EKS-MAM-00212

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00212

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	457.9	1.8E-137	13	299	287

Status

Unreviewed

Ensembl Protein

ENSMMUP00000006707

UniProt Accession

F7C500;

Protein Name

Protein Synonyms/Alias

Gene Name

LOC693974

Gene Synonyms/Alias

LOC693974;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000005063	ENSMMUP00000006707	ENSMMUT00000007138

Organism

Macaca mulatta

Functional Description

Protein Length

935

Protein Sequence
(FASTA)

MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKARETHEI VAIKKFKDSE ENEEVKETTL 60

RELKMLRTLK QENIVELKEA FRRRGKLYLV FEYVEKNMLE LLEEMPNGVP PEKVKSYIYQ 120

LIKAIHWCHK NDIVHRDIKP ENLLISHNDV LKLCDFGFAR NLSEGNNANY TEYVATRWYR 180

SPELLLGAPY GKSVDMWSVG CILGELSDGQ PLFPGESEID QLFTIQKVLG PLPSEQMKLF 240

YSNPRFHGLR FPAVNHPQSL ERRYLGILNS VLLDLMKNLL KLDPADRYLT EQCLNHPTFQ 300

TQRLLDRSPS RSAKRKPYHV ESSTLSNRNQ AGKSTALQSH HRSNSKDIQN LSVGLPRADE 360

GLPANESFLN GNLAGASLSP LHTKTYQASS QPGSTSKDLT NNNIPHLLSP KEAKSKTEFD 420

FNIDPKPSEG PGTKYLKSNS RSQQNRHSFM ESSQSKAGTL QPNEKQSRHS YIDTIPQSSR 480

SPSYRTKAKS HGALSDSKSV SNLSEARAQI AEPSTSRYFP SSCLDLNSPT SPTPTRHSDT 540

RTLLSPSGRN NRNEGTLDSR RTTTRHSKTM EELKLPEHMD SSHSHSLSAP HESFSYGLGY 600

TSPFSSQQRP HRHSMYVTRD KVRAKGLDGS LSIGQGMAAR ANSLQLLSPQ PGEQLPPEMT 660

VARSSVKETT REGSSSFHTR QKSEGGVYHD PHSDDGTAPK ENRHLYNDPV PRRVGSFYRV 720

PSPRPDNSFH ENNVSTRVSS LPSESSSGTN HSKRQPAFDP WKSPENISHS EQLKEKEKQG 780

FFRSMKKKKK KSQTVPNSDS PDLLTLQKSI HSASTPSSRP KEWRPEKISD LQTQSQPLKS 840

LRKLLHLSSA SNHPASSDPR FQPLTAQQTK NSFSEIRIHP LSQASGGSSN IRQEPAPKGR 900

PALQLPECGC DGRTERHHSG PQDRRFMLRT TKQQG 935

Nucleotide Sequence
(FASTA)

ATGAAGATTC CTAACATTGG TAATGTGATG AATAAATTTG AGATCCTTGG GGTTGTAGGT 60

GAAGGAGCCT ATGGAGTTGT ACTTAAATGC AGACACAAGG CAAGGGAAAC ACATGAAATT 120

GTGGCAATCA AGAAATTCAA GGACAGTGAA GAAAATGAAG AAGTCAAAGA AACGACTTTA 180

CGAGAGCTTA AAATGCTTCG GACTCTCAAG CAGGAAAACA TTGTGGAGCT GAAGGAAGCA 240

TTTCGTCGGA GGGGGAAGTT GTACTTGGTG TTTGAGTATG TTGAAAAAAA TATGCTGGAA 300

TTGCTGGAAG AAATGCCAAA TGGAGTTCCA CCTGAGAAAG TAAAAAGCTA CATCTATCAG 360

CTAATCAAGG CTATTCATTG GTGCCATAAG AATGATATTG TCCATCGAGA TATAAAACCA 420

GAAAATCTCT TAATCAGCCA CAATGATGTC CTAAAACTGT GTGACTTTGG TTTTGCTCGT 480

AATCTGTCAG AAGGCAATAA TGCTAATTAC ACAGAGTACG TTGCCACCAG ATGGTATCGG 540

TCCCCAGAGC TCTTACTTGG CGCTCCCTAT GGAAAGTCCG TAGACATGTG GTCGGTGGGC 600

TGTATTCTTG GAGAGCTTAG TGATGGACAA CCTTTATTTC CTGGAGAAAG TGAAATTGAC 660

CAACTTTTTA CTATTCAGAA GGTGCTAGGA CCACTTCCAT CTGAGCAGAT GAAGCTTTTC 720

TACAGTAATC CTCGCTTCCA TGGGCTCCGG TTTCCAGCTG TTAACCATCC TCAGTCCTTG 780

GAAAGAAGAT ATCTTGGAAT TTTGAATAGT GTTCTACTTG ACCTAATGAA GAATTTATTG 840

AAGTTGGACC CAGCTGACAG ATACTTGACA GAACAGTGTT TGAATCACCC AACATTTCAA 900

ACCCAGAGAC TTCTGGATCG TTCTCCTTCA AGGTCAGCAA AAAGAAAACC TTACCATGTG 960

GAAAGCAGCA CATTGTCTAA TAGAAACCAA GCCGGCAAAA GTACTGCTTT GCAGTCTCAC 1020

CACAGATCTA ACAGCAAAGA CATCCAGAAC CTGAGTGTAG GCCTGCCCCG GGCTGACGAA 1080

GGTCTCCCTG CCAATGAAAG CTTCCTAAAT GGAAACCTTG CTGGAGCTAG TCTTAGTCCA 1140

TTGCACACCA AAACCTACCA AGCAAGCAGC CAGCCTGGGT CTACCAGCAA AGATCTCACC 1200

AACAACAACA TACCACACCT TCTTAGCCCA AAAGAAGCCA AGTCAAAAAC AGAGTTTGAT 1260

TTTAATATTG ACCCAAAGCC TTCAGAAGGC CCAGGGACAA AGTACCTCAA GTCGAACAGC 1320

AGATCTCAGC AGAACCGCCA CTCATTCATG GAAAGCTCTC AAAGCAAAGC TGGGACACTG 1380

CAGCCCAATG AAAAGCAGAG TCGGCATAGC TATATTGACA CCATTCCCCA GTCCTCTAGG 1440

AGTCCCTCCT ACAGGACCAA GGCCAAAAGC CATGGGGCAC TGAGTGACTC CAAGTCTGTG 1500

AGCAACCTTT CTGAAGCCAG GGCCCAAATT GCGGAGCCCA GTACCAGTAG GTACTTCCCA 1560

TCTAGCTGCC TAGACTTGAA TTCTCCCACC AGCCCAACCC CCACCAGACA CAGTGACACG 1620

AGAACTTTGC TCAGCCCTTC TGGGAGAAAT AACCGAAATG AAGGAACGCT GGACTCACGT 1680

CGAACCACAA CCAGACATTC TAAGACAATG GAGGAATTGA AGCTGCCTGA GCACATGGAC 1740

AGTAGCCATT CCCATTCGCT GTCTGCGCCT CACGAATCTT TTTCTTATGG ACTGGGCTAC 1800

ACCAGCCCCT TTTCTTCCCA GCAACGTCCT CATAGGCATT CTATGTATGT GACCCGTGAC 1860

AAAGTGAGAG CCAAAGGCTT GGATGGAAGC TTGAGCATAG GGCAAGGGAT GGCAGCTAGA 1920

GCCAACAGCC TGCAACTCTT GTCACCCCAG CCTGGAGAAC AGCTCCCTCC AGAGATGACT 1980

GTGGCAAGAT CGTCGGTCAA AGAGACCACC AGAGAAGGCA GCTCTTCCTT CCATACACGC 2040

CAGAAGTCTG AGGGTGGAGT GTATCATGAC CCACACTCTG ATGATGGCAC AGCCCCCAAA 2100

GAAAATAGAC ATCTGTACAA TGATCCTGTG CCAAGGAGAG TTGGTAGCTT TTACAGAGTG 2160

CCATCTCCAC GTCCAGACAA TTCCTTCCAT GAAAATAATG TGTCAACTAG AGTTTCTTCT 2220

CTACCATCAG AGAGCAGTTC TGGAACCAAC CACTCAAAAA GACAACCAGC ATTCGATCCA 2280

TGGAAAAGTC CTGAAAATAT TAGTCATTCA GAGCAACTCA AGGAAAAAGA GAAGCAAGGA 2340

TTTTTCAGGT CAATGAAAAA GAAAAAGAAG AAATCTCAAA CAGTACCCAA TTCCGACAGC 2400

CCTGATCTTC TAACGTTGCA GAAATCCATT CATTCTGCTA GCACTCCAAG CAGCAGACCA 2460

AAGGAGTGGC GCCCCGAGAA GATCTCAGAT CTACAGACCC AAAGCCAGCC ATTAAAATCA 2520

CTGCGCAAGT TGTTACATCT CTCTTCGGCC TCGAATCACC CGGCTTCTTC AGACCCCCGC 2580

TTCCAGCCCT TAACAGCTCA ACAAACCAAA AATTCCTTCT CAGAAATTCG GATTCACCCC 2640

CTGAGCCAGG CCTCTGGCGG GAGCAGCAAC ATCCGGCAGG AGCCCGCACC GAAGGGCAGG 2700

CCAGCCCTCC AGCTGCCAGA ATGTGGATGT GATGGTAGAA CAGAGAGACA CCATTCTGGA 2760

CCCCAAGATA GACGCTTCAT GTTAAGGACG ACAAAACAAC AAGGT 2805

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnk..dtgqivaikkfleseddkevkkialreikllkqlkhe  58

         +e lg+vGeG+yGvvlkcr+k  +t++ivaikkf++se+++evk+++lre+k+l++lk+e

Q: 13    FEILGVVGEGAYGVVLKCRHKarETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQE  72

         799****************96448************************************

S: 59    nlvnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknn  118

         n+v+l+e+frr+ klylvfeyv+k++l+ le++pnGv+ e+vk+++yq++kai++chkn+

Q: 73    NIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKND  132

         ************************************************************

S: 119   iihrdikpenilisksgvvklcdfGfarlla.apgdvytdyvatrwyrapellvgdtkyG  177

         i+hrdikpen+lis+++v+klcdfGfar+l+ +++++yt+yvatrwyr+pell+g + yG

Q: 133   IVHRDIKPENLLISHNDVLKLCDFGFARNLSeGNNANYTEYVATRWYRSPELLLG-APYG  191

         ******************************98999********************.9***

S: 178   ksvdvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvkl  237

         ksvd+w++Gc+l el++G+plfpg+s++dql++i+k+lG+l ++++k+f++n++f+G+++

Q: 192   KSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRF  251

         ************************************************************

S: 238   pevedleslekkyp.klnevlldllkkclkldpaerlsceellkheyf  284

         p+v++++sle++y   ln+vlldl+k++lkldpa+r+++e++l+h++f

Q: 252   PAVNHPQSLERRYLgILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF  299

         *************9899****************************998

Domain Sequence
(FASTA)

FEILGVVGEG AYGVVLKCRH KARETHEIVA IKKFKDSEEN EEVKETTLRE LKMLRTLKQE 60

NIVELKEAFR RRGKLYLVFE YVEKNMLELL EEMPNGVPPE KVKSYIYQLI KAIHWCHKND 120

IVHRDIKPEN LLISHNDVLK LCDFGFARNL SEGNNANYTE YVATRWYRSP ELLLGAPYGK 180

SVDMWSVGCI LGELSDGQPL FPGESEIDQL FTIQKVLGPL PSEQMKLFYS NPRFHGLRFP 240

AVNHPQSLER RYLGILNSVL LDLMKNLLKL DPADRYLTEQ CLNHPTF 287

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013