EKS-MAM-00339

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00339

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	271.7	1.1E-80	27	276	250

Status

Unreviewed

Ensembl Protein

ENSMMUP00000006761

UniProt Accession

F7BYM2;

Protein Name

Protein Synonyms/Alias

Gene Name

TAOK3

Gene Synonyms/Alias

TAOK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000005099	ENSMMUP00000006761	ENSMMUT00000007195
ENSMMUG00000005099	ENSMMUP00000038558	ENSMMUT00000045525

Organism

Macaca mulatta

Functional Description

Protein Length

898

Protein Sequence
(FASTA)

MRKGVLKDPE IADLFYKDDP EELFIGLHEI GHGSFGAVYF ATNAHTNEVV AIKKMSYSGK 60

QTHEKWQDIL KEVKFLRQLK HPNTIEYKGC YLKEHTAWLV MEYCLGSASD LLEVHKKPLQ 120

EVEIAAITHG ALHGLAYLHS HALIHRDIKA GNILLTEPGQ VKLADFGSAS MASPANSFVG 180

TPYWMAPEVI LAMDEGQYDG KVDIWSLGIT CIELGEKSYC FHCIFKNSIL QINFHLSPDH 240

ASSLQTDSFR RFVDYCLQKI PQERPTSAEL LRHDFVRRDR PIRVLIDLIQ RTKDAVRELD 300

NLQYRKMKKI LFQETRNGPL NESQEDEEDS EHGTSLNREM DSLDSNHSIP SMSVSTGSQS 360

SSVNSMQEVM DESSSELVMM HDDESTINSS SSVVHKKDHV FIRDEAGHGD PRPEPRPTQS 420

VQSQALHYRN RERFATIKSA SLVTRQIHEH EQENELREQM SGYKRMRRQH QKQLIALENK 480

LKAEMDEHRL KLQKEVETHA NNSSIELEKL AKKQVAIIEK EQEAGVGDGG KLLVQIATEN 540

VLSLSLNTQL TGKFLKKWGK DIQHQEMNED HSTPKKEKQE RISKHKENLQ HTQAEEEAHL 600

LTQQRLYYDK NCRFFKRKIM IKRHEVEQQN IREELNKKRT QKEMEHAMLI RHDESTRELE 660

YRQLHTLQKL RMDLIRLQHQ TELENQLEYN KRRERELHRK HVMELRQQPK NLKAMEMQIK 720

KQFQDTCKVQ TKQYKALKNH QLEVTPKNEH KTILKTLKDE QTRKLAILAE QYEQSINEMM 780

ASQALRLDEA QEAECQALRL QLQQEMELLN AYQSKIKMQT EAQHERELQK LEQRVSLRRA 840

HLEQKIEEEL AALQKERSER IKNLLERQER EIETFDMESL RMGFGNLVTL DFPKEDYR 898

Nucleotide Sequence
(FASTA)

ATGCGTAAAG GGGTGTTGAA GGACCCAGAG ATTGCCGATC TATTCTACAA AGATGATCCT 60

GAGGAACTTT TTATTGGTTT GCATGAAATT GGACATGGAA GTTTTGGAGC AGTTTATTTT 120

GCTACAAATG CTCATACCAA TGAAGTGGTG GCAATTAAGA AGATGTCCTA TAGTGGGAAG 180

CAGACCCATG AGAAATGGCA AGATATTCTT AAGGAAGTTA AATTTTTACG ACAATTGAAG 240

CATCCTAATA CTATTGAGTA CAAAGGCTGT TACTTGAAAG AGCACACTGC TTGGTTGGTG 300

ATGGAATATT GCTTAGGCTC AGCCTCTGAT TTATTAGAAG TTCATAAAAA ACCACTTCAG 360

GAAGTGGAGA TCGCTGCCAT TACTCATGGA GCCTTGCATG GACTAGCCTA CCTACATTCT 420

CATGCATTGA TTCATAGGGA TATTAAAGCA GGAAATATTC TTCTAACAGA GCCAGGTCAG 480

GTAAAACTAG CTGATTTTGG ATCTGCCTCA ATGGCTTCTC CTGCCAACTC CTTCGTGGGC 540

ACACCTTACT GGATGGCTCC AGAGGTGATC TTAGCTATGG ATGAAGGACA GTATGATGGG 600

AAAGTTGATA TTTGGTCACT TGGCATCACT TGTATTGAAT TGGGTGAGAA GAGTTATTGT 660

TTTCATTGTA TTTTTAAAAA TTCTATTTTG CAGATTAATT TTCATTTGAG CCCAGATCAT 720

GCCTCTTCAC TCCAGACAGA CTCCTTTAGG AGATTTGTTG ATTACTGCTT GCAGAAAATA 780

CCTCAGGAAA GGCCAACATC AGCGGAACTA TTAAGGCATG ACTTTGTTCG ACGAGACCGG 840

CCAATACGTG TCCTCATTGA CCTCATACAG AGGACAAAAG ATGCTGTTCG TGAGCTAGAT 900

AACCTACAGT ACCGAAAAAT GAAAAAAATA CTTTTCCAAG AGACACGAAA TGGACCCTTG 960

AATGAGTCAC AGGAGGATGA GGAAGACAGT GAACATGGAA CCAGCCTGAA CAGGGAAATG 1020

GACAGCCTGG ACAGCAACCA TTCCATTCCA AGCATGTCCG TGAGCACAGG CAGCCAGAGC 1080

AGCAGTGTGA ATAGCATGCA GGAGGTCATG GATGAGAGCA GTTCTGAACT TGTCATGATG 1140

CACGACGATG AAAGCACAAT CAATTCCAGC TCCTCTGTCG TGCACAAGAA GGATCATGTA 1200

TTCATAAGGG ATGAGGCGGG CCACGGCGAT CCCAGGCCTG AGCCGCGGCC TACCCAGTCA 1260

GTTCAGAGCC AGGCCCTCCA CTACCGGAAC AGAGAGCGCT TTGCCACGAT CAAATCAGCA 1320

TCTTTGGTTA CACGACAGAT CCATGAGCAT GAGCAGGAGA ACGAGTTGCG GGAACAGATG 1380

TCAGGTTATA AGCGGATGCG GCGCCAGCAC CAGAAGCAGC TGATCGCCCT GGAGAACAAG 1440

CTGAAGGCTG AGATGGACGA GCACCGCCTC AAGCTGCAGA AGGAGGTGGA GACGCATGCC 1500

AACAACTCGT CCATCGAGCT GGAGAAGCTG GCCAAGAAGC AAGTGGCTAT CATAGAAAAG 1560

GAGCAGGAGG CAGGAGTTGG GGATGGAGGA AAATTGTTAG TTCAAATAGC AACTGAAAAT 1620

GTATTGTCCC TCTCACTTAA TACTCAATTA ACAGGCAAAT TTTTAAAAAA ATGGGGGAAG 1680

GATATACAAC ACCAAGAAAT GAATGAGGAC CACAGCACAC CCAAGAAAGA GAAGCAAGAG 1740

CGGATCTCCA AACATAAAGA GAACTTGCAG CACACGCAGG CTGAAGAGGA AGCCCACCTT 1800

CTCACTCAAC AGAGACTGTA CTACGACAAA AATTGTCGTT TCTTCAAGCG GAAAATAATG 1860

ATCAAGCGGC ACGAGGTGGA GCAGCAGAAC ATTCGGGAGG AACTAAATAA AAAGAGGACC 1920

CAGAAGGAGA TGGAGCATGC CATGCTAATC CGGCACGACG AGTCCACCCG AGAGCTAGAG 1980

TACAGGCAGC TGCACACGTT ACAGAAGCTA CGCATGGATC TGATCCGTTT ACAGCACCAG 2040

ACTGAACTAG AAAACCAGCT GGAGTACAAT AAGAGGCGAG AAAGGGAACT GCACAGAAAG 2100

CATGTCATGG AACTTCGGCA ACAGCCAAAA AACTTAAAGG CCATGGAAAT GCAAATTAAA 2160

AAACAGTTTC AGGACACTTG CAAAGTACAG ACCAAACAGT ATAAAGCACT CAAGAATCAC 2220

CAGTTGGAAG TTACTCCAAA GAATGAGCAC AAAACAATCT TAAAGACACT GAAAGATGAG 2280

CAGACAAGAA AACTTGCCAT TTTGGCAGAG CAGTATGAAC AGAGTATAAA TGAAATGATG 2340

GCCTCTCAAG CGTTACGGCT AGATGAGGCT CAAGAAGCAG AATGCCAGGC CTTGAGGCTA 2400

CAGCTCCAGC AGGAAATGGA GCTGCTCAAC GCCTACCAGA GCAAAATCAA GATGCAAACA 2460

GAGGCACAAC ATGAACGTGA GCTCCAGAAG CTAGAGCAGA GGGTGTCTCT GCGCAGAGCA 2520

CATCTTGAGC AGAAGATTGA AGAGGAGCTG GCTGCCCTTC AGAAGGAACG CAGCGAGAGA 2580

ATAAAGAACC TATTGGAAAG GCAAGAGCGA GAGATTGAAA CTTTTGACAT GGAGAGCCTC 2640

AGAATGGGAT TTGGGAATTT GGTTACATTA GATTTTCCTA AGGAGGACTA TAGATGA 2697

Domain Profile

S: 4     leeigkGalgkvylarekktgelvaikkinlekq...ekleelqkeisvlkklkhpnive  60

         l+eig+G++g+vy a++ +t+e+vaikk++++ +   ek++++ ke+++l++lkhpn +e

Q: 27    LHEIGHGSFGAVYFATNAHTNEVVAIKKMSYSGKqthEKWQDILKEVKFLRQLKHPNTIE  86

         689****************************988899***********************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y +++lke++ wlvmey+  Gs+sdl++ ++k++l+E +ia+i++++l++L+ylHs+  i

Q: 87    YKGCYLKEHTAWLVMEYCL-GSASDLLE-VHKKPLQEVEIAAITHGALHGLAYLHSHALI  144

         ******************7.********.*******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179

         Hrdika+niLlte g+VkL+dfg+a+  +      +++vgtpywmAPEvi ++ e +Yd

Q: 145   HRDIKAGNILLTEPGQVKLADFGSASMASP----ANSFVGTPYWMAPEVILAMdEGQYDG  200

         ***********************9998888....69**************9887999***

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclq  239

         k+DiwslGIt+iel e +  f+ + + + +l+i  + +p+  s+   +++f++fv+ clq

Q: 201   KVDIWSLGITCIELGEKSYCFHCIFKNS-ILQINFHLSPDHASS-LQTDSFRRFVDYCLQ  258

         **************99998887665544.456666667777555.7789***********

S: 240   knpekRpsasellkhkFl  257

         k p++Rp+++ell+h F+

Q: 259   KIPQERPTSAELLRHDFV  276

         ****************97

Domain Sequence
(FASTA)

LHEIGHGSFG AVYFATNAHT NEVVAIKKMS YSGKQTHEKW QDILKEVKFL RQLKHPNTIE 60

YKGCYLKEHT AWLVMEYCLG SASDLLEVHK KPLQEVEIAA ITHGALHGLA YLHSHALIHR 120

DIKAGNILLT EPGQVKLADF GSASMASPAN SFVGTPYWMA PEVILAMDEG QYDGKVDIWS 180

LGITCIELGE KSYCFHCIFK NSILQINFHL SPDHASSLQT DSFRRFVDYC LQKIPQERPT 240

SAELLRHDFV 250

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0031572	; P:G2/M transition DNA damage checkpoint
GO:0000165	; P:MAPK cascade
GO:0046329	; P:negative regulation of JNK cascade
GO:0046330	; P:positive regulation of JNK cascade
GO:0043507	; P:positive regulation of JUN kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013