EKS-MAM-00372

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00372

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	384.3	4.3E-115	231	479	249

Status

Unreviewed

Ensembl Protein

ENSMMUP00000007969

UniProt Accession

F6W367;

Protein Name

Protein Synonyms/Alias

Gene Name

SRMS

Gene Synonyms/Alias

SRMS;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000006067	ENSMMUP00000007969	ENSMMUT00000008481

Organism

Macaca mulatta

Functional Description

Protein Length

488

Protein Sequence
(FASTA)

MEPFLRRRLA FLSFFWDKIW PAGGEPDHGT PGSTDPGADP VPALPAEPCS PFPQLFLALY 60

DFAARRGEEL SVRRGDRLCA LEEGGGFIFA RRLSGQPSAG LVPITHVAKA SPETLSDQPW 120

YFSGVSRTQA QQLLLSPPNA PGAFLIRPSE SSLGGYSLSV RAQAKVCHYR VSMAADGSLY 180

LQKGRLFPGL EELLTYYKAN WKLIQNPLLQ PCVRQKAPRQ DAWERPHSEF ALGRKLGEGY 240

FGEVWEGLWL GSLPVAIKVI KSADMKLADL AKEIQTLKGL RHERLIRLHA VCSGGEPVYI 300

VTELMRKGNL QVFLGSPEGR ALRLPPLLGF ACQVAEGMNY LEGQRIVHRD LAARNVLVDD 360

GLACKVADFG LARLLKDDIY SPSSGSKIPV KWTAPEAASY RVFSQKSDVW SFGVLLYEVF 420

TYGQCPYEGM TNHETLQQIM RGYRLPRPAA CPAEVYVLML ECWRSSPEER PSFATLWEKL 480

HAIHRCLP 488

Nucleotide Sequence
(FASTA)

ATGGAGCCCT TCCTCAGGAG GCGGCTGGCC TTCCTGTCCT TCTTCTGGGA CAAGATCTGG 60

CCTGCGGGCG GCGAGCCGGA CCACGGCACC CCCGGGTCCA CGGACCCCGG CGCCGACCCA 120

GTGCCCGCGC TCCCCGCGGA GCCCTGCAGC CCCTTCCCGC AGCTCTTCCT TGCGCTCTAC 180

GACTTCGCGG CGCGGCGCGG GGAGGAGCTG AGTGTCCGCC GCGGGGACAG GCTCTGCGCC 240

CTCGAGGAGG GGGGCGGCTT CATCTTCGCG CGCAGGCTCT CGGGCCAGCC CAGCGCCGGG 300

CTCGTGCCCA TCACTCATGT GGCCAAGGCT TCTCCCGAGA CGCTCTCAGA CCAACCCTGG 360

TACTTCAGTG GAGTCAGCCG GACCCAGGCA CAGCAGCTGC TCCTCTCCCC ACCCAACGCA 420

CCGGGAGCCT TCCTCATCCG GCCCAGCGAG AGCAGCCTCG GGGGCTACTC ACTGTCAGTC 480

CGGGCCCAGG CCAAGGTCTG CCACTACCGG GTCTCCATGG CAGCCGATGG CAGCCTCTAC 540

CTGCAGAAGG GACGGCTCTT TCCTGGCCTG GAGGAGCTGC TCACCTACTA CAAGGCCAAC 600

TGGAAGCTGA TCCAGAACCC CCTGCTGCAG CCCTGCGTGC GTCAGAAGGC CCCGCGGCAG 660

GATGCGTGGG AGCGACCACA CTCCGAATTT GCCCTTGGGA GGAAGCTGGG TGAAGGCTAC 720

TTTGGGGAGG TGTGGGAAGG CCTGTGGCTG GGCTCCCTGC CCGTGGCGAT CAAGGTCATC 780

AAGTCAGCCG ACATGAAGCT CGCTGACCTC GCCAAGGAGA TCCAGACGCT GAAGGGCCTG 840

CGGCACGAGC GGCTCATCCG GCTGCACGCA GTGTGCTCGG GCGGGGAGCC TGTGTATATC 900

GTCACGGAGC TCATGCGCAA GGGAAACCTG CAGGTCTTCC TGGGCAGCCC CGAGGGCCGG 960

GCCCTGCGTC TGCCGCCGCT CCTGGGCTTT GCCTGCCAGG TGGCTGAGGG CATGAACTAC 1020

CTGGAGGGGC AGCGCATTGT GCATCGGGAC TTGGCCGCCA GGAACGTGCT TGTGGACGAT 1080

GGCCTGGCTT GCAAGGTGGC TGACTTTGGC CTGGCCCGGC TGCTCAAGGA CGACATCTAC 1140

TCCCCGAGCA GCGGCTCCAA GATCCCGGTG AAGTGGACAG CACCTGAGGC GGCCAGTTAT 1200

CGTGTCTTCT CCCAGAAGTC GGACGTCTGG TCCTTCGGTG TCCTGCTGTA TGAGGTTTTC 1260

ACCTATGGCC AGTGTCCCTA CGAAGGCATG ACCAACCACG AGACGCTGCA GCAGATCATG 1320

CGAGGGTACC GGCTGCCGCG CCCGGCTGCC TGCCCGGCAG AGGTCTACGT GCTCATGCTG 1380

GAGTGCTGGA GAAGCAGCCC CGAGGAACGG CCCTCCTTCG CCACGCTGTG GGAGAAGCTG 1440

CACGCCATCC ACAGATGCCT TCCC 1464

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61

          l +klGeG+fGevw+g+w gs++va+k++k+++++ +++ +e+q+lk lrhe+l++l+a

Q: 231   ALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSADMKLADLAKEIQTLKGLRHERLIRLHA  290

         5789********************************************************

S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121

         v+s +eP+yivtelm+kG+l+ fl + eg++l+lp l+ +a+qvaeGm+yle ++++hrd

Q: 291   VCSGGEPVYIVTELMRKGNLQVFLGSPEGRALRLPPLLGFACQVAEGMNYLEGQRIVHRD  350

         ************************************************************

S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181

         laarnvlv++ l++kvadfGlarl++dd+y++++g+k+P+kWtaPea+++++f++ksdvW

Q: 351   LAARNVLVDDGLACKVADFGLARLLKDDIYSPSSGSKIPVKWTAPEAASYRVFSQKSDVW  410

         ************************************************************

S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241

         sfG+ll+e++t+G++Py+Gmtn+e+l+q+ rgyrlprp++cp+e+y l+lecw+++peer

Q: 411   SFGVLLYEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEER  470

         ************************************************************

S: 242   Ptfetlqev  250

         P+f tl e+

Q: 471   PSFATLWEK  479

         *****9876

Domain Sequence
(FASTA)

ALGRKLGEGY FGEVWEGLWL GSLPVAIKVI KSADMKLADL AKEIQTLKGL RHERLIRLHA 60

VCSGGEPVYI VTELMRKGNL QVFLGSPEGR ALRLPPLLGF ACQVAEGMNY LEGQRIVHRD 120

LAARNVLVDD GLACKVADFG LARLLKDDIY SPSSGSKIPV KWTAPEAASY RVFSQKSDVW 180

SFGVLLYEVF TYGQCPYEGM TNHETLQQIM RGYRLPRPAA CPAEVYVLML ECWRSSPEER 240

PSFATLWEK 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013