EKS-MAM-00281

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00281

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	452.4	1.1E-135	204	491	288

Status

Unreviewed

Ensembl Protein

ENSMMUP00000008818

UniProt Accession

G7MTF0;

Protein Name

Protein Synonyms/Alias

Putative uncharacterized protein;

Gene Name

BMPR1B

Gene Synonyms/Alias

EGK_15927;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000006702	ENSMMUP00000008818	ENSMMUT00000009385

Organism

Macaca mulatta

Functional Description

Protein Length

502

Protein Sequence
(FASTA)

MLLRSAGKLN VGTKKEDGES TAPTPRPKIL RCKCHHHCPE DSVNNICSTD GYCFTMIEED 60

DSGMPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKNRDFVD 120

GPIHHKALLI SVTVCSLLLV LIILFCYFRY KRQETRPRYS IGLEQDETYI PPGESLRDLI 180

EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS 240

WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDTKS 300

MLKLAYSSVS GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD 360

TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEV ARRCVSGGIV 420

EEYQLPYHDL VPSDPSYEDM REIVCIKKLR PSFPNRWSSD ECLRQMGKLM TECWAHNPAS 480

RLTALRVKKT LAKMSESQDI KL 502

Nucleotide Sequence
(FASTA)

ATGCTTTTGC GAAGTGCAGG AAAATTAAAC GTGGGCACCA AGAAAGAGGA TGGTGAGAGT 60

ACAGCCCCCA CCCCCCGTCC AAAGATCTTG CGTTGTAAAT GCCACCACCA TTGTCCAGAA 120

GACTCGGTCA ACAATATTTG CAGCACAGAC GGATATTGTT TCACGATGAT AGAAGAAGAT 180

GACTCTGGGA TGCCTGTCGT CACTTCTGGA TGCCTAGGAC TAGAAGGCTC GGATTTTCAG 240

TGTCGGGACA CTCCCATTCC TCATCAAAGA AGATCAATTG AATGCTGCAC AGAAAGGAAC 300

GAATGTAATA AAGACCTGCA CCCTACACTG CCTCCACTGA AAAACAGAGA TTTTGTGGAT 360

GGACCTATAC ACCACAAGGC TTTACTTATA TCTGTGACTG TCTGTAGTTT GCTCTTGGTC 420

CTTATCATTT TATTTTGTTA CTTCCGGTAT AAAAGACAAG AAACCAGACC TCGATACAGC 480

ATTGGGTTAG AACAGGATGA AACTTACATT CCTCCTGGAG AATCCCTGAG AGACTTAATT 540

GAGCAGTCTC AGAGCTCAGG AAGTGGATCA GGCCTCCCTC TGCTGGTCCA AAGGACTATA 600

GCTAAGCAGA TTCAGATGGT GAAACAGATT GGAAAAGGTC GCTATGGGGA AGTTTGGATG 660

GGAAAGTGGC GTGGCGAAAA GGTAGCTGTG AAAGTGTTCT TCACCACAGA GGAAGCCAGC 720

TGGTTTAGAG AGACAGAAAT ATATCAGACA GTGTTGATGA GGCATGAAAA CATTTTGGGT 780

TTCATTGCTG CAGATATCAA AGGGACGGGG TCCTGGACCC AGTTGTACCT AATCACAGAC 840

TATCATGAAA ATGGTTCCCT TTATGATTAT CTGAAGTCCA CCACCCTAGA CACTAAATCA 900

ATGCTGAAGT TAGCCTACTC TTCTGTCAGT GGCTTATGTC ACTTACACAC AGAAATCTTT 960

AGCACTCAAG GCAAACCAGC AATTGCCCAT CGAGATCTGA AAAGTAAAAA CATTCTGGTG 1020

AAGAAAAATG GAACTTGCTG TATTGCTGAC TTGGGCCTGG CTGTTAAATT TATTAGTGAT 1080

ACAAATGAAG TTGACATACC ACCTAACACT CGAGTTGGCA CCAAACGCTA TATGCCTCCA 1140

GAAGTGTTGG ACGAGAGCTT GAACAGAAAT CACTTCCAGT CTTACATCAT GGCTGACATG 1200

TATAGTTTTG GCCTCATCCT TTGGGAGGTT GCTAGGAGAT GTGTATCAGG AGGTATAGTG 1260

GAAGAATACC AGCTTCCTTA TCATGACCTA GTGCCCAGTG ACCCCTCCTA CGAGGACATG 1320

AGAGAGATTG TGTGCATCAA GAAGTTACGC CCCTCATTCC CAAACCGATG GAGCAGTGAT 1380

GAGTGTCTAA GGCAGATGGG GAAACTCATG ACAGAATGCT GGGCTCACAA TCCTGCATCA 1440

AGGCTGACAG CCCTGCGTGT TAAGAAAACA CTTGCCAAAA TGTCAGAGTC CCAGGACATT 1500

AAACTCTGA 1509

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 204   IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  263

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+dyLk++tld++++l+la+s +sGl+hLH+ei+ t+

Q: 264   ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDTKSMLKLAYSSVSGLCHLHTEIFSTQ  323

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa+k+ ++++e+d+  n++vGtkRYm PE

Q: 324   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE  381

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aD+Ys+gL+lWEva+Rc + +++veey+lp+++ v+sdPs+e+m

Q: 382   VLDESLNRNHFQSYIMADMYSFGLILWEVARRCVS-GGIVEEYQLPYHDLVPSDPSYEDM  440

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +e+v+ kklrP++p++w+++e+l+++ kl++ecW+++p++Rltalrvkk+l

Q: 441   REIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL  491

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDTKSMLK LAYSSVSGLC HLHTEIFSTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMPPEVL 180

DESLNRNHFQ SYIMADMYSF GLILWEVARR CVSGGIVEEY QLPYHDLVPS DPSYEDMREI 240

VCIKKLRPSF PNRWSSDECL RQMGKLMTEC WAHNPASRLT ALRVKKTL 288

Keyword

ATP-binding; Kinase; Nucleotide-binding; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0030509	; P:BMP signaling pathway
GO:0001502	; P:cartilage condensation
GO:0009953	; P:dorsal/ventral pattern formation
GO:0006954	; P:inflammatory response
GO:0035108	; P:limb morphogenesis
GO:0001550	; P:ovarian cumulus expansion
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0060041	; P:retina development in camera-type eye
GO:0031290	; P:retinal ganglion cell axon guidance
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013