EKS-MAM-00278

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00278

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	456.4	6.6E-137	207	494	288

Status

Unreviewed

Ensembl Protein

ENSMMUP00000008149

UniProt Accession

F7HNS7;

Protein Name

Protein Synonyms/Alias

Activin receptor type-1B isoform a;

Gene Name

ACVR1B

Gene Synonyms/Alias

ACVR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000006200	ENSMMUP00000008149	ENSMMUT00000008672

Organism

Macaca mulatta

Functional Description

Protein Length

505

Protein Sequence
(FASTA)

MAESARASSF FPLVVLLLAG SGGSGPRGIQ ALLCACTSCL QANYTCETDG ACMVSIFNLD 60

GMEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYTDY CNRIDLRVPS GHLKEPEHPS 120

MWGPVELVGI IAGPVFLLFL IIIIVFLVIN YHQRVYHNRQ RLDMEDPSCE MCLSKDKTLQ 180

DLVYDLSTSG SGSGLPLFVQ RTVARTIVLQ EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE 240

ERSWFREAEI YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT 300

IEGMIKLALS AASGLAHLHM EIVGTQGKPG IAHRDLKSKN ILVKKNGMCA IADLGLAVRH 360

DAVTDTIDIA PNQRVGTKRY MAPEVLDETI NMKHFDSFKC ADIYALGLVY WEIARRCNSG 420

GVHEEYQLPY YDLVPSDPSI EEMRKVVCDQ KLRPNIPNWW QSYEALRVMG KMMRECWYAN 480

GAARLTALRI KKTLSQLSVQ EDVKI 505

Nucleotide Sequence
(FASTA)

ATGGCGGAGT CGGCCAGAGC CTCCTCCTTC TTCCCCCTTG TTGTCCTCCT GCTCGCCGGC 60

AGCGGCGGGT CCGGGCCCCG GGGAATCCAG GCTCTGCTGT GTGCGTGCAC CAGCTGCCTC 120

CAGGCCAACT ACACGTGTGA GACAGATGGG GCCTGCATGG TTTCCATTTT CAACCTGGAT 180

GGGATGGAGC ACCATGTGCG CACCTGCATC CCCAAAGTGG AGCTGGTCCC TGCCGGGAAG 240

CCCTTCTACT GCCTGAGCTC AGAGGACCTG CGCAACACCC ACTGCTGCTA CACTGACTAC 300

TGCAACAGGA TCGACTTGAG GGTGCCCAGT GGTCACCTCA AGGAGCCTGA GCACCCGTCC 360

ATGTGGGGCC CAGTGGAGCT GGTAGGCATC ATCGCCGGCC CGGTGTTCCT CCTGTTCCTC 420

ATCATCATCA TTGTTTTCCT TGTCATTAAC TATCATCAGC GTGTCTATCA CAACCGCCAG 480

AGACTGGACA TGGAAGATCC CTCATGTGAG ATGTGTCTCT CCAAAGACAA GACGCTCCAG 540

GATCTTGTCT ACGATCTCTC CACCTCAGGG TCTGGCTCAG GGTTACCTCT CTTTGTCCAG 600

CGCACAGTGG CCCGAACCAT CGTTTTACAA GAGATTATTG GCAAGGGTCG GTTTGGGGAA 660

GTATGGCGCG GCCGCTGGAG GGGTGGTGAT GTGGCTGTGA AAATATTCTC TTCTCGTGAA 720

GAACGGTCTT GGTTCCGGGA AGCGGAGATA TACCAGACGG TCATGCTGCG CCATGAAAAC 780

ATCCTTGGAT TTATTGCCGC TGACAATAAA GATAATGGCA CCTGGACACA GCTGTGGCTC 840

GTTTCTGACT ATCATGAGCA CGGGTCCCTG TTTGATTATC TGAACCGGTA CACAGTGACA 900

ATTGAGGGGA TGATTAAGCT GGCCTTGTCT GCTGCTAGTG GGCTGGCACA CCTGCACATG 960

GAGATTGTGG GCACCCAAGG GAAGCCTGGA ATTGCTCATC GAGACTTAAA GTCAAAGAAC 1020

ATTCTGGTGA AGAAAAATGG CATGTGTGCC ATAGCAGACC TGGGCCTGGC TGTCCGTCAC 1080

GATGCAGTCA CTGACACCAT CGACATTGCC CCAAATCAGA GGGTGGGGAC CAAACGATAT 1140

ATGGCCCCTG AAGTACTTGA TGAAACCATT AATATGAAAC ACTTTGACTC CTTTAAATGT 1200

GCTGATATTT ATGCCCTCGG GCTTGTATAT TGGGAGATTG CTCGAAGATG CAATTCTGGA 1260

GGAGTCCATG AAGAATATCA GCTGCCATAT TACGACTTAG TGCCCTCTGA CCCTTCCATT 1320

GAGGAAATGC GAAAGGTCGT ATGTGATCAG AAGCTGCGTC CCAACATCCC CAACTGGTGG 1380

CAGAGTTATG AGGCGCTGCG GGTGATGGGG AAGATGATGC GAGAGTGTTG GTATGCCAAC 1440

GGCGCGGCCC GCCTGACGGC CCTGCGCATC AAGAAGACAC TCTCCCAGCT CAGCGTGCAG 1500

GAAGACGTGA AGATCTAA 1518

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++++rg +vAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 207   IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  266

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t+++e +++lals+asGlahLH+eivgt+

Q: 267   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQ  326

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk+++c+iaDlGLa+++++ ++++d+a n++vGtkRYmaPE

Q: 327   G--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPE  384

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem

Q: 385   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNS-GGVHEEYQLPYYDLVPSDPSIEEM  443

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP+ip+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 444   RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL  494

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGRW RGGDVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTIEGMIK LALSAASGLA HLHMEIVGTQ 120

GKPGIAHRDL KSKNILVKKN GMCAIADLGL AVRHDAVTDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CNSGGVHEEY QLPYYDLVPS DPSIEEMRKV 240

VCDQKLRPNI PNWWQSYEAL RVMGKMMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005887	; C:integral to plasma membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0001942	; P:hair follicle development
GO:0001701	; P:in utero embryonic development
GO:0006917	; P:induction of apoptosis
GO:0030308	; P:negative regulation of cell growth
GO:0038092	; P:nodal signaling pathway
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:0046777	; P:protein autophosphorylation
GO:0006355	; P:regulation of transcription, DNA-dependent

KEGG

mcc:696587

;

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013