EKS-MAM-00375
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00375
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK347.58.1E-104119376258
StatusUnreviewed
Ensembl ProteinENSMMUP00000009715
UniProt AccessionF6T3F7;
Protein Name
Protein Synonyms/Alias Mitogen-activated protein kinase kinase kinase 11;
Gene NameMAP3K11
Gene Synonyms/Alias MAP3K11; EGK_06004;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000007404ENSMMUP00000009715ENSMMUT00000010353
OrganismMacaca mulatta
Functional Description
Protein Length847
Protein Sequence
(FASTA)
MEPLKSLFLK SPLGSWNGSG SGGGGGSGGG RPEGSPKAAG YANPVWTALF DYEPSGQDEL 60
ALRKGDRVEV LSRDAAISGD EGWWAGQVGG QVGIFPSNYV SRGGGPPPCE VASFQELRLE 120
EVIGIGGFGK VYRGSWRGEL VAVKAARQDP DEDISVTAES VRQEARLFAM LAHPNIIALK 180
AVCLEEPNLC LVMEYAAGGP LSRALAGRRV PPHVLVNWAV QIARGMHYLH CEALVPVIHR 240
DLKSNNILLL QPIEGDDMEH KTLKITDFGL AREWHKTTQM SAAGTYAWMA PEVIKASTFS 300
KGSDVWSFGV LLWELLTGEV PYRGIDCLAV AYGVAVNKLT LPIPSTCPEP FAQLMADCWA 360
QDPHRRPDFA SILQQLEALE AQVLREMPRD SFHSMQEGWK REIQGLFDEL RAKEKELLSR 420
EEELTRAARE QRSQAEQLRR REHLLAQWEL EVFERELTLL LQQVDRERPH VRRRRGTFKR 480
SKLRARDGGE RISMPLDFKH RITVQASPGL DRRRNVFEVG PGDSPTFPRF RAIQLEPAEP 540
GQAWGRQSPR RLEDSSNGER RACWAWGPSS PKPGEAQNGR RRSRMDEATW YLDSDDSSPL 600
GSPSTPPALN GHPLRPSLEP EEPKRPLPAE RGSSSGTPKL IQRALLRGTA LLASLGLGRD 660
LQPPGSQGRE RGDPPTTPPT PMPAPCPTEP PPSPLIRFSP KTPDSPPTPA PLLLDLGIPA 720
GQRSAKSPRR EEEPRGGTVS PPPGTSRSAP GTPGTPRSPP LGLISRPRPS PLRSRIDPWS 780
FVSAGPRPSP LPSPQPAPRR APWTLFPDSD PFWDSPPANP FRGGPQDCRA QTKDMGAQAP 840
WVPEAGP 847
Nucleotide Sequence
(FASTA)
ATGGAGCCCT TGAAGAGCCT CTTCCTCAAG AGCCCTCTAG GGTCATGGAA TGGCAGTGGC 60
AGCGGGGGTG GTGGGGGCAG TGGAGGAGGC CGGCCTGAGG GGTCTCCAAA GGCAGCGGGT 120
TATGCCAACC CGGTGTGGAC AGCCCTGTTC GACTACGAGC CCAGTGGGCA GGACGAGCTG 180
GCCCTGAGGA AGGGTGACCG TGTGGAGGTG CTGTCCCGGG ACGCAGCCAT CTCAGGAGAC 240
GAGGGCTGGT GGGCAGGCCA GGTGGGTGGC CAGGTGGGCA TCTTCCCATC CAACTATGTG 300
TCTCGGGGTG GCGGCCCGCC CCCCTGCGAG GTGGCCAGCT TCCAGGAGCT GCGGCTGGAG 360
GAGGTGATCG GCATTGGAGG CTTCGGCAAG GTGTACCGGG GCAGCTGGCG AGGTGAGCTG 420
GTGGCTGTGA AGGCAGCTCG CCAGGACCCC GATGAGGACA TCAGTGTGAC AGCTGAGAGT 480
GTTCGCCAGG AGGCCCGGCT CTTCGCCATG CTAGCACACC CCAACATCAT TGCCCTCAAG 540
GCTGTGTGCC TGGAGGAGCC CAACCTGTGC CTGGTGATGG AGTATGCAGC TGGTGGACCC 600
CTCAGCCGAG CTCTGGCAGG GCGGCGCGTG CCTCCCCATG TGCTGGTTAA CTGGGCTGTG 660
CAGATTGCCC GTGGGATGCA CTACCTGCAC TGCGAGGCCC TGGTGCCCGT CATCCATCGC 720
GACCTCAAGT CCAACAACAT TTTGCTGCTG CAGCCCATTG AGGGTGACGA CATGGAGCAC 780
AAGACCCTGA AGATCACCGA CTTTGGTCTG GCCCGAGAGT GGCACAAAAC CACACAAATG 840
AGTGCCGCGG GCACCTACGC CTGGATGGCT CCTGAGGTTA TCAAGGCCTC CACCTTCTCT 900
AAGGGCAGTG ACGTCTGGAG TTTTGGGGTG CTGCTGTGGG AACTGCTGAC CGGGGAGGTG 960
CCGTACCGTG GCATTGACTG CCTTGCTGTG GCCTATGGCG TAGCTGTTAA CAAGCTCACA 1020
CTGCCCATCC CATCCACCTG CCCCGAGCCC TTCGCACAGC TTATGGCAGA CTGCTGGGCG 1080
CAGGACCCTC ACCGCAGGCC CGACTTCGCC TCCATCCTGC AGCAGTTGGA GGCGCTGGAG 1140
GCACAAGTCC TACGGGAAAT GCCGCGGGAC TCCTTCCATT CCATGCAGGA AGGCTGGAAG 1200
CGCGAGATCC AGGGTCTTTT CGACGAGCTG CGAGCCAAGG AAAAGGAACT ACTGAGCCGC 1260
GAAGAGGAGC TGACGCGAGC AGCGCGCGAG CAGAGGTCAC AGGCGGAGCA GCTGCGGCGG 1320
CGCGAGCACC TGCTGGCCCA GTGGGAGCTA GAAGTGTTCG AGCGCGAGCT GACGCTGCTG 1380
CTGCAGCAGG TGGACCGCGA GCGACCGCAC GTGCGCCGCC GCCGCGGCAC ATTCAAGCGC 1440
AGCAAGCTCC GGGCGCGCGA CGGCGGCGAG CGCATCAGCA TGCCACTCGA CTTCAAGCAC 1500
CGCATCACCG TGCAGGCCTC ACCCGGCCTC GACCGGAGGA GAAACGTCTT CGAGGTCGGG 1560
CCTGGGGATT CGCCCACCTT CCCCCGGTTC CGGGCCATCC AGTTGGAGCC TGCAGAGCCA 1620
GGCCAGGCAT GGGGCCGCCA GTCCCCCCGA CGTCTGGAGG ACTCAAGCAA TGGAGAGCGG 1680
CGAGCATGCT GGGCTTGGGG TCCCAGTTCC CCCAAGCCTG GGGAAGCCCA GAATGGGAGG 1740
AGAAGGTCCC GCATGGACGA AGCCACATGG TACCTGGATT CAGATGACTC ATCCCCCTTA 1800
GGATCTCCTT CCACACCCCC AGCACTCAAT GGTCACCCCC TACGGCCTAG CCTGGAGCCC 1860
GAGGAACCCA AGAGGCCTCT CCCCGCAGAG CGCGGTAGCA GCTCTGGGAC GCCCAAGCTG 1920
ATCCAGCGTG CGCTACTGCG TGGCACCGCC CTGCTTGCCT CCCTGGGCCT CGGCCGCGAC 1980
CTGCAGCCAC CGGGAAGCCA AGGACGTGAG CGTGGGGATC CCCCCACAAC ACCCCCAACG 2040
CCAATGCCCG CGCCCTGCCC GACCGAGCCG CCCCCTTCCC CGCTCATTCG CTTCTCGCCC 2100
AAGACGCCCG ACTCCCCGCC CACTCCTGCA CCCCTGTTGC TGGACCTGGG TATTCCTGCA 2160
GGCCAGCGGT CAGCCAAGAG CCCCCGACGT GAGGAGGAGC CCCGCGGAGG CACTGTCTCA 2220
CCCCCACCCG GGACATCACG CTCTGCTCCT GGCACCCCAG GCACCCCACG TTCACCACCC 2280
CTGGGCCTCA TCAGCCGACC TCGGCCCTCA CCCCTTCGCA GCCGCATTGA TCCCTGGAGC 2340
TTTGTGTCGG CTGGGCCACG GCCTTCTCCC CTGCCTTCGC CACAGCCTGC ACCCCGCCGG 2400
GCACCCTGGA CCTTGTTCCC AGACTCAGAC CCCTTCTGGG ACTCCCCACC TGCCAACCCC 2460
TTCCGGGGAG GCCCCCAGGA CTGCAGGGCA CAGACCAAAG ACATGGGTGC CCAGGCCCCT 2520
TGGGTGCCGG AGGCGGGACC TTGA 2544
Domain Profile
S: 3     leeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpniie  60
         lee+ig g fgkvy+++wr++ vavK++r++  e  + ++e++++ea+l+++l+hpnii+
Q: 119   LEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEdiSVTAESVRQEARLFAMLAHPNIIA  178
         789****************************99988999*********************
S: 61    llGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120
         l++vcleepnl+lvmey++gg Ls++l++   r+++++vlv+wa+qiArGm+YLh ea +
Q: 179   LKAVCLEEPNLCLVMEYAAGGPLSRALAG---RRVPPHVLVNWAVQIARGMHYLHCEALV  235
         *****************************...9***************************
S: 121   kiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvlk  173
         ++ihrdLks+n+Ll       ++e+ktlki+dFG are++k+t+msaagt+awmaPEv+k
Q: 236   PVIHRDLKSNNILLlqpiegdDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIK  295
         *********************9**************************************
S: 174   eekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLm  233
         ++++s+ sDvwS+gv+LWellt+evPy++++ la+ay+va+++l+lpips+cpe++++Lm
Q: 296   ASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLM  355
         ************************************************************
S: 234   kecwnedpekRpsfseivksl  254
          +cw++dp++Rp+f++i+++l
Q: 356   ADCWAQDPHRRPDFASILQQL  376
         *****************9986
Domain Sequence
(FASTA)
LEEVIGIGGF GKVYRGSWRG ELVAVKAARQ DPDEDISVTA ESVRQEARLF AMLAHPNIIA 60
LKAVCLEEPN LCLVMEYAAG GPLSRALAGR RVPPHVLVNW AVQIARGMHY LHCEALVPVI 120
HRDLKSNNIL LLQPIEGDDM EHKTLKITDF GLAREWHKTT QMSAAGTYAW MAPEVIKAST 180
FSKGSDVWSF GVLLWELLTG EVPYRGIDCL AVAYGVAVNK LTLPIPSTCP EPFAQLMADC 240
WAQDPHRRPD FASILQQL 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00376
EKS-CAJ-00383
EKS-CAF-00376
EKS-CAP-00409
EKS-DIO-00059
EKS-EQC-00374
EKS-FEC-00364
EKS-GAA-00460
EKS-GOG-00367
EKS-HOS-00383
EKS-ICT-00356
EKS-LAC-00397
EKS-LOA-00385
EKS-MOD-00366
EKS-MUM-00408
EKS-MUP-00370
EKS-MYL-00374
EKS-NOL-00344
EKS-ORN-00483
EKS-ORC-00352
EKS-ORL-00446
EKS-OTG-00378
EKS-PAT-00356
EKS-PES-00335
EKS-POA-00366
EKS-PTV-00099
EKS-RAN-00391
EKS-SAH-00352
EKS-TAR-00479
EKS-TEN-00477
EKS-XIM-00473
Gene Ontology
GO:0005813; C:centrosome
GO:0005874; C:microtubule
GO:0005524; F:ATP binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0007257; P:activation of JUN kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0008283; P:cell proliferation
GO:0000080; P:G1 phase of mitotic cell cycle
GO:0007017; P:microtubule-based process
GO:0046330; P:positive regulation of JNK cascade
KEGG
mcc:716038;
InterPros
IPR011009; Kinase-like_dom.
IPR015785; MAPKKK9/10/11-like.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR011511; SH3_2.
IPR001452; SH3_domain.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF07653; SH3_2; 1.
SMARTs
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50002; SH3; 1.
Prints
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013