGAEIV SALEYLHSRD VVYRDIKLEN LMLDKDGHIK ITDFGLCKEG 300
ISDGATMKTF CGTPEYLAPE VLEDNDYGRA VDWWGLGVVM YEMMCGRLPF YNQDHERLFE 360
LILMEEIRFP RTLSPEAKSL LAGLLKKDPK QRLGGGPSDA KEVMEHRFFL SINWQDVVQK 420
KLLPPFKPQV TSEVDTRYFD DEFTAQSITI TPPDRYDSLG LLELDQRTHF PQFSYSASIR 480
E 481
Nucleotide Sequence
(FASTA)
ATGAACGAGG TGTCTGTCAT CAAAGAAGGC TGGCTCCACA AGCGCGGTGA ATACATCAAG 60
ACCTGGAGGC CACGGTACTT CCTGCTGAAG AGCGACGGCT CCTTCATTGG GTACAAGGAG 120
AGGCCCGAGG CCCCTGATCA GACCCTTCCC CCCTTAAACA ACTTCTCTGT AGCAGAATGC 180
CAGCTGATGA AGACCGAGAG GCCGCGGCCC AACACCTTCG TCATACGCTG CCTGCAGTGG 240
ACCACAGTCA TCGAGAGGAC CTTCCACGTG GATTCTCCAG ACGAGAGGGA GGAATGGATG 300
CGGGCCATCC AGATGGTTGC CAACAGCCTC AAGCAGCGGG CCCCAGGTGA GGACCCCATG 360
GACTACAAGT GTGGCTCCCC CAGTGACTCC TCCGCGGCCG AGGAGATGGA AGTGGCGGTC 420
AGCAAGGCAC GGGCTAAAGT GACCATGAAT GATTTCGACT ATCTCAAACT CCTTGGCAAG 480
GGAACCTTTG GCAAAGTCAT CCTGGTGCGG GAGAAGGCCA CTGGCCGCTA CTACGCCATG 540
AAGATCCTGC GGAAGGAAGT CATCATTGCC AAGGATGAAG TCGCTCACAC AGTCACCGAG 600
AGCCGGGTCC TCCAGAACAC CAGGCACCCG TTCCTCACTG CGCTGAAGTA CGCCTTCCAG 660
ACCCACGACC GCCTGTGCTT CGTGATGGAG TACGCCAACG GTGGCGAGCT GTTCTTCCAC 720
CTGTCCCGGG AGCGTGTCTT CACAGAGGAG CGGGCCCGGT TTTATGGTGC AGAGATCGTC 780
TCGGCTCTTG AGTACTTGCA CTCGCGGGAC GTGGTGTACC GCGACATCAA GCTGGAAAAC 840
CTCATGCTGG ACAAAGACGG CCACATCAAG ATCACTGACT TTGGCCTCTG CAAAGAAGGC 900
ATCAGTGACG GGGCTACCAT GAAAACCTTC TGTGGGACCC CGGAGTACCT GGCGCCTGAG 960
GTGCTGGAGG ACAATGACTA TGGCCGGGCC GTGGACTGGT GGGGGCTGGG TGTGGTCATG 1020
TACGAGATGA TGTGCGGCCG CCTGCCTTTC TACAACCAGG ACCACGAGCG CCTCTTCGAG 1080
CTCATCCTCA TGGAAGAGAT CCGCTTCCCG CGCACGCTCA GCCCCGAGGC CAAGTCCCTG 1140
CTTGCCGGGC TGCTTAAGAA GGACCCCAAG CAGAGGCTTG GTGGGGGGCC CAGCGATGCC 1200
AAGGAGGTCA TGGAGCACAG GTTCTTCCTC AGCATCAACT GGCAGGACGT GGTCCAGAAG 1260
AAGCTCCTGC CACCCTTCAA ACCTCAGGTC ACGTCCGAGG TCGACACAAG GTACTTTGAT 1320
GATGAATTCA CCGCCCAGTC CATCACAATC ACACCCCCCG ACCGCTATGA CAGCCTGGGC 1380
TTACTGGAGC TGGACCAGCG GACCCACTTC CCCCAGTTCT CCTACTCGGC CAGCATCCGC 1440
GAGTGA 1446
Domain Profile
S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60
         fd+lkllGkGtfGkvilvrekat+++ya+kil+kevi+akdevaht+te+rvl++t+hpf
Q: 152   FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPF  211
         9***********************************************************
S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120
         l+alky+fqt+++lc+v+ey+nGGelffhls+ervf+e+rarfygaeivsal+ylhs+dv
Q: 212   LTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDV  271
         ************************************************************
S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180
         vyrd+klenl+ldkdGhikitdfGlcke+i+dg+++ktfcGtpeylapevled+dyg+av
Q: 272   VYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAV  331
         ************************************************************
S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240
         dwwglGvv+yem+cGrlpfyn+dhe+lfelil+ee++fpr+ls+eaksll+Gllkkdpk+
Q: 332   DWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQ  391
         ************************************************************
S: 241   rlGggkddakeireheff  258
         rlGgg++dake++eh+ff
Q: 392   RLGGGPSDAKEVMEHRFF  409
         *****************9
Domain Sequence
(FASTA)
FDYLKLLGKG TFGKVILVRE KATGRYYAMK ILRKEVIIAK DEVAHTVTES RVLQNTRHPF 60
LTALKYAFQT HDRLCFVMEY ANGGELFFHL SRERVFTEER ARFYGAEIVS ALEYLHSRDV 120
VYRDIKLENL MLDKDGHIKI TDFGLCKEGI SDGATMKTFC GTPEYLAPEV LEDNDYGRAV 180
DWWGLGVVMY EMMCGRLPFY NQDHERLFEL ILMEEIRFPR TLSPEAKSLL AGLLKKDPKQ 240
RLGGGPSDAK EVMEHRFF 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00132
EKS-ANC-00134
EKS-BOT-00140
EKS-CAJ-00144
EKS-CAF-00146
EKS-CAP-00139
EKS-DAR-00423
EKS-DAN-00010
EKS-ECT-00022
EKS-EQC-00137
EKS-FEC-00131
EKS-GAM-00069
EKS-GAA-00163
EKS-GOG-00141
EKS-HOS-00145
EKS-ICT-00133
EKS-LOA-00138
EKS-MOD-00139
EKS-MUM-00144
EKS-MUP-00143
EKS-MYL-00150
EKS-ORN-00172
EKS-ORL-00161
EKS-OTG-00145
EKS-POA-00135
EKS-PTV-00130
EKS-RAN-00137
EKS-SUS-00123
EKS-TAR-00182
EKS-TEN-00173
EKS-XET-00128
EKS-XIM-00167
Gene Ontology
GO:0030027; C:lamellipodium
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0008286; P:insulin receptor signaling pathway
GO:0010748; P:negative regulation of plasma membrane long-chain fatty acid transport
GO:0032287; P:peripheral nervous system myelin maintenance
GO:2000147; P:positive regulation of cell motility
GO:0032000; P:positive regulation of fatty acid beta-oxidation
GO:2001275; P:positive regulation of glucose import in response to insulin stimulus
GO:0045725; P:positive regulation of glycogen biosynthetic process
GO:0072659; P:protein localization to plasma membrane
GO:0046328; P:regulation of JNK cascade
KEGG
mcc:700591;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR017892; Pkinase_C.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00169; PH; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00233; PH; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013