EKS-MAM-00146
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00146
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR526.71.8E-158427703277
StatusUnreviewed
Ensembl ProteinENSMMUP00000006529
UniProt AccessionF7A5Z8;
Protein Name
Protein Synonyms/Alias
Gene NameFGFR4
Gene Synonyms/Alias FGFR4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000004919ENSMMUP00000012564ENSMMUT00000013409
ENSMMUG00000004919ENSMMUP00000006528ENSMMUT00000006942
ENSMMUG00000004919ENSMMUP00000006529ENSMMUT00000006943
OrganismMacaca mulatta
Functional Description
Protein Length762
Protein Sequence
(FASTA)
MRLLSALLGV LLSVPGPPVL SLEASEEVEL EPCLAPSMEQ QEQELTVALG QPVRLCCGRA 60
ERGGHWYKEG SRLAPAGRVR GWRGRLEIAS FLPEDAGRYL CLARASMIVL QNLTLTIDDS 120
LTSSNDDEDP QSHRDSSNGH IYPQQAPYWT HPQRMEKKLH AVPAGNTVKF RCPAAGNPTP 180
TIRWLKDGQA FHGENRIGGI RLRHQHWSLV MESVVPSDRG TYTCLVENAV GIIRYNYLLD 240
VLERSPHRPI LQAGLPANTT AVVGSDVELL CKVYSDAQPH IQWLKHIVIN GSSFGADGFP 300
YVQVLKTADI NSSEVEVLYL RNVSAEDAGE YTCLAGNSIG LSYQSAWLTV LPGTGRIPHL 360
ACGSLTPAGR TKSPTLQFSL ESGSSSKSSS SLVRGVRLSS SGPALLAGLV SLDLPLDPLW 420
EFPRDRLVLG KPLGEGCFGQ VVRAEAFGMD PARPDQASTV AVKMLKDNAS DKDLADLVSE 480
MEVMKLIGRH KNIINLLGVC TQEGPLYVIV ECAAKGNLRE FLRARRPPGP DLSPDGPQSS 540
EGPLAFPVLV SCAYQVARGM QYLESRKCIH RDLAARNVLV TEDNVMKIAD FGLARGIHHI 600
DYYKKTSNGR LPVKWMAPEA LFDRVYTHQS DVWSFGVLLW EIFTLGGSPY PGIPVEELFS 660
LLREGHRMDR PPHCPPELYG LMRECWHAAP SQRPTFKQLV EALDKVLLAV SEEYLDLRLT 720
FGPYSPAGGD TSSTCSSSDS VFSHDPLPLG SSSFPFGSGV QT 762
Nucleotide Sequence
(FASTA)
ATGCGGCTGC TGTCGGCCCT CTTGGGGGTC CTGCTGAGTG TGCCTGGGCC TCCAGTCTTG 60
TCCCTGGAGG CCTCGGAGGA AGTGGAGCTG GAGCCCTGCC TGGCTCCCAG CATGGAGCAG 120
CAAGAGCAGG AGCTGACAGT AGCCCTTGGG CAGCCTGTGC GGCTGTGCTG TGGGCGGGCT 180
GAGCGTGGTG GCCACTGGTA CAAGGAGGGC AGTCGCCTGG CACCTGCTGG CCGTGTACGG 240
GGCTGGAGGG GCCGCCTAGA GATTGCCAGC TTCCTACCTG AGGATGCTGG CCGCTATCTC 300
TGCCTGGCCC GAGCCTCCAT GATCGTCCTG CAAAATCTCA CCTTGACTAT AGATGACTCC 360
TTGACCTCCA GCAACGATGA TGAGGACCCC CAGTCCCATA GGGACTCCTC GAATGGGCAC 420
ATTTACCCCC AGCAAGCACC CTACTGGACA CACCCCCAGC GCATGGAGAA GAAACTGCAT 480
GCAGTACCGG CTGGGAACAC CGTCAAGTTC CGCTGTCCGG CTGCAGGCAA CCCCACGCCC 540
ACCATCCGCT GGCTTAAGGA TGGACAGGCC TTTCATGGGG AGAACCGCAT TGGAGGCATT 600
CGGCTGCGCC ACCAGCACTG GAGTCTCGTG ATGGAGAGCG TGGTGCCCTC GGACCGCGGC 660
ACATACACTT GCCTGGTGGA GAACGCTGTG GGCATCATCC GCTATAACTA CCTGCTGGAT 720
GTGCTGGAGC GGTCCCCGCA CCGGCCCATC CTGCAGGCTG GGCTCCCGGC CAACACCACA 780
GCCGTGGTGG GCAGTGACGT GGAGCTGCTG TGCAAGGTGT ACAGCGATGC CCAGCCCCAC 840
ATCCAGTGGC TGAAGCACAT CGTCATCAAC GGCAGCAGCT TCGGGGCCGA CGGCTTCCCC 900
TATGTGCAAG TCCTGAAGAC TGCAGACATC AATAGCTCAG AGGTGGAGGT CCTGTACCTG 960
CGGAACGTGT CAGCCGAGGA CGCAGGCGAG TACACCTGCC TTGCAGGCAA TTCCATCGGC 1020
CTCTCCTACC AGTCTGCCTG GCTCACGGTG CTGCCAGGTA CTGGGCGCAT CCCCCACCTC 1080
GCATGTGGCA GCCTGACTCC AGCAGGCAGA ACCAAGTCTC CCACTTTGCA GTTCTCCCTG 1140
GAGTCAGGCT CTTCCAGCAA GTCAAGCTCA TCCCTGGTGC GAGGCGTGCG TCTCTCCTCC 1200
AGCGGCCCCG CCTTGCTCGC CGGCCTCGTG AGTCTAGACC TACCTCTCGA CCCACTGTGG 1260
GAGTTCCCCC GGGACAGGCT GGTGCTTGGG AAGCCCCTGG GCGAGGGCTG CTTTGGACAG 1320
GTAGTACGTG CAGAGGCCTT TGGCATGGAC CCTGCCCGGC CTGACCAAGC CAGTACTGTG 1380
GCTGTCAAGA TGCTCAAAGA CAACGCCTCT GACAAGGACC TGGCTGACCT GGTCTCGGAG 1440
ATGGAGGTGA TGAAGCTGAT TGGCCGACAC AAGAACATCA TCAACCTGCT GGGTGTCTGC 1500
ACCCAGGAAG GGCCCCTGTA TGTAATCGTG GAGTGCGCTG CCAAGGGAAA CCTTCGGGAG 1560
TTCCTGCGGG CCCGGCGCCC CCCGGGCCCT GACCTCAGCC CGGACGGTCC TCAGAGCAGT 1620
GAGGGGCCAC TCGCCTTCCC AGTCCTGGTC TCCTGCGCCT ACCAGGTGGC CCGAGGCATG 1680
CAGTATCTGG AGTCCCGGAA GTGTATCCAC CGGGACCTGG CTGCCCGCAA TGTGCTGGTG 1740
ACGGAGGACA ATGTGATGAA GATAGCTGAC TTTGGGCTGG CCCGTGGCAT CCACCACATT 1800
GACTACTATA AGAAAACCAG CAACGGCCGC CTGCCTGTCA AGTGGATGGC GCCCGAGGCC 1860
TTGTTTGACC GAGTGTACAC ACACCAGAGT GACGTGTGGT CTTTTGGGGT CCTGCTGTGG 1920
GAGATCTTCA CCCTCGGGGG CTCCCCGTAT CCTGGCATCC CGGTGGAGGA GCTGTTCTCA 1980
CTGCTGCGGG AGGGACATCG GATGGACCGA CCCCCACACT GCCCCCCAGA GCTGTACGGG 2040
CTGATGCGTG AGTGCTGGCA TGCAGCACCC TCCCAGAGGC CCACCTTCAA GCAGCTGGTG 2100
GAGGCGCTGG ACAAGGTCTT ACTGGCCGTC TCTGAGGAGT ACCTCGACCT CCGCCTGACC 2160
TTCGGACCCT ATTCCCCTGC TGGTGGGGAC ACCAGCAGCA CCTGCTCCTC CAGTGACTCC 2220
GTCTTCAGCC ACGACCCCCT GCCACTGGGA TCCAGCTCCT TCCCCTTTGG GTCTGGGGTG 2280
CAGACATGA 2289
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         lvlgk+lGeG+fGqvv+aea+g+d  ++++++tvavkmlk++a+dkdladlvsemev+kl
Q: 427   LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKL  486
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iG+hkniinllG+ctqeGplyvive+aakGnlreflrarrp+g + s d +++se  l++
Q: 487   IGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPQSSEGPLAF  546
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
           lvs+ayqvarGm+yl+s+kcihrdlaarnvlvtednv+kiadfGlar++h+idyykkt
Q: 547   PVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGIHHIDYYKKT  606
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         +nGrlpvkwmapealfdrvyt+qsdvwsfGvllwei+tlGgspypgi+veelf+ll+eGh
Q: 607   SNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFSLLREGH  666
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm++p +c+ ely lmrecwha++s+rptfkqlve+l
Q: 667   RMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL  703
         **********************************986
Domain Sequence
(FASTA)
LVLGKPLGEG CFGQVVRAEA FGMDPARPDQ ASTVAVKMLK DNASDKDLAD LVSEMEVMKL 60
IGRHKNIINL LGVCTQEGPL YVIVECAAKG NLREFLRARR PPGPDLSPDG PQSSEGPLAF 120
PVLVSCAYQV ARGMQYLESR KCIHRDLAAR NVLVTEDNVM KIADFGLARG IHHIDYYKKT 180
SNGRLPVKWM APEALFDRVY THQSDVWSFG VLLWEIFTLG GSPYPGIPVE ELFSLLREGH 240
RMDRPPHCPP ELYGLMRECW HAAPSQRPTF KQLVEAL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Callithrix jacchus"; ?>Gorilla gorilla"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00141
EKS-CAJ-00153
EKS-GOG-00149
EKS-OTG-00155
EKS-PAT-00140
EKS-POA-00145
EKS-PTV-00140
EKS-SAH-00144
EKS-XET-00138
EKS-XIM-00178
Gene Ontology
GO:0005911; C:cell-cell junction
GO:0005783; C:endoplasmic reticulum
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0008201; F:heparin binding
GO:0004713; F:protein tyrosine kinase activity
GO:0061144; P:alveolar secondary septum development
GO:0016477; P:cell migration
GO:0008543; P:fibroblast growth factor receptor signaling pathway
GO:0042593; P:glucose homeostasis
GO:0001759; P:organ induction
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0055062; P:phosphate ion homeostasis
GO:0008284; P:positive regulation of cell proliferation
GO:2000573; P:positive regulation of DNA biosynthetic process
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048554; P:positive regulation of metalloenzyme activity
GO:0045862; P:positive regulation of proteolysis
GO:0046777; P:protein autophosphorylation
GO:0070857; P:regulation of bile acid biosynthetic process
GO:2000188; P:regulation of cholesterol homeostasis
GO:0010715; P:regulation of extracellular matrix disassembly
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013