EPS-MAM-00011

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MAM-00011

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	117.1	9.8E-34	29	169	141

Status

Unreviewed

Ensembl Protein

ENSMMUP00000005407

UniProt Accession

F6ZR84;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP12

Gene Synonyms/Alias

DUSP12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000004047	ENSMMUP00000005407	ENSMMUT00000005743

Organism

Macaca mulatta

Functional Description

Protein Length

340

Protein Sequence
(FASTA)

MLEAPGPSHG CEPCNPSASR ATCAGQMLEV QPGLYLGGVA AVAEPDHLRE AGITAVLTVD 60

SEEPSFKAGP GVEDLWRLFV PALDKPETDL LSHLDRCVAF IGQARAEGRA VLVHCHAGVS 120

RSVAIITAFL MKTDLLPFEK AYEKLQILKP EAKMNEGFEW QLKLYQAMGY EVDTSSAIYK 180

QYRLQKVTEK YPELQNLPQE LFAVDPTTVS QGLKDEVLYK CRKCRRSLFR SSSILDHHEG 240

SGPIAFAHKR MTSSFMLTTG RQAQCTSYFI EPVQWMESAL LGVMDGQLLC PKCSAKLGSF 300

NWYGEQCSCG RWITPAFQIH KNRVDEMKIL PVLRSQTRKI 340

Nucleotide Sequence
(FASTA)

ATGTTGGAGG CTCCGGGCCC GAGTCATGGC TGCGAGCCCT GCAACCCCAG TGCCAGCAGA 60

GCCACCTGCG CCGGGCAGAT GCTGGAAGTG CAGCCAGGAC TGTATCTCGG TGGGGTCGCG 120

GCCGTCGCGG AGCCAGACCA CTTGAGGGAA GCGGGCATCA CGGCCGTGCT AACGGTGGAC 180

TCGGAGGAGC CCAGCTTCAA GGCGGGGCCT GGGGTCGAGG ATCTGTGGCG CCTCTTCGTG 240

CCAGCGCTGG ACAAACCCGA GACCGATCTG CTCAGCCATC TGGACCGGTG CGTGGCCTTC 300

ATCGGTCAGG CCCGCGCTGA GGGCCGTGCG GTGTTGGTGC ACTGTCACGC AGGAGTCAGT 360

CGAAGTGTGG CCATAATAAC TGCTTTTCTC ATGAAGACTG ACCTACTTCC CTTTGAAAAA 420

GCCTATGAAA AGCTCCAGAT TCTCAAACCA GAGGCCAAGA TGAATGAGGG GTTTGAGTGG 480

CAACTGAAAT TATACCAGGC AATGGGATAT GAAGTGGATA CCTCTAGTGC AATTTATAAG 540

CAATATCGTT TACAAAAGGT TACAGAGAAG TATCCAGAAT TGCAGAATTT ACCTCAAGAA 600

CTCTTTGCTG TTGACCCAAC CACGGTTTCA CAAGGATTGA AAGATGAGGT TCTCTACAAG 660

TGTAGAAAGT GCAGGCGATC ATTATTTCGA AGTTCTAGTA TTCTGGATCA CCATGAAGGA 720

AGTGGACCTA TAGCCTTTGC ACACAAGAGA ATGACATCAT CTTTCATGCT TACCACAGGG 780

AGACAAGCTC AATGTACATC TTATTTCATT GAACCTGTAC AGTGGATGGA ATCTGCTTTG 840

TTGGGAGTGA TGGATGGACA GCTTCTTTGC CCAAAATGCA GTGCCAAGTT GGGTTCCTTC 900

AACTGGTATG GTGAACAGTG CTCGTGTGGT AGGTGGATAA CACCTGCTTT TCAAATACAT 960

AAGAACAGAG TGGATGAAAT GAAAATATTG CCTGTTTTGA GATCACAAAC AAGAAAAATA 1020

TGA 1023

Domain Profile

S: 4     eilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvdDs  63

         e+ pglylg+ a + +  +L+++git v+++  +   ++++P +    +   + +p+ D+

Q: 29    EVQPGLYLGGVAAVAEPDHLREAGITAVLTVDSEEPSFKAGPGVE---DLWRLFVPALDK  85

         799***************************************986...888899******

S: 64    dvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAieav  123

         ++tdll+++d++++fi +a+ +g++vlvHC+aGvsRS+++++a+Lmk+  l +++A+e++

Q: 86    PETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKTDLLPFEKAYEKL  145

         ************************************************************

S: 124   krkrpsiepnegfleQLlelekkl  147

         +  +p++++negf +QL +++ ++

Q: 146   QILKPEAKMNEGFEWQLKLYQAMG  169

         ********************9886

Domain Sequence
(FASTA)

EVQPGLYLGG VAAVAEPDHL REAGITAVLT VDSEEPSFKA GPGVEDLWRL FVPALDKPET 60

DLLSHLDRCV AFIGQARAEG RAVLVHCHAG VSRSVAIITA FLMKTDLLPF EKAYEKLQIL 120

KPEAKMNEGF EWQLKLYQAM G 141

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR016278	; DUSP12.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

Created Date

20-Feb-2013