EKS-MAM-00078
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00078
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Musk626.59.8E-189575855281
StatusUnreviewed
Ensembl ProteinENSMMUP00000009260
UniProt AccessionF7HFZ8;
Protein Name
Protein Synonyms/Alias
Gene NameMUSK
Gene Synonyms/Alias MUSK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000007065ENSMMUP00000039670ENSMMUT00000046633
ENSMMUG00000007065ENSMMUP00000039672ENSMMUT00000046635
ENSMMUG00000007065ENSMMUP00000009260ENSMMUT00000009865
ENSMMUG00000007065ENSMMUP00000039675ENSMMUT00000046638
OrganismMacaca mulatta
Functional Description
Protein Length869
Protein Sequence
(FASTA)
MRELVNIPLV HILTLVAFSG TEKLPKAPVI TTPLETVDAL VEEVATFMCA VESYPQPEIS 60
WTRNKILIKL FDTRYSIREN GQLLTILSVE DSDDGIYCCT ANNGVGGAVE SCGALQVKMK 120
PKITRPPINV KIIEGLKAVL PCTTMGNPKP SVSWIKGDSP LRENSRTAVL ESGSLRIHNV 180
QKEDAGQYRC VAKNSLGTAY SKVVKLEVEV FARILRAPES HNVTFGSFVT LHCTATGIPV 240
PTITWIENGN AVSSGSIQES VKDRVIDSRL QLFITKPGLY TCIATNKHGE KFSTAKAAAT 300
VSIAEMFKPQ KDNKGYCAQY RGEVCNAVLA KDALVFLNTS YADPEEAQEL LVHTAWNELK 360
VVSPLCRPAA EALLCNHVFQ ECSPGVVPTP IPICREYCLA VKELFCAKEW LAMEEKTHRG 420
LYRSEMHLLS VPECSKLPSM HWDPTACARL PHLDYNKENP KTFPPMTSSK PSVDIPNLPS 480
SSSSSFSVSP TYSMTVIISI MSSFAIFALL TITTLYCCRR RKQWKNKKRE SAAVTLTTLP 540
SELLLDRLHP NPMYQRMPLL LNPKLLSLEY PRNNIEYVRD IGEGAFGRVF QARAPGLLPY 600
EPFTMVAVKM LKEEASADMQ ADFQREAALM AEFDNPNIVK LLGVCAVGKP MCLLFEYMAY 660
GDLNEFLRSM SPHTVCSLSH SDLSMRAQVS SPGPPPLSCA EQLCIARQVA AGMAYLSERK 720
FVHRDLATRN CLVGENMVVK IADFGLSRNI YSADYYKANE NDAIPIRWMP PESIFYNRYT 780
TESDVWAYGV VLWEIFSYGL QPYYGMAHEE VIYYVRDGNI LSCPENCPVE LYNLMRLCWS 840
KLPADRPSFT SIHRILERMC ERAEGTVSV 869
Nucleotide Sequence
(FASTA)
ATGAGAGAGC TCGTCAACAT TCCACTGGTA CATATTCTTA CTCTGGTTGC CTTCAGCGGA 60
ACTGAGAAAC TTCCAAAAGC TCCTGTCATC ACCACTCCTC TTGAAACTGT GGATGCCTTA 120
GTTGAAGAAG TGGCTACTTT CATGTGTGCA GTGGAATCCT ACCCCCAGCC TGAGATTTCC 180
TGGACCAGAA ATAAAATTCT CATTAAGCTC TTTGACACCC GGTACAGCAT CCGGGAGAAT 240
GGTCAGCTCC TCACCATCCT GAGTGTGGAA GACAGTGATG ATGGCATTTA CTGCTGCACG 300
GCCAACAATG GTGTGGGAGG AGCTGTGGAG AGTTGTGGAG CCCTGCAAGT GAAGATGAAA 360
CCTAAAATAA CTCGTCCTCC GATAAATGTG AAAATAATAG AGGGATTAAA AGCAGTCCTA 420
CCATGTACTA CAATGGGTAA TCCCAAACCA TCAGTGTCTT GGATAAAGGG AGACAGCCCT 480
CTCAGGGAAA ATTCCCGAAC TGCAGTTCTT GAATCTGGGA GCTTGAGGAT TCATAACGTA 540
CAAAAGGAAG ATGCAGGACA GTATCGATGT GTGGCAAAAA ACAGCCTTGG GACAGCATAT 600
TCAAAAGTGG TGAAGCTGGA AGTTGAGGTT TTTGCCAGGA TCCTGCGGGC TCCTGAATCC 660
CACAATGTCA CCTTTGGCTC CTTTGTGACC CTGCACTGTA CAGCAACAGG CATTCCTGTC 720
CCCACCATCA CCTGGATTGA AAACGGAAAT GCTGTTTCTT CTGGGTCCAT TCAAGAGAGT 780
GTAAAAGACC GAGTAATTGA CTCAAGACTG CAGCTGTTTA TCACCAAGCC AGGACTCTAC 840
ACATGCATAG CTACCAATAA GCATGGGGAG AAGTTCAGTA CTGCCAAGGC TGCAGCCACT 900
GTCAGCATAG CAGAAATGTT TAAACCACAG AAAGATAACA AAGGCTACTG CGCCCAGTAT 960
AGAGGGGAGG TGTGTAATGC AGTCCTGGCA AAAGACGCTC TTGTTTTTCT CAACACCTCC 1020
TATGCGGACC CTGAGGAGGC CCAAGAGCTG CTGGTCCACA CGGCCTGGAA TGAACTGAAA 1080
GTAGTGAGCC CACTCTGCAG GCCAGCTGCT GAGGCTTTGT TGTGTAACCA CGTCTTCCAG 1140
GAGTGCAGTC CTGGAGTAGT GCCGACTCCT ATTCCCATTT GCAGAGAGTA CTGCTTGGCA 1200
GTAAAGGAGC TCTTCTGTGC AAAAGAATGG CTGGCAATGG AAGAGAAGAC CCACAGAGGA 1260
CTCTACAGAT CTGAGATGCA TTTGCTGTCG GTGCCAGAAT GCAGCAAGCT TCCCAGCATG 1320
CACTGGGACC CTACAGCCTG TGCCAGACTG CCACATTTAG ATTATAACAA AGAAAACCCA 1380
AAAACATTCC CACCAATGAC GTCCTCAAAG CCAAGTGTGG ACATTCCAAA TTTGCCTTCC 1440
TCCTCCTCTT CTTCCTTCTC TGTCTCACCT ACATACTCCA TGACTGTAAT AATCTCCATC 1500
ATGTCCAGCT TTGCAATATT TGCGCTTCTT ACCATCACTA CTCTCTATTG CTGCCGAAGA 1560
AGAAAACAAT GGAAAAATAA GAAAAGAGAA TCAGCAGCAG TAACCCTCAC CACACTGCCT 1620
TCTGAGCTCT TACTAGATAG ACTTCATCCC AACCCCATGT ACCAGAGGAT GCCGCTCCTT 1680
CTGAACCCCA AATTGCTCAG CCTGGAGTAT CCAAGAAATA ACATTGAATA TGTGAGAGAC 1740
ATTGGAGAGG GAGCGTTTGG AAGGGTGTTT CAAGCAAGGG CACCAGGTTT ACTTCCCTAT 1800
GAACCTTTCA CTATGGTGGC AGTAAAGATG CTCAAAGAAG AAGCCTCGGC AGATATGCAA 1860
GCGGACTTTC AGAGGGAGGC AGCCCTCATG GCAGAATTTG ACAACCCTAA CATTGTGAAG 1920
CTCTTAGGCG TGTGTGCTGT CGGGAAGCCA ATGTGCCTGC TCTTTGAATA CATGGCCTAT 1980
GGTGATCTCA ATGAGTTCCT CCGCAGCATG TCCCCTCACA CCGTGTGCAG CCTCAGTCAC 2040
AGTGACTTGT CTATGAGGGC CCAGGTCTCC AGCCCTGGAC CCCCACCCCT CTCCTGTGCT 2100
GAGCAGCTTT GCATTGCCAG GCAAGTGGCA GCTGGTATGG CTTACCTCTC AGAACGTAAG 2160
TTTGTTCACC GAGATTTAGC CACCAGGAAC TGCCTGGTGG GCGAGAACAT GGTGGTAAAA 2220
ATTGCCGACT TTGGCCTCTC CAGGAACATC TACTCAGCAG ACTACTACAA AGCTAATGAA 2280
AACGACGCTA TCCCTATCCG TTGGATGCCA CCAGAGTCCA TTTTTTATAA CCGCTACACT 2340
ACAGAGTCTG ATGTGTGGGC CTACGGCGTG GTCCTCTGGG AGATCTTCTC CTATGGCCTG 2400
CAGCCCTACT ATGGGATGGC CCATGAGGAG GTCATTTACT ACGTGCGAGA TGGCAACATC 2460
CTCTCCTGCC CTGAGAACTG CCCTGTGGAG CTGTACAATC TCATGCGTCT ATGTTGGAGC 2520
AAGCTGCCTG CAGACAGACC CAGTTTCACC AGTATTCACC GAATTCTGGA ACGCATGTGT 2580
GAGAGGGCAG AGGGAACTGT GAGTGTCTAA 2610
Domain Profile
S: 1     ieyvrdlgegafgrvfqarapgllpyeefllvavkmlkeeasadmqadfereaallaefd  60
         ieyvrd+gegafgrvfqarapgllpye+f++vavkmlkeeasadmqadf+reaal+aefd
Q: 575   IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFD  634
         89**********************************************************
S: 61    npnivkllgvcavgkpmcllfeymaygdlneflrslspytvcslshsdlslraqvsspdr  120
         npnivkllgvcavgkpmcllfeymaygdlneflrs+sp+tvcslshsdls+raqvssp++
Q: 635   NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGP  694
         ************************************************************
S: 121   lplseaellciarqvaagmaylserkfvhrdlatrnclvgetmvvkiadfglsrkiysad  180
         +pls+ae+lciarqvaagmaylserkfvhrdlatrnclvge+mvvkiadfglsr+iysad
Q: 695   PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSAD  754
         ************************************************************
S: 181   yykadendaipirwmplesilynrytlesdvwaygvvlweifsyalqpyyglaheeviky  240
         yyka+endaipirwmp+esi+ynryt+esdvwaygvvlweifsy+lqpyyg+aheevi+y
Q: 755   YYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYY  814
         ************************************************************
S: 241   vrdgnilacpentplelyalmrlcwsklpadrpsfasihri  281
         vrdgnil+cpen+p+ely+lmrlcwsklpadrpsf+sihri
Q: 815   VRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRI  855
         ***************************************98
Domain Sequence
(FASTA)
IEYVRDIGEG AFGRVFQARA PGLLPYEPFT MVAVKMLKEE ASADMQADFQ REAALMAEFD 60
NPNIVKLLGV CAVGKPMCLL FEYMAYGDLN EFLRSMSPHT VCSLSHSDLS MRAQVSSPGP 120
PPLSCAEQLC IARQVAAGMA YLSERKFVHR DLATRNCLVG ENMVVKIADF GLSRNIYSAD 180
YYKANENDAI PIRWMPPESI FYNRYTTESD VWAYGVVLWE IFSYGLQPYY GMAHEEVIYY 240
VRDGNILSCP ENCPVELYNL MRLCWSKLPA DRPSFTSIHR I 281
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00073
EKS-ANC-00070
EKS-BOT-00079
EKS-CAJ-00080
EKS-CAP-00079
EKS-DAR-00333
EKS-DRM-00037
EKS-EQC-00077
EKS-FEC-00076
EKS-GAG-00063
EKS-GAA-00097
EKS-GOG-00078
EKS-HOS-00081
EKS-ICT-00074
EKS-LAC-00084
EKS-LOA-00078
EKS-MEG-00059
EKS-MOD-00079
EKS-MUM-00082
EKS-MUP-00082
EKS-MYL-00087
EKS-NOL-00075
EKS-ORN-00106
EKS-ORA-00065
EKS-ORC-00074
EKS-ORL-00098
EKS-OTG-00083
EKS-PAT-00071
EKS-PES-00069
EKS-PEM-00043
EKS-POA-00076
EKS-RAN-00075
EKS-SAH-00075
EKS-TAG-00114
EKS-TAR-00112
EKS-TEN-00104
EKS-XET-00074
EKS-XIM-00101
Gene Ontology
GO:0016021; C:integral to membrane
GO:0031594; C:neuromuscular junction
GO:0005886; C:plasma membrane
GO:0045211; C:postsynaptic membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043525; P:positive regulation of neuron apoptotic process
GO:2000541; P:positive regulation of protein geranylgeranylation
GO:0001934; P:positive regulation of protein phosphorylation
GO:0008582; P:regulation of synaptic growth at neuromuscular junction
GO:0006355; P:regulation of transcription, DNA-dependent
GO:0071340; P:skeletal muscle acetylcholine-gated channel clustering
KEGG
InterPros
IPR020067; Frizzled_dom.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF01392; Fz; 1.
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50038; FZ; 1.
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013