EKS-MAM-00380
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00380
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK316.22.9E-94128363236
StatusUnreviewed
Ensembl ProteinENSMMUP00000008695
UniProt AccessionF7HKF1;
Protein Name
Protein Synonyms/Alias Mitogen-activated protein kinase kinase kinase 12; Mitogen-activated protein kinase kinase kinase 12 isoform 1;
Gene NameMAP3K12
Gene Synonyms/Alias MAP3K12; EGK_03714;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000006613ENSMMUP00000008695ENSMMUT00000009254
ENSMMUG00000006613ENSMMUP00000008693ENSMMUT00000009252
OrganismMacaca mulatta
Functional Description
Protein Length857
Protein Sequence
(FASTA)
MACLHETRTP SPSFGGFVST LSEASMRKLD PDTSDCTPEK DLTPTHVLQL HEQDAGGPGG 60
AAGSPESRAS RVRADEVRLQ CQSGSGFLEG LFGCLRPVWT MIGKAYSTEH KQQQEDLWEV 120
PFEEILDLQW VGSGAQGAVF LGRFHGEEVA VKKVRDLKET DIKHLRKLKH PNIITFKGVC 180
TQAPCYCILM EFCAQGQLYE VLRAGRPVTP SLLVDWSMGI AGGMNYLHLH KIIHRDLKSP 240
NMLITYDDVV KISDFGTSKE LSDKSTKMSF AGTVAWMAPE VIRNEPVSEK VDIWSFGVVL 300
WELLTGEIPY KDVDSSAIIW GVGSNSLHLP VPSSCPDGFK ILLRQCWNSK PRNRPSFRQI 360
LLHLDIASAD VLSTPQETYF KSQAEWREEV KLHFEKIKSE GTCLHRLEEE LVMRRREELR 420
HALDIREHYE RKLERANNLY MELNALMLQL ELKERELLRR EQALERRCPG LLKTHPSRGL 480
LHGNTMEKLI KKRNVPQKLS PHSKRPDILK TESLLPKLDA ALSGVGLPGC PKGPPSPGRS 540
RRGKTRHRKA SAKGSCGDLP GLRTAVPPNE PGGPGSLGGG PSAWEACPPA LRGLHHDLLL 600
RKMSSSSPDL LSAALGSRGR GATSGAGDPG SPPPARGDTP PSEGSAPGST SPDSPGGAKG 660
EPPPPVGPGE GVGLLGTGRE GTSGRGGSRA GSQHLTPAAL LYRAAVTRSQ KRGISSEEEE 720
GEVDSEVELT SSQRWPQSLN MRQSLSTFSS ENPSDGEEGT ASEPSPSGTP EVGSTNTDER 780
PDERSDDMCS QGSEIPLDPP PSEVIPSPEP SSLPIPHQEL LRGKQGPPNS EDSDCDSTEL 840
DNSSSVDALR PPASLPP 857
Nucleotide Sequence
(FASTA)
ATGGCTTGCC TCCATGAGAC CCGAACACCC TCTCCTTCCT TTGGGGGCTT CGTGTCTACC 60
CTAAGTGAGG CATCCATGCG CAAGCTGGAC CCAGACACTT CTGACTGCAC TCCCGAGAAG 120
GACCTGACGC CTACCCATGT CCTGCAGCTA CATGAGCAGG ATGCAGGGGG CCCAGGGGGC 180
GCAGCTGGGT CACCTGAGAG TCGGGCATCC AGAGTTCGAG CTGATGAGGT GCGACTGCAG 240
TGCCAGAGTG GCAGTGGCTT CCTTGAGGGC CTCTTTGGCT GCCTGCGCCC TGTCTGGACC 300
ATGATTGGCA AAGCCTACTC CACTGAGCAC AAGCAGCAGC AGGAAGACCT TTGGGAGGTC 360
CCCTTTGAGG AAATCCTGGA CCTGCAGTGG GTGGGCTCAG GGGCCCAGGG TGCTGTCTTC 420
CTGGGGCGCT TCCACGGGGA GGAGGTGGCT GTGAAGAAGG TGCGAGACCT CAAAGAAACC 480
GACATCAAGC ACTTGCGAAA GCTGAAGCAC CCCAACATCA TCACCTTCAA GGGTGTGTGT 540
ACCCAGGCTC CCTGCTACTG CATCCTCATG GAGTTCTGCG CCCAGGGCCA GCTATATGAG 600
GTACTGCGGG CCGGCCGCCC TGTCACCCCC TCCTTACTGG TTGACTGGTC CATGGGCATC 660
GCCGGTGGCA TGAACTACCT GCACCTACAC AAGATTATCC ACAGGGATCT CAAGTCACCC 720
AACATGCTAA TCACCTACGA CGATGTGGTG AAGATCTCAG ATTTTGGCAC TTCCAAGGAG 780
CTGAGTGACA AGAGCACCAA GATGTCCTTT GCAGGGACAG TAGCCTGGAT GGCCCCTGAG 840
GTGATCCGCA ATGAGCCTGT GTCTGAGAAG GTCGACATCT GGTCCTTCGG TGTGGTGCTG 900
TGGGAACTGC TGACTGGTGA GATCCCCTAC AAAGACGTAG ATTCCTCAGC CATCATCTGG 960
GGTGTGGGAA GCAACAGTCT CCATCTGCCC GTGCCCTCCA GTTGCCCAGA TGGTTTCAAG 1020
ATCCTACTTC GCCAGTGCTG GAATAGCAAA CCGCGAAATC GCCCATCATT CCGACAGATT 1080
CTGCTGCATC TGGACATTGC CTCAGCTGAT GTACTCTCCA CACCCCAGGA GACTTACTTT 1140
AAGTCCCAGG CAGAGTGGCG GGAAGAAGTA AAACTGCACT TTGAAAAGAT AAAGTCAGAA 1200
GGGACCTGTC TGCACCGCCT AGAAGAGGAA CTGGTGATGA GAAGGAGGGA GGAGCTCAGA 1260
CATGCCCTGG ACATCAGGGA GCACTATGAA AGGAAGCTGG AGAGAGCCAA CAACCTGTAT 1320
ATGGAACTTA ATGCCCTCAT GTTGCAGCTG GAACTCAAGG AGAGGGAGCT GCTCAGGCGA 1380
GAGCAAGCTT TAGAGCGGAG GTGCCCAGGC CTGCTGAAGA CACACCCTTC CCGGGGCCTC 1440
CTGCATGGAA ACACAATGGA GAAGCTTATC AAGAAGAGGA ATGTGCCACA GAAGCTGTCA 1500
CCCCATAGCA AAAGACCAGA TATCCTCAAG ACAGAGTCTT TGCTACCTAA ACTAGATGCA 1560
GCCCTAAGTG GGGTTGGGCT TCCTGGGTGT CCTAAGGGTC CCCCCTCACC AGGACGGAGT 1620
CGCCGTGGCA AGACCCGTCA CCGCAAGGCC AGCGCCAAGG GGAGCTGTGG GGACCTGCCT 1680
GGGCTTCGTA CAGCTGTGCC ACCCAATGAA CCTGGAGGAC CAGGAAGCCT AGGAGGGGGA 1740
CCCTCAGCCT GGGAGGCCTG CCCTCCTGCC CTCCGTGGGC TTCATCATGA CCTCCTGCTC 1800
CGCAAAATGT CTTCTTCATC CCCAGACCTG CTGTCAGCAG CACTAGGGTC CCGGGGCCGG 1860
GGGGCCACAA GCGGAGCTGG GGATCCTGGC TCACCACCTC CGGCCCGGGG TGACACCCCA 1920
CCAAGTGAGG GATCAGCCCC TGGCTCCACC AGCCCAGATT CACCTGGGGG AGCCAAAGGG 1980
GAGCCACCTC CTCCAGTAGG GCCTGGTGAA GGTGTGGGGC TTCTGGGAAC TGGAAGGGAA 2040
GGGACCTCGG GCCGGGGAGG AAGCCGGGCT GGGTCCCAGC ACTTGACCCC AGCTGCACTG 2100
CTGTACAGGG CTGCCGTCAC CCGAAGTCAG AAACGTGGCA TCTCATCAGA AGAGGAGGAA 2160
GGAGAGGTGG ACAGTGAAGT AGAGCTGACA TCAAGCCAGA GGTGGCCTCA GAGTCTGAAC 2220
ATGCGCCAGT CACTATCTAC CTTCAGCTCA GAGAATCCAT CAGATGGGGA GGAAGGCACA 2280
GCTAGTGAAC CTTCCCCCAG TGGCACACCT GAAGTCGGCA GCACCAACAC TGATGAGCGG 2340
CCAGATGAGC GGTCTGATGA CATGTGTTCC CAGGGCTCAG AAATCCCACT GGACCCACCT 2400
CCTTCAGAGG TCATCCCCAG CCCAGAACCC AGCTCCCTGC CCATTCCACA CCAGGAACTT 2460
CTCAGAGGAA AGCAGGGCCC TCCCAATTCT GAGGACTCAG ACTGTGACAG CACTGAATTG 2520
GACAACTCCA GCAGCGTTGA TGCCTTGCGG CCCCCAGCTT CCCTCCCTCC ATGA 2574
Domain Profile
S: 4     eeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellG  63
          +++gsga+g+v+ ++++++evavKk+r+ +e+         ++k+l+kl+hpnii+++G
Q: 128   LQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET---------DIKHLRKLKHPNIITFKG  178
         689**************************9999.........******************
S: 64    vcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkkii  123
         vc++ p+++++me++++g+L++vl++   r ++++ lv+w++ iA Gm+YLh +   kii
Q: 179   VCTQAPCYCILMEFCAQGQLYEVLRA--GRPVTPSLLVDWSMGIAGGMNYLHLH---KII  233
         **************************..99************************...9**
S: 124   hrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseksD  182
         hrdLks+n+L+ + ++++ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+D
Q: 234   HRDLKSPNMLI-TYDDVVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKVD  292
         ***********.99****************99****************************
S: 183   vwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedpe  242
         +wS+gvvLWellt+e+Pykd+++ ai+++v++++l+lp+psscp+ +k L+++cwn++p+
Q: 293   IWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPR  352
         ************************************************************
S: 243   kRpsfseivks  253
         +Rpsf++i+ +
Q: 353   NRPSFRQILLH  363
         ********876
Domain Sequence
(FASTA)
LQWVGSGAQG AVFLGRFHGE EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC 60
ILMEFCAQGQ LYEVLRAGRP VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD 120
DVVKISDFGT SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE 180
IPYKDVDSSA IIWGVGSNSL HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLH 236
KeywordComplete proteome; Kinase; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00355
EKS-ANC-00369
EKS-BOT-00381
EKS-CAE-00303
EKS-CAJ-00386
EKS-CAF-00381
EKS-CAP-00413
EKS-DAR-00760
EKS-DIO-00060
EKS-DRM-00177
EKS-EQC-00370
EKS-FEC-00368
EKS-GAG-00319
EKS-GAA-00464
EKS-GOG-00371
EKS-HOS-00388
EKS-ICT-00359
EKS-LAC-00398
EKS-LOA-00389
EKS-MEG-00311
EKS-MIM-00052
EKS-MOD-00369
EKS-MUM-00414
EKS-MUP-00373
EKS-MYL-00378
EKS-NOL-00348
EKS-OCP-00078
EKS-ORN-00489
EKS-ORA-00328
EKS-ORC-00358
EKS-ORL-00451
EKS-OTG-00383
EKS-PAT-00361
EKS-PES-00337
EKS-PEM-00201
EKS-POA-00371
EKS-PRC-00080
EKS-PTV-00100
EKS-RAN-00396
EKS-SAH-00348
EKS-SUS-00332
EKS-TAG-00449
EKS-TAR-00485
EKS-TEN-00482
EKS-VIP-00053
EKS-XET-00494
EKS-XIM-00478
Gene Ontology
GO:0033267; C:axon part
GO:0005829; C:cytosol
GO:0030426; C:growth cone
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0016572; P:histone phosphorylation
GO:0000165; P:MAPK cascade
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0046777; P:protein autophosphorylation
KEGG
mcc:703059;
InterPros
IPR011009; Kinase-like_dom.
IPR017419; MAP3K12_MAP3K13.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013