EKS-MAM-00206

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00206

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/RCK	459.9	5.5E-138	4	286	283

Status

Unreviewed

Ensembl Protein

ENSMMUP00000007069

UniProt Accession

F7GEP8;

Protein Name

Protein Synonyms/Alias

Gene Name

ICK

Gene Synonyms/Alias

ICK; EGK_15018;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000005344	ENSMMUP00000007070	ENSMMUT00000007524
ENSMMUG00000005344	ENSMMUP00000007069	ENSMMUT00000007523

Organism

Macaca mulatta

Functional Description

Protein Length

636

Protein Sequence
(FASTA)

MNRYTTIRQL GDGTYGSVLL GRSIESGELI AIKKMKRKFY SWEECMNLRE VKSLKKLNHA 60

NVTSLTNMEK PQEIFLFLYA MLEENLFFWL TIKCLNKLFP ESAIRNIMYQ ILQGLAFIHK 120

HGFFHRDLKP ENLLCMGPEL VKIADFGLAR EIRSKPPYTD YVSTRWYRAP EVLLRSTNYS 180

SPIDVWAVGC IMAEVYTLRP LFPGASEIDT IFKICQVLGT PKKTDWPEGY QLSSAMNFRW 240

PQCVPNNLKT LIPNASSEAI QLLRDMLQWD PKKRPTASQA LRYPYFQVGH PLGSTTQNLQ 300

DSEKPQKGIL EKAGPPPHIK PVPPAQPPTK PHTRISSRQH QASQPPLHLT YPYKAEVSRT 360

DHPSHLQEDK PSPLLFPSLH NKNPQSKITA GLEHKNGEIK PKSRRRWGLI SRSTKDSDDW 420

ADLDDLDFSP SLSRIDLKNK KRQSDDTLCR QVFESVLDLK PSEPVGTGNS APTQMSYQRR 480

DTPTLRSAAK QHYLKHSRYL PGINIRNGIL SNPGKDFIPP NPWSSSGLSG KSSGTVSVIS 540

KVNSVGSSST SSSGLTGNYV PSFLKKEIGS AMQRVHLAPI PDPSPGYSSL KALRPHPGRP 600

FFHTQPRSTP GLIPRPPAAQ PVHGRTDWAS KYASRR 636

Nucleotide Sequence
(FASTA)

ATGAATAGAT ACACAACAAT CAGGCAGCTC GGGGATGGAA CCTATGGTTC TGTGCTGCTG 60

GGAAGAAGCA TTGAGTCTGG GGAGCTGATT GCTATTAAAA AAATGAAAAG AAAGTTTTAT 120

TCCTGGGAGG AATGCATGAA CCTTCGAGAG GTTAAGTCTT TAAAGAAGCT CAACCATGCC 180

AATGTAACCA GCCTGACCAA CATGGAGAAA CCCCAGGAGA TTTTTTTATT TTTATATGCT 240

ATGTTGGAGG AAAACCTTTT TTTTTGGCTT ACTATCAAAT GTTTAAATAA GTTGTTTCCT 300

GAGTCTGCCA TAAGGAATAT CATGTATCAG ATATTACAAG GACTTGCATT TATTCACAAA 360

CACGGCTTCT TTCATCGAGA CTTAAAGCCT GAGAACCTCC TCTGCATGGG ACCAGAACTT 420

GTGAAAATCG CAGACTTTGG TTTGGCCCGA GAAATCCGAT CAAAACCTCC ATATACAGAT 480

TATGTATCTA CCAGATGGTA CAGGGCTCCA GAAGTACTCC TGAGGTCTAC CAACTACAGC 540

TCCCCCATTG ACGTCTGGGC CGTGGGCTGC ATCATGGCAG AAGTTTACAC CCTCAGGCCG 600

CTCTTTCCTG GAGCCAGTGA AATTGACACG ATATTCAAAA TTTGCCAAGT GCTGGGGACA 660

CCAAAAAAGA CTGACTGGCC TGAAGGCTAT CAACTTTCAA GTGCAATGAA CTTCCGTTGG 720

CCACAGTGTG TACCCAATAA CTTAAAGACC TTGATTCCCA ATGCTAGCAG TGAAGCAATC 780

CAGCTCCTGA GAGACATGCT TCAGTGGGAT CCCAAGAAAC GACCAACGGC TAGTCAGGCA 840

CTTCGATATC CTTACTTCCA AGTTGGACAC CCACTAGGCA GCACCACACA GAACCTTCAG 900

GATTCAGAAA AACCACAGAA AGGCATCCTG GAAAAGGCAG GCCCACCTCC TCATATTAAG 960

CCAGTCCCTC CTGCCCAGCC GCCAACCAAG CCACACACAC GAATTTCTTC ACGACAACAT 1020

CAAGCCAGCC AGCCCCCTCT GCATCTCACG TACCCCTACA AAGCAGAGGT CTCCAGGACA 1080

GATCACCCAA GCCATCTCCA GGAGGACAAG CCAAGCCCGT TGCTTTTCCC ATCCCTTCAC 1140

AACAAGAATC CCCAGTCGAA AATCACAGCT GGCCTGGAGC ACAAAAATGG TGAGATAAAG 1200

CCAAAGAGTA GGAGAAGGTG GGGTCTTATT TCCAGGTCAA CAAAGGATTC AGATGATTGG 1260

GCTGACTTGG ATGACTTGGA TTTCAGTCCA TCCCTCAGCA GGATTGACCT GAAAAACAAG 1320

AAAAGACAGA GTGATGACAC TCTCTGCAGG CAAGTGTTTG AGAGTGTTTT GGACCTGAAG 1380

CCCTCTGAGC CTGTGGGCAC AGGAAACAGC GCCCCCACCC AGATGTCATA TCAGCGGCGA 1440

GACACGCCCA CCCTGAGATC TGCAGCGAAG CAACACTATT TGAAGCACTC TCGATACTTG 1500

CCTGGCATCA ATATAAGAAA TGGCATACTC TCGAATCCAG GCAAGGACTT TATTCCACCT 1560

AATCCATGGT CTAGTTCTGG CTTGTCTGGA AAATCTTCAG GGACAGTGTC AGTAATCAGC 1620

AAAGTAAATT CAGTTGGTTC CAGCTCTACA AGTTCTAGTG GACTGACTGG AAACTATGTC 1680

CCTTCCTTTC TGAAAAAAGA AATAGGTTCT GCTATGCAGA GGGTACACCT GGCACCTATT 1740

CCAGACCCTT CCCCTGGTTA TTCCTCCCTG AAGGCCCTGA GACCTCATCC TGGGCGACCA 1800

TTCTTCCACA CCCAGCCTAG AAGCACTCCT GGGTTGATAC CACGGCCTCC AGCCGCCCAG 1860

CCAGTGCACG GCCGGACAGA CTGGGCTTCC AAGTACGCGT CTCGGCGATG A 1911

Domain Profile

S: 1     yklikklGdGtfgevllakslktgelvaikkmkrkfesleevtnlrevkslkklnahdni  60

         y++i++lGdGt+g+vll++s+++gel+aikkmkrkf+s+ee++nlrevkslkkln h+n+

Q: 4     YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLN-HANV  62

         99*****************************************************.****

S: 61    iklkeviidrendslylvlelmeenlyq..likdrrkllsesklksilyqilkglafihk  118

           l+++   + ++ + +++ ++eenl+    ik  +kl++es++++i+yqil+glafihk

Q: 63    TSLTNME--KPQEIFLFLYAMLEENLFFwlTIKCLNKLFPESAIRNIMYQILQGLAFIHK  120

         ***9976..8889999999******9862257889*************************

S: 119   hgffhrdlkPenilikgselvkladfGlarevrsknPytdyvstrwyraPevllrsgvys  178

         hgffhrdlkPen+l++g+elvk+adfGlare+rsk+PytdyvstrwyraPevllrs++ys

Q: 121   HGFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYS  180

         ************************************************************

S: 179   spldlwavGcvlaevavlrplfPGaseidqifkilevlGtPkkkewdeayklasalnlkf  238

         sp+d+wavGc++aev++lrplfPGaseid+ifki++vlGtPkk++w+e+y+l+sa+n+++

Q: 181   SPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRW  240

         ************************************************************

S: 239   pqvegsslktlvsnaskealellkdllaydPderataqqalkypyf  284

         pq+++++lktl++nas+ea++ll+d+l++dP++r+ta+qal+ypyf

Q: 241   PQCVPNNLKTLIPNASSEAIQLLRDMLQWDPKKRPTASQALRYPYF  286

         *********************************************9

Domain Sequence
(FASTA)

YTTIRQLGDG TYGSVLLGRS IESGELIAIK KMKRKFYSWE ECMNLREVKS LKKLNHANVT 60

SLTNMEKPQE IFLFLYAMLE ENLFFWLTIK CLNKLFPESA IRNIMYQILQ GLAFIHKHGF 120

FHRDLKPENL LCMGPELVKI ADFGLAREIR SKPPYTDYVS TRWYRAPEVL LRSTNYSSPI 180

DVWAVGCIMA EVYTLRPLFP GASEIDTIFK ICQVLGTPKK TDWPEGYQLS SAMNFRWPQC 240

VPNNLKTLIP NASSEAIQLL RDMLQWDPKK RPTASQALRY PYF 283

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0043231	; C:intracellular membrane-bounded organelle
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013