EKS-MAM-00119

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00119

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	481.9	8.3E-145	1078	1338	261

Status

Unreviewed

Ensembl Protein

ENSMMUP00000008920

UniProt Accession

F7H1K4;

Protein Name

Protein Synonyms/Alias

Gene Name

MET

Gene Synonyms/Alias

MET; EGK_14061;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000006779	ENSMMUP00000008920	ENSMMUT00000009490

Organism

Macaca mulatta

Functional Description

Protein Length

1381

Protein Sequence
(FASTA)

MKAPAVLVPG ILVLLFTLVQ RSNGECKEAL AKSEMNVNMK YQLPNFTAET AIQNVILHEH 60

HIFLGATNYI YVLNEEDLQK VAEYKTGPVL EHPDCFPCQD CSSKANLSGG VWKDNINMAL 120

VVDTYYDDQL ISCGSVNRGT CQRHVFPHNH TADIQSEVHC IFSPQIEEPN QCPDCVVSAL 180

GAKVLSSVKD RFINFFVGNT INSSYFPHHP LHSISVRRLK ETKDGFMFLT DQSYIDVLPE 240

FRDSYPIKYI HAFESNNFIY FLTVQRETLN AQTFHTRIIR FCSLNSGLHS YMEMPLECIL 300

TEKRKKRSTK KEVFNILQAA YVSKPGAQLA RQIGASLNDD ILFGVFAQSK PDSAEPMDRS 360

AMCAFPIKYV NDFFNKIVNK NNVRCLQHFY GPNHEHCFNR TLLRNSSGCE ARRDEYRAEF 420

TTALQRVDLF MGQFSEVLLT SISTFVKGDL TIANLGTSEG RFMQVVVSRS GPSTPHVNFL 480

LDSHPVSPEV IVEHPLNQNG YTLVVTGKKI TKIPLNGLGC RHFQSCSQCL SAPPFVQCGW 540

CHDKCVRSEE CPSGTWTQQI CLPAIYKVFP TSAPLEGGTR LTICGWDFGF RRNNKFDLKK 600

TRVLLGNESC TLTLSESTMN TLKCTVGPAM NKHFNMSIII SNGHGTTQYS TFSYVDPIIT 660

SISPKYGPMA GGTLLTLTGN YLNSGNSRHI SIGGKTCTLK SVSNSILECY TPAQTISTEF 720

AVKLKIDLAN RETSIFSYRE DPIVYEIHPT KSFISGGSTI TGVGKNLHSV SVPRMVINVH 780

EAGRNFTVAC QHRSNSEIIC CTTPSLQQLN LQLPLKTKAF FMLDGILSKY FDLIYVHNPV 840

FKPFEKPVMI SMGNENVLEI KGNDIDPEAV KGEVLKVGNK SCENIHLHSE AVLCTVPNDL 900

LKLNSELNIE WKQAISSTVL GKVIVQPDQN FTGLIAGVVS ISIALLLLLG LFLWLKKRKQ 960

IKDLGSELVR YDARVHTPHL DRLVSARSVS PTTEMVSNES VDYRATFPED QFPNSSQNGS 1020

CRQVQYPLTD MSPILTSGDS DISSPLLQNT VHIDLSALNP ELVQAVQHVV IGPSSLIVHF 1080

NEVIGRGHFG CVYHGTLLDN DGKKIHCAVK SLNRITDIGE VSQFLTEGII MKDFSHPNVL 1140

SLLGICLRSE GSPLVVLPYM KHGDLRNFIR NETHNPTVKD LIGFGLQVAK GMKYLASKKF 1200

VHRDLAARNC MLDEKFTVKV ADFGLARDMY DKEYYSVHNK TGAKLPVKWM ALESLQTQKF 1260

TTKSDVWSFG VLLWELMTRG APPYPDVNTF DITVYLLQGR RLLQPEYCPD PLYEVMLKCW 1320

HPKAEMRPSF SELVSRISAI FSTFIGEHYV HVNATYVNVK CVAPYPSLLS SEDNADDEVD 1380

T 1381

Nucleotide Sequence
(FASTA)

ATGAAGGCCC CCGCTGTGCT TGTACCTGGC ATCCTCGTGC TCCTGTTTAC CTTGGTGCAG 60

AGGAGCAATG GGGAGTGTAA AGAGGCACTA GCAAAGTCCG AGATGAATGT GAATATGAAG 120

TATCAGCTTC CCAACTTCAC CGCGGAAACA GCCATCCAGA ATGTCATTCT ACATGAGCAT 180

CACATTTTCC TCGGTGCCAC CAACTACATT TATGTTTTAA ATGAGGAAGA CCTTCAGAAG 240

GTTGCTGAGT ACAAGACCGG GCCTGTGCTG GAACACCCAG ATTGTTTCCC GTGTCAGGAC 300

TGCAGCAGCA AAGCCAATTT ATCAGGAGGC GTTTGGAAAG ATAACATCAA CATGGCTCTG 360

GTTGTCGACA CCTACTATGA TGATCAACTC ATTAGCTGTG GCAGCGTCAA CAGAGGGACC 420

TGCCAGCGAC ATGTCTTTCC CCATAATCAT ACTGCTGACA TACAGTCGGA GGTTCACTGC 480

ATATTCTCCC CACAGATAGA AGAGCCCAAC CAGTGCCCTG ACTGTGTGGT GAGCGCCCTG 540

GGAGCCAAAG TCCTTTCATC TGTAAAGGAC CGGTTCATCA ACTTCTTTGT AGGCAATACC 600

ATAAATTCTT CTTATTTCCC ACATCATCCG TTGCATTCGA TATCAGTGAG AAGGCTAAAG 660

GAAACGAAAG ATGGTTTTAT GTTTTTGACG GACCAGTCCT ACATTGATGT TTTACCTGAG 720

TTCAGAGATT CTTACCCCAT TAAGTACATC CATGCTTTTG AAAGCAACAA TTTTATTTAC 780

TTCTTGACGG TCCAAAGGGA AACTCTAAAT GCTCAGACTT TTCACACAAG AATAATCAGG 840

TTCTGTTCCT TAAACTCTGG ATTGCACTCC TACATGGAAA TGCCTCTAGA GTGTATTCTC 900

ACAGAAAAGA GAAAAAAGAG ATCCACAAAG AAGGAAGTGT TTAATATCCT TCAGGCTGCA 960

TATGTCAGCA AGCCCGGGGC CCAGCTTGCT AGACAAATAG GAGCCAGCCT GAATGATGAC 1020

ATTCTCTTTG GGGTGTTCGC ACAAAGCAAG CCAGATTCTG CCGAACCAAT GGATCGATCT 1080

GCAATGTGTG CATTCCCTAT CAAATATGTC AACGACTTCT TCAACAAGAT CGTCAACAAA 1140

AACAATGTGA GATGTCTCCA GCATTTTTAT GGACCCAATC ATGAGCACTG TTTTAATAGG 1200

ACACTTCTGA GAAATTCATC AGGCTGTGAA GCGCGCCGTG ATGAATATCG AGCAGAGTTT 1260

ACCACAGCTT TGCAGCGCGT TGACTTATTC ATGGGTCAAT TCAGCGAAGT CCTCTTAACA 1320

TCTATATCCA CCTTCGTGAA AGGAGACCTC ACCATCGCTA ATCTTGGGAC ATCAGAGGGT 1380

CGCTTCATGC AGGTTGTGGT TTCTCGATCA GGACCATCAA CCCCTCATGT GAATTTTCTC 1440

CTGGACTCTC ACCCGGTGTC TCCAGAAGTG ATTGTGGAGC ATCCATTAAA CCAGAATGGC 1500

TACACACTGG TTGTCACGGG GAAGAAGATC ACCAAGATCC CATTGAATGG CTTGGGCTGC 1560

AGACATTTCC AGTCCTGCAG TCAGTGCCTC TCTGCCCCAC CCTTTGTGCA GTGTGGCTGG 1620

TGCCACGACA AATGTGTGCG ATCGGAGGAG TGCCCCAGTG GGACATGGAC TCAACAGATC 1680

TGTCTGCCTG CAATCTACAA GGTTTTCCCA ACTAGTGCAC CCCTTGAAGG AGGGACAAGA 1740

CTGACCATAT GTGGCTGGGA CTTTGGATTT CGGAGGAATA ATAAATTTGA TTTAAAGAAA 1800

ACTAGAGTTC TCCTTGGAAA TGAGAGCTGC ACCTTGACTT TAAGTGAGAG CACGATGAAT 1860

ACATTGAAAT GCACAGTTGG TCCTGCCATG AATAAACATT TCAATATGTC CATAATTATT 1920

TCAAATGGCC ATGGGACAAC ACAATACAGT ACATTTTCCT ATGTGGATCC TATAATAACA 1980

AGTATTTCGC CAAAATATGG CCCTATGGCT GGTGGCACTT TACTTACTTT AACTGGAAAT 2040

TACCTAAACA GTGGGAATTC TAGACACATT TCAATTGGTG GAAAAACATG TACTTTAAAA 2100

AGTGTGTCAA ACAGTATTCT CGAATGTTAT ACCCCAGCCC AAACCATTTC AACTGAGTTT 2160

GCTGTTAAAT TGAAAATTGA CTTAGCCAAC CGAGAGACAA GCATCTTCAG TTACCGGGAA 2220

GACCCCATTG TCTATGAAAT TCATCCAACC AAATCTTTTA TTAGTGGTGG GAGCACAATA 2280

ACAGGTGTTG GGAAAAACCT GCATTCAGTT AGTGTCCCGA GGATGGTCAT AAATGTGCAT 2340

GAAGCAGGAA GGAACTTTAC AGTGGCATGT CAGCATCGCT CTAATTCAGA GATAATCTGC 2400

TGTACCACTC CTTCCCTGCA ACAGCTGAAT CTGCAACTCC CTCTGAAAAC CAAAGCCTTT 2460

TTCATGTTAG ATGGGATCCT TTCCAAATAC TTTGATCTCA TTTATGTACA TAATCCTGTG 2520

TTTAAGCCTT TTGAAAAGCC AGTAATGATC TCAATGGGCA ATGAAAATGT ACTGGAAATT 2580

AAGGGAAATG ATATTGACCC TGAAGCAGTT AAAGGTGAAG TGTTAAAAGT TGGAAATAAG 2640

AGCTGTGAGA ATATACACTT ACATTCTGAA GCCGTTTTAT GCACGGTCCC CAATGACCTG 2700

CTGAAATTGA ACAGCGAGCT AAATATAGAG TGGAAGCAAG CAATTTCTTC AACCGTCCTT 2760

GGAAAAGTAA TAGTTCAACC AGATCAGAAT TTCACCGGAT TGATTGCTGG TGTTGTCTCA 2820

ATATCAATAG CACTCTTACT ACTACTTGGG CTTTTCCTGT GGCTGAAAAA GAGAAAGCAA 2880

ATTAAAGATC TGGGCAGTGA ATTAGTTCGC TATGATGCAA GAGTACACAC TCCTCATTTG 2940

GATAGGCTTG TAAGTGCCCG AAGTGTAAGC CCAACAACAG AAATGGTTTC AAATGAATCT 3000

GTAGACTACC GAGCTACTTT TCCAGAAGAT CAGTTTCCTA ATTCATCTCA GAACGGTTCA 3060

TGCCGACAAG TGCAGTATCC TCTGACAGAC ATGTCCCCCA TCCTGACTAG TGGGGACTCT 3120

GATATATCCA GTCCATTACT GCAAAACACT GTCCACATTG ACCTCAGCGC TCTAAATCCA 3180

GAGCTGGTCC AGGCAGTGCA GCATGTAGTG ATTGGGCCCA GTAGCCTGAT TGTGCATTTC 3240

AATGAAGTCA TAGGAAGAGG GCATTTTGGT TGTGTATATC ATGGGACTTT GTTGGACAAT 3300

GATGGCAAGA AAATTCACTG TGCTGTGAAA TCCTTGAACA GAATCACTGA CATAGGAGAA 3360

GTTTCCCAGT TTCTGACCGA GGGAATCATC ATGAAAGATT TTAGTCATCC CAATGTCCTC 3420

TCGCTCCTGG GAATCTGCCT GCGAAGTGAA GGGTCTCCGC TGGTGGTCCT ACCCTACATG 3480

AAACATGGAG ATCTTCGAAA TTTCATTCGA AATGAGACTC ATAATCCAAC TGTAAAAGAT 3540

CTTATTGGCT TTGGTCTTCA AGTAGCCAAA GGCATGAAAT ATCTTGCAAG CAAAAAGTTT 3600

GTCCACAGAG ACTTGGCTGC AAGAAACTGT ATGCTGGATG AAAAATTCAC AGTCAAGGTT 3660

GCTGATTTTG GTCTTGCCAG AGACATGTAT GATAAAGAAT ACTATAGTGT GCACAACAAA 3720

ACAGGTGCAA AGCTGCCAGT GAAGTGGATG GCTTTGGAAA GTCTGCAAAC TCAAAAGTTT 3780

ACCACCAAGT CAGATGTGTG GTCCTTTGGT GTGCTCCTCT GGGAGCTCAT GACAAGAGGA 3840

GCCCCACCCT ATCCTGACGT GAACACCTTT GATATAACTG TTTACTTGTT GCAAGGGAGA 3900

AGGCTCCTAC AACCCGAATA CTGCCCAGAC CCCTTATATG AAGTAATGCT AAAATGCTGG 3960

CACCCTAAAG CAGAAATGCG CCCATCCTTT TCTGAACTGG TGTCCCGGAT ATCAGCGATC 4020

TTCTCTACTT TCATTGGGGA GCACTACGTC CATGTAAACG CTACTTATGT GAACGTAAAA 4080

TGTGTCGCTC CATATCCTTC TCTGTTGTCA TCAGAAGATA ACGCTGATGA CGAGGTGGAC 4140

ACATGA 4146

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v+++eviG+GhfG+vy+g+l+d+++kki++avksl+ritdi++v++fl+eg++mk+++hp

Q: 1078  VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP  1137

         799*********************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas

Q: 1138  NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS  1197

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+ldek+tvkvadfGlard++dke+y+v+++++a+lpvkw+aleslqt

Q: 1198  KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQT  1257

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k fttksdvwsfGvllwel+trga+py++v++fd+t+yl +grrl +peycpd ly+vm

Q: 1258  QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM  1316

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         lkcw++k+++rp+fs+lvs+is

Q: 1317  LKCWHPKAEMRPSFSELVSRIS  1338

         ********************98

Domain Sequence
(FASTA)

VHFNEVIGRG HFGCVYHGTL LDNDGKKIHC AVKSLNRITD IGEVSQFLTE GIIMKDFSHP 60

NVLSLLGICL RSEGSPLVVL PYMKHGDLRN FIRNETHNPT VKDLIGFGLQ VAKGMKYLAS 120

KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DMYDKEYYSV HNKTGAKLPV KWMALESLQT 180

QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NTFDITVYLL QGRRLLQPEY CPDPLYEVML 240

KCWHPKAEMR PSFSELVSRI S 261

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0009925	; C:basal plasma membrane
GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005008	; F:hepatocyte growth factor-activated receptor activity
GO:0000187	; P:activation of MAPK activity
GO:0030534	; P:adult behavior
GO:0007420	; P:brain development
GO:0048754	; P:branching morphogenesis of a tube
GO:0042593	; P:glucose homeostasis
GO:0001889	; P:liver development
GO:0014812	; P:muscle cell migration
GO:0051450	; P:myoblast proliferation
GO:0014902	; P:myotube differentiation
GO:0001890	; P:placenta development
GO:0010828	; P:positive regulation of glucose transport
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

KEGG

mcc:704562

;

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 4.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013