EKS-MAM-00381

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00381

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	315.1	6.3E-94	36	283	248

Status

Unreviewed

Ensembl Protein

ENSMMUP00000033340

UniProt Accession

F7H6S1;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase kinase 7 isoform B;

Gene Name

MAP3K7

Gene Synonyms/Alias

MAP3K7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000006512	ENSMMUP00000008581	ENSMMUT00000009134
ENSMMUG00000006512	ENSMMUP00000008580	ENSMMUT00000009133
ENSMMUG00000006512	ENSMMUP00000033340	ENSMMUT00000040272

Organism

Macaca mulatta

Functional Description

Protein Length

491

Protein Sequence
(FASTA)

MSTASAASSS SSSSAGEMIE APSQVLNFEE IDYKEIEVEE VVGRGAFGVV CKAKWRAKDV 60

AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV CLVMEYAEGG SLYNVLHGAE 120

PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK ALIHRDLKPP NLLLVAGGTV LKICDFGTAC 180

DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM 240

WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY FPGADEPLQY 300

PCQYSDEGQS NSATSTGSFM DIASTNTSNK SDTNMEQVPA TNDTIKRLES KLLKNQAKQQ 360

SESGRLSLGA SRGSSVESLP PTSEGKRMSA DMSEIEARIA ATTGNGQPRR RSIQDLTVTG 420

TEPGQVSSRS SSPSVRMITT SGPTSEKPTR SHPWTPDDST DTNGSDNSIP MAYLTLDHQL 480

QARTSCRTGP G 491

Nucleotide Sequence
(FASTA)

ATGTCTACAG CCTCTGCCGC CTCCTCCTCC TCCTCGTCTT CGGCCGGTGA GATGATCGAA 60

GCCCCTTCTC AAGTCCTCAA CTTTGAAGAG ATCGACTACA AGGAAATCGA GGTGGAAGAG 120

GTTGTTGGAA GAGGAGCCTT TGGAGTTGTT TGCAAAGCTA AGTGGAGAGC AAAAGATGTT 180

GCTATTAAAC AAATAGAAAG TGAATCTGAG AGGAAAGCCT TTATTGTAGA GCTTCGGCAG 240

TTATCCCGTG TGAACCATCC TAATATTGTA AAGCTTTATG GAGCCTGCTT GAATCCAGTG 300

TGTCTTGTGA TGGAATATGC TGAAGGGGGC TCTTTATATA ATGTGCTGCA TGGTGCTGAA 360

CCATTGCCAT ATTATACTGC TGCCCACGCA ATGAGTTGGT GTTTACAGTG TTCCCAAGGA 420

GTGGCTTATC TTCACAGCAT GCAACCCAAA GCGCTAATTC ACAGGGACCT GAAACCACCA 480

AACTTACTGC TGGTTGCAGG GGGGACAGTT CTGAAAATTT GTGATTTTGG TACAGCCTGT 540

GACATTCAGA CACACATGAC CAATAACAAG GGGAGTGCTG CTTGGATGGC ACCTGAAGTT 600

TTTGAAGGTA GTAATTACAG TGAAAAATGT GACGTCTTCA GCTGGGGTAT TATTCTTTGG 660

GAAGTGATAA CGCGTCGGAA ACCCTTTGAT GAGATTGGTG GCCCAGCTTT CCGAATCATG 720

TGGGCTGTTC ATAATGGTAC TCGACCACCA CTGATAAAAA ATTTACCTAA GCCCATTGAG 780

AGCCTGATGA CTCGTTGTTG GTCTAAAGAT CCTTCCCAGC GCCCTTCAAT GGAGGAAATT 840

GTGAAAATAA TGACTCACTT GATGCGGTAC TTTCCAGGAG CAGATGAGCC ATTACAGTAT 900

CCTTGTCAGT ATTCAGATGA AGGACAGAGC AACTCTGCCA CCAGTACAGG CTCATTCATG 960

GACATTGCTT CTACAAATAC GAGTAATAAA AGTGACACTA ATATGGAGCA AGTTCCTGCC 1020

ACAAATGATA CTATTAAGCG CTTAGAGTCA AAATTGTTGA AAAATCAGGC AAAGCAACAG 1080

AGTGAATCTG GACGTTTAAG CTTGGGAGCC TCCCGTGGGA GCAGTGTGGA GAGCTTGCCC 1140

CCAACCTCTG AGGGAAAGAG GATGAGTGCT GACATGTCTG AAATAGAAGC TAGGATCGCT 1200

GCAACCACAG GCAACGGACA GCCAAGACGT AGATCCATCC AAGACTTGAC TGTAACTGGA 1260

ACAGAACCTG GTCAGGTGAG CAGTAGGTCA TCCAGTCCCA GTGTCAGAAT GATTACTACC 1320

TCAGGACCAA CCTCAGAAAA GCCAACTCGA AGTCATCCAT GGACCCCTGA TGATTCCACA 1380

GATACCAATG GATCAGATAA CTCCATCCCA ATGGCTTATC TTACACTGGA TCACCAGCTA 1440

CAGGCAAGAA CTAGTTGCAG AACTGGACCA GGATGA 1476

Domain Profile

S: 1     ieleeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniie  60

         ie+ee++g+gafg v+kakwr+k+va+K++++e+e+    +++  e+++ls+++hpni++

Q: 36    IEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESER----KAFIVELRQLSRVNHPNIVK  91

         5789****************************9888....********************

S: 61    llGvcleepnlllvmeyveggsLsnvlhe.kskreidlevlvswalqiArGmaYLhseap  119

         l+G+cl++  ++lvmey+eggsL+nvlh+ +  + ++ ++++sw+lq+++G+aYLhs++p

Q: 92    LYGACLNP--VCLVMEYAEGGSLYNVLHGaEPLPYYTAAHAMSWCLQCSQGVAYLHSMQP  149

         *******9..89*****************778899*************************

S: 120   kkiihrdLksknvLlseekktlkicdFGtarelskstkmsaagtlawmaPEvlkeekvse  179

         k++ihrdLk++n+Ll +  ++lkicdFGta++++ +++++++g++awmaPEv++ +++se

Q: 150   KALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ-THMTNNKGSAAWMAPEVFEGSNYSE  208

         ********************************99.9************************

S: 180   ksDvwSygvvLWelltrevPykdlse..laiaykvalkglrlpipsscpeklkkLmkecw  237

         k+Dv+S+g++LWe++tr++P++++    ++i+++v ++g+r+p+++++p+++++Lm++cw

Q: 209   KCDVFSWGIILWEVITRRKPFDEIGGpaFRIMWAV-HNGTRPPLIKNLPKPIESLMTRCW  267

         **********************9987447889999.99**********************

S: 238   nedpekRpsfseivks  253

         ++dp++Rps++eivk+

Q: 268   SKDPSQRPSMEEIVKI  283

         *************986

Domain Sequence
(FASTA)

IEVEEVVGRG AFGVVCKAKW RAKDVAIKQI ESESERKAFI VELRQLSRVN HPNIVKLYGA 60

CLNPVCLVME YAEGGSLYNV LHGAEPLPYY TAAHAMSWCL QCSQGVAYLH SMQPKALIHR 120

DLKPPNLLLV AGGTVLKICD FGTACDIQTH MTNNKGSAAW MAPEVFEGSN YSEKCDVFSW 180

GIILWEVITR RKPFDEIGGP AFRIMWAVHN GTRPPLIKNL PKPIESLMTR CWSKDPSQRP 240

SMEEIVKI 248

Keyword

Complete proteome; Kinase; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005671	; C:Ada2/Gcn5/Ada3 transcription activator complex
GO:0008385	; C:IkappaB kinase complex
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004708	; F:MAP kinase kinase activity
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0007250	; P:activation of NF-kappaB-inducing kinase activity
GO:0001525	; P:angiogenesis
GO:0043966	; P:histone H3 acetylation
GO:0007252	; P:I-kappaB phosphorylation
GO:0007254	; P:JNK cascade
GO:0043066	; P:negative regulation of apoptotic process
GO:0001841	; P:neural tube formation
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032743	; P:positive regulation of interleukin-2 production
GO:0046330	; P:positive regulation of JNK cascade
GO:0043507	; P:positive regulation of JUN kinase activity
GO:0002726	; P:positive regulation of T cell cytokine production
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017421	; MAPKKK7.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013