EKS-MAM-00240

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00240

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	388.9	1.6E-116	56	307	252

Status

Unreviewed

Ensembl Protein

ENSMMUP00000004858

UniProt Accession

F6Q5Q2;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK3

Gene Synonyms/Alias

MARK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000003641	ENSMMUP00000004858	ENSMMUT00000005157
ENSMMUG00000003641	ENSMMUP00000004857	ENSMMUT00000005156

Organism

Macaca mulatta

Functional Description

Protein Length

753

Protein Sequence
(FASTA)

MSTRTPLPTV NERDTENHTS HGDGRQEVTS RTSRSGARCR NSIASCADEQ PHIGNYRLLK 60

TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE 120

VIETEKTLYL IMEYASGGEV FDYLVAHGRM KEKEARAKFR QIVSAVQYCH QKRIVHRDLK 180

AENLLLDADM NIKIADFGFS NEFTVGSKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG 240

VILYTLVSGS LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPIKRGTLEQ 300

IMKDRWINAG HEEDELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS KMKYDEITAT 360

YLLLGRKSSE LDASDSSSSS NLSLAKVRPS SDLNNSTGQS PHHKVQRSVS SSQKQRRYSD 420

HAGPAIPSVV AYPKRSQTST ADSDLKEDGI SSRKSSGSAV GGKGIAPASP MLGNASNPNK 480

ADIPERKKSS TVPSVSVAEA GEWRKPGRLC LNNKKKNYLI QAGHGGSHLT IPDQRTPVAS 540

THSISSAATP DRIRFPRGTA SRSTFHGQPR ERRTATYNGP PASPSLSHEA TPLSQTRSRG 600

STNLFSKLTS KLTRRNMSFR FIKRLPTEYE RNGRYEGSSR NVSAEQKDEN KEAKPRSLRF 660

TWSMKTTSSM DPGDMMREIR KVLDANNCDY EQRERFLLFC VHGDGHAENL VQWEMEVCKL 720

PRLSLNGVRF KRISGTSIAF KNIASKIANE LKL 753

Nucleotide Sequence
(FASTA)

ATGTCCACTA GGACCCCATT GCCAACGGTG AATGAACGAG ACACTGAAAA CCACACGTCA 60

CATGGAGATG GGCGTCAAGA AGTTACCTCT CGTACCAGCC GTTCAGGAGC TCGGTGTAGA 120

AACTCTATAG CTTCCTGTGC AGACGAACAA CCTCACATCG GAAACTACAG ACTGTTGAAA 180

ACAATCGGCA AGGGGAATTT TGCAAAAGTA AAATTGGCAA GACATATCCT TACAGGCAGA 240

GAGGTTGCAA TAAAAATAAT TGACAAAACT CAGTTGAATC CAACAAGTCT ACAAAAGCTC 300

TTCAGAGAAG TAAGAATAAT GAAGATTTTA AATCATCCCA ATATAGTGAA GTTATTCGAA 360

GTCATTGAAA CTGAAAAAAC ACTCTACCTA ATCATGGAAT ATGCAAGTGG AGGTGAAGTA 420

TTTGACTATT TGGTTGCACA TGGCAGGATG AAGGAAAAAG AAGCAAGAGC TAAATTTAGA 480

CAGATTGTGT CTGCAGTTCA ATACTGCCAT CAGAAACGGA TCGTACATCG AGACCTCAAG 540

GCTGAAAATC TATTGTTAGA TGCCGATATG AACATTAAAA TAGCAGATTT CGGTTTTAGC 600

AATGAATTTA CCGTTGGCAG TAAACTCGAC ACGTTTTGTG GCAGTCCTCC ATACGCAGCA 660

CCTGAGCTCT TCCAGGGCAA GAAATACGAC GGGCCAGAAG TGGATGTATG GAGTCTGGGG 720

GTCATTTTAT ACACACTAGT CAGTGGCTCA CTTCCCTTTG ATGGGCAAAA CCTAAAGGAA 780

CTGAGAGAGA GAGTATTAAG AGGGAAATAC AGAATTCCCT TCTACATGTC TACAGACTGT 840

GAAAACCTTC TCAAACGTTT CCTGGTGCTA AATCCAATTA AACGCGGCAC TCTAGAGCAA 900

ATCATGAAGG ACAGGTGGAT CAATGCAGGG CATGAAGAAG ATGAACTGAA ACCATTCGTT 960

GAACCAGAGC TAGACATCTC AGACCAAAAA AGAATAGATA TTATGGTGGG AATGGGATAT 1020

TCACAAGAAG AAATTCAAGA ATCTCTTAGT AAAATGAAAT ATGATGAAAT CACAGCTACA 1080

TATTTGTTAC TGGGGAGAAA ATCTTCAGAG CTGGATGCTA GTGATTCCAG TTCTAGCAGC 1140

AATCTTTCAC TTGCTAAGGT TAGGCCAAGC AGTGATCTCA ACAACAGTAC TGGCCAGTCT 1200

CCTCACCACA AAGTGCAGAG AAGTGTTTCT TCAAGCCAGA AGCAAAGACG CTACAGTGAC 1260

CATGCTGGAC CAGCTATTCC TTCTGTTGTG GCGTATCCGA AAAGGAGTCA GACCAGCACC 1320

GCAGATAGTG ACCTCAAAGA AGATGGAATT TCCTCTCGGA AGTCAAGTGG CAGTGCTGTT 1380

GGAGGAAAGG GAATTGCTCC AGCCAGTCCC ATGCTTGGGA ATGCAAGTAA TCCCAATAAG 1440

GCGGATATTC CTGAACGCAA GAAAAGCTCC ACTGTCCCTA GTGTAAGTGT TGCTGAGGCA 1500

GGAGAATGGC GCAAACCCGG GAGACTCTGT CTCAACAACA AAAAAAAAAA TTATCTGATA 1560

CAGGCCGGGC ACGGTGGCTC ACACCTCACT ATTCCTGATC AGAGAACTCC AGTCGCTTCA 1620

ACACACAGTA TTAGCAGTGC AGCCACCCCG GATCGAATCC GCTTCCCAAG AGGCACTGCC 1680

AGTCGTAGCA CTTTCCACGG CCAGCCCCGG GAACGGCGAA CTGCGACATA CAATGGCCCT 1740

CCTGCCTCTC CCAGCCTGTC CCATGAAGCC ACACCATTGT CCCAGACTCG AAGCCGAGGC 1800

TCCACTAATC TCTTTAGTAA ATTAACTTCA AAACTCACAA GGAGAAACAT GTCATTCAGG 1860

TTTATCAAAA GACTTCCAAC TGAATATGAG AGGAACGGGA GATATGAGGG CTCAAGTCGC 1920

AATGTATCTG CTGAGCAAAA GGATGAAAAC AAAGAAGCAA AGCCTCGATC CCTACGCTTC 1980

ACCTGGAGCA TGAAAACCAC TAGTTCAATG GATCCCGGGG ACATGATGCG GGAAATCCGC 2040

AAAGTGTTGG ATGCCAATAA CTGCGACTAT GAGCAGAGGG AGCGCTTCTT GCTCTTCTGT 2100

GTCCACGGTG ATGGGCACGC AGAGAACCTC GTGCAGTGGG AAATGGAAGT ATGCAAGCTG 2160

CCAAGACTGT CTCTGAATGG GGTCCGGTTT AAGCGGATAT CGGGGACATC CATAGCCTTC 2220

AAAAATATTG CTTCCAAAAT TGCCAATGAG CTAAAGCTGT AA 2262

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++va+Kii+k++l+ +sl+k++rE++i+k+l+hpni

Q: 56    YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI  115

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lyl++eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k+iv

Q: 116   VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIV  175

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 176   HRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVD  235

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+++Lv +p kR

Q: 236   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKR  295

         ************************************************************

S: 241   atieeilkhewl  252

          t+e+i+k++w+

Q: 296   GTLEQIMKDRWI  307

         ***********7

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH ILTGREVAIK IIDKTQLNPT SLQKLFREVR IMKILNHPNI 60

VKLFEVIETE KTLYLIMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKRIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTV GSKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK RFLVLNPIKR 240

GTLEQIMKDR WI 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 2.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013