EKS-MAM-00280
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00280
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR453.36.0E-136115402288
StatusUnreviewed
Ensembl ProteinENSMMUP00000004946
UniProt AccessionF7GDQ6;
Protein Name
Protein Synonyms/Alias Activin receptor type-1C isoform 1;
Gene NameACVR1C
Gene Synonyms/Alias ACVR1C;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000003707ENSMMUP00000004946ENSMMUT00000005250
ENSMMUG00000003707ENSMMUP00000004947ENSMMUT00000005251
ENSMMUG00000003707ENSMMUP00000004948ENSMMUT00000005252
ENSMMUG00000003707ENSMMUP00000038320ENSMMUT00000045296
OrganismMacaca mulatta
Functional Description
Protein Length413
Protein Sequence
(FASTA)
MTRALRSALR QALLLLAAAA ELSAGLKCVC LLCDSSNFTC QTEGACWASV MLTNGKEQVI 60
KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITLHLP TGLPLLVQRT IARTIVLQEI 120
VGKGRFGEVW HGRWCGEDVA VKIFSSRDER SWFREAEIYQ TVMLRHENIL GFIAADNKDN 180
GTWTQLWLVS EYHEQGSLYD YLNRNIVTVA GMIKLALSIA SGLAHLHMEI VGTQGKPAIA 240
HRDIKSKNIL VKKCETCAIA DLGLAVKHDS ILNTIDIPQN PKVGTKRYMA PEMLDDTMNV 300
SIFESFKRAD IYSVGLVYWE IARRCSVGGI VEEYQLPYYD MVPSDPSIEE MRKVVCDQKF 360
RPSIPNQWQS CEALRVMGRI MRECWYANGA ARLTALRIKK TISQLCVKED CKA 413
Nucleotide Sequence
(FASTA)
ATGACCCGGG CGCTCCGCTC AGCGCTCCGC CAGGCTCTCC TGCTGCTCGC CGCGGCCGCC 60
GAGCTCTCGG CAGGACTGAA GTGTGTATGT CTTTTGTGTG ATTCTTCAAA CTTTACCTGC 120
CAAACAGAAG GAGCATGTTG GGCATCAGTC ATGCTAACCA ATGGAAAAGA ACAGGTGATC 180
AAATCCTGTG TCTCCCTTCC AGAATTGAAT GCTCAAGTCT TCTGTCATAG TTCCAACAAT 240
GTTACCAAAA CCGAATGCTG CTTCACAGAT TTTTGCAACA ACATAACACT GCACCTTCCA 300
ACAGGTCTAC CTCTGTTGGT TCAAAGGACA ATTGCAAGGA CGATTGTGCT TCAGGAAATA 360
GTAGGAAAAG GTAGATTTGG TGAGGTGTGG CATGGAAGAT GGTGTGGGGA AGATGTGGCT 420
GTGAAAATAT TCTCCTCCAG AGATGAAAGA TCTTGGTTTC GTGAGGCAGA AATTTACCAG 480
ACGGTCATGC TGCGACATGA AAACATCCTT GGTTTCATTG CTGCTGACAA CAAAGATAAT 540
GGAACCTGGA CTCAACTTTG GCTGGTATCT GAATATCATG AACAGGGCTC CTTATATGAC 600
TATTTGAATA GAAATATAGT GACGGTGGCT GGAATGATCA AGCTGGCGCT CTCAATTGCT 660
AGTGGTCTGG CACACCTTCA TATGGAGATT GTTGGGACAC AAGGTAAACC TGCTATTGCT 720
CATCGAGACA TAAAATCAAA GAATATCTTA GTGAAAAAAT GTGAAACTTG TGCCATAGCG 780
GACTTAGGGT TGGCTGTGAA GCATGATTCA ATACTGAACA CTATCGACAT ACCTCAGAAT 840
CCTAAAGTGG GAACGAAGAG GTATATGGCT CCTGAAATGC TTGATGATAC AATGAATGTG 900
AGTATCTTTG AGTCCTTCAA ACGAGCGGAC ATCTATTCTG TTGGTCTGGT TTACTGGGAA 960
ATAGCCCGGA GGTGTTCGGT CGGAGGAATT GTTGAGGAGT ACCAATTGCC TTATTATGAC 1020
ATGGTGCCTT CAGATCCCTC GATAGAGGAA ATGAGAAAGG TTGTTTGTGA CCAGAAGTTT 1080
CGACCAAGTA TCCCAAACCA GTGGCAAAGT TGTGAAGCAC TCCGAGTCAT GGGGAGAATA 1140
ATGCGTGAAT GTTGGTATGC CAACGGAGCG GCCCGCCTAA CTGCTCTTCG TATTAAGAAG 1200
ACTATATCTC AACTTTGTGT CAAAGAAGAC TGCAAAGCCT AA 1242
Domain Profile
S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60
         + l+e++gkGr+geVw++++ ge+vAvKifs++de+sw+rE+eiyqtv+lrhenil+fia
Q: 115   IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA  174
         5789********************************************************
S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120
         ad+k+++++t+l+lv+eyhe+gsL+dyL+r++++v  +++lals+asGlahLH+eivgt+
Q: 175   ADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQ  234
         ************************************************************
S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180
         g  KpaiaHRD+kskNilvkk +tc+iaDlGLa+k+++  +++d+ +n +vGtkRYmaPE
Q: 235   G--KPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPE  292
         *..*********************************************************
S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240
         +l++++n++ fe+fkraD+Ys+gLv+WE+a+Rc+  +++veey+lp++++v+sdPs+eem
Q: 293   MLDDTMNVSIFESFKRADIYSVGLVYWEIARRCSV-GGIVEEYQLPYYDMVPSDPSIEEM  351
         **********************************9.************************
S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291
         ++vv+++k rP+ip++w+++eal+++ ++++ecW+a+++aRltalr+kk++
Q: 352   RKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTI  402
         ************************************************986
Domain Sequence
(FASTA)
IVLQEIVGKG RFGEVWHGRW CGEDVAVKIF SSRDERSWFR EAEIYQTVML RHENILGFIA 60
ADNKDNGTWT QLWLVSEYHE QGSLYDYLNR NIVTVAGMIK LALSIASGLA HLHMEIVGTQ 120
GKPAIAHRDI KSKNILVKKC ETCAIADLGL AVKHDSILNT IDIPQNPKVG TKRYMAPEML 180
DDTMNVSIFE SFKRADIYSV GLVYWEIARR CSVGGIVEEY QLPYYDMVPS DPSIEEMRKV 240
VCDQKFRPSI PNQWQSCEAL RVMGRIMREC WYANGAARLT ALRIKKTI 288
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>
EKS-AIM-00260
EKS-BOT-00278
EKS-CAJ-00283
EKS-CAF-00284
EKS-CAP-00313
EKS-EQC-00270
EKS-FEC-00263
EKS-GOG-00277
EKS-HOS-00283
EKS-ICT-00262
EKS-MUM-00308
EKS-MUP-00273
EKS-MYL-00281
EKS-NOL-00255
EKS-ORC-00263
EKS-PAT-00262
EKS-PTV-00039
EKS-SUS-00245
EKS-TAG-00293
EKS-TAS-00018
EKS-TUT-00036
EKS-VIP-00015
Gene Ontology
GO:0048179; C:activin receptor complex
GO:0016361; F:activin receptor activity, type I
GO:0005524; F:ATP binding
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0030154; P:cell differentiation
GO:0019915; P:lipid storage
GO:0008285; P:negative regulation of cell proliferation
GO:0046676; P:negative regulation of insulin secretion
GO:0038092; P:nodal signaling pathway
GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0002021; P:response to dietary excess
GO:0009749; P:response to glucose stimulus
GO:0032868; P:response to insulin stimulus
KEGG
mcc:697826;
InterPros
IPR000472; Activin_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR003605; TGF_beta_rcpt_GS.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
SMARTs
SM00467; GS; 1.
Prosites
PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013