EKS-MAM-00152

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00152

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	364.1	8.6E-109	69	330	262

Status

Unreviewed

Ensembl Protein

ENSMMUP00000037650

UniProt Accession

F7G271;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB2

Gene Synonyms/Alias

RPS6KB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000005483	ENSMMUP00000037649	ENSMMUT00000044625
ENSMMUG00000005483	ENSMMUP00000007248	ENSMMUT00000007717
ENSMMUG00000005483	ENSMMUP00000007246	ENSMMUT00000007715
ENSMMUG00000005483	ENSMMUP00000037651	ENSMMUT00000044627
ENSMMUG00000005483	ENSMMUP00000037650	ENSMMUT00000044626
ENSMMUG00000005483	ENSMMUP00000037653	ENSMMUT00000044629

Organism

Macaca mulatta

Functional Description

Protein Length

394

Protein Sequence
(FASTA)

MAAVFDLDLE TEEGSEGEGE GEPELSSADV CPFAELRAAG LEPVGHYEEV ELTETSVNLC 60

PERIGPHCFE LLRVLGKGGY GKVFQVRKVQ GTNLGKIYAM KVLRKAKIVR NAKDTAHTRA 120

ERNILESVKH PFIVELAYAF QTGGKLYLIL ECLSGGELFT HLEREGIFLE DTACFYLAEI 180

TLALGHLHSQ GIIYRDLKPE NIMLSSQGHI KLTDFGLCKE SIHEGAVTHT FCGTIEYMAP 240

EILVRSGHNR AVDWWSLGAL MYDMLTGSPP FTAENRKKTM DKIIKGKLAL PPYLTPDARD 300

LVKKFLKRNP SQRIGGGPGD AADVQRHPFF RHVNWDDLLA RRVDPPFRPC LQSEEDVSQF 360

DTRFTRQTPV DSPDDTALSE SANQAFLPPQ VLPL 394

Nucleotide Sequence
(FASTA)

ATGGCGGCCG TGTTTGATTT GGATTTGGAG ACGGAGGAAG GCAGCGAGGG CGAGGGCGAG 60

GGCGAGCCAG AGCTCAGCTC CGCGGACGTG TGTCCCTTTG CCGAGTTGAG GGCAGCTGGC 120

CTGGAGCCTG TGGGACACTA TGAAGAGGTG GAGCTGACTG AGACCAGCGT GAACCTCTGC 180

CCAGAGCGCA TCGGGCCCCA CTGCTTTGAG CTGCTGCGTG TGCTGGGCAA GGGGGGCTAT 240

GGCAAGGTGT TCCAGGTGCG AAAGGTGCAA GGCACCAACT TGGGCAAAAT ATATGCCATG 300

AAAGTCCTAA GGAAGGCCAA AATTGTGCGC AACGCCAAGG ACACAGCACA CACACGGGCT 360

GAGCGGAACA TTCTGGAGTC TGTGAAGCAC CCCTTTATTG TGGAACTGGC CTATGCCTTC 420

CAGACTGGTG GCAAACTCTA CCTCATCCTT GAGTGCCTCA GTGGTGGCGA GCTCTTCACG 480

CATCTGGAGC GAGAGGGCAT CTTCCTGGAA GATACAGCCT GCTTCTACCT GGCCGAGATC 540

ACGCTGGCCT TGGGCCATCT CCACTCCCAG GGCATCATCT ACCGGGACCT CAAGCCCGAG 600

AACATCATGC TCAGCAGCCA GGGCCACATC AAACTGACTG ACTTTGGACT CTGCAAGGAG 660

TCGATCCATG AGGGCGCTGT CACTCACACC TTCTGCGGCA CCATTGAGTA CATGGCTCCT 720

GAGATTCTGG TGCGCAGTGG CCACAACCGG GCTGTGGACT GGTGGAGCCT GGGGGCCCTG 780

ATGTACGACA TGCTCACTGG ATCGCCCCCC TTCACTGCAG AGAACCGGAA GAAAACCATG 840

GATAAGATCA TCAAGGGCAA GCTGGCGCTG CCCCCCTACC TCACCCCAGA TGCCCGGGAC 900

CTTGTCAAAA AGTTTCTGAA ACGGAATCCC AGCCAGAGGA TTGGGGGTGG TCCAGGGGAT 960

GCTGCTGATG TGCAGAGGCA TCCCTTTTTC CGGCACGTGA ATTGGGACGA CCTTCTGGCC 1020

CGGCGTGTGG ACCCCCCTTT CAGGCCCTGT CTGCAGTCGG AGGAGGACGT GAGCCAGTTT 1080

GATACCCGCT TCACACGGCA GACGCCGGTG GACAGTCCCG ATGACACGGC CCTCAGTGAG 1140

AGTGCCAACC AGGCCTTCCT GCCCCCTCAA GTTCTCCCCC TTTGA 1185

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv++++ gk+ya+Kvl+ka++v+  k++++t++er+iLe+v

Q: 69    FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRnaKDTAHTRAERNILESV  128

         89***************************************999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f e++a+f+lae++lal +lH

Q: 129   KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH  188

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         s+g++yrDLkpeNi+l+++gh+kltDfgl+ke+i +++  +++fcgT+ey+aPe+l r+g

Q: 189   SQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI-HEGAVTHTFCGTIEYMAPEILVRSG  247

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pft+e+rk+t+++i kgk  l lp +  l+++a+dlvk

Q: 248   HNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGK--LALPPY--LTPDARDLVK  303

         ****************************************..9*****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         k+Lk++p++R+g    +a+++++h+f+

Q: 304   KFLKRNPSQRIGGgpgDAADVQRHPFF  330

         ***********99999*********97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK VQGTNLGKIY AMKVLRKAKI VRNAKDTAHT RAERNILESV 60

KHPFIVELAY AFQTGGKLYL ILECLSGGEL FTHLEREGIF LEDTACFYLA EITLALGHLH 120

SQGIIYRDLK PENIMLSSQG HIKLTDFGLC KESIHEGAVT HTFCGTIEYM APEILVRSGH 180

NRAVDWWSLG ALMYDMLTGS PPFTAENRKK TMDKIIKGKL ALPPYLTPDA RDLVKKFLKR 240

NPSQRIGGGP GDAADVQRHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045948	; P:positive regulation of translational initiation
GO:0043491	; P:protein kinase B signaling cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013