EKS-MAM-00389
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00389
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11349.03.6E-10411791437259
StatusUnreviewed
Ensembl ProteinENSMMUP00000008078
UniProt AccessionF6PR50;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K4
Gene Synonyms/Alias MAP3K4; EGK_15488;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000006143ENSMMUP00000008076ENSMMUT00000008591
ENSMMUG00000006143ENSMMUP00000008078ENSMMUT00000008593
OrganismMacaca mulatta
Functional Description
Protein Length1444
Protein Sequence
(FASTA)
EKMNAPNQPP HKDTGKTVEN VEEYSYKQEK KIRAALRTTE RDHKKNVQCS FMLDSVGGSL 60
PKKSIPDVDL NKPYLSLGCS NAKLPVSVPM PIARPARQTS RTDCPADRLK FFETLRLLLK 120
LTSVSKKKDR EQRGQENTSG FWLNRSNELI WLELQAWHAG RTINDQDFFL YTARQAIPDI 180
INEILTFKVN YGSFAFVRDG AGFNGTSVEG QCKATPGTKT VGYSTHHEHL QRQRVSFEQV 240
KRIMELLEYI EALYPSLQAL QKDYEKYAAK DFQDRVQALC LWLNITKDLN QKLRIMGTVL 300
GIKNLSDIGW PVFEIPSPRP SKGNEPEYEG DDTEGELKEL ESSTDESEEE QISDPGVPEI 360
RQPADNSFDI RSQDCISKKL ERLESEDDSI GWGAPDCSAE AGFSRHCLTS IYRPFVDKAL 420
KQMGLRKLIL RLHKLMDGSL QRARVALVKN DRPVEFSEFP DPMWGSDYVQ LSRTPPSSEQ 480
KCSAVSWEEL KAMDLPSFEP AFLVLCRVLL NVIHECLKLR LEQRPAGEPS LLSIKQLVRE 540
CKEVLKGGLL MKQYYQFMLQ EVLEDLEKPD CNIDAFEEDL HKMLMVYFDY MRSWIQMLQQ 600
LPQASHSLKN LLEEEWNFTK EITHYIRGGE AQAGKLFCDI AGMLLKSTGS FLEFGLQESC 660
AEFWTSADDS SASDEIRRSV IEISRALKEL FHEARERASK ALGFAKMLRK DLEIAAEFRL 720
SAPVRDLLDV LKLKQYVKVQ IPGLENLQVF VPDTLAEEKS IILQLLNAAA GKDCSKDSDD 780
VLFDAYLLLT KHSDRARDSE DSWGTWEAQP VKVVPQVETV DTLRSMQVDN LLLVVMQSAH 840
LTIQRKAFQQ SIEGLMTLCQ EQTSSQPVIA KALQQLKNDA LELCNRISNA IDRVDHMFTS 900
EFDAEVDESE SVTLQQYYRE AMIQGYNFGF EYHKEVVRLM SGEFRQKIGD KYISFARKWM 960
NYVLTKCESG RGTRPRWATQ GFDFLQAIEP AFISALPEDD FLSLQALMNE CIGHVIGKPH 1020
SPVTGLYLAI HRNSPRPMKV PRCHSDPPNP HLIIPTPEGF RGSSVPENDR LASIAAELQF 1080
RSLSRHSSPT EERDEPAYPR GDSSGSTRRS WELRTLISQS KDTASKLGPI EAIQKSVRLF 1140
EEKRYREMRR KNIIGQVCDT PKSYDNVMHV GLRKVTFKWQ RGNKIGEGQY GKVYTCISVD 1200
TGELMAMKEI RFQPNDHKTI KETADELKIF EGIKHPNLVR YFGVELHREE MYIFMEYCDE 1260
GTLEEVSRLG LQEHVIRLYS KQITIAINVL HEHGIVHRDI KGANIFLTSS GLIKLGDFGC 1320
SVKLKNNAQT MPGEVNSTLG TAAYMAPEVI TRAKGEGHGR AADIWSLGCV VIEMVTGKRP 1380
WHEYEHNFQI MYKVGMGHKP PIPERLSPEG KDFLSHCLES DPKMRWTASQ LLDHSFVKVC 1440
TDEE 1444
Nucleotide Sequence
(FASTA)
GAAAAAATGA ATGCACCAAA TCAGCCTCCA CATAAAGACA CTGGAAAAAC AGTGGAGAAT 60
GTGGAAGAAT ACAGCTATAA GCAGGAGAAA AAGATCCGAG CAGCTCTTAG AACAACAGAG 120
CGTGATCATA AAAAAAACGT ACAGTGCTCA TTCATGTTAG ACTCAGTGGG TGGATCTTTG 180
CCAAAAAAAT CAATTCCAGA TGTGGATCTC AATAAGCCTT ACCTCAGCCT TGGCTGTAGC 240
AACGCTAAGC TTCCAGTATC TGTGCCCATG CCTATAGCCA GACCTGCACG CCAGACTTCT 300
AGGACTGACT GTCCAGCAGA TCGTTTAAAG TTTTTTGAAA CATTACGACT TTTGCTAAAG 360
CTTACCTCAG TCTCAAAGAA GAAAGACAGG GAGCAAAGAG GACAAGAAAA TACATCTGGT 420
TTCTGGCTTA ACCGATCTAA CGAACTGATC TGGTTAGAGC TACAAGCCTG GCATGCAGGA 480
CGGACAATTA ATGACCAGGA CTTCTTTTTA TATACAGCCC GTCAAGCCAT CCCAGATATT 540
ATCAATGAAA TCCTTACTTT CAAAGTCAAC TATGGGAGCT TCGCCTTTGT TAGAGATGGA 600
GCTGGTTTTA ATGGTACTTC AGTAGAAGGG CAGTGCAAAG CCACTCCTGG AACAAAGACT 660
GTAGGTTACT CAACACATCA CGAGCATCTC CAACGCCAGA GGGTCTCATT TGAGCAGGTA 720
AAACGGATAA TGGAGCTGCT AGAGTACATA GAAGCACTTT ATCCATCATT GCAGGCGCTT 780
CAGAAGGACT ACGAAAAATA TGCTGCAAAA GACTTCCAGG ACAGGGTGCA GGCACTCTGT 840
TTGTGGTTAA ACATCACAAA AGACTTAAAT CAGAAATTAA GGATTATGGG CACTGTTTTG 900
GGCATCAAGA ATTTATCAGA CATTGGCTGG CCAGTGTTTG AAATCCCTTC CCCTCGACCA 960
TCCAAAGGTA ATGAGCCGGA GTATGAGGGT GATGACACAG AAGGAGAGTT GAAGGAGTTG 1020
GAAAGTAGTA CGGATGAGAG TGAGGAAGAA CAAATCTCTG ATCCTGGGGT ACCGGAAATC 1080
AGACAGCCCG CAGACAACAG CTTCGACATC CGGTCGCAGG ACTGCATATC CAAGAAGCTT 1140
GAGAGGCTGG AGTCTGAGGA TGATTCTATT GGCTGGGGAG CACCAGACTG CAGCGCAGAA 1200
GCAGGCTTTA GTAGACATTG TCTGACTTCT ATTTATAGAC CATTTGTAGA CAAAGCACTG 1260
AAGCAGATGG GGTTAAGAAA GTTAATTTTA AGACTTCACA AGCTAATGGA TGGTTCCTTG 1320
CAAAGGGCAC GTGTAGCATT GGTAAAGAAC GATCGTCCAG TGGAGTTTTC TGAATTTCCA 1380
GATCCCATGT GGGGTTCAGA TTATGTGCAG TTGTCAAGGA CACCGCCTTC ATCTGAGCAG 1440
AAATGCAGCG CTGTGTCGTG GGAGGAGCTG AAGGCCATGG ATTTACCTTC ATTCGAACCT 1500
GCCTTCCTAG TTCTCTGCCG AGTCCTTCTG AATGTCATCC ATGAGTGTCT GAAGTTAAGA 1560
CTGGAGCAAA GACCTGCTGG AGAACCATCT CTCTTGAGTA TTAAGCAGCT GGTGAGAGAG 1620
TGTAAGGAGG TCCTGAAGGG AGGCCTGCTG ATGAAGCAGT ACTACCAGTT CATGCTGCAG 1680
GAGGTTCTGG AGGACTTGGA GAAGCCCGAC TGCAACATTG ACGCTTTTGA AGAGGATCTG 1740
CATAAAATGC TTATGGTGTA TTTTGATTAC ATGAGAAGCT GGATCCAAAT GCTACAGCAA 1800
TTACCTCAAG CATCCCATAG TTTAAAAAAT CTGTTAGAAG AAGAATGGAA TTTCACCAAA 1860
GAAATAACTC ATTACATACG GGGAGGAGAA GCACAGGCCG GGAAGCTTTT CTGTGACATT 1920
GCAGGAATGC TGCTGAAGTC TACAGGAAGT TTTTTAGAAT TTGGCTTACA GGAGAGCTGT 1980
GCCGAATTTT GGACTAGTGC GGATGATAGC AGTGCTTCCG ACGAAATCAG GAGGTCTGTT 2040
ATAGAGATCA GCCGAGCCCT GAAGGAGCTC TTCCATGAAG CCAGAGAAAG GGCCTCCAAA 2100
GCACTTGGAT TTGCTAAAAT GTTGAGAAAG GACCTGGAAA TAGCAGCAGA ATTCAGGCTT 2160
TCAGCCCCAG TTAGAGACCT CCTGGATGTT CTGAAATTAA AACAGTATGT CAAGGTACAA 2220
ATTCCTGGGT TAGAAAACTT GCAAGTGTTT GTTCCAGACA CTCTTGCTGA GGAGAAGAGT 2280
ATTATTTTGC AGTTACTCAA TGCAGCCGCA GGAAAGGACT GTTCAAAAGA TTCAGACGAC 2340
GTACTCTTCG ATGCCTATCT GCTTCTGACC AAGCACAGTG ATCGAGCCCG TGATTCAGAG 2400
GACAGCTGGG GCACGTGGGA GGCACAGCCT GTCAAAGTCG TGCCTCAGGT GGAGACTGTT 2460
GACACCCTGA GAAGCATGCA GGTGGATAAT CTTTTACTAG TTGTCATGCA GTCTGCCCAT 2520
CTCACAATTC AGAGAAAAGC TTTCCAGCAG TCCATTGAGG GACTTATGAC TCTGTGCCAG 2580
GAGCAGACAT CCAGTCAGCC GGTCATCGCC AAAGCTTTGC AGCAGCTGAA GAATGATGCA 2640
TTAGAGCTAT GCAACAGAAT AAGCAATGCC ATTGACCGCG TGGACCACAT GTTCACATCA 2700
GAATTCGATG CTGAAGTTGA TGAATCCGAA TCTGTCACCT TGCAACAGTA CTACCGAGAA 2760
GCAATGATTC AGGGGTACAA TTTTGGATTT GAGTATCATA AAGAAGTTGT TCGTTTGATG 2820
TCTGGGGAGT TTAGACAGAA GATAGGAGAC AAATATATAA GCTTTGCCCG GAAGTGGATG 2880
AATTATGTCC TGACTAAATG TGAGAGTGGT AGAGGTACAA GACCCAGGTG GGCGACTCAA 2940
GGATTTGATT TTCTACAAGC AATTGAACCT GCCTTTATTT CAGCTTTACC AGAAGATGAC 3000
TTCTTGAGTT TACAAGCCTT GATGAATGAA TGCATTGGCC ATGTCATAGG AAAACCACAC 3060
AGTCCTGTTA CAGGTTTGTA CCTTGCCATT CATCGGAACA GCCCCCGTCC TATGAAGGTA 3120
CCTCGATGCC ATAGTGACCC TCCTAACCCA CACCTCATTA TCCCCACTCC AGAGGGATTC 3180
AGGGGTTCCA GCGTCCCTGA AAATGATCGA TTGGCTTCCA TAGCTGCTGA ATTGCAGTTT 3240
AGGTCCCTGA GTCGTCACTC AAGCCCCACG GAGGAACGAG ACGAACCAGC ATATCCAAGA 3300
GGAGATTCAA GTGGGTCCAC CAGAAGAAGT TGGGAACTTC GGACACTAAT CAGCCAGAGT 3360
AAAGATACTG CTTCTAAACT AGGACCCATA GAAGCTATCC AGAAGTCAGT CCGATTGTTC 3420
GAAGAAAAGA GGTACCGAGA AATGAGGAGA AAGAATATCA TTGGTCAAGT TTGTGATACG 3480
CCTAAGTCCT ATGATAACGT CATGCATGTT GGCTTGAGGA AGGTGACCTT CAAGTGGCAA 3540
AGAGGAAACA AAATCGGGGA AGGCCAGTAC GGGAAGGTGT ACACCTGCAT CAGCGTCGAC 3600
ACCGGGGAGC TGATGGCCAT GAAGGAGATT CGATTTCAAC CTAATGACCA TAAGACTATC 3660
AAGGAAACTG CAGATGAATT GAAAATATTC GAAGGCATCA AACACCCCAA TCTGGTTCGG 3720
TATTTTGGTG TGGAGCTTCA TAGAGAAGAA ATGTACATCT TCATGGAGTA CTGCGATGAG 3780
GGGACATTAG AAGAGGTGTC AAGGCTGGGA CTTCAGGAAC ATGTGATTAG GCTGTATTCA 3840
AAGCAGATCA CCATTGCGAT CAATGTCCTC CATGAGCATG GCATAGTCCA CCGTGACATT 3900
AAAGGTGCCA ATATCTTCCT TACCTCATCT GGATTAATCA AACTGGGAGA TTTTGGATGC 3960
TCAGTAAAGC TCAAAAACAA TGCCCAGACC ATGCCTGGTG AAGTGAACAG CACCCTGGGG 4020
ACAGCAGCAT ACATGGCACC TGAAGTCATC ACTCGCGCCA AAGGAGAAGG CCATGGGCGT 4080
GCGGCCGACA TCTGGAGTCT GGGGTGTGTT GTCATAGAGA TGGTGACTGG CAAGAGGCCT 4140
TGGCATGAGT ATGAGCACAA CTTTCAAATT ATGTATAAAG TGGGGATGGG ACATAAGCCA 4200
CCAATCCCTG AAAGATTAAG CCCTGAAGGC AAGGACTTCC TTTCTCACTG CCTTGAGAGT 4260
GACCCAAAGA TGAGATGGAC CGCCAGCCAG CTCCTCGACC ATTCGTTTGT CAAGGTTTGC 4320
ACAGATGAAG AATGA 4335
Domain Profile
S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60
         wq+++ ig+G++g+vy++++vdtgel+a+Ke++++p++++   ++k+ ++E+k+++ +kH
Q: 1179  WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHK---TIKETADELKIFEGIKH  1235
         99********************************999876...799**************
S: 61    enivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHek  120
         +n+v+y+Gve ++ee++if+Ey+++G+l+++ +    l+e+vi+ y+kqi  ++++LHe+
Q: 1236  PNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITIAINVLHEH  1293
         *******************************884..7***********************
S: 121   kivHRDiKgaNilldssgvvklsDFGaskrlaelntka.aelesltGtlaymaPEvikk.  178
         +ivHRDiKgaNi+l+ssg++kl+DFG+s +l+++++++ +e++s+ Gt+aymaPEvi++ 
Q: 1294  GIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMpGEVNSTLGTAAYMAPEVITRa  1353
         *******************************9988776256*****************98
S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238
         k +g+gr+aDiWslgcvviem+tgkrP++e++++++im+kvg+ + kP+ipe+ls+egkd
Q: 1354  KGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-KPPIPERLSPEGKD  1412
         899******************************************.**************
S: 239   flekcleldpkkrpsaeeLLkhefl  263
         fl++cle+dpk r++a++LL+h+f+
Q: 1413  FLSHCLESDPKMRWTASQLLDHSFV  1437
         ***********************96
Domain Sequence
(FASTA)
WQRGNKIGEG QYGKVYTCIS VDTGELMAMK EIRFQPNDHK TIKETADELK IFEGIKHPNL 60
VRYFGVELHR EEMYIFMEYC DEGTLEEVSR LGLQEHVIRL YSKQITIAIN VLHEHGIVHR 120
DIKGANIFLT SSGLIKLGDF GCSVKLKNNA QTMPGEVNST LGTAAYMAPE VITRAKGEGH 180
GRAADIWSLG CVVIEMVTGK RPWHEYEHNF QIMYKVGMGH KPPIPERLSP EGKDFLSHCL 240
ESDPKMRWTA SQLLDHSFV 259
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00363
EKS-ANC-00381
EKS-BOT-00390
EKS-CAE-00317
EKS-CAJ-00393
EKS-CAF-00392
EKS-CAP-00421
EKS-CII-00218
EKS-CIS-00140
EKS-DAR-00773
EKS-DRM-00183
EKS-EQC-00383
EKS-FEC-00378
EKS-GAG-00330
EKS-GAA-00478
EKS-GOG-00381
EKS-HOS-00397
EKS-ICT-00369
EKS-LAC-00406
EKS-LOA-00402
EKS-MEG-00323
EKS-MOD-00379
EKS-MUM-00423
EKS-MUP-00385
EKS-MYL-00388
EKS-ORN-00502
EKS-ORA-00341
EKS-ORC-00367
EKS-ORL-00462
EKS-OTG-00393
EKS-PES-00348
EKS-PEM-00210
EKS-POA-00381
EKS-RAN-00405
EKS-SAH-00360
EKS-SUS-00341
EKS-TAG-00462
EKS-TAR-00499
EKS-TEN-00495
EKS-XIM-00492
EKS-SAC-00002
EKS-SCP-00002
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
GO:0019100; P:male germ-line sex determination
GO:0043507; P:positive regulation of JUN kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013