EKS-MAM-00160
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00160
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb448.41.3E-134427687261
StatusUnreviewed
Ensembl ProteinENSMMUP00000007383
UniProt AccessionF7G4I3;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA5
Gene Synonyms/Alias RPS6KA5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000005586ENSMMUP00000007383ENSMMUT00000007856
OrganismMacaca mulatta
Functional Description
Protein Length802
Protein Sequence
(FASTA)
MEEKGGSSGG AAGTSADGGD GEEQLLTVKH ELRTANLTGH AEKVGIENFE LLKVLGTGAY 60
GKVFLVRKIS GHDTGKLYAM KVLKKATIVQ KAKTTEHTRT ERQVLEHIRQ SPFLVTLHYA 120
FQTETKLHLI LDYINGGELF THLSQRERFT EHEVQIYVGE IVLALEHLHN LGIIYRDIKL 180
ENILLDSNGH VVLTDFGLSK EFVADETERA YSFCGTIEYM APDIVRGGDS GHDKAVDWWS 240
LGVLMYELLT GASPFTVDGE KNSQAEISRR ILKSEPPYPQ EMSALAKDLI QRLLMKDPKK 300
RLGCGPRDAD EIKEHLFFQK INWDDLAAKK VPAPFKPVIR DELDVSNFAE EFTEMDPTYS 360
PAALPQSSEK LFQGYSFVAP SILFKRNAAV IDPLQFHMGV ERPGVTNVAR SAMMKDSPFY 420
QHYDLDLKDK PLGEGSFSIC RKCVHKKSNQ AFAVKIISKR MEANTQKEIT ALKLCEGHPN 480
IVKLHEVFHD QLHTFLVMEL LNGGELFERI KRKKHFSETE ASYIMRKLVS AVSHMHDVGV 540
VHRDLKPENL LFTDENDNLE IKIIDFGFAR LKPPDNQPLK TPCFTLHYAA PELLNQNGYD 600
ESCDLWSLGV ILYTMLSGQV PFQSHDRSLT CTSAVEIMKK IKKGDFSFEG EAWKNVSQEA 660
KDLIQGLLTV DPNKRLKMSG LRYNEWLQDG SQLSSNPLMT PDILGSSGAA VHTCVKATFH 720
AFNKYKREGF CLQNVDKAPL AKRRKMKKTS TSTETRSSSS ESSHSSSSHS HGKTTPTKTL 780
QPSNPADSNN PETLFQFSDS VA 802
Nucleotide Sequence
(FASTA)
ATGGAGGAGA AGGGCGGCAG CAGCGGCGGC GCCGCGGGGA CCAGCGCGGA CGGCGGCGAC 60
GGGGAAGAGC AGCTCCTCAC GGTCAAGCAC GAGCTGCGGA CTGCTAATTT GACAGGACAT 120
GCAGAGAAGG TGGGGATAGA AAATTTTGAG CTCCTGAAGG TCCTAGGAAC TGGAGCTTAT 180
GGAAAAGTAT TTCTAGTTCG TAAAATAAGC GGTCATGATA CTGGAAAGCT GTATGCCATG 240
AAAGTTTTGA AAAAGGCAAC AATAGTTCAA AAGGCCAAAA CCACAGAGCA TACAAGGACA 300
GAACGACAAG TCCTGGAGCA CATTAGGCAG TCGCCGTTTT TGGTGACATT ACATTATGCT 360
TTCCAGACAG AAACCAAACT TCATCTCATT TTAGATTATA TAAATGGTGG AGAACTTTTT 420
ACTCATCTTT CTCAAAGAGA GCGTTTCACA GAGCACGAGG TGCAGATTTA TGTTGGAGAG 480
ATTGTGCTTG CCCTCGAACA TCTCCACAAC TTGGGGATTA TATATCGTGA CATTAAGCTT 540
GAGAATATTC TGCTTGATTC TAATGGCCAT GTAGTGCTGA CAGATTTTGG TCTGAGTAAG 600
GAGTTTGTGG CTGATGAAAC TGAAAGAGCA TATTCCTTTT GTGGAACTAT TGAATACATG 660
GCACCAGATA TTGTCAGAGG GGGAGATTCA GGACATGACA AGGCAGTTGA TTGGTGGAGT 720
TTAGGTGTTC TAATGTATGA ATTACTAACT GGAGCATCTC CTTTCACTGT TGATGGAGAA 780
AAAAATTCCC AAGCTGAGAT ATCTAGGAGA ATATTAAAAA GTGAGCCTCC ATATCCCCAA 840
GAAATGAGTG CTTTAGCTAA AGACCTAATT CAGCGTCTTT TGATGAAAGA TCCCAAGAAG 900
AGATTGGGAT GTGGTCCACG CGATGCAGAT GAAATCAAAG AACATCTCTT CTTTCAGAAA 960
ATAAATTGGG ATGATTTAGC CGCCAAAAAA GTGCCTGCAC CATTTAAGCC GGTCATTCGA 1020
GATGAATTAG ACGTGAGTAA CTTTGCAGAA GAGTTCACAG AAATGGATCC CACTTATTCT 1080
CCTGCAGCCC TGCCCCAGAG CTCTGAGAAG CTGTTTCAGG GCTATTCCTT TGTTGCTCCT 1140
TCCATCCTAT TCAAGCGTAA TGCAGCTGTC ATAGACCCTC TTCAGTTTCA CATGGGAGTT 1200
GAACGTCCTG GAGTGACAAA TGTTGCCAGG AGTGCGATGA TGAAGGACTC TCCATTCTAT 1260
CAACACTATG ACCTAGATTT GAAGGACAAA CCACTGGGAG AAGGTAGTTT TTCAATTTGT 1320
CGGAAGTGCG TGCATAAAAA AAGTAACCAA GCTTTTGCAG TCAAAATAAT CAGCAAAAGG 1380
ATGGAAGCCA ATACTCAGAA GGAAATAACA GCTCTGAAAC TCTGTGAAGG ACACCCCAAT 1440
ATTGTGAAGT TGCATGAAGT TTTTCATGAT CAGCTTCACA CATTTCTGGT GATGGAACTT 1500
CTGAATGGGG GAGAACTGTT TGAACGCATT AAGAGAAAGA AGCACTTCAG TGAGACGGAA 1560
GCCAGCTATA TCATGAGGAA GCTTGTTTCA GCTGTCAGCC ACATGCATGA TGTTGGAGTG 1620
GTGCACAGAG ATTTGAAACC TGAGAATTTA TTGTTCACCG ATGAAAATGA CAATTTGGAA 1680
ATTAAAATAA TTGATTTTGG GTTTGCACGG CTAAAGCCAC CGGATAATCA GCCCCTGAAG 1740
ACTCCATGCT TCACCCTTCA TTACGCAGCC CCAGAGCTCT TGAATCAGAA CGGCTACGAT 1800
GAGTCCTGTG ACCTGTGGAG CTTGGGTGTC ATTTTGTACA CAATGTTGTC AGGACAGGTT 1860
CCCTTCCAAT CTCATGACCG AAGTTTGACG TGTACCAGCG CAGTGGAAAT CATGAAGAAA 1920
ATTAAAAAGG GAGATTTCTC CTTTGAAGGA GAAGCCTGGA AGAATGTATC CCAAGAGGCT 1980
AAAGATTTGA TCCAAGGACT TCTCACAGTT GATCCAAACA AAAGGCTTAA AATGTCTGGC 2040
TTGAGGTACA ATGAATGGCT TCAAGATGGC AGTCAGCTGT CCTCCAATCC TCTGATGACT 2100
CCGGATATTC TAGGATCTTC AGGAGCTGCC GTGCATACCT GTGTGAAAGC AACCTTCCAC 2160
GCCTTTAACA AATACAAGAG AGAGGGATTT TGCCTTCAGA ATGTTGATAA GGCCCCTTTG 2220
GCTAAGAGAA GAAAAATGAA AAAGACTAGC ACCAGTACCG AGACGCGCAG CAGTTCCAGC 2280
GAGAGTTCCC ATTCTTCTTC CTCTCATTCT CACGGTAAAA CTACACCCAC CAAGACACTG 2340
CAGCCCAGCA ATCCTGCCGA CAGCAATAAC CCGGAGACCC TCTTCCAGTT CTCAGACTCA 2400
GTAGCTTAG 2409
Domain Profile
S: 2     evkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkd  60
         +++++lG+Gs+s+c++cvhk++nq+favkii+k+ +++t++ei++l+++e+hpniv+l++
Q: 427   LKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRmEANTQKEITALKLCEGHPNIVKLHE  486
         5789******************************9*************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         v++d+++++lv+ell+GGel++rik+kk+fse+eas+i+r+lv+av+++h++Gvvhrdlk
Q: 487   VFHDQLHTFLVMELLNGGELFERIKRKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK  546
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         pen+l++de+dn+e ikiidfGfa+lk+++n++lktpc+tl+++ape+l+++Gyde+cdl
Q: 547   PENLLFTDENDNLE-IKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDL  605
         **************.*********************************************
S: 181   wslGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvs  236
         wslGv+lytml+G+vpf    +++++++a+ei++kik+G+fs++Geaw++vs+eakdl++
Q: 606   WSLGVILYTMLSGQVPFqshdRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQ  665
         *****************9998899************************************
S: 237   klltvdpakrlkleqllkhswl  258
         +lltvdp+krlk+++l++++wl
Q: 666   GLLTVDPNKRLKMSGLRYNEWL  687
         *********************7
Domain Sequence
(FASTA)
LKDKPLGEGS FSICRKCVHK KSNQAFAVKI ISKRMEANTQ KEITALKLCE GHPNIVKLHE 60
VFHDQLHTFL VMELLNGGEL FERIKRKKHF SETEASYIMR KLVSAVSHMH DVGVVHRDLK 120
PENLLFTDEN DNLEIKIIDF GFARLKPPDN QPLKTPCFTL HYAAPELLNQ NGYDESCDLW 180
SLGVILYTML SGQVPFQSHD RSLTCTSAVE IMKKIKKGDF SFEGEAWKNV SQEAKDLIQG 240
LLTVDPNKRL KMSGLRYNEW L 261
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00163
EKS-CAE-00125
EKS-CAJ-00167
EKS-CAF-00170
EKS-CAP-00162
EKS-CII-00093
EKS-CIS-00194
EKS-DAR-00452
EKS-DIO-00087
EKS-DRM-00077
EKS-EQC-00162
EKS-FEC-00153
EKS-GAG-00140
EKS-GAA-00192
EKS-GOG-00163
EKS-HOS-00169
EKS-ICT-00158
EKS-LAC-00173
EKS-LOA-00162
EKS-MEG-00130
EKS-MOD-00162
EKS-MUP-00167
EKS-MYL-00173
EKS-NOL-00156
EKS-ORN-00202
EKS-ORA-00141
EKS-ORC-00151
EKS-ORL-00189
EKS-OTG-00170
EKS-PAT-00153
EKS-PEM-00087
EKS-POA-00160
EKS-SAH-00157
EKS-TAG-00191
EKS-TAR-00209
EKS-TEN-00202
EKS-XET-00152
EKS-XIM-00197
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043990; P:histone H2A-S1 phosphorylation
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
mcc:699798;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013