EKS-MAM-00469

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00469

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	243.5	4.5E-72	137	296	160

Status

Unreviewed

Ensembl Protein

ENSMMUP00000007763

UniProt Accession

F6TKG2;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK13

Gene Synonyms/Alias

MAPK13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000005903	ENSMMUP00000007763	ENSMMUT00000008259

Organism

Macaca mulatta

Functional Description

Protein Length

353

Protein Sequence
(FASTA)

MSLIRKKGFY KQDVNKTAWE LPKTYVSPTH VGSGAYGAVC SAIDKRSGEK VAIKKLSRPF 60

QSEIFAKRAY RELLLLKHMQ HENVIGLLDV FTPASSLRNF HDLPYLLPES KVGRVQGFCS 120

GSPSLPQPSM HSLSSPQDLK PGNLAVNEDC ELKILDFGLA RHADAEMTGY VVTRWYRAPE 180

VILSWMHYNQ TVDIWSVGCI MAEMLTGKTL FKGKDYLDQL TQILKVTGVP GTEFVQKLND 240

KAAKSYIQSL PQTPKKDFTQ LFPRASPQAV DLLEKMLELD VDKRLTAAQA LTHPFFEPFR 300

DPEEETEAQQ PFDDSLEHEK LTVDEWKQHI YKEIVNFSPI ARKDSRRRSG MKL 353

Nucleotide Sequence
(FASTA)

ATGAGCCTCA TCCGGAAAAA GGGATTCTAC AAGCAGGACG TCAACAAGAC CGCCTGGGAG 60

CTGCCCAAGA CCTACGTGTC CCCGACGCAC GTCGGCAGCG GGGCCTATGG CGCGGTGTGC 120

TCGGCCATCG ACAAGCGGTC AGGGGAGAAG GTGGCCATCA AGAAGCTGAG CCGGCCCTTT 180

CAGTCCGAGA TCTTCGCCAA GCGCGCCTAC CGGGAGCTGC TGCTGCTGAA GCACATGCAG 240

CATGAGAACG TCATTGGGCT CCTGGATGTC TTCACCCCAG CCTCCTCCCT GCGCAACTTC 300

CATGACTTGC CTTACTTGCT GCCAGAGAGC AAGGTGGGGA GGGTCCAGGG TTTCTGTTCT 360

GGGTCTCCAT CTCTGCCTCA GCCTAGCATG CACTCCCTGT CCTCTCCCCA GGACCTGAAG 420

CCAGGCAACC TAGCTGTGAA CGAGGACTGT GAACTGAAGA TCCTGGATTT TGGGCTGGCG 480

CGGCATGCAG ATGCCGAGAT GACTGGCTAC GTGGTGACCC GCTGGTACCG GGCCCCCGAG 540

GTGATCCTCA GCTGGATGCA CTACAACCAG ACAGTGGACA TCTGGTCTGT GGGCTGTATC 600

ATGGCAGAGA TGCTGACAGG GAAAACTCTG TTCAAGGGGA AAGATTACCT GGACCAGCTG 660

ACCCAGATCC TGAAAGTGAC CGGGGTGCCA GGCACGGAGT TTGTGCAGAA GCTGAACGAC 720

AAAGCGGCCA AATCCTACAT CCAGTCCCTG CCACAGACCC CCAAGAAGGA TTTCACTCAG 780

CTCTTCCCGC GGGCCAGCCC CCAGGCTGTG GACCTGCTGG AGAAGATGCT GGAGCTAGAT 840

GTGGACAAGC GCCTGACAGC CGCGCAGGCC CTCACCCATC CCTTCTTTGA ACCCTTCCGG 900

GACCCTGAGG AAGAGACGGA GGCCCAACAG CCATTTGATG ATTCCTTAGA ACACGAGAAA 960

CTCACAGTGG ATGAATGGAA GCAGCACATC TACAAGGAGA TTGTGAACTT CAGCCCCATT 1020

GCCCGGAAGG ACTCGCGGCG CCGGAGTGGC ATGAAACTGT AG 1062

Domain Profile

S: 126   rDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslkeytkav  185

         +DlKP+Nl+vnedcelkildFGlar+ad+e    +t+yv+trwYraPe++ls+++y+++v

Q: 137   QDLKPGNLAVNEDCELKILDFGLARHADAE----MTGYVVTRWYRAPEVILSWMHYNQTV  192

         7*****************************....**************************

S: 186   DiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyikslpk  245

         DiWsvGCI+aE+ltgk+lf+gkd++dql++il+v+g p +ef++k++++ a++yi+slp+

Q: 193   DIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQ  252

         ************************************************************

S: 246   kkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         ++kkdf++lfp+as++a+dLlek+L+ld dkR+++++aL+hp++

Q: 253   TPKKDFTQLFPRASPQAVDLLEKMLELDVDKRLTAAQALTHPFF  296

         ******************************************95

Domain Sequence
(FASTA)

QDLKPGNLAV NEDCELKILD FGLARHADAE MTGYVVTRWY RAPEVILSWM HYNQTVDIWS 60

VGCIMAEMLT GKTLFKGKDY LDQLTQILKV TGVPGTEFVQ KLNDKAAKSY IQSLPQTPKK 120

DFTQLFPRAS PQAVDLLEKM LELDVDKRLT AAQALTHPFF 160

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0032755	; P:positive regulation of interleukin-6 production
GO:0006970	; P:response to osmotic stress

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013