EKS-MAM-00161
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00161
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb443.83.2E-133415646232
StatusUnreviewed
Ensembl ProteinENSMMUP00000007493
UniProt AccessionF6VQI9;
Protein Name
Protein Synonyms/Alias
Gene NameRPS6KA2
Gene Synonyms/Alias RPS6KA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000005670ENSMMUP00000032922ENSMMUT00000039861
ENSMMUG00000005670ENSMMUP00000007493ENSMMUT00000007972
OrganismMacaca mulatta
Functional Description
Protein Length646
Protein Sequence
(FASTA)
MDLSMKKFAV RRFFSVYLRR KSRSKSSSLS RLEEEGIVKE IDISHHVKEG FEKADPSQFE 60
LLKVLGQGSY GKVFLVRKVK GSDAGQLYAM KVLKKATLKV RDRVRSKMER DILAEVNHPF 120
IVKLHYAFQT EGKLYLILDF LRGGDLFTRL SKEVMFTEED VKFYLAELAL ALDHLHGLGI 180
IYRDLKPENI LLDEEGHIKI TDFGLSKEAI DHDKRAYSFC GTIEYMAPEV VNRRGHTQSA 240
DWWSFGVLMF EMLTGSLPFQ GKDRKETMAL ILKAKLGMPQ FLSGEAQSLL RALFKRNPCN 300
RLGAGIDGVE EIKRHPFFVT IDWNKLFRKE IKPPFKPAVG RPEDTFHFDP EFTARTPTDS 360
PGVPPSANAH NLFRGFSFVA SSLIQEPSQQ DLHKVAVHPI VQQLHGNNIH FTDGYEIKED 420
IGVGSYSVCK RCVHKATDTE YAVKIIDKSK RDPSEEIEIL LRYGQHPNII TLKDVYDDGK 480
FVYLVMELMR GGELLDRILQ QRYFSEREAS DVLCTITKTM DYLHSQGVVH RDLKPSNILY 540
RDESGSPESI RVCDFGFAKQ LRAGNGLLMT PCYTANFVAP EVLKRQGYDA ACDIWSLGIL 600
LYTMLAGFTP FANGPDDTPE EILARIGSGK YALSGGNWDS ISDAAK 646
Nucleotide Sequence
(FASTA)
ATGGACCTGA GCATGAAGAA GTTCGCCGTG CGCAGGTTCT TCTCCGTGTA CCTGCGCAGG 60
AAGTCGCGCT CCAAGAGCTC CAGCCTGAGC CGGCTCGAGG AGGAAGGCAT TGTGAAGGAG 120
ATTGACATCA GCCATCATGT GAAGGAAGGC TTTGAGAAAG CAGACCCTTC CCAGTTTGAG 180
TTGCTGAAGG TTTTAGGACA AGGATCCTAT GGAAAGGTGT TCCTGGTGAG GAAGGTGAAG 240
GGGTCCGATG CTGGGCAGCT CTATGCCATG AAGGTCCTTA AGAAAGCCAC TCTAAAAGTT 300
CGGGACCGAG TGAGATCGAA GATGGAGAGG GACATCCTGG CAGAGGTGAA TCACCCCTTC 360
ATTGTGAAGC TCCATTACGC CTTTCAGACA GAAGGAAAGC TCTACCTGAT CCTGGACTTC 420
CTGCGGGGAG GGGACCTCTT CACCCGGCTC TCCAAAGAGG TCATGTTCAC AGAGGAGGAT 480
GTCAAGTTCT ACCTGGCTGA ACTGGCCTTG GCTTTAGACC ATCTCCACGG CCTGGGGATC 540
ATCTACAGAG ATCTGAAGCC TGAGAACATC CTCCTGGATG AAGAGGGACA TATTAAGATC 600
ACAGATTTCG GCCTGAGTAA GGAGGCCATT GACCACGACA AGAGAGCGTA CTCCTTCTGC 660
GGGACAATCG AGTACATGGC CCCCGAGGTG GTGAACCGGC GAGGACACAC GCAGAGCGCC 720
GACTGGTGGT CTTTCGGTGT GCTCATGTTC GAGATGCTCA CGGGGTCCCT GCCGTTCCAG 780
GGGAAGGATA GGAAGGAGAC CATGGCCCTC ATCCTCAAAG CCAAGCTGGG GATGCCGCAG 840
TTCCTCAGTG GGGAGGCACA GAGTTTGCTG CGAGCTCTCT TCAAACGGAA CCCCTGCAAC 900
CGGCTGGGTG CTGGCATTGA TGGAGTGGAG GAAATTAAGC GCCATCCCTT CTTTGTGACC 960
ATAGACTGGA ACAAGCTGTT CCGGAAGGAG ATCAAGCCAC CATTCAAACC AGCAGTGGGC 1020
AGGCCTGAGG ACACCTTCCA CTTTGACCCC GAGTTCACAG CACGGACGCC CACAGACTCT 1080
CCTGGTGTCC CCCCGAGTGC AAATGCTCAT AACCTGTTTA GAGGATTCAG CTTTGTGGCC 1140
TCAAGCCTGA TCCAGGAGCC CTCACAGCAA GATCTGCACA AAGTCGCAGT TCATCCAATT 1200
GTACAGCAGT TACACGGGAA CAACATCCAC TTCACCGATG GCTACGAGAT CAAGGAGGAC 1260
ATCGGGGTGG GCTCCTACTC AGTGTGCAAG CGATGTGTGC ATAAAGCCAC TGACACAGAG 1320
TACGCTGTGA AGATCATCGA TAAGAGCAAG AGAGACCCCT CGGAAGAGAT CGAGATCCTG 1380
CTGCGGTACG GCCAGCACCC GAACATCATC ACCCTCAAAG ATGTCTATGA CGATGGCAAG 1440
TTCGTGTACC TGGTGATGGA GCTGATGCGT GGCGGGGAGC TCCTGGACCG CATCCTCCAG 1500
CAGAGATACT TCTCGGAGCG TGAGGCCAGT GACGTCCTGT GCACCATCAC CAAGACCATG 1560
GACTACCTCC ATTCCCAGGG GGTTGTTCAT CGAGACCTGA AGCCGAGTAA CATCCTGTAC 1620
AGGGATGAGT CGGGGAGCCC GGAATCCATC CGAGTCTGTG ACTTCGGCTT TGCCAAGCAG 1680
CTGCGCGCGG GGAACGGGCT GCTCATGACG CCCTGCTACA CGGCCAACTT CGTGGCCCCG 1740
GAGGTCCTGA AGCGTCAAGG CTACGATGCG GCGTGTGACA TCTGGAGTTT GGGAATCCTG 1800
TTGTACACCA TGCTGGCAGG ATTTACCCCT TTTGCAAATG GGCCAGACGA TACCCCTGAG 1860
GAGATTTTGG CGCGGATCGG CAGTGGGAAG TATGCCCTTT CTGGGGGAAA CTGGGACTCC 1920
ATATCTGACG CAGCCAAA 1938
Domain Profile
S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60
         ye+ked+GvGsysvckrcvhkat++e+avkiidkskrd+seeieillry+qhpni+tlkd
Q: 415   YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKD  474
         789*********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         vyddgk+vylv+el++GGelldri+++++fsereas++l+t++k+++ylh+qGvvhrdlk
Q: 475   VYDDGKFVYLVMELMRGGELLDRILQQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLK  534
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         p+nily+des+++esi+++dfGfak++ra ngll+tpcyt+nfvapevlkrqGyd+acd+
Q: 535   PSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDI  594
         ************************************************************
S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeak  232
         wslG+llytmlaG++pfangp+dt+eeila+i++Gk++lsG++wds+s++ak
Q: 595   WSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAK  646
         **************************************************98
Domain Sequence
(FASTA)
YEIKEDIGVG SYSVCKRCVH KATDTEYAVK IIDKSKRDPS EEIEILLRYG QHPNIITLKD 60
VYDDGKFVYL VMELMRGGEL LDRILQQRYF SEREASDVLC TITKTMDYLH SQGVVHRDLK 120
PSNILYRDES GSPESIRVCD FGFAKQLRAG NGLLMTPCYT ANFVAPEVLK RQGYDAACDI 180
WSLGILLYTM LAGFTPFANG PDDTPEEILA RIGSGKYALS GGNWDSISDA AK 232
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>
EKS-AIM-00154
EKS-ANC-00156
EKS-BOT-00161
EKS-CAJ-00165
EKS-CAF-00168
EKS-CAP-00161
EKS-DAR-00449
EKS-EQC-00163
EKS-GAG-00139
EKS-GOG-00162
EKS-HOS-00167
EKS-ICT-00156
EKS-LOA-00159
EKS-MEG-00128
EKS-MOD-00158
EKS-MUM-00167
EKS-MUP-00165
EKS-OTG-00167
EKS-PAT-00155
EKS-PES-00142
EKS-POA-00158
EKS-RAN-00159
EKS-SAH-00153
EKS-SUS-00139
EKS-TAG-00192
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005819; C:spindle
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004711; F:ribosomal protein S6 kinase activity
GO:0002035; P:brain renin-angiotensin system
GO:0010659; P:cardiac muscle cell apoptotic process
GO:0071322; P:cellular response to carbohydrate stimulus
GO:0060047; P:heart contraction
GO:0007507; P:heart development
GO:0007243; P:intracellular protein kinase cascade
GO:0000089; P:mitotic metaphase
GO:0045786; P:negative regulation of cell cycle
GO:0008285; P:negative regulation of cell proliferation
GO:0001556; P:oocyte maturation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0010628; P:positive regulation of gene expression
GO:0070613; P:regulation of protein processing
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013