EPS-MAM-00024

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MAM-00024

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	200.4	7.4E-59	158	412	255

Status

Unreviewed

Ensembl Protein

ENSMMUP00000007313

UniProt Accession

F7GFC1;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1F

Gene Synonyms/Alias

PPM1F; EGK_21485;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000005527	ENSMMUP00000007313	ENSMMUT00000007783

Organism

Macaca mulatta

Functional Description

Protein Length

455

Protein Sequence
(FASTA)

MSSGAPQKSS QMASGAEETP GFLDMLLQDF PAPLNPEDPL PWKAPGMVLS QEEVEGELAE 60

LAMGFLGSRK APPPLAAALT HEAVSQLLQT DLSEFRKLPR EEEEEEEEDD DEEEKAPVTL 120

LDAQSLARSF FNRLWEVAGQ WQKQVPLAAR ASQRQWLVSI HAIRNTRRKM EDRHVSLPSF 180

NQLFGLSDPV DRAYFAVFDG HGGVDAARYA AVHVHTNVAR QPELPTDPAG ALREAFQRTD 240

QMFLRKAKRE RLQSGTTGVC ALIAGVTLHV AWLGDSQVIL VQQGQVVKLM EPHRPERQDE 300

KARIEALGGF VSHMDCWRVN GTLAVSRAIG DVFQKPYVSG EADAASRALT GSEDYLLLAC 360

DGFFDVVPHQ EVVGLVQSHL MRQQGSGLHV AEELVSAARE RGSHDNITVM VVFLRDPQEL 420

LEGGNQGAGD PQAGGRSQDL PSSLPEPETQ APPRS 455

Nucleotide Sequence
(FASTA)

ATGTCCTCTG GAGCCCCACA GAAGAGCAGC CAGATGGCCA GTGGAGCTGA GGAGACCCCA 60

GGCTTCCTGG ACATGCTCCT TCAAGACTTC CCAGCCCCAC TGAACCCAGA GGACCCTCTG 120

CCATGGAAGG CCCCGGGAAT GGTGCTCAGC CAGGAGGAGG TGGAGGGCGA ACTGGCTGAG 180

CTGGCCATGG GCTTTCTGGG CAGCAGGAAG GCCCCGCCAC CACTTGCCGC TGCTCTGACT 240

CATGAAGCGG TTTCACAGCT TCTACAGACA GACCTTTCCG AATTCAGGAA GTTGCCCAGG 300

GAGGAGGAAG AAGAGGAGGA GGAGGATGAC GACGAGGAGG AAAAGGCCCC TGTGACCTTG 360

CTGGATGCCC AAAGCCTGGC ACGGAGTTTC TTTAACCGGC TCTGGGAAGT TGCCGGCCAG 420

TGGCAGAAGC AGGTCCCATT GGCTGCCCGG GCCTCACAGC GGCAGTGGCT GGTCTCCATC 480

CACGCCATCC GGAACACTCG CCGCAAGATG GAGGACCGGC ACGTGTCCCT CCCTTCCTTC 540

AACCAGCTCT TCGGCTTGTC TGACCCTGTG GACCGTGCCT ACTTTGCTGT GTTTGATGGT 600

CACGGAGGCG TGGATGCTGC GAGGTACGCT GCTGTCCACG TGCACACCAA TGTTGCCCGC 660

CAGCCAGAGC TGCCCACAGA CCCTGCAGGA GCCCTCAGAG AAGCCTTCCA GCGTACTGAC 720

CAGATGTTTC TCAGGAAAGC CAAGCGAGAG CGGCTGCAGA GCGGCACCAC AGGTGTGTGT 780

GCGCTCATTG CAGGAGTGAC CCTGCACGTC GCCTGGCTCG GGGACTCCCA GGTCATTTTG 840

GTACAGCAGG GACAGGTGGT GAAGCTGATG GAGCCACACA GACCAGAACG GCAGGATGAG 900

AAGGCACGCA TTGAAGCATT GGGTGGCTTT GTGTCTCACA TGGACTGCTG GAGAGTCAAC 960

GGGACCCTGG CTGTCTCCAG AGCCATTGGG GATGTCTTCC AGAAGCCCTA CGTGTCTGGG 1020

GAGGCCGATG CAGCTTCCCG GGCGCTGACA GGCTCCGAGG ACTACCTGCT GCTCGCCTGC 1080

GATGGCTTCT TTGATGTCGT ACCCCACCAG GAAGTTGTTG GCCTCGTCCA GAGCCACCTG 1140

ATGAGGCAGC AGGGCAGCGG GCTCCATGTT GCTGAGGAGC TGGTGTCTGC GGCCCGGGAA 1200

CGGGGGTCCC ACGACAACAT CACGGTCATG GTGGTCTTCC TCAGGGACCC CCAAGAGCTG 1260

CTGGAGGGTG GGAACCAGGG AGCAGGGGAC CCCCAGGCAG GTGGGAGGAG CCAGGACTTG 1320

CCCTCCAGCC TTCCAGAACC TGAGACCCAG GCTCCACCAA GAAGCTAG 1368

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklhei  60

         v++ ++ + r++med++ s p+f +  + +d    a+f+v+DGhgg ++a++++ ++h+

Q: 158   VSIHAIRNTRRKMEDRHVSLPSFNQLFGLSDPvdRAYFAVFDGHGGVDAARYAAVHVHTN  217

         6678999******************9988888778*************************

S: 61    laeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyva  120

         +a++ e      ++   al++aF++td+ +  l +++ +  +sG+t v+ali + +l+va

Q: 218   VARQPE----LPTDPAGALREAFQRTDQMF--LRKAKRERLQSGTTGVCALIAGVTLHVA  271

         ****77....7788889*************..8888889999******************

S: 121   nvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRalGd  180

          +GdS+++L ++g++v+l + H+p+r+dE++Rie+ gg v   d+ Rv+G LavsRa+Gd

Q: 272   WLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSRAIGD  331

         ********************************************99**************

S: 181   lylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqeaa  239

         ++ kpyv+ e +  s  lt ++++l La+DG +dvv+ +e+v lv+++l  ++ +   +a

Q: 332   VFQKPYVSGEADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLMrQQGSGLHVA  391

         **********************************************99875778899***

S: 240   kkLvklalargskdnvsaivv  260

         ++Lv  a++rgs+dn++++vv

Q: 392   EELVSAARERGSHDNITVMVV  412

         *****************9997

Domain Sequence
(FASTA)

VSIHAIRNTR RKMEDRHVSL PSFNQLFGLS DPVDRAYFAV FDGHGGVDAA RYAAVHVHTN 60

VARQPELPTD PAGALREAFQ RTDQMFLRKA KRERLQSGTT GVCALIAGVT LHVAWLGDSQ 120

VILVQQGQVV KLMEPHRPER QDEKARIEAL GGFVSHMDCW RVNGTLAVSR AIGDVFQKPY 180

VSGEADAASR ALTGSEDYLL LACDGFFDVV PHQEVVGLVQ SHLMRQQGSG LHVAEELVSA 240

ARERGSHDNI TVMVV 255

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0043234	; C:protein complex
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0046872	; F:metal ion binding
GO:0035690	; P:cellular response to drug
GO:0097193	; P:intrinsic apoptotic signaling pathway
GO:0033137	; P:negative regulation of peptidyl-serine phosphorylation
GO:0044387	; P:negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045892	; P:negative regulation of transcription, DNA-dependent
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0050921	; P:positive regulation of chemotaxis
GO:0043280	; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0051894	; P:positive regulation of focal adhesion assembly
GO:0010628	; P:positive regulation of gene expression
GO:0045927	; P:positive regulation of growth
GO:0051496	; P:positive regulation of stress fiber assembly

KEGG

mcc:698441

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013