EKS-MAM-00374
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00374
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src233.54.5E-69192360169
StatusUnreviewed
Ensembl ProteinENSMMUP00000007965
UniProt AccessionF6W3B9;
Protein Name
Protein Synonyms/Alias
Gene NamePTK6
Gene Synonyms/Alias PTK6;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000006065ENSMMUP00000007965ENSMMUT00000008477
OrganismMacaca mulatta
Functional Description
Protein Length362
Protein Sequence
(FASTA)
MVSRDQAHLG PKYVGLWDFK ARTDEELSFR AGDVFHVARK EEQWWWATLL DEAGGAVAQG 60
YVPHSYLAER ETVESEPWFF GCISRSEAVR LLQAEGNAAG TFLIRVSEKP GANYVLSVRD 120
AQAVRHYKIW WRAGGQLHLN EAVSFPSLSE LVNYHRAQSL SHGLRLAAPC RKHEPEPLPH 180
WDDWERPREE FTLCRKLGSG YFGEVFEGLW KDRVQVAIKV ISRDNLLHQQ TLQSEIQAMK 240
KLRHKHILAL YAVVSVGDPV YIITELMGKG SLLELLRDSD KKVLPVSELL DIAWQVAEGM 300
CYLESQNYIH RDLAARNILV GENTLCKVGD FGLARLIKED VYLSHDRNIP YKDGPEALSR 360
GH 362
Nucleotide Sequence
(FASTA)
ATGGTGTCCC GGGACCAGGC TCACCTGGGC CCCAAGTATG TGGGCCTCTG GGACTTCAAG 60
GCCCGGACGG ACGAGGAGCT GAGCTTCCGA GCGGGGGACG TCTTCCACGT GGCCAGGAAG 120
GAGGAGCAGT GGTGGTGGGC CACGCTGCTG GACGAGGCGG GTGGGGCCGT GGCCCAGGGC 180
TATGTGCCCC ACAGCTACCT GGCCGAGAGG GAGACCGTGG AGTCGGAACC GTGGTTCTTC 240
GGCTGCATCT CCCGCTCAGA AGCTGTGCGT CTGCTGCAGG CCGAGGGTAA CGCCGCCGGC 300
ACCTTCCTGA TCAGGGTCAG CGAGAAGCCA GGCGCCAACT ACGTCCTGTC GGTGCGGGAC 360
GCGCAGGCTG TGCGGCACTA CAAGATCTGG TGGCGAGCCG GGGGCCAGCT GCACCTGAAC 420
GAGGCGGTGT CCTTCCCCAG CCTGTCCGAG CTTGTGAACT ACCACAGGGC CCAGAGCCTG 480
TCCCACGGCC TGCGGCTGGC CGCGCCCTGC CGGAAGCATG AGCCTGAGCC TCTGCCCCAC 540
TGGGATGACT GGGAGAGGCC GAGGGAGGAG TTCACGCTCT GCAGGAAGCT GGGGTCTGGC 600
TACTTTGGGG AGGTCTTCGA GGGGCTCTGG AAAGACCGGG TCCAGGTGGC CATTAAGGTG 660
ATTTCTCGAG ACAACCTCCT GCACCAGCAG ACGCTGCAGT CGGAGATCCA GGCCATGAAG 720
AAGCTGCGGC ACAAACACAT CCTGGCACTG TACGCCGTGG TGTCCGTGGG GGACCCTGTG 780
TACATCATCA CGGAGCTCAT GGGCAAGGGC AGCCTGCTGG AGCTGCTTCG TGATTCTGAC 840
AAGAAAGTCC TGCCCGTTTC GGAGCTGCTG GACATCGCCT GGCAGGTGGC TGAGGGCATG 900
TGTTACCTGG AGTCTCAGAA TTACATCCAC CGGGACCTGG CCGCCAGGAA CATCCTTGTC 960
GGGGAAAACA CTCTCTGCAA AGTTGGGGAC TTTGGGCTAG CCAGGCTCAT CAAGGAGGAC 1020
GTCTACCTCT CCCATGACCG TAACATCCCC TACAAGGACG GCCCCGAAGC ACTCTCCCGA 1080
GGCCAT 1086
Domain Profile
S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegt.lspeafleeaqilkklrheklvkly  60
         +l++klG+G+fGev++g+wk++v+va+k++++++ l+++++++e+q++kklrh+++++ly
Q: 192   TLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNlLHQQTLQSEIQAMKKLRHKHILALY  251
         799******************************9789999********************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvs ++P+yi+telm kGsll++l+++++k l++++l+d+a+qvaeGm+yle++n+ihr
Q: 252   AVVSVGDPVYIITELMGKGSLLELLRDSDKKVLPVSELLDIAWQVAEGMCYLESQNYIHR  311
         ************************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaikl  171
         dlaarn+lvge++++kv+dfGlarli++d y +++  ++P+k   Pea++ 
Q: 312   DLAARNILVGENTLCKVGDFGLARLIKEDVYLSHD-RNIPYK-DGPEALSR  360
         *******************************9876.99***9.57999876
Domain Sequence
(FASTA)
TLCRKLGSGY FGEVFEGLWK DRVQVAIKVI SRDNLLHQQT LQSEIQAMKK LRHKHILALY 60
AVVSVGDPVY IITELMGKGS LLELLRDSDK KVLPVSELLD IAWQVAEGMC YLESQNYIHR 120
DLAARNILVG ENTLCKVGDF GLARLIKEDV YLSHDRNIPY KDGPEALSR 169
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>
EKS-AIM-00349
EKS-ANC-00363
EKS-BOT-00375
EKS-CAJ-00379
EKS-CAP-00407
EKS-EQC-00366
EKS-ERE-00055
EKS-FEC-00362
EKS-GOG-00364
EKS-HOS-00381
EKS-ICT-00355
EKS-LOA-00382
EKS-MAE-00042
EKS-MOD-00364
EKS-MUM-00407
EKS-MUP-00369
EKS-MYL-00371
EKS-NOL-00342
EKS-ORA-00325
EKS-PES-00332
EKS-POA-00364
EKS-PRC-00072
EKS-PTV-00096
EKS-RAN-00389
EKS-SAH-00345
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0001726; C:ruffle
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0016477; P:cell migration
GO:0071300; P:cellular response to retinoic acid
GO:0060575; P:intestinal epithelial cell differentiation
GO:0045926; P:negative regulation of growth
GO:0061099; P:negative regulation of protein tyrosine kinase activity
GO:0010976; P:positive regulation of neuron projection development
GO:0046777; P:protein autophosphorylation
GO:0042503; P:tyrosine phosphorylation of Stat3 protein
GO:0042506; P:tyrosine phosphorylation of Stat5 protein
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013