EPS-MAM-00134

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MAM-00134

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PDP	403.6	3.5E-121	228	439	212

Status

Unreviewed

Ensembl Protein

ENSMMUP00000006073

UniProt Accession

H9FW49;

Protein Name

Protein Synonyms/Alias

[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform 1;

Gene Name

PDP1

Gene Synonyms/Alias

PDP1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000004568	ENSMMUP00000006073	ENSMMUT00000006459
ENSMMUG00000004568	ENSMMUP00000032051	ENSMMUT00000038960

Organism

Macaca mulatta

Functional Description

Protein Length

537

Protein Sequence
(FASTA)

MPAPTQLFFP LIRNCELSRI YGTACYCHHK HLCCSSPYVP QSRLRYTPHP AYATFCRPKE 60

NWWQYTQGRR YASTPQKFYL TPPQVNSILK ANEYSFKVPE FDGKNVSSIL GFDSNQLPAN 120

APIEDRRSAA TCLQTRGMLL GVFDGHAGCA CSQAVSERLF YYIAVSLLPH ETLLEIENAV 180

ESGRALLPIL QWHKHPNDYF SKEASKLYFN SLRTYWQELI DLNTGESTDI DVKEALINAF 240

KRLDNDISLE AQVGDPNSFL NYLVLRVAFS GATACVAHVD GVDLHVANTG DSRAMLGVQE 300

EDGSWSAVTL SNDHNAQNER ELERLKLEHP KSEAKSVVKQ DRLLGLLMPF RAFGDVKFKW 360

SIDLQKRVIE SGPDQLNDNE YTKFIPPNYH TPPYLTAEPE VTYHRLRPQD KFLVLATDGL 420

WETMHRQDVV RIVGEYLTGM HHQQPIAVGG YKVTLGQMHG LLTERRTKMS SVFEDQNAAT 480

HLIRHAVGNN EFGTVDHERL SKMLSLPEEL ARMYRDDITI IVVQFNSHVV GAYQNQE 537

Nucleotide Sequence
(FASTA)

ATGCCAGCAC CAACTCAACT GTTTTTTCCT CTGATCCGTA ACTGTGAACT GAGCAGGATC 60

TATGGCACTG CATGTTACTG CCACCACAAA CATCTCTGTT GTTCCTCACC CTACGTTCCT 120

CAGAGTCGAC TGAGATATAC ACCTCATCCA GCATATGCTA CCTTTTGCAG GCCAAAGGAG 180

AACTGGTGGC AGTACACCCA AGGAAGGAGA TATGCTTCCA CACCACAGAA ATTTTACCTC 240

ACACCTCCAC AAGTCAATAG CATCCTTAAA GCTAATGAAT ACAGTTTCAA AGTGCCAGAA 300

TTTGATGGCA AAAATGTCAG TTCTATCCTT GGATTTGACA GCAATCAGCT GCCTGCAAAT 360

GCGCCCATTG AGGACCGGAG AAGTGCAGCA ACCTGCCTGC AGACCAGAGG GATGCTTTTG 420

GGGGTTTTTG ATGGCCATGC AGGTTGTGCT TGTTCCCAGG CAGTCAGTGA GAGACTTTTT 480

TATTATATTG CTGTCTCTTT GTTACCCCAT GAGACTTTGC TAGAGATTGA AAATGCAGTG 540

GAGAGTGGCC GGGCACTGCT ACCCATTCTC CAGTGGCACA AGCACCCCAA TGATTACTTT 600

AGTAAGGAGG CATCCAAATT GTACTTTAAC AGCTTGAGGA CTTACTGGCA AGAGCTTATA 660

GACCTCAACA CTGGTGAGTC AACTGATATT GATGTTAAGG AGGCCCTAAT TAATGCTTTC 720

AAGAGGCTTG ATAATGACAT CTCCTTGGAG GCACAAGTTG GTGATCCTAA TTCCTTCCTC 780

AACTATCTGG TGCTTCGAGT GGCATTTTCT GGAGCCACTG CTTGTGTGGC CCATGTGGAT 840

GGTGTTGACC TTCATGTGGC CAATACTGGC GATAGCAGAG CCATGCTGGG TGTGCAGGAA 900

GAGGACGGCT CATGGTCAGC AGTCACGCTG TCTAATGACC ACAATGCTCA GAATGAAAGA 960

GAACTAGAAC GGCTGAAATT GGAACATCCA AAGAGTGAGG CCAAGAGTGT GGTGAAACAG 1020

GATCGGCTGC TTGGCTTGCT GATGCCATTT AGGGCTTTTG GAGATGTAAA GTTCAAATGG 1080

AGCATTGACC TTCAAAAGAG AGTGATAGAA TCTGGCCCAG ACCAGTTGAA TGACAATGAA 1140

TATACCAAAT TTATTCCTCC TAATTATCAC ACACCTCCTT ATCTCACTGC TGAGCCAGAG 1200

GTAACTTACC ACCGATTAAG GCCACAGGAT AAGTTTCTGG TGTTGGCTAC TGATGGGTTG 1260

TGGGAGACTA TGCATAGGCA GGATGTGGTT AGGATTGTGG GTGAGTACTT AACTGGCATG 1320

CATCACCAAC AGCCAATAGC TGTTGGTGGC TACAAGGTGA CTCTGGGACA GATGCACGGC 1380

CTTTTAACAG AAAGGAGAAC CAAAATGTCC TCGGTATTTG AGGATCAGAA TGCAGCAACC 1440

CATCTCATTC GCCATGCTGT GGGCAACAAC GAGTTTGGGA CTGTTGATCA TGAGCGCCTC 1500

TCCAAAATGC TTAGTCTTCC TGAAGAGCTT GCTCGAATGT ACAGAGATGA CATTACAATC 1560

ATTGTAGTTC AGTTCAATTC TCATGTCGTA GGGGCGTATC AAAACCAAGA ATAG 1614

Domain Profile

S: 1     tdidvkealvnafkrldedisleaqvsdedevlrylvlrvalsGataclahvdGvdlhva  60

         tdidvkeal+nafkrld+disleaqv+d++++l+ylvlrva+sGatac+ahvdGvdlhva

Q: 228   TDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVA  287

         699*********************************************************

S: 61    ntGdsravlGvqeedgswsavklsrdhnaqneselerlkaehpkseaktvikedrllgll  120

         ntGdsra+lGvqeedgswsav+ls+dhnaqne+elerlk+ehpkseak+v+k+drllgll

Q: 288   NTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLL  347

         ************************************************************

S: 121   iplrafGdvkfkwskelqkrvvesgfdvladney.kfiapnyytppyltaepevtyhrlr  179

         +p+rafGdvkfkws++lqkrv+esg+d+l+dney kfi+pny+tppyltaepevtyhrlr

Q: 348   MPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYtKFIPPNYHTPPYLTAEPEVTYHRLR  407

         ************************************************************

S: 180   pqdkflvlasdGlwdllsredvvrlvgeylae  211

         pqdkflvla+dGlw++++r+dvvr+vgeyl+

Q: 408   PQDKFLVLATDGLWETMHRQDVVRIVGEYLTG  439

         *****************************875

Domain Sequence
(FASTA)

TDIDVKEALI NAFKRLDNDI SLEAQVGDPN SFLNYLVLRV AFSGATACVA HVDGVDLHVA 60

NTGDSRAMLG VQEEDGSWSA VTLSNDHNAQ NERELERLKL EHPKSEAKSV VKQDRLLGLL 120

MPFRAFGDVK FKWSIDLQKR VIESGPDQLN DNEYTKFIPP NYHTPPYLTA EPEVTYHRLR 180

PQDKFLVLAT DGLWETMHRQ DVVRIVGEYL TG 212

Keyword

Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Pyruvate.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013