EKS-MAM-00376

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00376

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	346.3	1.8E-103	145	403	259

Status

Unreviewed

Ensembl Protein

ENSMMUP00000032783

UniProt Accession

F6VUC2;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K9

Gene Synonyms/Alias

MAP3K9;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000005786	ENSMMUP00000007634	ENSMMUT00000008118
ENSMMUG00000005786	ENSMMUP00000032783	ENSMMUT00000039717

Organism

Macaca mulatta

Functional Description

Protein Length

1104

Protein Sequence
(FASTA)

MEPSRALLGC LASAAAAAPP GEDGAGAGAE EEEEEEEEAA AAAGPGELGC DAPLPYWTAV 60

FEYEAAGEDE LTLRLGDVVE VLSKDSQVSG DEGWWTGQLN QRVGIFPSNY VTPRSAFSSR 120

CQPGGEDPSC YPPIQLLEID FAELTLEEII GIGGFGKVYR AFWIGDEVAV KAARHDPDED 180

ISQTIENVRQ EAKLFTMLKH PNIIALRGVC LKEPNLCLVM EFARGGPLNR VLSGKRIPPD 240

ILVNWAVQIA RGMNYLHDEA IVPIIHRDLK SSNILILQKV ENGDLSNKIL KITDFGLARE 300

WHRTTKMSAA GTYAWMAPEV IRASMFSKGS DVWSYGVLLW ELLTGEVPFR GIDGLAVAYG 360

VAMNKLALPI PSTCPEPFAK LMEDCWNPDP HSRPSFTNIL DQLTTIEESG FFEMPKDSFH 420

CLQDDWKHEI QEMFDQLRAK EKELRTWEEE LTRAALQQKN QEELLRRREQ ELAEREIDIL 480

ERELNIIIHQ LCQEKPRVKK RKGKFRKSRL KLKDGNRISL PSDFQHKFTV QASPTMDKRK 540

SLINSRSSPP ASPTIIPRLR AIQLTPGESS KTWGRSSVVP KEEGEEEEKR APKKKGRTWG 600

PGTLGQKELA SGDEGSPQRR EKANGLSTPS ESPHFHLGLK SLVDGYKQWS SSAPNLVKGP 660

RSSPALPGFT SLMEMEDEDS EGPGSGESRL QHSPSQSYLC IPFPRGEDGD GPSSDGIHEE 720

PTPVNSATST PQLTPTNSLK RGSAHHRRCE VALLGCGAVL AATGLGFDLL EAGKCQLLPL 780

EEPEPPPREE KKRREGLFQR SSRPRRSTSP PSRKLFKKEE PMLLLGDPAA SLTLLSLSSI 840

SECNSTRSLL RSDSDEIVVY EMPVSPIEAP PMTPCTHNPL VNVRVERFKR DPNQSLTPTH 900

VTLTAPSQPS SHRRTPSDGA LKPETLLASR SPSSNGLSPS PGAGMLKTPS PSRDPGEFPR 960

LPDPNVVFPP TPRRWNTQQD STLERPKTLE FLPRPRPSAN RQRLDPWWFV SPSHARSTSP 1020

ANSSSTETPS NLDSCFASSS STVEERPGLP ALLPFQAGPL PPTERTLLDL DAEGQSQDST 1080

VPLCRAELNT HRPAPYEIQQ EFWS 1104

Nucleotide Sequence
(FASTA)

ATGGAGCCCT CCAGAGCGCT TCTCGGCTGC CTAGCGAGCG CCGCCGCTGC CGCCCCGCCG 60

GGGGAGGATG GAGCCGGGGC CGGGGCCGAG GAGGAGGAGG AGGAGGAGGA GGAGGCGGCG 120

GCGGCGGCGG GCCCCGGGGA GCTGGGCTGC GACGCGCCGC TGCCCTACTG GACGGCCGTG 180

TTCGAGTACG AGGCGGCGGG CGAGGACGAG CTGACTCTGC GGCTGGGCGA CGTGGTGGAG 240

GTGCTGTCCA AGGACTCGCA GGTGTCCGGC GACGAGGGCT GGTGGACTGG GCAGCTGAAC 300

CAGCGGGTGG GCATCTTCCC CAGCAACTAC GTGACCCCGC GCAGCGCCTT CTCCAGCCGC 360

TGCCAGCCCG GCGGCGAGGA CCCCAGCTGC TACCCGCCCA TTCAGTTGTT AGAAATTGAT 420

TTTGCGGAGC TAACCTTGGA AGAGATTATT GGCATCGGGG GCTTTGGCAA GGTCTATCGT 480

GCTTTCTGGA TAGGGGATGA GGTTGCTGTG AAAGCAGCTC GCCATGACCC CGATGAGGAC 540

ATCAGCCAGA CTATAGAGAA TGTTCGCCAA GAGGCCAAAC TCTTCACCAT GCTGAAGCAC 600

CCCAACATCA TTGCCCTAAG AGGGGTATGT CTGAAGGAGC CCAACCTCTG CTTGGTCATG 660

GAGTTTGCTC GTGGAGGACC TTTGAATAGA GTGTTATCTG GGAAAAGGAT TCCCCCAGAC 720

ATCCTGGTGA ACTGGGCTGT GCAGATTGCC AGAGGGATGA ACTACTTACA TGATGAGGCA 780

ATTGTCCCCA TCATCCACCG TGACCTTAAG TCCAGCAACA TATTGATCCT CCAGAAGGTG 840

GAGAATGGAG ACCTGAGCAA CAAGATTCTG AAGATCACTG ATTTTGGCCT GGCTCGGGAA 900

TGGCACCGAA CCACCAAGAT GAGTGCAGCA GGGACGTATG CTTGGATGGC ACCCGAAGTC 960

ATCCGGGCCT CCATGTTTTC CAAAGGCAGT GACGTGTGGA GCTACGGGGT GCTACTTTGG 1020

GAGTTGCTGA CTGGTGAAGT GCCCTTTCGA GGCATTGATG GCTTAGCGGT CGCTTATGGA 1080

GTGGCCATGA ACAAACTCGC CCTTCCTATT CCTTCTACAT GCCCAGAGCC TTTTGCCAAA 1140

CTCATGGAAG ACTGCTGGAA TCCTGATCCC CACTCACGAC CATCTTTCAC GAATATCCTG 1200

GACCAGCTAA CCACCATAGA GGAGTCTGGT TTCTTTGAAA TGCCCAAGGA CTCCTTCCAC 1260

TGCCTGCAGG ATGACTGGAA ACACGAGATT CAGGAGATGT TTGACCAACT CAGGGCCAAA 1320

GAGAAGGAAC TTCGCACATG GGAGGAGGAG CTGACACGGG CTGCGCTGCA GCAGAAGAAC 1380

CAGGAGGAAC TGCTGCGGCG TCGGGAGCAA GAGCTGGCGG AGCGGGAGAT TGACATCCTG 1440

GAACGGGAGC TCAACATCAT CATCCACCAG CTGTGCCAGG AGAAGCCCCG AGTGAAGAAA 1500

CGCAAGGGCA AGTTCAGGAA GAGCCGGCTG AAGCTCAAGG ATGGCAACCG CATCAGCCTC 1560

CCTTCCGATT TCCAGCACAA GTTCACGGTG CAGGCCTCCC CCACCATGGA TAAAAGGAAG 1620

AGTCTTATCA ACAGCCGCTC AAGTCCTCCT GCAAGCCCCA CCATCATTCC TCGTCTTCGA 1680

GCCATCCAGT TGACACCAGG TGAAAGCAGC AAAACTTGGG GCAGGAGCTC AGTCGTCCCA 1740

AAGGAGGAAG GGGAGGAGGA GGAGAAGAGG GCCCCAAAGA AGAAGGGGCG AACGTGGGGG 1800

CCAGGGACGC TTGGTCAGAA GGAGCTTGCC TCGGGAGATG AAGGATCCCC TCAGAGACGT 1860

GAGAAAGCTA ATGGTTTAAG TACCCCGTCA GAATCTCCAC ATTTCCACTT GGGCCTCAAG 1920

TCCCTGGTAG ATGGATATAA GCAGTGGTCG TCCAGTGCCC CCAACCTGGT GAAGGGCCCG 1980

AGGAGTAGCC CGGCCCTGCC AGGGTTCACC AGCCTTATGG AGATGGAAGA TGAGGACAGT 2040

GAAGGCCCAG GGAGTGGAGA GAGTCGCCTA CAGCATTCAC CCAGCCAGTC CTACCTCTGT 2100

ATCCCATTCC CTCGTGGAGA GGATGGGGAT GGCCCCTCCA GTGATGGAAT CCATGAGGAG 2160

CCCACCCCAG TCAACTCAGC CACCAGTACC CCTCAGCTGA CGCCAACCAA CAGCCTCAAG 2220

CGGGGCAGTG CTCACCACCG CCGCTGCGAG GTGGCTCTAC TCGGCTGTGG GGCTGTTCTG 2280

GCAGCCACAG GCCTAGGGTT TGACTTGCTG GAAGCTGGCA AGTGCCAGCT GCTTCCCCTG 2340

GAGGAGCCTG AGCCACCACC TCGGGAAGAG AAGAAAAGAC GGGAGGGTCT TTTTCAGAGG 2400

TCCAGCCGTC CTCGTCGGAG CACCAGCCCC CCATCCCGAA AGCTCTTCAA GAAGGAAGAG 2460

CCCATGCTGT TGCTAGGAGA CCCCGCTGCC TCCCTGACAC TGCTCTCCCT CTCCTCCATC 2520

TCCGAGTGCA ACTCCACACG CTCCCTGCTG CGCTCTGACA GCGATGAAAT TGTCGTGTAT 2580

GAGATGCCAG TCAGCCCAAT TGAGGCCCCT CCCATGACCC CTTGTACCCA CAACCCCCTG 2640

GTCAATGTCC GAGTGGAGCG CTTCAAACGG GATCCTAACC AATCTCTGAC TCCCACCCAC 2700

GTCACCCTCA CCGCCCCCTC GCAGCCCAGC AGTCACCGGC GGACTCCTTC TGATGGGGCC 2760

CTTAAGCCAG AGACTCTCCT AGCCAGCAGG AGCCCCTCCA GCAATGGGTT GAGCCCCAGT 2820

CCTGGAGCAG GAATGTTGAA AACCCCCAGT CCCAGCCGAG ACCCAGGTGA ATTCCCCCGT 2880

CTCCCTGACC CCAATGTGGT CTTCCCCCCA ACCCCAAGGC GCTGGAACAC TCAGCAGGAC 2940

TCTACCTTGG AGAGACCCAA GACCCTGGAG TTTCTGCCTC GGCCACGTCC TTCTGCCAAC 3000

CGGCAACGAC TGGACCCTTG GTGGTTTGTG TCCCCCAGCC ATGCCCGCAG CACCTCCCCA 3060

GCCAACAGCT CTAGCACAGA GACGCCCAGC AACCTGGACT CCTGCTTCGC TAGCAGTAGC 3120

AGCACTGTAG AGGAGCGGCC TGGACTTCCA GCCCTGCTCC CCTTCCAGGC GGGGCCACTG 3180

CCCCCCACCG AGCGGACGCT CCTGGACCTG GACGCAGAGG GGCAGAGTCA GGACAGCACC 3240

GTGCCGCTGT GCAGAGCGGA ACTGAACACG CACAGGCCTG CCCCTTATGA GATCCAGCAG 3300

GAGTTCTGGT CTTAA 3315

Domain Profile

S: 2     eleeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpnii  59

         +lee+ig g fgkvy+a w ++evavK++r++  e  ++++e++++eakl+++l+hpnii

Q: 145   TLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEdiSQTIENVRQEAKLFTMLKHPNII  204

         5799****************************9998999*********************

S: 60    ellGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseap  119

         +l+Gvcl+epnl+lvme+++gg L++vl++   ++i+++ lv+wa+qiArGm+YLh+ea

Q: 205   ALRGVCLKEPNLCLVMEFARGGPLNRVLSG---KRIPPDILVNWAVQIARGMNYLHDEAI  261

         ******************************...99*************************

S: 120   kkiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvl  172

         ++iihrdLks+n+L+       + ++k lki+dFG are++++tkmsaagt+awmaPEv+

Q: 262   VPIIHRDLKSSNILIlqkvengDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVI  321

         ********************99999***********************************

S: 173   keekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkL  232

         +++ +s+ sDvwSygv+LWellt+evP+++++ la+ay+va+++l lpips+cpe+++kL

Q: 322   RASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKL  381

         ************************************************************

S: 233   mkecwnedpekRpsfseivksl  254

         m++cwn dp++Rpsf++i+++l

Q: 382   MEDCWNPDPHSRPSFTNILDQL  403

         ******************9876

Domain Sequence
(FASTA)

TLEEIIGIGG FGKVYRAFWI GDEVAVKAAR HDPDEDISQT IENVRQEAKL FTMLKHPNII 60

ALRGVCLKEP NLCLVMEFAR GGPLNRVLSG KRIPPDILVN WAVQIARGMN YLHDEAIVPI 120

IHRDLKSSNI LILQKVENGD LSNKILKITD FGLAREWHRT TKMSAAGTYA WMAPEVIRAS 180

MFSKGSDVWS YGVLLWELLT GEVPFRGIDG LAVAYGVAMN KLALPIPSTC PEPFAKLMED 240

CWNPDPHSRP SFTNILDQL 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade
GO:0046777	; P:protein autophosphorylation

KEGG

mcc:693835

;

InterPros

IPR011009	; Kinase-like_dom.
IPR016231	; MAPKKK9/10/11.
IPR015785	; MAPKKK9/10/11-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR011511	; SH3_2.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF07653	; SH3_2; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50002	; SH3; 1.

Prints

PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013