EKS-MAM-00283
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00283
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR431.72.2E-129203489287
StatusUnreviewed
Ensembl ProteinENSMMUP00000039646
UniProt AccessionF7AU14;
Protein Name
Protein Synonyms/Alias
Gene NameACVRL1
Gene Synonyms/Alias ACVRL1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000004982ENSMMUP00000006601ENSMMUT00000007023
ENSMMUG00000004982ENSMMUP00000039646ENSMMUT00000046610
OrganismMacaca mulatta
Functional Description
Protein Length503
Protein Sequence
(FASTA)
MTLGSPRGGL LMLLMALVTQ GDPVKPSRGP LVTCTCESPH CRGPTCQGAW CTVVLVREEG 60
RHPQEHRGCG NLHRELCRGR PTEFVNHYCC DSHLCNRNVS LVLEATQTPS EQPGTDSQLA 120
LILGPVLALL ALVALGVVGL WHVRRRQEKQ RGLHSELGES SLILKASEQG DSMLGDLLDS 180
DCTTGSGSGL PFLVQRTVAR QVALVECVGK GRYGEVWRGL WHGESVAVKI FSSRDEQSWF 240
RETEIYNTVL LRHDNILGFI ASDMTSRNSS TQLWLITHYH EHGSLYDFLQ RQTLEPHLAL 300
RLAVSAACGL AHLHVEIFGT QGKPAIAHRD FKSRNVLVKS NLQCCIADLG LAVMHSQGSD 360
YLDIGNNPRV GTKRYMAPEV LDEQIRTDCF ESYKWTDIWA FGLVLWEIAR RTIVNGIVED 420
YRPPFYDVVP NDPSFEDMKK VVCVDQQTPT IPNRLAADPV LSGLAQMMRE CWYPNPSARL 480
TALRIKKTLQ KISNSPEKPK VIQ 503
Nucleotide Sequence
(FASTA)
ATGACCTTGG GCTCCCCGAG GGGAGGCCTT CTGATGCTGC TGATGGCCTT GGTGACCCAG 60
GGTGACCCCG TGAAGCCCTC TCGGGGCCCG CTGGTGACCT GCACATGTGA GAGCCCACAT 120
TGCAGGGGGC CTACCTGCCA GGGGGCCTGG TGCACAGTAG TGCTGGTGCG GGAGGAGGGG 180
AGGCACCCCC AGGAACATCG GGGCTGCGGG AACTTGCACA GGGAGCTCTG CAGGGGGCGC 240
CCCACCGAGT TCGTCAACCA CTACTGCTGT GACAGCCACC TCTGCAACCG CAACGTGTCC 300
CTGGTGCTGG AGGCCACCCA AACTCCTTCG GAGCAGCCGG GAACAGACAG CCAGCTGGCC 360
CTGATCCTGG GCCCCGTGCT GGCCTTGCTG GCCCTGGTGG CCCTGGGTGT CGTGGGCCTG 420
TGGCATGTCC GACGGAGGCA GGAGAAGCAG CGGGGCCTGC ACAGCGAGCT GGGAGAGTCC 480
AGTCTCATCC TGAAAGCATC TGAGCAGGGC GACAGCATGT TGGGGGACCT CCTGGACAGT 540
GACTGCACCA CAGGGAGTGG CTCGGGGCTC CCCTTCCTGG TGCAGAGGAC AGTGGCACGG 600
CAGGTTGCCT TGGTGGAGTG TGTGGGAAAA GGCCGCTATG GCGAAGTGTG GCGGGGCTTG 660
TGGCACGGTG AGAGTGTGGC CGTCAAGATC TTCTCCTCGA GGGACGAACA GTCCTGGTTC 720
CGGGAGACTG AGATCTACAA CACAGTGTTG CTCAGACACG ACAACATCCT AGGCTTCATC 780
GCCTCAGACA TGACCTCCCG CAACTCGAGC ACGCAGCTGT GGCTCATCAC GCATTACCAC 840
GAGCACGGCT CCCTCTACGA CTTTCTGCAG AGACAGACGC TGGAGCCGCA TTTGGCTCTG 900
AGGCTAGCTG TGTCCGCAGC CTGTGGCCTG GCACACCTGC ACGTGGAGAT CTTCGGTACA 960
CAGGGCAAAC CGGCCATTGC CCACCGTGAC TTCAAGAGCC GCAACGTGCT GGTCAAGAGC 1020
AACCTGCAGT GTTGCATTGC TGACCTGGGC CTGGCTGTGA TGCACTCACA GGGCAGCGAT 1080
TACCTGGACA TCGGCAACAA CCCGAGAGTA GGCACCAAGA GGTACATGGC ACCCGAGGTG 1140
CTGGATGAGC AGATCCGCAC GGACTGCTTT GAGTCCTATA AGTGGACTGA CATCTGGGCC 1200
TTTGGCCTGG TGCTGTGGGA GATCGCCCGC CGGACCATCG TGAATGGCAT CGTGGAGGAC 1260
TATAGACCAC CCTTCTATGA TGTGGTGCCC AATGACCCCA GCTTTGAGGA CATGAAGAAG 1320
GTGGTGTGTG TGGATCAGCA GACCCCCACC ATCCCTAACC GGCTGGCTGC AGACCCGGTC 1380
CTCTCAGGCC TAGCTCAGAT GATGCGGGAG TGCTGGTACC CAAACCCCTC TGCCCGACTC 1440
ACTGCGCTGC GGATCAAGAA GACACTACAG AAAATTAGCA ACAGTCCAGA GAAGCCCAAA 1500
GTGATTCAGT AG 1512
Domain Profile
S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61
          l+e++gkGrygeVw++ ++ge+vAvKifs++de+sw+rE+eiy+tvllrh+nil+fia+
Q: 203   ALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIAS  262
         689*********************************************************
S: 62    dkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkg  121
         d+++++s+t+l+l+t+yhe+gsL+d+L+r+tl+ + +lrla s+a+GlahLH ei+gt+g
Q: 263   DMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQG  322
         ************************************************************
S: 122   kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEv  181
           KpaiaHRD+ks+N+lvk++l+cciaDlGLa+++++ ++ ld+ +n +vGtkRYmaPEv
Q: 323   --KPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEV  380
         ..**********************************************************
S: 182   leealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemk  241
         l+e++ +++fe++k++D++++gLvlWE+a+R+   +++ve+y++pf++vv++dPs+e+mk
Q: 381   LDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIV-NGIVEDYRPPFYDVVPNDPSFEDMK  439
         ********************************99.*************************
S: 242   evvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291
         +vv+++++ P+ip+++ ++++l+ l+++++ecW+ +p+aRltalr+kk+l
Q: 440   KVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTL  489
         ************************************************97
Domain Sequence
(FASTA)
ALVECVGKGR YGEVWRGLWH GESVAVKIFS SRDEQSWFRE TEIYNTVLLR HDNILGFIAS 60
DMTSRNSSTQ LWLITHYHEH GSLYDFLQRQ TLEPHLALRL AVSAACGLAH LHVEIFGTQG 120
KPAIAHRDFK SRNVLVKSNL QCCIADLGLA VMHSQGSDYL DIGNNPRVGT KRYMAPEVLD 180
EQIRTDCFES YKWTDIWAFG LVLWEIARRT IVNGIVEDYR PPFYDVVPND PSFEDMKKVV 240
CVDQQTPTIP NRLAADPVLS GLAQMMRECW YPNPSARLTA LRIKKTL 287
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>
EKS-AIM-00263
EKS-BOT-00281
EKS-CAJ-00287
EKS-CAF-00287
EKS-CAP-00316
EKS-ECT-00031
EKS-EQC-00273
EKS-FEC-00267
EKS-GOG-00280
EKS-HOS-00287
EKS-ICT-00265
EKS-LOA-00291
EKS-MAE-00018
EKS-MUM-00312
EKS-MUP-00276
EKS-MYL-00284
EKS-NOL-00259
EKS-OCP-00028
EKS-OTG-00286
EKS-PAT-00265
EKS-PES-00250
EKS-POA-00271
EKS-PRC-00026
EKS-RAN-00296
EKS-SAH-00263
EKS-SOA-00026
EKS-SUS-00247
EKS-TUT-00043
EKS-VIP-00020
Gene Ontology
GO:0009986; C:cell surface
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0004702; F:receptor signaling protein serine/threonine kinase activity
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0001525; P:angiogenesis
GO:0060840; P:artery development
GO:0001974; P:blood vessel remodeling
GO:0030509; P:BMP signaling pathway
GO:0071773; P:cellular response to BMP stimulus
GO:0071560; P:cellular response to transforming growth factor beta stimulus
GO:0061154; P:endothelial tube morphogenesis
GO:0001701; P:in utero embryonic development
GO:0001946; P:lymphangiogenesis
GO:0060836; P:lymphatic endothelial cell differentiation
GO:0043537; P:negative regulation of blood vessel endothelial cell migration
GO:0030308; P:negative regulation of cell growth
GO:2000279; P:negative regulation of DNA biosynthetic process
GO:0045602; P:negative regulation of endothelial cell differentiation
GO:0001937; P:negative regulation of endothelial cell proliferation
GO:0051895; P:negative regulation of focal adhesion assembly
GO:0045603; P:positive regulation of endothelial cell differentiation
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0008217; P:regulation of blood pressure
GO:0061298; P:retina vasculature development in camera-type eye
GO:0023014; P:signal transduction by phosphorylation
GO:0007179; P:transforming growth factor beta receptor signaling pathway
GO:0060841; P:venous blood vessel development
GO:0035313; P:wound healing, spreading of epidermal cells
KEGG
InterPros
IPR000333; Activin_II/TGFBeta-II_recpt.
IPR000472; Activin_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR003605; TGF_beta_rcpt_GS.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
SMARTs
SM00467; GS; 1.
Prosites
PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00653; ACTIVIN2R.
Created Date20-Feb-2013