EKS-MAM-00049
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00049
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/RAF412.81.2E-123349606258
StatusUnreviewed
Ensembl ProteinENSMMUP00000009777
UniProt AccessionF6SWC0;
Protein Name
Protein Synonyms/Alias RAF proto-oncogene serine/threonine-protein kinase;
Gene NameRAF1
Gene Synonyms/Alias RAF1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000007450ENSMMUP00000009777ENSMMUT00000010416
OrganismMacaca mulatta
Functional Description
Protein Length648
Protein Sequence
(FASTA)
MEHIQGAWKT ISNGFGFKDA VFDGSSCISP TIVQQFGYQR RASDDGKLTD PSKTSNTIRV 60
FLPNKQRTVV NVRNGMSLHD CLMKALKVRG LQPECCAVFR LLHEHKGKKA RLDWNTDAAS 120
LIGEELQVDF LDHVPLTTHN FARKTFLKLA FCDICQKFLL NGFRCQTCGY KFHEHCSTKV 180
PTMCVDWSNI RQLLLFPNST IGDSGVPALP SLTMRRMRES VSRMPVSSQH RYSTPHAFTF 240
NTSSPSSEGS LSQRQRSTST PNVHMVSTTL PVDSRMIEDA IRSHSESASP SALSSSPNNL 300
SPTGWSQPKT PVPAQRERAP VSGTQEKNKI RPRGQRDSSY YWEIEASEVM LSTRIGSGSF 360
GTVYKGKWHG DVAVKILKVV DPTPEQFQAF RNEVAVLRKT RHVNILLFMG YMTKDNLAIV 420
TQWCEGSSLY KHLHVQETKF QMFQLIDIAR QTAQGMDYLH AKNIIHRDMK SNNIFLHEGL 480
TVKIGDFGLA TVKSRWSGSQ QVEQPTGSVL WMAPEVIRMQ DNNPFSFQSD VYSYGIVLYE 540
LMTGELPYSH INNRDQIIFM VGRGYASPDL SKLYKNCPKA MKRLVADCVK KVKEERPLFP 600
QILSSIELLQ HSLPKINRSA SEPSLHRAAH TEDINACTLT TSPRLPVF 648
Nucleotide Sequence
(FASTA)
ATGGAGCACA TACAGGGAGC TTGGAAGACG ATCAGCAATG GTTTTGGATT CAAAGATGCC 60
GTGTTTGATG GCTCCAGCTG CATCTCTCCT ACAATAGTTC AGCAGTTTGG CTATCAGCGC 120
CGGGCATCAG ATGATGGCAA ACTCACAGAT CCTTCTAAGA CAAGCAATAC TATCCGTGTT 180
TTCTTGCCAA ACAAGCAAAG AACAGTGGTC AATGTACGAA ATGGAATGAG CTTGCATGAC 240
TGCCTTATGA AAGCACTCAA GGTGAGGGGC CTTCAACCAG AGTGCTGTGC AGTGTTCAGA 300
CTTCTCCATG AACACAAAGG TAAAAAAGCA CGCTTAGATT GGAATACTGA TGCTGCCTCT 360
TTGATTGGGG AAGAACTTCA AGTAGATTTC CTGGATCATG TTCCGCTCAC AACACACAAC 420
TTTGCTCGGA AGACGTTCCT GAAGCTTGCC TTCTGTGACA TCTGTCAGAA ATTCCTGCTC 480
AATGGATTTC GATGTCAGAC TTGTGGCTAC AAATTTCATG AGCACTGTAG CACCAAAGTA 540
CCTACTATGT GTGTGGACTG GAGTAATATC AGACAACTCT TATTGTTTCC AAATTCCACT 600
ATTGGTGATA GTGGAGTCCC AGCACTACCT TCTTTGACTA TGCGTCGTAT GCGAGAGTCT 660
GTTTCCAGGA TGCCTGTTAG TTCTCAGCAC AGGTATTCTA CACCTCACGC CTTCACCTTT 720
AACACCTCCA GTCCCTCATC TGAAGGTTCC CTTTCCCAGA GGCAGAGGTC GACGTCCACA 780
CCTAATGTCC ACATGGTCAG CACCACCCTG CCTGTGGACA GCAGGATGAT TGAGGATGCA 840
ATTCGAAGTC ACAGCGAATC AGCCTCACCT TCAGCCCTGT CCAGTAGCCC CAACAATCTG 900
AGCCCAACAG GCTGGTCACA GCCGAAAACA CCCGTGCCAG CACAAAGAGA GCGGGCACCA 960
GTATCTGGGA CCCAGGAGAA AAACAAAATT AGGCCTCGTG GACAGAGAGA TTCAAGCTAT 1020
TACTGGGAAA TAGAAGCCAG TGAAGTGATG CTGTCCACTC GGATTGGGTC AGGCTCTTTT 1080
GGAACTGTTT ATAAGGGCAA ATGGCACGGA GACGTTGCAG TAAAGATCCT AAAGGTTGTC 1140
GACCCAACCC CAGAGCAATT CCAGGCCTTC AGGAATGAGG TGGCTGTTCT GCGCAAAACA 1200
CGGCATGTGA ACATTCTGCT TTTCATGGGG TACATGACAA AGGACAACCT GGCAATTGTG 1260
ACCCAGTGGT GCGAGGGCAG CAGCCTCTAC AAACACCTGC ATGTCCAGGA GACCAAGTTT 1320
CAGATGTTCC AGCTAATTGA CATTGCCCGG CAGACGGCTC AGGGAATGGA CTATTTGCAT 1380
GCAAAGAACA TCATCCACAG AGACATGAAA TCCAACAATA TATTTCTCCA TGAAGGCCTA 1440
ACAGTGAAAA TTGGAGATTT TGGTTTGGCA ACAGTAAAGT CACGCTGGAG TGGTTCTCAG 1500
CAGGTTGAAC AACCTACTGG CTCTGTCCTG TGGATGGCCC CAGAGGTGAT CCGAATGCAG 1560
GATAACAACC CATTCAGTTT CCAGTCAGAT GTCTACTCCT ATGGCATCGT ATTGTATGAG 1620
CTGATGACGG GGGAACTTCC TTACTCTCAC ATCAACAACC GAGATCAGAT CATCTTCATG 1680
GTGGGCCGAG GGTATGCCTC CCCAGATCTT AGTAAGCTAT ATAAGAACTG CCCCAAAGCA 1740
ATGAAGAGGC TGGTAGCTGA CTGTGTGAAG AAAGTAAAGG AAGAGAGGCC TCTTTTTCCC 1800
CAGATCCTGT CTTCCATTGA GCTGCTCCAA CACTCTCTAC CGAAGATCAA CCGGAGCGCT 1860
TCCGAGCCAT CCTTGCATCG GGCAGCCCAC ACTGAGGATA TCAATGCTTG CACGCTGACC 1920
ACATCCCCGA GGCTGCCTGT CTTCTAG 1947
Domain Profile
S: 1     velaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLF  60
         v+l+++iGsG+fGtvy+gkwhGdvavk+l+v ++++eq++aF++eva+++ktRh+ni+LF
Q: 349   VMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLF  408
         57899*******************************************************
S: 61    mGyvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkD  120
         mGy++k++laivt++c+gssLyk+lh+qetk+++ +lidiarq+aqgmdYLhak+i+h+D
Q: 409   MGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRD  468
         ************************************************************
S: 121   lksknilleeglkvvitDFgllsvkrllsgrrekqleipkgwilylapeviralsidleq  180
         +ks+ni+l+egl+v+i+DFgl++vk+++sg  ++q+e+p+g++l++apevir+      q
Q: 469   MKSNNIFLHEGLTVKIGDFGLATVKSRWSG--SQQVEQPTGSVLWMAPEVIRM------Q  520
         ******************************..*********************......*
S: 181   delpfskesDvyafGivlyellarelpyke.esadqilfavgrG.lkpdlskvksklpke  238
         d++pfs++sDvy++Givlyel+++elpy++ +++dqi+f+vgrG ++pdlsk+++++pk+
Q: 521   DNNPFSFQSDVYSYGIVLYELMTGELPYSHiNNRDQIIFMVGRGyASPDLSKLYKNCPKA  580
         ************************************************************
S: 239   lkellleClkfekeeRPlftqilkkl  264
         +k+l+++C+k+ keeRPlf+qil+++
Q: 581   MKRLVADCVKKVKEERPLFPQILSSI  606
         **********************9875
Domain Sequence
(FASTA)
VMLSTRIGSG SFGTVYKGKW HGDVAVKILK VVDPTPEQFQ AFRNEVAVLR KTRHVNILLF 60
MGYMTKDNLA IVTQWCEGSS LYKHLHVQET KFQMFQLIDI ARQTAQGMDY LHAKNIIHRD 120
MKSNNIFLHE GLTVKIGDFG LATVKSRWSG SQQVEQPTGS VLWMAPEVIR MQDNNPFSFQ 180
SDVYSYGIVL YELMTGELPY SHINNRDQII FMVGRGYASP DLSKLYKNCP KAMKRLVADC 240
VKKVKEERPL FPQILSSI 258
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00047
EKS-ANC-00042
EKS-CAE-00039
EKS-CAJ-00050
EKS-CAF-00051
EKS-CAP-00051
EKS-CII-00019
EKS-CIS-00058
EKS-DAR-00066
EKS-DRM-00019
EKS-EQC-00049
EKS-FEC-00049
EKS-GAG-00042
EKS-GAA-00068
EKS-GOG-00050
EKS-HOS-00051
EKS-ICT-00048
EKS-LAC-00054
EKS-LOA-00050
EKS-MEG-00040
EKS-MOD-00049
EKS-MUM-00051
EKS-MUP-00053
EKS-MYL-00053
EKS-NOL-00049
EKS-OCP-00036
EKS-ORN-00070
EKS-ORA-00043
EKS-ORC-00047
EKS-ORL-00067
EKS-OTG-00054
EKS-PAT-00047
EKS-PES-00046
EKS-PEM-00028
EKS-POA-00048
EKS-PRC-00035
EKS-RAN-00050
EKS-SAH-00048
EKS-TAG-00047
EKS-TAR-00071
EKS-TEN-00074
EKS-VIP-00024
EKS-XET-00052
EKS-XIM-00068
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005057; F:receptor signaling protein activity
GO:0035556; P:intracellular signal transduction
KEGG
mcc:694725;
InterPros
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR003116; Raf-like_ras-bd.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF07714; Pkinase_Tyr; 1.
PF02196; RBD; 1.
SMARTs
SM00109; C1; 1.
SM00455; RBD; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50898; RBD; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013